Modified Gold Nanoparticles to Overcome the Chemoresistance to Gemcitabine in Mutant p53 Cancer Cells

Cancer therapeutic targeting using mutant–p53-specific siRNAs

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Autophagy induced by SAHA affects mutant P53 degradation and cancer cell survival

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Effect of the Protonation Level and Ionic Strength on the Structure of Linear Polyethyleneimine

(2019) Caleb E. Gallops et al.   ACS Omega

Mutant p53 drives cancer chemotherapy resistance due to loss of function on activating transcription of PUMA

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Gapmer antisense oligonucleotides containing 2’,3’‐dideoxy‐2’‐fluoro‐3’‐C‐hydroxymethyl‐β‐D‐lyxofuranosyl nucleotides display site‐specific RNase H cleavage and induce gene silencing.

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CHIP promotes autophagy-mediated degradation of aggregating mutant p53 in hypoxic conditions

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Andrographolide induces degradation of mutant p53 via activation of Hsp70

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Investigating the influence of polyplex size on toxicity properties of polyethylenimine mediated gene delivery

(2018) Reza Kazemi Oskuee et al.   LIFE SCIENCES

mTOR mediates a mechanism of resistance to chemotherapy and defines a rational combination strategy to treat KRAS-mutant lung cancer

(2018) Shun-Qing Liang et al.   ONCOGENE

Chemical Modification Study of Antisense Gapmers

(2018) Robert Stanton et al.   Nucleic Acid Therapeutics

Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2ˉ· production in cancer cells

(2018) Marco Cordani et al.   BRITISH JOURNAL OF CANCER

Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy

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The structure and binding mode of citrate in the stabilization of gold nanoparticles

(2017) Hind Al-Johani et al.   Nature Chemistry

Quantification of nucleobases/gold nanoparticles interactions: energetics of the interactions through apparent binding constants determination

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Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma

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Pancreatic Cancer Chemoresistance to Gemcitabine

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Size matters for in vitro gene delivery: investigating the relationships among complexation protocol, transfection medium, size and sedimentation

(2017) Daniele Pezzoli et al.   Scientific Reports

Mutant p53 stimulates cell invasion through an interaction with Rad21 in human ovarian cancer cells

(2017) Ji-Hye Ahn et al.   Scientific Reports

Interrogating the Role of Receptor-Mediated Mechanisms: Biological Fate of Peptide-Functionalized Radiolabeled Gold Nanoparticles in Tumor Mice

(2016) Francisco Silva et al.   BIOCONJUGATE CHEMISTRY

Mutant p53 proteins alter cancer cell secretome and tumour microenvironment: Involvement in cancer invasion and metastasis

(2016) Marco Cordani et al.   CANCER LETTERS

Mutant p53 Gain of Function and Chemoresistance: The Role of Mutant p53 in Response to Clinical Chemotherapy

(2016) Chao He et al.   CHEMOTHERAPY

Roadmap to Clinical Use of Gold Nanoparticles for Radiation Sensitization

(2016) Jan Schuemann et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

(2016) Marco Cordani et al.   Molecular Oncology

Nanomedicine strategies to overcome the pathophysiological barriers of pancreatic cancer

(2016) Pavan P. Adiseshaiah et al.   Nature Reviews Clinical Oncology

Src Inhibition Can Synergize with Gemcitabine and Reverse Resistance in Triple Negative Breast Cancer Cells via the AKT/c-Jun Pathway

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Improvement of gemcitabine sensitivity of p53-mutated pancreatic cancer MiaPaCa-2 cells by RUNX2 depletion-mediated augmentation of TAp73-dependent cell death

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Unusual Salt and pH Induced Changes in Polyethylenimine Solutions

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Plasmonic Nanobiosensor Based on Hairpin DNA for Detection of Trace Oligonucleotides Biomarker in Cancers

(2015) Yanling Hu et al.   ACS Applied Materials & Interfaces

Turkevich in New Robes: Key Questions Answered for the Most Common Gold Nanoparticle Synthesis

(2015) Maria Wuithschick et al.   ACS Nano

Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine

(2015) Claudia Fiorini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53

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Comparative evaluation and optimization of off-the-shelf cationic polymers for gene delivery purposes

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Mutant p53 confers chemoresistance in non-small cell lung cancer by upregulating Nrf2

(2015) Min-Che Tung et al.   Oncotarget

Metformin Increases Sensitivity of Pancreatic Cancer Cells to Gemcitabine by Reducing CD133+ Cell Populations and Suppressing ERK/P70S6K Signaling

(2015) Xinqun Chai et al.   Scientific Reports

Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression

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Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation

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The p53-Reactivating Small Molecule RITA Induces Senescence in Head and Neck Cancer Cells

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Gemcitabine resistance in breast cancer cells regulated by PI3K/AKT-mediated cellular proliferation exerts negative feedback via the MEK/MAPK and mTOR pathways

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New Gold Nanostructures for Sensor Applications: A Review

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Chaperone-mediated autophagy degrades mutant p53

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Recent advances in delivery of drug–nucleic acid combinations for cancer treatment

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Antisense Oligonucleotides: Treating Neurodegeneration at the Level of RNA

(2013) Sarah L. DeVos et al.   Neurotherapeutics

The Chemistry of the Sulfur–Gold Interface: In Search of a Unified Model

(2012) Evangelina Pensa et al.   ACCOUNTS OF CHEMICAL RESEARCH

Glutathione levels in human tumors

(2012) Michael P. Gamcsik et al.   BIOMARKERS

Instantaneous and Quantitative Functionalization of Gold Nanoparticles with Thiolated DNA Using a pH-Assisted and Surfactant-Free Route

(2012) Xu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cost-effective gene transfection by DNA compaction at pH 4.0 using acidified, long shelf-life polyethylenimine

(2010) Yasunori Fukumoto et al.   CYTOTECHNOLOGY

Ultrasmall near-infrared gold nanoclusters for tumor fluorescence imaging in vivo

(2010) Xu Wu et al.   Nanoscale

Tuning payload delivery in tumour cylindroids using gold nanoparticles

(2010) Byoungjin Kim et al.   Nature Nanotechnology

Nano-flares for mRNA Regulation and Detection

(2009) Andrew E. Prigodich et al.   ACS Nano

Delivery of Nucleic Acids via Disulfide-Based Carrier Systems

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PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

Gold nanoparticles in delivery applications☆

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Bcl-2 family proteins and cancer

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