Article
Medicine, General & Internal
Si Chen, Nan Wang, Siqi Xiong, Xiaobo Xia
Summary: This bioinformatic study identifies NFKB1, IL18, KITLG, TLR9, FKBP2, and HDAC4 as key genes for POAG and GM regulation. Immune response modulated by macrophages plays an important role in POAG and may be potential targets for future predictive, preventive, and personalized diagnosis and treatment.
Article
Pharmacology & Pharmacy
Youzhen Wei, Kun Wang, Yafang Zhang, Yi Duan, Yan Tian, Hongling Yin, Xuelian Fu, Zuan Ma, Jianjun Zhou, Min Yu, Qingbin Ni, Wenjie Tang
Summary: It has been proven that hydrogen has significant anti-inflammatory effects. However, the early dynamic process of the inflammatory response caused by lipopolysaccharide (LPS) and the anti-inflammatory effect of hydrogen has not been definitively reported.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Marek Samec, Alena Liskova, Lenka Koklesova, Kevin Zhai, Elizabeth Varghese, Samson Mathews Samuel, Miroslava Sudomova, Vincent Lucansky, Monika Kassayova, Martin Pec, Kamil Biringer, Aranka Brockmueller, Karol Kajo, Sherif T. S. Hassan, Mehdi Shakibaei, Olga Golubnitschaja, Dietrich Busselberg, Peter Kubatka
Summary: Metabolic reprogramming is crucial for cancer development, and melatonin plays a significant role in inhibiting tumorigenesis and metastasis by regulating key enzymes and glucose transporters, among other pathways. Melatonin also modulates critical metabolic processes and signaling cascades, highlighting its potential as an innovative approach for cancer prevention and therapy.
Review
Biochemistry & Molecular Biology
Stefan Rose-John
Summary: Interleukin-6 is an inflammatory cytokine whose level is elevated in inflammatory states, triggering cell-specific responses. The activation of gp130 in hepatocytes produces both liver-specific and systemic effects.
Review
Immunology
Lanxuan Wei, David Abraham, Voon Ong
Summary: IL-17 is a pro-inflammatory cytokine that plays an important role in host defense. It activates transcription and stabilizes mRNAs through multiple pathways, mainly acting on stromal cells to promote the secretion of other immunomodulatory factors and support the growth and differentiation of immune cells. IL-17 has a dual role in immune reactions and inflammatory diseases, and it also plays a significant role in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Kim Jun Cheng, Elsa Haniffah Mejia Mohammed, Tak Loon Khong, Shamsul Mohd Zain, Surendran Thavagnanam, Zaridatul Aini Ibrahim
Summary: IL-1 alpha plays a crucial role in the pathogenesis of colorectal cancer, promoting various mechanisms of disease progression. This systematic review highlights the potential therapeutic strategies targeting IL-1 alpha and associated pathways to find effective treatments for CRC patients.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Yunfei He, Wenqian Luo, Yingjie Liu, Yuan Wang, Chengxin Ma, Qiuyao Wu, Pu Tian, Dasa He, Zhenchang Jia, Xianzhe Lv, Yu-Shui Ma, Haitang Yang, Ke Xu, Xue Zhang, Yansen Xiao, Peiyuan Zhang, Yajun Liang, Da Fu, Feng Yao, Guohong Hu
Summary: This study revealed the role of IL-20RB in promoting bone metastasis of lung cancer. IL-20RB facilitated the growth of lung cancer cells in the bone by activating JAK1/STAT3 signaling. Blocking IL-20RB significantly suppressed the bone metastasis of lung cancer.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Tomoko Tashiro, Yu Sawada
Summary: Psoriasis is not only a skin disease but can also cause systemic inflammatory diseases. Clinical and experimental studies have shown that there is an important interaction between psoriasis and systemic inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
M. L. Cuellar-Nunez, E. Gonzalez de Mejia, G. Loarca-Pina
Summary: Moringa oleifera leaves have shown chemopreventive properties against inflammatory response and colon carcinogenesis by modulating gene expression and reducing proinflammatory mediators.
FOOD RESEARCH INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Sakshi Taneja, Stefan W. Vetter, Estelle Leclerc
Summary: Hypoxia, characterized by inadequate oxygen supply to tissues, is common in solid tumors. Cellular response to hypoxic conditions is mediated by activating HIFs, which control the expression of many target genes. Recent studies suggest that RAGE signaling plays a crucial role in tumor biology under hypoxic conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Ying Zhang, Qinghui Zhuang, Fang Wang, Can Zhang, Chang Xu, Aiqin Gu, William H. Zhong, Yi Hu, Xiaosong Zhong
Summary: In this study, we successfully constructed CD19 specific armored CAR-T cells overexpressing IL-15 and IL-15 receptor alpha (IL-15Ra). CAR-T cells overexpressing IL-15 alone showed enhanced viability and superior tumor-inhibitory effects, but also resulted in serious liver injuries in tumor-free mice. However, CAR-T cells overexpressing IL-15 combined with IL-15Ra had reduced adverse effects and improved mouse survival.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Zhilan Xiao, Shubhra Singh, Manisha Singh
Summary: IL-1 in tumors can induce immune suppression and resistance to immunotherapy, thus targeting the IL-1 pathway may enhance the efficacy of immunotherapy.
Article
Dermatology
Xiuju Dai, Ryo Utsunomiya, Ken Shiraishi, Hideki Mori, Jun Muto, Masamoto Murakami, Koji Sayama
Summary: IL-33 is highly expressed in atopic dermatitis (AD) lesions, potentially participating in the pathogenesis of AD by inhibiting keratinocyte differentiation and skin barrier function.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Immunology
Attila Szabo, Kevin S. O'Connell, Thor Ueland, Mashhood A. Sheikh, Ingrid Agartz, Dimitrios Andreou, Pal Aukrust, Birgitte Boye, Erlend Boen, Ole Kristian Drange, Torbjorn Elvsashagen, John Abel Engh, Sigrun Hope, Margrethe Collier Hoegh, Inge Joa, Erik Johnsen, Rune Andreas Kroken, Trine Vik Lagerberg, Tove Lekva, Ulrik Fredrik Malt, Ingrid Melle, Gunnar Morken, Terje Naerland, Vidar Martin Steen, Kjetil Sorensen, Kirsten Wedervang-Resell, Melissa Auten Weibell, Lars T. Westlye, Nils Eiel Steen, Ole Andreassen, Srdjan Djurovic
Summary: Patients with severe mental illnesses often have dysregulated immune responses, and dyslipidemia linked to systemic inflammasome activation plays a crucial role, yet specific immune mechanisms remain unknown in these disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Immunology
Ewa Oleszycka, Eoin C. OBrien, Michael Freeley, Ed C. Lavelle, Aideen Long
Summary: Bile acids, synthesized from cholesterol, play a role in promoting intestinal absorption and have been associated with inflammatory diseases. This study demonstrates that bile acids can induce the secretion of pro-inflammatory cytokines and the recruitment of innate immune cells, suggesting their mechanistic role in inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Aranka Brockmueller, Negin Mahmoudi, Amir Kian Movaeni, Anna-Lena Mueller, Abdol-Mohammad Kajbafzadeh, Mehdi Shakibaei, Masoumeh Majidi Zolbin
Summary: Neurodegenerative diseases are a group of neurological disorders caused by various destructive illnesses, affecting neurons in the central nervous system and resulting in impaired brain functions. The combination of stem cells and natural products offers a new perspective for the treatment of these diseases.
NEUROCHEMICAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Amir Reza Moravejolahkami, Mehdi Shakibaei, Andrea Mary Fairley, Manoj Sharma
Summary: Dysbiosis in the gut has been linked to T1DM, and this review analyzed the effects of probiotics, prebiotics, and synbiotics on T1DM patients. After evaluating 258 entries, five trials were included, showing that probiotic supplementation decreased fasting blood glucose but had no significant effect on HbA1c, C-peptide, and insulin requirements. Probiotics may serve as a complementary therapeutic strategy for T1DM, but more trials are needed.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Aranka Brockmueller, Sosmitha Girisa, Ajaikumar B. B. Kunnumakkara, Mehdi Shakibaei
Summary: Resveratrol can enhance the sensitivity of colorectal cancer cells to 5-FU by regulating the beta 1-integrin/HIF-1α signaling axis, leading to suppression of cancer cell growth and invasion, inhibition of inflammation and cancer stem cell production. These findings highlight the potential application of resveratrol in the treatment of colorectal cancer by overcoming chemoresistance to 5-FU.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Aranka Brockmueller, Samson Mathews Samuel, Alena Mazurakova, Dietrich Busselberg, Peter Kubatka, Mehdi Shakibaei
Summary: Colorectal cancer (CRC) is a major global malignant disease often resistant to chemotherapy drugs. Two polyphenolic turmeric ingredients, calebin A and curcumin, show anti-inflammatory and anticancer effects, including the ability to sensitize CRC cells to chemotherapy drugs. They modulate inflammation, proliferation, cell cycle, cancer stem cells, and apoptotic signaling to convert chemoresistant CRC cells into non-chemoresistant cells. Further studies and clinical trials are needed to test their effectiveness in overcoming cancer chemoresistance.
Review
Pharmacology & Pharmacy
Alena Mazurakova, Lenka Koklesova, Desanka Vybohova, Marek Samec, Erik Kudela, Kamil Biringer, Miroslava Sudomova, Sherif T. S. Hassan, Martin Kello, Dietrich Busselberg, Olga Golubnitschaja, Peter Kubatka
Summary: The limitation of reactive medical approach in breast cancer management is evident from the worldwide statistics. Breast malignancies have become the most common cancer type, with an increasing number of aggressive cases in premenopausal women. Stem cells play a crucial role in tumor biology, metastasis, and therapy resistance in aggressive breast cancer. Targeting breast cancer stem cells using naturally occurring substances shows promise in cost-effective management. Flavonoids are highlighted as potential agents for targeting breast cancer stem cells and overcoming therapy resistance.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Degiri Kalana Lasanga Senevirathne, Anns Mahboob, Kevin Zhai, Pradipta Paul, Alexandra Kammen, Darrin Jason Lee, Mohammad S. Yousef, Ali Chaari
Summary: Deep brain stimulation (DBS) is a potential treatment for neurodegenerative disorders like Parkinson's disease (PD) and Alzheimer's disease (AD), but its effectiveness in AD is still under research, unlike its approved use in PD. Further studies are needed to determine optimal parameters and address potential side effects of DBS. This review emphasizes the importance of foundational and clinical research on DBS in different brain regions for treating AD, as well as the development of a classification system for adverse effects. Furthermore, it suggests using either a low-frequency system (LFS) or high-frequency system (HFS) based on specific patient symptoms for both PD and AD.
Article
Engineering, Chemical
Kevin Zhai, Mohammad S. Yousef, Sawsan Mohammed, Nader I. Al-Dewik, M. Walid Qoronfleh
Summary: Precision medicine, with precision prescribing as a core component, is becoming a new frontier in healthcare. Artificial intelligence and machine learning have the potential to enhance data understanding and improve patient diagnosis and treatment. By leveraging these technologies, we can uncover genomic associations, identify disease biomarkers, fine-tune patient selection, reduce costs, and accelerate drug discovery. Integration of precision medicine into healthcare is critical, despite challenges in real-world data.
Review
Oncology
Peter Kubatka, Lenka Koklesova, Alena Mazurakova, Aranka Brockmueller, Dietrich Busselberg, Martin Kello, Mehdi Shakibaei
Summary: Cancer cell plasticity plays a crucial role in tumor initiation, progression, and metastasis. Flavonoids, as phytochemicals, act as significant regulators of the NF-kappa B signaling pathway, mitigating cancer resistance.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Oncology
Aranka Brockmueller, Anjana Sajeev, Lenka Koklesova, Samson Mathews Samuel, Peter Kubatka, Dietrich Busselberg, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei
Summary: Despite medical treatment successes, colorectal cancer (CRC) remains a leading cause of cancer deaths worldwide. Chemotherapy can lead to side effects and drug resistance, highlighting the need for natural compounds that can sensitize cancer cells to overcome resistance. Resveratrol, a natural polyphenolic compound, has been shown to enhance the effectiveness of chemotherapy by modulating multiple pathways in CRC cells.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Oncology
Evan K. Noch, Laura N. Palma, Isaiah Yim, Nayah Bullen, Yuqing Qiu, Hiranmayi Ravichandran, Junbum Kim, Andre Rendeiro, Melissa B. Davis, Olivier Elemento, David J. Pisapia, Kevin Zhai, Hongbiao Carl LeKaye, Jason A. Koutcher, Patrick Y. Wen, Keith L. Ligon, Lewis C. Cantley
Summary: This study investigated the critical role of insulin feedback in the poor clinical efficacy of phosphatidylinositol 3-kinase (PI3K) inhibition in cancer and the independent association between hyperglycemia and poor prognosis in glioblastoma (GBM). It was found that combining anti-hyperglycemic therapy with PI3K inhibition improved treatment efficacy in a GBM mouse model. Analysis of clinical trial data revealed that hyperglycemia was independently associated with poor progression-free survival in GBM patients.
Review
Oncology
Raghad Sabaawi Ibrahim, Shahad Sabaawi Ibrahim, Ahmed El-Naas, Lenka Koklesova, Peter Kubatka, Dietrich Buesselberg
Summary: This review examines how the antidiabetic drug metformin and dietary supplement resveratrol can complement current treatment methods for glioblastoma. Metformin and resveratrol exert anticancer effects on major metabolic pathways, resulting in reduced proliferation and increased apoptosis. So far, there is a lack of clinical studies, warranting further investigations.
Article
Health Care Sciences & Services
Kevin Zhai
Summary: With the increasing use of semiconductor devices in healthcare, the health sector has become highly dependent on the semiconductor industry. However, even slight turbulence in the industry can disrupt patient care. Stakeholder collaboration is necessary to ensure an adequate supply of semiconductor-powered medical devices.
FRONTIERS IN HEALTH SERVICES
(2023)