Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2

Compartmentalized acyl-CoA metabolism and roles in chromatin regulation

(2020) Sophie Trefely et al.   Molecular Metabolism

Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer

(2020) Kezhi Yan et al.   Science Advances

Chromatin as a key consumer in the metabolite economy

(2020) Katharine L. Diehl et al.   Nature Chemical Biology

Non-enzymatic covalent modifications: a new link between metabolism and epigenetics

(2020) Qingfei Zheng et al.   Protein & Cell

Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics

(2019) Kelsey H. Fisher-Wellman et al.   Cell Reports

Early‐onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1)

(2019) Prabakaran Nagarajan et al.   AGING CELL

HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding

(2019) Joshua J. Gruber et al.   MOLECULAR CELL

Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription

(2019) Leonie Kollenstart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis

(2018) He Huang et al.   MOLECULAR CELL

Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation

(2018) Sharanya Sivanand et al.   TRENDS IN BIOCHEMICAL SCIENCES

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

(2018) Rachel Fellows et al.   Nature Communications

Supramolecular assembly of KAT2A with succinyl-CoA for histone succinylation

(2018) Yugang Wang et al.   Cell Discovery

Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis

(2017) Shumeng Liu et al.   MOLECULAR CELL

KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase

(2017) Yugang Wang et al.   NATURE

AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1

(2017) Traci L. Marin et al.   Science Signaling

AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1

(2017) Traci L. Marin et al.   Science Signaling

MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase-deficient and crotonyltransferase-competent CBP/p300

(2017) Xiaoguang Liu et al.   Cell Discovery

The Substrate Specificity of Sirtuins

(2016) Poonam Bheda et al.   Annual Review of Biochemistry

YEATS2 is a selective histone crotonylation reader

(2016) Dan Zhao et al.   CELL RESEARCH

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters

(2016) Afsaneh Goudarzi et al.   MOLECULAR CELL

Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain

(2016) Yuanyuan Li et al.   MOLECULAR CELL

Structure of p300 in complex with acyl-CoA variants

(2016) Zuzanna Kaczmarska et al.   Nature Chemical Biology

Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2

(2016) Xiaozhe Xiong et al.   Nature Chemical Biology

The Taf14 YEATS domain is a reader of histone crotonylation

(2016) Forest H Andrews et al.   Nature Chemical Biology

Metabolic regulation of gene expression through histone acylations

(2016) Benjamin R. Sabari et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain

(2016) Qiang Zhang et al.   STRUCTURE

Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation

(2015) Gozde Colak et al.   MOLECULAR & CELLULAR PROTEOMICS

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

(2015) Benjamin R. Sabari et al.   MOLECULAR CELL

ECHS1 mutations in Leigh disease: a new inborn error of metabolism affecting valine metabolism

(2014) Heidi Peters et al.   BRAIN

SnapShot: Histone Modifications

(2014) He Huang et al.   CELL

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism

(2014) Olga Pougovkina et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach

(2014) Xiucong Bao et al.   eLife

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Lysine Modification by an Intrinsically Reactive Primary Glycolytic Metabolite

(2013) R. E. Moellering et al.   SCIENCE

A Role for SIRT2-Dependent Histone H3K18 Deacetylation in Bacterial Infection

(2013) H. A. Eskandarian et al.   SCIENCE

Histone Acetyl Transferase 1 Is Essential for Mammalian Development, Genome Stability, and the Processing of Newly Synthesized Histones H3 and H4

(2013) Prabakaran Nagarajan et al.   PLoS Genetics

Protein Lysine Acylation and Cysteine Succination by Intermediates of Energy Metabolism

(2012) Hening Lin et al.   ACS Chemical Biology

Lysine Succinylation and Lysine Malonylation in Histones

(2012) Zhongyu Xie et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1

(2012) H. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

Analysis of protein dynamics at active, stalled, and collapsed replication forks

(2011) B. M. Sirbu et al.   GENES & DEVELOPMENT

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

(2011) Chao Peng et al.   MOLECULAR & CELLULAR PROTEOMICS

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE