Two-Pore-Domain Potassium (K2P-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes
出版年份 2021 全文链接
标题
Two-Pore-Domain Potassium (K2P-) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes
作者
关键词
-
出版物
Cells
Volume 10, Issue 11, Pages 2914
出版商
MDPI AG
发表日期
2021-10-28
DOI
10.3390/cells10112914
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Kcnk3 Dysfunction Exaggerates The Development Of Pulmonary Hypertension Induced By Left Ventricular Pressure Overload
- (2021) Mélanie Lambert et al. CARDIOVASCULAR RESEARCH
- The Experimental TASK-1 Potassium Channel Inhibitor A293 Can Be Employed for Rhythm Control of Persistent Atrial Fibrillation in a Translational Large Animal Model
- (2021) Felix Wiedmann et al. Frontiers in Physiology
- Current Drug Treatment Strategies for Atrial Fibrillation and TASK-1 Inhibition as an Emerging Novel Therapy Option
- (2021) Manuel Kraft et al. Frontiers in Pharmacology
- KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models
- (2021) James D. West et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Small Conductance Ca2 +-Activated K+ (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and Heart Failure Tissue
- (2021) Elisa Darkow et al. Frontiers in Physiology
- Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy
- (2021) Felix Wiedmann et al. CARDIOVASCULAR RESEARCH
- A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young
- (2021) Sarah M. Graff et al. JCI Insight
- TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction
- (2020) Wei Duan et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- A lower X-gate in TASK channels traps inhibitors within the vestibule
- (2020) Karin E. J. Rödström et al. NATURE
- Pharmacologic TWIK‐Related Acid‐Sensitive K+ Channel (TASK‐1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model
- (2020) Felix Wiedmann et al. Journal of the American Heart Association
- Mechanosensitive TREK-1 two-pore-domain potassium (K2P) channels in the cardiovascular system
- (2020) Felix Wiedmann et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- TASK‐1 channel blockade by AVE1231 increases vasocontractile responses and BP in 1‐ to 2‐week‐old but not adult rats
- (2020) Anastasia A. Shvetsova et al. BRITISH JOURNAL OF PHARMACOLOGY
- Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine
- (2019) David Ramírez et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Atria-selective antiarrhythmic drugs in need of alliance partners
- (2019) Rémi Peyronnet et al. PHARMACOLOGICAL RESEARCH
- Characterization of Kcnk3 -Mutated Rat, a Novel Model of Pulmonary Hypertension
- (2019) Mélanie Lambert et al. CIRCULATION RESEARCH
- Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2
- (2019) Paul D. Wright et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Genetic Ablation of TASK-1 (Tandem of P Domains in a Weak Inward Rectifying K + Channel–Related Acid-Sensitive K + Channel-1) (K 2P 3.1) K + Channels Suppresses Atrial Fibrillation and Prevents Electrical Remodeling
- (2019) Constanze Schmidt et al. Circulation-Arrhythmia and Electrophysiology
- N-Glycosylation of TREK-1/hK2P2.1 Two-Pore-Domain Potassium (K2P) Channels
- (2019) Felix Wiedmann et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Antiarrhythmic Properties of Ranolazine: Inhibition of Atrial Fibrillation Associated TASK-1 Potassium Channels
- (2019) Antonius Ratte et al. Frontiers in Pharmacology
- Atrial fibrillation and heart failure-associated remodeling of two-pore-domain potassium (K2P) channels in murine disease models: focus on TASK-1
- (2018) Felix Wiedmann et al. BASIC RESEARCH IN CARDIOLOGY
- Identification and functional characterization of zebrafish K 2P 17.1 (TASK-4, TALK-2) two-pore-domain K + channels
- (2018) Ingo Staudacher et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Verapamil Inhibits TRESK (K2P18.1) Current in Trigeminal Ganglion Neurons Independently of the Blockade of Ca2+ Influx
- (2018) Hyun Park et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity
- (2018) Sam Chai et al. JOURNAL OF CLINICAL INVESTIGATION
- New Targets for Old Drugs: Cardiac Glycosides Inhibit Atrial-Specific K2P3.1 (TASK-1) Channels
- (2018) Constanze Schmidt et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Cardiovascular pharmacology of K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels
- (2018) Ingo Staudacher et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Cardiac K 2P 13.1 (THIK-1) two-pore-domain K + channels: Pharmacological regulation and remodeling in atrial fibrillation
- (2018) Ingo Staudacher et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels
- (2018) Lianne Pope et al. ACS Chemical Neuroscience
- Antidepressive and anxiolytic effects of ostruthin, a TREK-1 channel activator
- (2018) Ancy Joseph et al. PLoS One
- The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto-Kakizaki Type 2 Diabetic Rat Heart
- (2018) F. C. Howarth et al. Journal of Diabetes Research
- The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction
- (2018) Dennis M. Abraham et al. JOURNAL OF CLINICAL INVESTIGATION
- Cloning and characterization of zebrafish K2P13.1 (THIK-1) two-pore-domain K+ channels
- (2018) Ingo Staudacher et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Inverse remodelling of K2P3.1 K+channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy
- (2017) Constanze Schmidt et al. EUROPEAN HEART JOURNAL
- Activation of TREK-1, but Not TREK-2, Channel by Mood Stabilizers
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- K2P2.1 (TREK-1)–activator complexes reveal a cryptic selectivity filter binding site
- (2017) Marco Lolicato et al. NATURE
- Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants
- (2017) Bendik S. Winsvold et al. PLoS One
- Stretch-activated two-pore-domain (K 2P ) potassium channels in the heart: Focus on atrial fibrillation and heart failure
- (2017) Constanze Schmidt et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Stretch-activated potassium currents in the heart: Focus on TREK-1 and arrhythmias
- (2017) Niels Decher et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Heterodimerization of two pore domain K+ channel TASK1 and TALK2 in living heterologous expression systems
- (2017) Yoshiaki Suzuki et al. PLoS One
- Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels
- (2017) Nicole Bobak et al. Scientific Reports
- Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx
- (2016) Prasanna K. Dadi et al. ACS Chemical Neuroscience
- TREK-1 (K2P2.1) K+ channels are suppressed in patients with atrial fibrillation and heart failure and provide therapeutic targets for rhythm control
- (2016) Patrick Lugenbiel et al. BASIC RESEARCH IN CARDIOLOGY
- A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels
- (2016) Marcus Schewe et al. CELL
- Cardiac Mechano-Gated Ion Channels and Arrhythmias
- (2016) Rémi Peyronnet et al. CIRCULATION RESEARCH
- KCNK3 Variants Are Associated With Hyperaldosteronism and HypertensionNovelty and Significance
- (2016) Ani Manichaikul et al. HYPERTENSION
- The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size
- (2016) Alex Hørby Christensen et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts
- (2016) Mark A. Skarsfeldt et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels
- (2016) Joshua Levitz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mixing and matching TREK/TRAAK subunits generate heterodimeric K2Pchannels with unique properties
- (2016) Sandy Blin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Two‐Pore K+Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability
- (2016) Sathya D. Unudurthi et al. Journal of the American Heart Association
- Differential sensitivity of TREK-1, TREK-2 and TRAAK background potassium channels to the polycationic dye ruthenium red
- (2015) G Braun et al. BRITISH JOURNAL OF PHARMACOLOGY
- Upregulation of K2P3.1 K+Current Causes Action Potential Shortening in Patients With Chronic Atrial FibrillationCLINICAL PERSPECTIVE
- (2015) Constanze Schmidt et al. CIRCULATION
- POPDC1S201F causes muscular dystrophy and arrhythmia by affecting protein trafficking
- (2015) Roland F.R. Schindler et al. JOURNAL OF CLINICAL INVESTIGATION
- TASK-1 and TASK-3 may form heterodimers in human atrial cardiomyocytes
- (2015) Susanne Rinné et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- The family of K2Pchannels: salient structural and functional properties
- (2015) Sylvain Feliciangeli et al. JOURNAL OF PHYSIOLOGY-LONDON
- Vernakalant activates human cardiac K2P17.1 background K+ channels
- (2014) Claudia Seyler et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Modulation of K2P2.1 and K2P10.1 K+channel sensitivity to carvedilol by alternative mRNA translation initiation
- (2014) J Kisselbach et al. BRITISH JOURNAL OF PHARMACOLOGY
- βIV-Spectrin regulates TREK-1 membrane targeting in the heart
- (2014) Thomas J. Hund et al. CARDIOVASCULAR RESEARCH
- Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder
- (2014) C. Friedrich et al. EMBO Molecular Medicine
- Identification of novel small molecule modulators of K2P18.1 two-pore potassium channel
- (2014) J. Kyle Bruner et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Inhibition of cardiac two-pore-domain K+ (K2P) channels by the antiarrhythmic drug vernakalant – Comparison with flecainide
- (2014) Claudia Seyler et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Cloning, functional characterization, and remodeling of K2P3.1 (TASK-1) potassium channels in a porcine model of atrial fibrillation and heart failure
- (2014) Constanze Schmidt et al. HEART RHYTHM
- TWIK-2 Channel Deficiency Leads to Pulmonary Hypertension Through a Rho-Kinase–Mediated Process
- (2014) Lavannya M. Pandit et al. HYPERTENSION
- Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis
- (2014) Bo Liang et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?
- (2014) Aytug K. Kiper et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Properties, regulation, pharmacology, and functions of the K2P channel, TRESK
- (2014) Péter Enyedi et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Over-Expression of TRESK K+ Channels Reduces the Excitability of Trigeminal Ganglion Nociceptors
- (2014) Zhaohua Guo et al. PLoS One
- A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes
- (2014) Eun Mi Hwang et al. Nature Communications
- A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels
- (2013) Sviatoslav N. Bagriantsev et al. ACS Chemical Biology
- Endothelium-dependent relaxations in the aorta from K2p6.1 knockout mice
- (2013) Eric E. Lloyd et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- TASK-1 (KCNK3) and TASK-3 (KCNK9) Tandem Pore Potassium Channel Antagonists Stimulate Breathing in Isoflurane-Anesthetized Rats
- (2013) Joseph F. Cotten ANESTHESIA AND ANALGESIA
- Cloxyquin (5-chloroquinolin-8-ol) is an activator of the two-pore domain potassium channel TRESK
- (2013) Paul D. Wright et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Class I antiarrhythmic drugs inhibit human cardiac two-pore-domain K+ (K2P) channels
- (2013) Constanze Schmidt et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- The inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on K2P (two-pore domain potassium) channel TREK-1
- (2013) Hye Won Shin et al. Journal of Anesthesia
- Silencing of the Tandem Pore Domain Halothane-inhibited K+Channel 2 (THIK2) Relies on Combined Intracellular Retention and Low Intrinsic Activity at the Plasma Membrane
- (2013) Franck C. Chatelain et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cardiac expression and atrial fibrillation-associated remodeling of K2P2.1 (TREK-1) K+ channels in a porcine model
- (2013) Constanze Schmidt et al. LIFE SCIENCES
- Novel electrophysiological properties of dronedarone: inhibition of human cardiac two-pore-domain potassium (K2P) channels
- (2013) Constanze Schmidt et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Functional characterization of zebrafish K2P18.1 (TRESK) two-pore-domain K+ channels
- (2013) Ann-Kathrin Rahm et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- A Novel Channelopathy in Pulmonary Arterial Hypertension
- (2013) Lijiang Ma et al. NEW ENGLAND JOURNAL OF MEDICINE
- A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels
- (2013) Susanne Rinné et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2
- (2013) Vijay Renigunta et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Popeye domain-containing proteins and stress-mediated modulation of cardiac pacemaking
- (2013) Subreena Simrick et al. TRENDS IN CARDIOVASCULAR MEDICINE
- Activation of TREK-1 by morphine results in analgesia without adverse side effects
- (2013) Maïly Devilliers et al. Nature Communications
- The inhibitor of volume-regulated anion channels DCPIB activates TREK potassium channels in cultured astrocytes
- (2012) L Minieri et al. BRITISH JOURNAL OF PHARMACOLOGY
- The Popeye domain containing 2 (popdc2) gene in zebrafish is required for heart and skeletal muscle development
- (2012) Bettina C. Kirchmaier et al. DEVELOPMENTAL BIOLOGY
- Ability to Induce Atrial Fibrillation in the Peri-operative Period Is Associated with Phosphorylation-dependent Inhibition of TWIK Protein-related Acid-sensitive Potassium Channel 1 (TASK-1)
- (2012) Erin Harleton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An Increased TREK-1–like Potassium Current in Ventricular Myocytes During Rat Cardiac Hypertrophy
- (2012) Weiping Wang et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice
- (2012) Alexander Froese et al. JOURNAL OF CLINICAL INVESTIGATION
- Deletion of TRAAK Potassium Channel Affects Brain Metabolism and Protects against Ischemia
- (2012) Christophe Laigle et al. PLoS One
- SUMOylation Silences Heterodimeric TASK Potassium Channels Containing K2P1 Subunits in Cerebellar Granule Neurons
- (2012) L. D. Plant et al. Science Signaling
- Behavioral characterization of mice lacking Trek channels
- (2012) Kelsey Mirkovic et al. Frontiers in Behavioral Neuroscience
- The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4
- (2011) Chilman Bae et al. BIOCHEMISTRY
- Carvedilol targets human K2P3.1 (TASK1) K+leak channels
- (2011) K Staudacher et al. BRITISH JOURNAL OF PHARMACOLOGY
- TASK-1 Channels May Modulate Action Potential Duration of Human Atrial Cardiomyocytes
- (2011) Sven H. Limberg et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Knock-Out of the Potassium Channel TASK-1 Leads to a Prolonged QT Interval and a Disturbed QRS Complex
- (2011) Niels Decher et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Disruption of K 2P 6.1 Produces Vascular Dysfunction and Hypertension in Mice
- (2011) Eric E. Lloyd et al. HYPERTENSION
- A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the TASK-1 Open Pore
- (2011) Anne K. Streit et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TREK-1 isoforms generated by alternative translation initiation display different susceptibility to the antidepressant fluoxetine
- (2011) Michaela Eckert et al. NEUROPHARMACOLOGY
- TWIK-1 Two-Pore Domain Potassium Channels Change Ion Selectivity and Conduct Inward Leak Sodium Currents in Hypokalemia
- (2011) L. Ma et al. Science Signaling
- Functional role of TASK-1 in the heart: studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability
- (2010) Birgit C. Donner et al. BASIC RESEARCH IN CARDIOLOGY
- TREK-1 K+ Channels in the Cardiovascular System: Their Significance and Potential as a Therapeutic Target
- (2010) Lakshman Goonetilleke et al. Cardiovascular Therapeutics
- Molecular Background of Leak K+ Currents: Two-Pore Domain Potassium Channels
- (2010) Péter Enyedi et al. PHYSIOLOGICAL REVIEWS
- Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design
- (2010) Jean Mazella et al. PLOS BIOLOGY
- KCNK17 genetic variants in ischemic stroke
- (2009) Sophie Domingues-Montanari et al. ATHEROSCLEROSIS
- Integrative Predictive Model of Coronary Artery Calcification in Atherosclerosis
- (2009) Michael McGeachie et al. CIRCULATION
- The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences
- (2009) B. Heidecker et al. EUROPEAN HEART JOURNAL
- Heteromeric TASK-1/TASK-3 is the major oxygen-sensitive background K+channel in rat carotid body glomus cells
- (2009) Donghee Kim et al. JOURNAL OF PHYSIOLOGY-LONDON
- Inhibition of Human Two-Pore Domain K+ Channel TREK1 by Local Anesthetic Lidocaine: Negative Cooperativity and Half-of-Sites Saturation Kinetics
- (2009) T. K. Nayak et al. MOLECULAR PHARMACOLOGY
- The human cardiac K2P3.1 (TASK-1) potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone
- (2009) Jakob Gierten et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Knockout of the gene encoding the K2P channel KCNK7 does not alter volatile anesthetic sensitivity
- (2008) C. Spencer Yost et al. BEHAVIOURAL BRAIN RESEARCH
- Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein
- (2008) J Gierten et al. BRITISH JOURNAL OF PHARMACOLOGY
- Transcriptional profiling of ion channel genes in Brugada syndrome and other right ventricular arrhythmogenic diseases
- (2008) Nathalie Gaborit et al. EUROPEAN HEART JOURNAL
- PPARα-mediated remodeling of repolarizing voltage-gated K+ (Kv) channels in a mouse model of metabolic cardiomyopathy
- (2008) Céline Marionneau et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Temperature-sensitive TREK currents contribute to setting the resting membrane potential in embryonic atrial myocytes
- (2008) Hengtao Zhang et al. JOURNAL OF PHYSIOLOGY-LONDON
- Alternative Translation Initiation in Rat Brain Yields K2P2.1 Potassium Channels Permeable to Sodium
- (2008) Dierk Thomas et al. NEURON
- TASK channel deletion in mice causes primary hyperaldosteronism
- (2008) L. A. Davies et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now