Genetic Ablation of TASK-1 (Tandem of P Domains in a Weak Inward Rectifying K + Channel–Related Acid-Sensitive K + Channel-1) (K 2P 3.1) K + Channels Suppresses Atrial Fibrillation and Prevents Electrical Remodeling

German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management

(2018) Dierk Thomas et al.   Clinical Research in Cardiology

Improving Atrial Fibrillation Therapy

(2017) William J. Hucker et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Constitutive Expression of a Dominant-Negative TGF-β Type II Receptor in the Posterior Left Atrium Leads to Beneficial Remodeling of Atrial Fibrillation SubstrateNovelty and Significance

(2016) Aaron Kunamalla et al.   CIRCULATION RESEARCH

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

(2016) Paulus Kirchhof et al.   EUROPEAN HEART JOURNAL

Antiarrhythmic gene therapy – will biologics replace catheters, drugs and devices?

(2016) Patrick Lugenbiel et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TASK-1 current is inhibited by phosphorylation during human and canine chronic atrial fibrillation

(2015) Erin Harleton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Upregulation of K2P3.1 K+Current Causes Action Potential Shortening in Patients With Chronic Atrial FibrillationCLINICAL PERSPECTIVE

(2015) Constanze Schmidt et al.   CIRCULATION

Defining the major health modifiers causing atrial fibrillation: a roadmap to underpin personalized prevention and treatment

(2015) Larissa Fabritz et al.   Nature Reviews Cardiology

Biological pacemakers: Ready for the clinic?

(2015) Eugenio Cingolani   TRENDS IN CARDIOVASCULAR MEDICINE

Cloning, functional characterization, and remodeling of K2P3.1 (TASK-1) potassium channels in a porcine model of atrial fibrillation and heart failure

(2014) Constanze Schmidt et al.   HEART RHYTHM

Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis

(2014) Bo Liang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genetic suppression of Gαs protein provides rate control in atrial fibrillation

(2012) Patrick Lugenbiel et al.   BASIC RESEARCH IN CARDIOLOGY

Ability to Induce Atrial Fibrillation in the Peri-operative Period Is Associated with Phosphorylation-dependent Inhibition of TWIK Protein-related Acid-sensitive Potassium Channel 1 (TASK-1)

(2012) Erin Harleton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model

(2011) Olympia Bikou et al.   CARDIOVASCULAR RESEARCH

Suppression of persistent atrial fibrillation by genetic knockdown of caspase 3: a pre-clinical pilot study

(2011) Kerstin Trappe et al.   EUROPEAN HEART JOURNAL

Pathophysiological Mechanisms of Atrial Fibrillation: A Translational Appraisal

(2011) Ulrich Schotten et al.   PHYSIOLOGICAL REVIEWS