Identification of a Chemotherapeutic Lead Molecule for the Potential Disruption of the FAM72A-UNG2 Interaction to Interfere with Genome Stability, Centromere Formation, and Genome Editing

FAM72 serves as a biomarker of poor prognosis in human lung adenocarcinoma

(2021) Yilin Yu et al.   Aging-US

FAM72, Glioblastoma Multiforme (GBM) and Beyond

(2021) Nguyen Thi Thanh Ho et al.   Cancers

Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors

(2021) Elisa Bonandi et al.   CHEMISTRY-A EUROPEAN JOURNAL

The N-terminal domain of uracil-DNA glycosylase: Roles for disordered regions

(2021) Jacob L. Perkins et al.   DNA REPAIR

Identification of Mitochondrial-Related Prognostic Biomarkers Associated With Primary Bile Acid Biosynthesis and Tumor Microenvironment of Hepatocellular Carcinoma

(2021) Tao Zhang et al.   Frontiers in Oncology

On the roles of intrinsically disordered proteins and regions in cell communication and signaling

(2021) Sarah E. Bondos et al.   Cell Communication and Signaling

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

Author Correction: Structure based pharmacophore modeling, virtual screening, molecular docking and ADMET approaches for identification of natural anti-cancer agents targeting XIAP protein

(2021) Firoz A. Dain Md Opo et al.   Scientific Reports

Withaferin A inhibits proliferation of human endometrial cancer cells via transforming growth factor-β (TGF-β) signalling

(2021) Kejun Xu et al.   3 Biotech

Phytochemical Profiling in Conjunction with In Vitro and In Silico Studies to Identify Human α-Amylase Inhibitors in Leucaena leucocephala (Lam.) De Wit for the Treatment of Diabetes Mellitus

(2021) Senthil Renganathan et al.   ACS Omega

Proteomic Atomics Reveals a Distinctive Uracil‐5‐Methyltransferase

(2020) Subrata Pramanik et al.   Molecular Informatics

Structure-based drug design of peroxisome proliferator-activated receptor gamma inhibitors: ferulic acid and derivatives

(2020) Renganathan Senthil et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

HawkDock: a web server to predict and analyze the protein–protein complex based on computational docking and MM/GBSA

(2019) Gaoqi Weng et al.   NUCLEIC ACIDS RESEARCH

Eukaryotic Base Excision Repair: New Approaches Shine Light on Mechanism

(2019) William A. Beard et al.   Annual Review of Biochemistry

Structural, functional, and stability change predictions in human telomerase upon specific point mutations

(2019) U. Kalathiya et al.   Scientific Reports

Macromolecular crowding induces compaction and DNA binding in the disordered N-terminal domain of hUNG2

(2019) Gaddiel Rodriguez et al.   DNA REPAIR

HPEPDOCK: a web server for blind peptide–protein docking based on a hierarchical algorithm

(2018) Pei Zhou et al.   NUCLEIC ACIDS RESEARCH

N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA–dsDNA junctions

(2018) Brian P Weiser et al.   NUCLEIC ACIDS RESEARCH

A cancer tissue-specific FAM72 expression profile defines a novel glioblastoma multiform (GBM) gene-mutation signature

(2018) Chinmay Satish Rahane et al.   JOURNAL OF NEURO-ONCOLOGY

PubChem 2019 update: improved access to chemical data

(2018) Sunghwan Kim et al.   NUCLEIC ACIDS RESEARCH

Establishing a human adrenocortical carcinoma (ACC)-specific gene mutation signature

(2018) Chinmay Satish Rahane et al.   Cancer Genetics

Cognitive Functions: Human vs. Animal – 4:1 Advantage |-FAM72–SRGAP2-|

(2017) Nguyen Thi Thanh Ho et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database

(2017) Xia Wang et al.   NUCLEIC ACIDS RESEARCH

Fully automated antibody structure prediction using BIOVIA tools: Validation study

(2017) Helen Kemmish et al.   PLoS One

Molecular insights into cancer therapeutic effects of the dietary medicinal phytochemical withaferin A

(2017) Chandra Sekhar Chirumamilla et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer

(2017) Dharmendra Kumar Yadav et al.   Drug Design Development and Therapy

BDDCS, the Rule of 5 and drugability

(2016) Leslie Z. Benet et al.   ADVANCED DRUG DELIVERY REVIEWS

Assessing the performance of the MM/PBSA and MM/GBSA methods. 6. Capability to predict protein–protein binding free energies and re-rank binding poses generated by protein–protein docking

(2016) Fu Chen et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Anti-cancer activity of withaferin A in B-cell lymphoma

(2015) MK McKenna et al.   CANCER BIOLOGY & THERAPY

Functional roles of transiently and intrinsically disordered regions within proteins

(2015) Vladimir N. Uversky   FEBS Journal

All-or-(N)One – an epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci

(2015) Arne Kutzner et al.   GENOMICS

Evolutionary volatile Cysteines and protein disorder in the fast evolving tunicate Oikopleura dioica

(2015) Luisa Berná et al.   Marine Genomics

3D Structure, Dimerization Modeling, and Lead Discovery by Ligand-protein Interaction Analysis of p60 Transcription Regulator Protein (p60TRP)

(2015) Subrata Pramanik et al.   Molecular Informatics

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

I-TASSER server: new development for protein structure and function predictions

(2015) Jianyi Yang et al.   NUCLEIC ACIDS RESEARCH

MTiOpenScreen: a web server for structure-based virtual screening

(2015) Céline M. Labbé et al.   NUCLEIC ACIDS RESEARCH

JPred4: a protein secondary structure prediction server

(2015) Alexey Drozdetskiy et al.   NUCLEIC ACIDS RESEARCH

Uracil-DNA glycosylases-Structural and functional perspectives on an essential family of DNA repair enzymes

(2014) N. Schormann et al.   PROTEIN SCIENCE

Lead discovery and in silico 3D structure modeling of tumorigenic FAM72A (p17)

(2014) Subrata Pramanik et al.   TUMOR BIOLOGY

Docking-Based Virtual Screening of Covalently Binding Ligands: An Orthogonal Lead Discovery Approach

(2013) Jörg Schröder et al.   JOURNAL OF MEDICINAL CHEMISTRY

BioLiP: a semi-manually curated database for biologically relevant ligand–protein interactions

(2012) Jianyi Yang et al.   NUCLEIC ACIDS RESEARCH

Improving the Physical Realism and Structural Accuracy of Protein Models by a Two-Step Atomic-Level Energy Minimization

(2011) Dong Xu et al.   BIOPHYSICAL JOURNAL

iScreen: world’s first cloud-computing web server for virtual screening and de novo drug design based on TCM database@Taiwan

(2011) Tsung-Ying Tsai et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Radiation damage in protein serial femtosecond crystallography using an x-ray free-electron laser

(2011) Lukas Lomb et al.   PHYSICAL REVIEW B

Uracil DNA N-Glycosylase Promotes Assembly of Human Centromere Protein A

(2011) Samantha G. Zeitlin et al.   PLoS One

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Abasic sites preferentially form at regions undergoing DNA replication

(2010) Paul D. Chastain et al.   FASEB JOURNAL

Cysteine-Free Proteins in the Immunobiology of Arthropod-Borne Diseases

(2010) J. Santiago Mejia et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Identification and characterisation of the novel amyloid-beta peptide-induced protein p17

(2009) Saheen Nehar et al.   FEBS LETTERS

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8

(2009) Elmar Krieger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

Ugene, a Newly Identified Protein That Is Commonly Overexpressed in Cancer and Binds Uracil DNA Glycosylase

(2008) C. Guo et al.   CANCER RESEARCH