Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease

Tumor microenvironments self-activated nanoscale metal organic frameworks for ferroptosis based cancer chemodynamic/photothermal/chemo therapy

(2021) Yu Liang et al.   Acta Pharmaceutica Sinica B

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer

(2021) Ying Liu et al.   Acta Pharmaceutica Sinica B

Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1

(2021) Na Kong et al.   Acta Pharmaceutica Sinica B

Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy

(2021) Shuyi Wang et al.   Acta Pharmaceutica Sinica B

YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis

(2021) Ruize Gao et al.   EMBO Molecular Medicine

N6-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells

(2021) Min Shen et al.   Redox Biology

Iron overload as a risk factor for hepatic ischemia‐reperfusion injury in liver transplantation: Potential role of ferroptosis

(2020) Naoya Yamada et al.   AMERICAN JOURNAL OF TRANSPLANTATION

P7C3‐A20, a neuroprotective agent, alleviates fatty liver by inducing FGF21/FGF1 in a LKB1/AMPK/CRTC2‐dependent manner and shaping gut microbiota

(2020) Xia Hua et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly

(2020) Jorge Simon et al.   Cell Metabolism

Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

(2020) Naoya Yamada et al.   Cell Death & Disease

Hepatic Transferrin Plays a Role in Systemic Iron Homeostasis and Liver Ferroptosis

(2020) Yingying Yu et al.   BLOOD

TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

(2020) Dan Liu et al.   Cell Metabolism

Iron chaperone PCBP1 protects murine liver from lipid peroxidation and steatosis

(2020) Olga Protchenko et al.   HEPATOLOGY

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

(2020) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Targeting ferroptosis alleviates methionine‐choline deficient (MCD)‐diet induced NASH by suppressing liver lipotoxicity

(2020) Xiaoya Li et al.   LIVER INTERNATIONAL

From NAFLD to MAFLD: when pathophysiology succeeds

(2020) Herbert Tilg et al.   Nature Reviews Gastroenterology & Hepatology

Transferrin Receptor Is a Specific Ferroptosis Marker

(2020) Huizhong Feng et al.   Cell Reports

The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells

(2020) Zili Zhang et al.   Redox Biology

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis

(2019) Zhou Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice

(2019) Jing Qi et al.   AMERICAN JOURNAL OF PATHOLOGY

Herbal drug discovery for the treatment of nonalcoholic fatty liver disease

(2019) Tingting Yan et al.   Acta Pharmaceutica Sinica B

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Preclinical models of non-alcoholic fatty liver disease

(2018) Prasanna K. Santhekadur et al.   JOURNAL OF HEPATOLOGY

Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway

(2018) Zhaoyan Kong et al.   BIOMEDICINE & PHARMACOTHERAPY

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances

(2016) Jennie Ka Ching Lau et al.   JOURNAL OF PATHOLOGY

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Evolutionary and Structural Insights Into the Multifaceted Glutathione Peroxidase (Gpx) Superfamily

(2008) Stefano Toppo et al.   ANTIOXIDANTS & REDOX SIGNALING

Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis

(2008) Paolo Sorrentino et al.   JOURNAL OF HEPATOLOGY

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE