DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal adenocarcinoma

BXCL701, first-in-class oral activator of systemic innate immunity pathway, combined with pembrolizumab (Keytruda) in men with metastatic castration-resistant prostate cancer (mCRPC).

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Pancreatic ductal adenocarcinoma: Treatment hurdles, tumor microenvironment and immunotherapy

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Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

MCL-1Matrix maintains neuronal survival by enhancing mitochondrial integrity and bioenergetic capacity under stress conditions

(2020) Ujval Anilkumar et al.   Cell Death & Disease

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NLRP3 Inflammasome Activation in Cancer: A Double-Edged Sword

(2020) Shaima'a Hamarsheh et al.   Frontiers in Immunology

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Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy

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Distinct prognostic value of circulating anti-telomerase CD4+ Th1 immunity and exhausted PD-1+/TIM-3+ T cells in lung cancer

(2019) Caroline Laheurte et al.   BRITISH JOURNAL OF CANCER

DPP-4 Inhibition and the Path to Clinical Proof

(2019) Bo Ahrén   Frontiers in Endocrinology

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Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Ductal Adenocarcinoma

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(2019) Xiao Han et al.   EBioMedicine

Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade

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Curation of the Pancreatic Ductal Adenocarcinoma Subset of the Cancer Genome Atlas Is Essential for Accurate Conclusions about Survival-Related Molecular Mechanisms

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The Immune Landscape of Cancer

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Tumor Regression and Cure Depends on Sustained Th1 Responses

(2018) Min Dai et al.   JOURNAL OF IMMUNOTHERAPY

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

(2018) Darren C. Johnson et al.   NATURE MEDICINE

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

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STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

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Inflammasomes: Emerging Central Players in Cancer Immunology and Immunotherapy

(2018) Dev Karan   Frontiers in Immunology

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

(2017) Vinod P. Balachandran et al.   NATURE

Reproducible RNA-seq analysis using recount2

(2017) Leonardo Collado-Torres et al.   NATURE BIOTECHNOLOGY

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

NOD-Like Receptor P3 Inflammasome Controls Protective Th1/Th17 Immunity against Pulmonary Paracoccidioidomycosis

(2017) Claudia Feriotti et al.   Frontiers in Immunology

Unravelling the immunological roles of dipeptidyl peptidase 4 (DPP4) activity and/or structure homologue (DASH) proteins

(2016) L. Wagner et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Augmentation of Immune Checkpoint Cancer Immunotherapy with IL18

(2016) Z. Ma et al.   CLINICAL CANCER RESEARCH

Inhibition of DPP4 activity in humans establishes itsin vivorole in CXCL10 post‐translational modification: prospective placebo‐controlled clinical studies

(2016) Jérémie Decalf et al.   EMBO Molecular Medicine

Targeting of cancer-associated fibroblasts enhances the efficacy of cancer chemotherapy by regulating the tumor microenvironment

(2016) MINMIN LI et al.   Molecular Medicine Reports

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

(2016) Marian C Okondo et al.   Nature Chemical Biology

Suppression of CD26 inhibits growth and metastasis of pancreatic cancer

(2016) Chunxiang Ye et al.   TUMOR BIOLOGY

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Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis

(2015) Hui Zhang et al.   FEBS Journal

Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy

(2015) Rosa Barreira da Silva et al.   NATURE IMMUNOLOGY

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(2015) Aaron M Newman et al.   NATURE METHODS

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The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis

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The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Abstract 4653: DNA-PKcs dependent phosphorylation of topoI-S10 determines its ubiquitination by BRCA1/BARD1, rate of topoI degradation and CPT response.

(2014) Ankur K. Shah et al.   CANCER RESEARCH

Carcinoembryonic Antigen-Specific but Not Antiviral CD4+ T Cell Immunity Is Impaired in Pancreatic Carcinoma Patients

(2014) E. Tassi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Priming of NK Cells by IL-18

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Advances in Understanding the Expression and Function of Dipeptidyl Peptidase 8 and 9

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Genetic Alterations of K-ras, p53, c-erbB-2, and DPC4 in Pancreatic Ductal Adenocarcinoma and Their Correlation With Patient Survival

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Val-BoroPro Accelerates T Cell Priming via Modulation of Dendritic Cell Trafficking Resulting in Complete Regression of Established Murine Tumors

(2013) Meghaan P. Walsh et al.   PLoS One

Immune infiltrates as predictive markers of survival in pancreatic cancer patients

(2013) Maria Pia Protti et al.   Frontiers in Physiology

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(2013) Charles A. Dinarello et al.   Frontiers in Immunology

Effect of Pemetrexed on Innate Immune Killer Cells and Adaptive Immune T Cells in Subjects With Adenocarcinoma of the Pancreas

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The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis

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Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

(2011) Lucia De Monte et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pediatric Phase I Trial Design Using Maximum Target Inhibition as the Primary Endpoint

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(2009) Robert M Eager et al.   BMC CANCER

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(2009) R.M. Eager et al.   CLINICAL ONCOLOGY

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation

(2009) S. Z. Ben-Sasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stromal cell-derived factors 1α and 1β, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8

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