Minimal PD-1 expression in mouse and human NK cells under diverse conditions

Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis

(2019) Jing Zhou et al.   IMMUNITY

Targeting natural killer cells in solid tumors

(2019) Guillaume Habif et al.   Cellular & Molecular Immunology

Expression analysis and significance of PD-1, LAG-3 and TIM-3 in human non-small cell lung cancer using spatially-resolved and multiparametric single-cell analysis.

(2019) Ila J Datar et al.   CLINICAL CANCER RESEARCH

The mechanism of anti-PD-L1 antibody efficacy against PD-L1 negative tumors identifies NK cells expressing PD-L1 as a cytolytic effector

(2019) Wenjuan Dong et al.   Cancer Discovery

Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming

(2019) Aimee Merino et al.   JOURNAL OF CLINICAL INVESTIGATION

CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions

(2018) Masao Hashimoto et al.   Annual Review of Medicine

Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity

(2018) Qing Zhang et al.   NATURE IMMUNOLOGY

Dying cells expose a nuclear antigen cross-reacting with anti-PD-1 monoclonal antibodies

(2018) Philipp Metzger et al.   Scientific Reports

An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo-Expanded Natural Killer Cells

(2018) Nicole A. P. Lieberman et al.   Frontiers in Immunology

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

(2018) Joy Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells

(2018) Linda Quatrini et al.   NATURE IMMUNOLOGY

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

(2018) Ziming Wang et al.   NATURE MEDICINE

PD-1 in human NK cells: evidence of cytoplasmic mRNA and protein expression

(2018) Francesca R. Mariotti et al.   OncoImmunology

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers

(2017) Y Liu et al.   ONCOGENE

Natural killer cells unleashed: Checkpoint receptor blockade and BiKE/TriKE utilization in NK-mediated anti-tumor immunotherapy

(2017) Zachary B. Davis et al.   SEMINARS IN IMMUNOLOGY

NK Cell Exhaustion

(2017) Jiacheng Bi et al.   Frontiers in Immunology

Adoptive natural killer cell therapy is effective in reducing pulmonary metastasis of Ewing sarcoma

(2017) Alexander A. Tong et al.   OncoImmunology

Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial

(2017) Robert J. Canter et al.   Journal for ImmunoTherapy of Cancer

Analysis of Ly49 gene transcripts in mature NK cells supports a role for the Pro1 element in gene activation, not gene expression

(2016) M V McCullen et al.   GENES AND IMMUNITY

Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway

(2016) Yong Yu et al.   NATURE

PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma

(2016) Asma Beldi-Ferchiou et al.   Oncotarget

Canine cancer immunotherapy studies: linking mouse and human

(2016) Jiwon S. Park et al.   Journal for ImmunoTherapy of Cancer

Acquisition of Activation Receptor Ligand by Trogocytosis Renders NK Cells Hyporesponsive

(2015) Cathrine A. Miner et al.   JOURNAL OF IMMUNOLOGY

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Clinical utility of natural killer cells in cancer therapy and transplantation

(2014) David A. Knorr et al.   SEMINARS IN IMMUNOLOGY

Reversal of NK-Cell Exhaustion in Advanced Melanoma by Tim-3 Blockade

(2014) I. P. da Silva et al.   Cancer Immunology Research

Reversal of natural killer cell exhaustion by TIM-3 blockade

(2014) Anne Gallois et al.   OncoImmunology

T cell regulation of natural killer cells

(2013) Yann Kerdiles et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human NK Cells Selective Targeting of Colon Cancer-Initiating Cells: A Role for Natural Cytotoxicity Receptors and MHC Class I Molecules

(2013) R. Tallerico et al.   JOURNAL OF IMMUNOLOGY

PD-1 Expression on Peripheral Blood Cells Increases with Stage in Renal Cell Carcinoma Patients and Is Rapidly Reduced after Surgical Tumor Resection

(2013) A. W. MacFarlane et al.   Cancer Immunology Research

Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells

(2013) Franco Locatelli et al.   Frontiers in Immunology

PD-1 is a novel regulator of human B-cell activation

(2012) Marie-Laure Thibult et al.   INTERNATIONAL IMMUNOLOGY

Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells

(2012) Cecele J. Denman et al.   PLoS One

The 'T-cell-ness' of NK cells: unexpected similarities between NK cells and T cells

(2011) E. Narni-Mancinelli et al.   INTERNATIONAL IMMUNOLOGY

NK Cell-Depleting Anti-Asialo GM1 Antibody Exhibits a Lethal Off-Target Effect on Basophils In Vivo

(2011) H. Nishikado et al.   JOURNAL OF IMMUNOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Expansion, Purification, and Functional Assessment of Human Peripheral Blood NK Cells

(2011) Srinivas S. Somanchi et al.   Jove-Journal of Visualized Experiments

The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody

(2010) D. M. Benson et al.   BLOOD

Cytotoxicity of Activated Natural Killer Cells against Pediatric Solid Tumors

(2010) D. Cho et al.   CLINICAL CANCER RESEARCH

Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: How NK cells make the difference

(2009) Franco Locatelli et al.   CLINICAL IMMUNOLOGY

Interferon-sensitive response element (ISRE) is mainly responsible for IFN-α-induced upregulation of programmed death-1 (PD-1) in macrophages

(2008) Hae-Yun Cho et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Regulation of arginase I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells

(2008) Yu Liu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Differential Regulation of GM1 and Asialo-GM1 Expression by T Cells and Natural Killer (NK) Cells in Respiratory Syncytial Virus Infection

(2008) Martin L. Moore et al.   VIRAL IMMUNOLOGY