Palladium-catalyzed tandem Heck/carbonylation/aminocarbonylation en route to chiral heterocyclic α-ketoamides

Palladium-catalyzed enantioselective carbonylation reactions

(2022) Jin-Bao Peng et al.   Science China-Chemistry

The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities

(2021) Marco Robello et al.   JOURNAL OF MEDICINAL CHEMISTRY

Palladium-Catalyzed Enantioselective 7-exo-Trig Carbopalladation/Carbonylation: Cascade Reactions To Achieve Atropisomeric Dibenzo[b,d]azepin-6-ones

(2021) Huaanzi Hu et al.   ORGANIC LETTERS

Asymmetric biomimetic transamination of α-keto amides to peptides

(2021) Weiqi Cai et al.   Nature Communications

Manganese(III)‐Promoted Double Carbonylation of Anilines Toward α‐Ketoamides Synthesis

(2021) Bo Chen et al.   ADVANCED SYNTHESIS & CATALYSIS

Double Carbonylation Reactions: Overview and Recent Advances

(2020) Debarati Das et al.   ADVANCED SYNTHESIS & CATALYSIS

Palladium‐Catalyzed Enantioselective Heck Carbonylation with a Monodentate Phosphoramidite Ligand: Asymmetric Synthesis of (+)‐Physostigmine, (+)‐Physovenine, and (+)‐Folicanthine

(2020) Ming Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes

(2020) Zhenbo Yuan et al.   Nature Communications

Enantioselective Synthesis of 2-Oxindole Spirofused Lactones and Lactams by Heck/Carbonylative Cylization Sequences: Method Development and Applications

(2019) Huaanzi Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Biological Activity of Peptide α-Ketoamide Derivatives as Proteasome Inhibitors

(2019) Salvatore Pacifico et al.   ACS Medicinal Chemistry Letters

Development of Synthetic Methodologies via Catalytic Enantioselective Synthesis of 3,3-Disubstituted Oxindoles

(2018) Zhong-Yan Cao et al.   ACCOUNTS OF CHEMICAL RESEARCH

N,N-Chiral Ligands Enabling Palladium-catalyzed Enantioselective Intramolecular Heck-Matsuda Carbonylation Reactions by Sequential Migratory and CO Insertions

(2018) Carlos Roque Duarte Correia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Facile photochemical synthesis of α -ketoamides and quinoxalines from amines and benzoylacetonitrile under mild conditions

(2018) Chao Zhou et al.   CHINESE CHEMICAL LETTERS

Natural product syntheses via carbonylative cyclizations

(2018) Kaiqing Ma et al.   NATURAL PRODUCT REPORTS

Carbon Nanofibrous Microspheres Promote the Oxidative Double Carbonylation of Alkanes with CO

(2018) Lijun Lu et al.   Chem

Natural Product Synthesis via Palladium-Catalyzed Carbonylation

(2017) Yu Bai et al.   JOURNAL OF ORGANIC CHEMISTRY

Covalent triazine framework-supported palladium as a ligand-free catalyst for the selective double carbonylation of aryl iodides under ambient pressure of CO

(2016) Zhifang Wang et al.   CHEMICAL COMMUNICATIONS

Recent Developments in General Methodologies for the Synthesis of α-Ketoamides

(2016) Carmela De Risi et al.   CHEMICAL REVIEWS

Recent Advances in the Catalytic Synthesis of α-Ketoamides

(2016) Dinesh Kumar et al.   ACS Catalysis

Double carbonylation of aryl iodides with amines under an atmospheric pressure of carbon monoxide using sulfur-modified Au-supported palladium

(2015) Nozomi Saito et al.   GREEN CHEMISTRY

Ligand-Free Pd-Catalyzed Double Carbonylation of Aryl Iodides with Amines to α-Ketoamides under Atmospheric Pressure of Carbon Monoxide and at Room Temperature

(2015) Hongyan Du et al.   JOURNAL OF ORGANIC CHEMISTRY

Transition-Metal-Catalyzed Carbonylation Reactions of Olefins and Alkynes: A Personal Account

(2014) Xiao-Feng Wu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the α-Ketoamide Electrophile as an Auspicious Reversible Lead Motif

(2014) Martin L. Stein et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of β-amino-α.-ketoamides

(2014) Samir Kher et al.   CURRENT ORGANIC CHEMISTRY

Copper(I)-Catalyzed Aryl or Vinyl Addition to Electron-Deficient Alkenes Cascaded by Cationic Cyclization

(2014) Bing Zhou et al.   ORGANIC LETTERS

Cu(ii)-catalyzed decarboxylative acylation of acyl C–H of formamides with α-oxocarboxylic acids leading to α-ketoamides

(2013) Dengke Li et al.   CHEMICAL COMMUNICATIONS

Copper-catalyzed oxidative condensation of α-oxocarboxylic acids with formamides: synthesis of α-ketoamides

(2013) Hua Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Silver-catalyzed amidation of benzoylformic acids with tertiary amines via selective carbon–nitrogen bond cleavage

(2013) Xiaobin Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

Synthesis of Heterocycles via Palladium-Catalyzed Carbonylations

(2012) Xiao-Feng Wu et al.   CHEMICAL REVIEWS

A phosphine-free Pd catalyst for the selective double carbonylation of aryl iodides

(2011) Verónica de la Fuente et al.   CHEMICAL COMMUNICATIONS

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Convergent Synthesis of α-Ketoamide Inhibitors of Pin1

(2010) Guoyan G. Xu et al.   ORGANIC LETTERS

Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

(2008) F. George Njoroge et al.   ACCOUNTS OF CHEMICAL RESEARCH