Plasma FGF21 concentrations are regulated by glucose independently of insulin and GLP-1 in lean, healthy humans

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

(2020) S. Fleur W. Meddens et al.   MOLECULAR PSYCHIATRY

Exercise-Induced Improvements in Postprandial Glucose Response Are Blunted by Pre-Exercise Hyperglycemia: A Randomized Crossover Trial in Healthy Individuals

(2020) Steven Carter et al.   Frontiers in Endocrinology

The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol

(2018) Parkyong Song et al.   Cell Metabolism

FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys

(2018) Birgitte Andersen et al.   INTERNATIONAL JOURNAL OF OBESITY

A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure

(2018) Timothy M. Frayling et al.   Cell Reports

FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at Oktoberfest

(2018) Susanna Søberg et al.   Molecular Metabolism

FGF21 is a Hormonal Mediator of the Human “Thrifty” Metabolic Phenotype

(2018) Karyne L. Vinales et al.   DIABETES

Fibroblast growth factor 21 improves glucose homeostasis partially via down-regulation of Na+-d-glucose cotransporter SGLT1 in the small intestine

(2018) Nan Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Pegbelfermin (BMS-986036), PEGylated FGF21, in Patients with Obesity and Type 2 Diabetes: Results from a Randomized Phase 2 Study

(2018) Edgar D. Charles et al.   Obesity

FGF21 Is an Insulin-Dependent Postprandial Hormone in Adult Humans

(2017) Ricardo J Samms et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury

(2017) Bhavna N. Desai et al.   Molecular Metabolism

A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism

(2017) ffolliott M. Fisher et al.   Molecular Metabolism

Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates

(2017) Anne-Marie Lundsgaard et al.   Molecular Metabolism

Understanding the Physiology of FGF21

(2016) Ffolliott Martin Fisher et al.   Annual Review of Physiology

FGF21 Regulates Sweet and Alcohol Preference

(2016) Saswata Talukdar et al.   Cell Metabolism

Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework

(2016) Samantha M. Solon-Biet et al.   Cell Metabolism

A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects

(2016) Saswata Talukdar et al.   Cell Metabolism

FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver

(2016) Stephanie von Holstein-Rathlou et al.   Cell Metabolism

Increased glucose-stimulated FGF21 response to oral glucose in obese nondiabetic subjects after Roux-en-Y gastric bypass

(2016) S.G. Vienberg et al.   CLINICAL ENDOCRINOLOGY

A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution

(2016) Adriano Maida et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacologic stimulation of central GLP-1 receptors has opposite effects on the alterations of plasma FGF21 levels induced by feeding and fasting

(2016) Katsunori Nonogaki et al.   NEUROSCIENCE LETTERS

Direct effect of incretin hormones on glucose and glycerol metabolism and hemodynamics

(2015) Kristian Karstoft et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

FGF21 and the late adaptive response to starvation in humans

(2015) Pouneh K. Fazeli et al.   JOURNAL OF CLINICAL INVESTIGATION

Fructose ingestion acutely stimulates circulating FGF21 levels in humans

(2015) Jody R. Dushay et al.   Molecular Metabolism

Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans

(2015) Jakob Schiøler Hansen et al.   Molecular Metabolism

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

FGF21 is an endocrine signal of protein restriction

(2014) Thomas Laeger et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel sandwich immunoassays for the measurement of total and active FGF21

(2014) Tara S Umberger et al.   Bioanalysis

Liraglutide Suppresses Obesity and Hyperglycemia Associated with Increases in Hepatic Fibroblast Growth Factor 21 Production in KKAyMice

(2014) Katsunori Nonogaki et al.   Biomed Research International

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys

(2013) Andrew C. Adams et al.   PLoS One

Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation

(2012) Ana Luísa De Sousa-Coelho et al.   BIOCHEMICAL JOURNAL

Dynamic Change of Serum FGF21 Levels in Response to Glucose Challenge in Human

(2012) Zhuofeng Lin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects

(2009) Jing Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

(2008) Cecilia Gälman et al.   Cell Metabolism

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL