Article
Medicine, General & Internal
Di Hu, Junhong Jiang, Zhong Lin, Cong Zhang, Nived Moonasar, Shaohong Qian
Summary: By analyzing gene functions, we identified 30 enriched GO terms and 20 associated KEGG pathways. Through a PPI network and module analysis, we selected 13 core candidate genes mainly associated with ECM degradation and cell proliferation and division. Enrichment of HIF-1 signaling pathway, FOXO signaling pathway, PI3K-Akt signaling pathway, and TGFB signaling pathway was observed.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Ophthalmology
Julia Szeto, Amanda Chow, Liam McCrea, Ann Mozzer, Thao D. Nguyen, Harry A. Quigley, Ian Pitha
Summary: The study revealed differences in cellular density and nuclear morphology in regions of the posterior sclera, while topography alters the cellular response to mechanical strain.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Kealan McElhinney, Mustapha Irnaten, Colm O'Brien
Summary: Fibrosis is a dysregulated wound repair response that leads to progressive disruption of tissue architecture and significant morbidity/mortality. Current treatments can slow disease progression but not restore organ function or reverse fibrotic changes. Myofibroblast apoptosis is absent in fibrosis, contributing to persistent myofibroblast activation and perpetuation of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Chen Qiu, Chuandong Wang, Xinghuai Sun, Jianjiang Xu, Jihong Wu, Rong Zhang, Gang Li, Kang Xue, Xiaoling Zhang, Shaohong Qian
Summary: This study found that mechanical strain can induce remodeling of sclera. By regulating the expression of CXCR2, it affects the proliferation, migration, and protein expression of scleral fibroblasts, which may be a potential therapeutic target for hypertensive scleral remodeling.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Cornelius Jakob Wiedenmann, Charlotte Gottwald, Kosovare Zeqiri, Janne Froemmichen, Emma Bungert, Moritz Glaeser, Jeanne Stroeble, Robert Lohmueller, Thomas Reinhard, Jan Luebke, Gunther Schlunck
Summary: This study evaluated the effects of fluid flow on human Tenon fibroblasts using 2D and 3D in vitro models. The results showed that slow, continuous fluid flow induced fibrotic responses and activated the intracellular TGF-beta signaling pathway. Intermittent fluid flow also caused fibrotic changes, which decreased with longer pause duration. This study suggests that slow interstitial fluid flow may contribute to the intractable nature of fibrosis following filtering glaucoma surgery and could be a potential target for antifibrotic therapy.
Article
Geriatrics & Gerontology
Nicolas Collao, Donna D'Souza, Laura Messeiller, Evan Pilon, Jessica Lloyd, Jillian Larkin, Matthew Ngu, Alexanne Cuillerier, Alexander E. Green, Keir J. Menzies, Yan Burelle, Michael De Lisio
Summary: This study suggests that fibro/adipogenic progenitors (FAPs) play an important role in radiation-induced muscle pathology, leading to muscle atrophy and fibrosis. Radiation exposure induces senescence and fibrogenic differentiation of FAPs, impairing the differentiation and fusion of muscle satellite (stem) cells. Therefore, targeting FAPs may be a potential therapeutic approach to alleviate the negative late effects of radiation exposure in skeletal muscle.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Dermatology
Edward J. Macarak, Peter J. Wermuth, Joel Rosenbloom, Jouni Uitto
Summary: Keloid disorder is a fibroproliferative skin disease characterized by the accumulation of extracellular matrix in skin, mainly collagen, with a strong genetic predisposition in individuals of African and Asian ancestry. The activation of biosynthetic pathways leading to ECM accumulation is driven by several cytokines, notably TGF-beta signaling, and the mechanical properties of the cellular microenvironment also play a critical role in the cell's response to these signals. Studies have shown that fibroblasts derived from keloids demonstrate different biosynthetic capacities when cultured on substrata with different degrees of stiffness, highlighting the complexity of factors involved in keloid pathogenesis.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu-ting Hsiao, Jong-Jer Lee, I-Hui Yang, Pei-Chang Wu, Mu-Chan Ke, Jung Lo
Summary: Previous studies have emphasized the importance of outdoor time in reducing the risk of myopia progression. However, the effects of ultraviolet A (UVA) radiation on the exposed anterior sclera have not been well studied. This study investigated the biological effects of UVA on human scleral fibroblasts (HSFs) at peak sunlight levels. The results suggest that high UVA exposure reduces TGF-0 signaling and collagen I production in HSF by modulating Smad levels. Further investigations are needed to understand the effects of overexposure to high-intensity UVA on myopia control.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Biotechnology & Applied Microbiology
Victor Alfonso Solarte David, Viviana Raquel Guiza-Argueello, Martha L. Arango-Rodriguez, Claudia L. Sossa, Silvia M. Becerra-Bayona
Summary: The absence or damage of tissue is a major cause of diseases, and novel therapeutic alternatives aim to recover lost functions through tissue regeneration. Chronic cutaneous lesions are common wounds that require regenerative medicine and tissue engineering interventions to develop bioactive medical products for proper healing and prevention of complications. The coordination of cells, extracellular matrix (ECM), and biomolecules is crucial in tissue repair and regeneration, with ECM acting as a biological platform for their interactions. Tissue engineering utilizes synthetic polymers and decellularized tissues to mimic native ECM and provide necessary functionalities for cell differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Rou Wan, Joshua P. Weissman, Kendra Grundman, Lin Lang, Damian J. Grybowski, Robert D. Galiano
Summary: Diabetes is a systemic disease that affects the body's ability to regulate blood sugar levels, leading to complications such as chronic non-healing wounds, which can significantly impact patients' quality of life. Scientific studies have shown that high glucose levels can interfere with fibroblast differentiation and myofibroblast function, affecting extracellular matrix production and wound contraction. Further research on potential treatments targeting these pathways is essential for improving wound healing in diabetic patients.
WOUND REPAIR AND REGENERATION
(2021)
Article
Cell Biology
Rebeca de Oliveira Camargo, Besher Abual'anaz, Sunil G. Rattan, Krista L. Filomeno, Ian M. C. Dixon
Summary: Heart disease with cardiac fibrosis is a leading cause of death in developed countries, surpassing cancer. Recent literature focuses on activating and deactivating mechanisms of cardiac fibroblasts. Activated fibroblasts contribute to acute wound healing and chronic fibrosis, while deactivation is less studied but shows potential therapeutic implications.
WOUND REPAIR AND REGENERATION
(2021)
Article
Biochemistry & Molecular Biology
Francis Migneault, Marie-Josee Hebert
Summary: Autophagy is a critical cellular process for cell survival and homeostasis, playing a significant role in tissue repair and fibrosis. Recent studies have identified autophagy as an important regulator of myofibroblast differentiation, tissue remodeling, and fibrogenesis.
Review
Biochemistry & Molecular Biology
Marina Marozzi, Arianna Parnigoni, Aide Negri, Manuela Viola, Davide Vigetti, Alberto Passi, Evgenia Karousou, Federica Rizzi
Summary: Cancer is a complex pathology characterized by uncontrolled cell proliferation and decreased apoptosis, often in an inflammatory environment. Changes in the extracellular matrix (ECM) and signaling pathways play crucial roles in tumor growth and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
David R. Brigstock
Summary: Fibrosis is characterized by unrelenting deposition of insoluble collagen due to chronic injury, leading to organ dysfunction and increased cancer risk. Extracellular vesicles play important roles in conveying pro-fibrotic signals as well as anti-fibrotic activities in chronic wound environment. EVs in body fluids of fibrotic individuals have potential as fibrosis biomarkers.
Article
Cell Biology
Yi Tang, Lingxin Zhu, Jung-Sun Cho, Xiao-Yan Li, Stephen J. Weiss
Summary: Skeletal stem cells control cytoskeletal and nucleoskeletal organization by remodeling the extracellular matrix through Mmp14, thereby regulating Wnt signaling and stem cell fate decisions.
DEVELOPMENTAL CELL
(2022)