Article
Cell Biology
Yizhou Zheng, Yaosheng Xiao, Di Zhang, Shanshan Zhang, Jing Ouyang, Linfu Li, Weimei Shi, Rui Zhang, Hai Liu, Qi Jin, Zhixi Chen, Daohua Xu, Longhuo Wu
Summary: Geniposide (GEN) alleviates dexamethasone (DEX)-induced cholesterol accumulation and inhibition of cell differentiation by mediating the GLP-1R/ABCA1 axis in MC3T3-E1 cells.
Article
Plant Sciences
Yaosheng Xiao, Qun Ren, Yizhou Zheng, Shanshan Zhang, Jing Ouyang, Linhui Jiao, Chunfang Tang, Linfu Li, Weimei Shi, Miaofei Wang, Sainan Zhang, Di Zhang, Bin Zhong, Fang Peng, Zhixi Chen, Longhuo Wu
Summary: The study showed that GEN effectively alleviated the pathological changes of trabecular bone induced by DEX in rats, and reduced the expression levels of ATF4/CHOP. In MC3T3-E1 cells, DEX triggered ER stress and mitochondrial apoptosis, which could be alleviated by inhibiting ER stress.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyo-Eun Son, Won-Gu Jang
Summary: This study reveals that Cip2A plays a critical role in regulating osteoblast differentiation by inducing ERK phosphorylation in MG63 cells.
Article
Cell & Tissue Engineering
Shan-Chuang Chen, Tao Jiang, Qi-Yu Liu, Zi-Tao Liu, Yu-Fei Su, Hai-Tao Su
Summary: This study demonstrates that hsa_circ_0001485 plays a crucial role in osteogenic differentiation. The circRNA activates the TGF beta-BMP pathway by targeting BMPR2, thereby positively regulating osteogenic differentiation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Gang Wang, Fengbin Wang, Lecheng Zhang, Chao Yan, Yuelei Zhang
Summary: miR-133a is strongly associated with GIO and similar disorders induced by glucocorticoids in MSCs. Silencing miR-133a resulted in positive effects on GC-treated MSCs and on bone loss in GIO animal models. Moreover, the FGFR1-MAPK/ERK signaling may be involved in the protective effect of miR-133a silencing.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Pharmacology & Pharmacy
Jinwen He, Xingwen Wang, Dacheng Zhao, Bin Geng, Yayi Xia
Summary: The study demonstrated that Mangiferin can promote osteogenic differentiation and alleviate osteoporosis, with the potential mechanism being through the AXL/ERK5 pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Hai-Tao Jiang, Rui Deng, Yan Deng, Mao Nie, Yi-Xuan Deng, Hong-Hong Luo, Yuan-Yuan Yang, Na Ni, Cheng-Cheng Ran, Zhong-Liang Deng
Summary: The study found that ATRA can reverse the inhibitory effect of DEX on osteogenic differentiation, which may be associated with the downregulation of Serpina3n promoted by DEX. Therefore, ATRA may be considered as a novel therapeutic agent, and Serpina3n could serve as a new target for GIOP.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jie Zhu, Chengcheng Feng, Weicheng Zhang, Zhidong Wang, Mengdan Zhong, Wenkai Tang, Zhifang Wang, Haiwei Shi, Zhengyu Yin, Jiandong Shi, Yu Huang, Long Xiao, Dechun Geng, Zhirong Wang
Summary: The research found that activation of dopamine receptor D1R promotes osteogenic differentiation induced by glucocorticoids and reduces bone loss by activating the ERK1/2 signaling pathway.
MOLECULAR MEDICINE
(2022)
Article
Immunology
Zhihui Kuang, Xiaowei Yang, Zhiyou Cao, Yanhua Li, Jiawei Hu, Xin Hong, Bo Li, Changjian Wu, Qihua Qi, Xuqiang Liu, Min Dai
Summary: Surfactin, a highly effective biosurfactant, inhibits osteoclastogenesis and promotes osteogenic differentiation, suggesting its potential as a treatment for osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Xiang Gao, Guanhao Hong, Weiqiang Zhan, Tianfeng Liu, Shouquan Yan, Mingzhu Deng, Chenlin Tu, Peng Li
Summary: This study found that DPA can promote the osteogenic differentiation of hBMSCs through the miR-9-5p/ERK/ALP signaling pathway. This provides a potential therapeutic strategy for patients with bone loss.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Immunology
Hongfeng Ruan, Huihao Zhang, Jing Feng, Huan Luo, Fangda Fu, Sai Yao, Chengcong Zhou, Zhiguo Zhang, Yishan Bian, Hongting Jin, Yuliang Zhang, Chengliang Wu, Peijian Tong
Summary: This study found that the levels of pyroptosis-related proteins were significantly increased in patients with osteoporosis and a mouse model, while osteogenic capacity was compromised. Bioinformatics analysis confirmed shared gene expression patterns between pyroptosis and osteoporosis pathology. In vitro experiments revealed that inhibition of Caspase-1-mediated pyroptosis promotes osteogenic differentiation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhixin Wu, Jiayong Zhu, Yinxian Wen, Pengfei Lei, Jie Xie, Haifei Shi, Ronghuan Wu, Xianfeng Lou, Yihe Hu
Summary: This study identified six essential genes related to the osteogenic differentiation of BMSCs and osteoporosis: Fbn2, Lrrc17, Hspb7, Hmga1, Nexn, and Esm1. Hmga1 was found to prevent bone loss caused by ovariectomy-induced osteoporosis through the Wnt signaling pathway, suggesting Hmga1 as a potential therapeutic target for postmenopausal osteoporosis.
Article
Pharmacology & Pharmacy
Yongxiang Xu, Shichun Chen, Linxuan Huang, Weichao Han, Yingying Shao, Minyi Chen, Yusheng Zhang, Ruirong He, Baocheng Xie
Summary: In this research, the protective impacts of epimedin C on the osteogenic inhibition impact of MC3T3-E1 cells and zebrafish larvae mediated by DEX were examined. The results showed that epimedin C could alleviate the suppressive impact of DEX on the osteogenesis of MC3T3-E1 cells and zebrafish larvae by triggering the PI3K and AKT signaling pathways. This suggests that epimedin C has significant potential in the development of innovative drugs for the treatment of glucocorticoid-mediated osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nika Lovsin, Janja Marc
Summary: The study demonstrates that glucocorticoid receptor can directly upregulate RANKL transcription in human cell lines, providing insight into the missing link in the mechanism of RANK/RANKL/OPG imbalance in glucocorticoid-induced osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Jiahuan Wu, Zhanwei Zeng, Yuyun Li, Huiyi Qin, Changqing Zuo, Chenhui Zhou, Daohua Xu
Summary: The study demonstrated that CAG could alleviate the inhibition of osteogenic differentiation induced by DEX both in vitro and in vivo, indicating its potential as a candidate drug for the treatment of GIOP. CAG increased ALP activity, mineralization, and mRNA expression of osteogenic markers in both normal and DEX-treated cells, and its protective effect was mediated by up-regulation of telomerase reverse transcriptase.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Medicinal
Bao-Cheng Xie, Shu-Yong Song, Xiao-Yang Xie, Yu-Tong Sun, Xiao-Yuan Zhang, Dao-Hua Xu, Yun-Sheng Huang
ARCHIV DER PHARMAZIE
(2019)
Review
Integrative & Complementary Medicine
Shichun Chen, Baocheng Xie, Hao Tian, Shaobo Ding, Chengyu Lu
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Letter
Sport Sciences
Bao-Cheng Xie, Shi-Chun Chen, Jia-Huan Wu, Qing-Hui Wang, Chen-Hui Zhou, Dao-Hua Xu
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2019)
Review
Sport Sciences
Shi-Chun Chen, Shao-Bo Ding, Bao-Cheng Xie, Hao Tian, Cheng-Yu Lu
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2019)
Review
Cell & Tissue Engineering
Baocheng Xie, Minyi Chen, Runkai Hu, Weichao Han, Shaobo Ding
STEM CELLS INTERNATIONAL
(2020)
Review
Cell & Tissue Engineering
Baocheng Xie, Shichun Chen, Yongxiang Xu, Weichao Han, Runkai Hu, Minyi Chen, Ruirong He, Shaobo Ding
Summary: This study found through meta-analysis that MSC therapy can significantly reduce VAS and ODI scores in patients with DDD, providing a new therapeutic strategy for chronic low back pain and lumbar dysfunction caused by DDD.
STEM CELLS INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Baocheng Xie, Shichun Chen, Yongxiang Xu, Weichao Han, Runkai Hu, Minyi Chen, Yusheng Zhang, Shaobo Ding
Summary: Diabetes mellitus and osteoporosis are closely related, and GLP-1RAs may help in controlling blood sugar levels and promoting bone formation, but more research is needed to clarify their specific effects and mechanisms.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Baocheng Xie, Zhanwei Zeng, Shiyi Liao, Chenhui Zhou, Longhuo Wu, Daohua Xu
Summary: Kaempferol exhibits beneficial effects on osteogenic differentiation and counteracts the inhibitory activity of dexamethasone by activating JNK and p38-MAPK signaling pathways, improving bone mineralization. This potential makes it a promising candidate for developing new drugs for treating glucocorticoid-induced osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Yu-Sheng Zhang, Yan-Dan Zheng, Yan Yuan, Shi-Chun Chen, Bao-Cheng Xie
Summary: The effects of anti-diabetic drugs on fracture risk in type 2 diabetes mellitus patients may vary. Specific drugs like trelagliptin may increase fracture risk, while voglibose and albiglutide may show benefits, with other drugs having comparable effects.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuyun Li, Xiaoyang Xie, Shiyi Liao, Zhanwei Zeng, Siyan Li, Baocheng Xie, Qunfa Huang, Huan Zhou, Chenhui Zhou, Jiantao Lin, Yunsheng Huang, Daohua Xu
Summary: Breast cancer has become the most commonly diagnosed cancer in women worldwide. A011, a potential therapeutic agent for breast cancer, exerts its anticancer effects by inducing endoplasmic reticulum stress and cell apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Yongxiang Xu, Shichun Chen, Linxuan Huang, Weichao Han, Yingying Shao, Minyi Chen, Yusheng Zhang, Ruirong He, Baocheng Xie
Summary: In this research, the protective impacts of epimedin C on the osteogenic inhibition impact of MC3T3-E1 cells and zebrafish larvae mediated by DEX were examined. The results showed that epimedin C could alleviate the suppressive impact of DEX on the osteogenesis of MC3T3-E1 cells and zebrafish larvae by triggering the PI3K and AKT signaling pathways. This suggests that epimedin C has significant potential in the development of innovative drugs for the treatment of glucocorticoid-mediated osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
June Wang, Shenlin Du, Chen Wang, Zinian Zhu, Baocheng Xie, Bashan Zhang
Summary: Our meta-analysis showed that elevated SNHG7 expression in cancers is associated with unfavorable overall survival, TNM stage, lymph node metastasis, and tumor differentiation. The correlation was verified through stratified analysis and TCGA dataset evaluation.
Review
Medicine, General & Internal
Yu-Sheng Zhang, Ye-Hua Hao, Hou-Long Luo, Bao-Cheng Xie, Jian-Ying Fu, Zhi-Kun Zhou
Letter
Medicine, General & Internal
Bao-Cheng Xie, Qing-Hui Wang, Zhou-Mei Xu, Chen-Hui Zhou, Jia-Huan Wu, Dao-Hua Xu