The Drug Repurposing for COVID-19 Clinical Trials Provide Very Effective Therapeutic Combinations: Lessons Learned From Major Clinical Studies
出版年份 2021 全文链接
标题
The Drug Repurposing for COVID-19 Clinical Trials Provide Very Effective Therapeutic Combinations: Lessons Learned From Major Clinical Studies
作者
关键词
-
出版物
Frontiers in Pharmacology
Volume 12, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2021-11-18
DOI
10.3389/fphar.2021.704205
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Promising Therapy for Heart Failure in Patients with Severe COVID-19: Calming the Cytokine Storm
- (2021) Xiang Peng et al. CARDIOVASCULAR DRUGS AND THERAPY
- Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19
- (2021) Robert L. Gottlieb et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- High mortality rate in COVID-19 patients with myeloproliferative neoplasms after abrupt withdrawal of ruxolitinib
- (2021) Tiziano Barbui et al. LEUKEMIA
- Missing clinical trial data: the evidence gap in primary data for potential COVID-19 drugs
- (2021) Florence Rodgers et al. Trials
- SARS-CoV-2 protein drug targets landscape: a potential pharmacological insight view for the new drug development
- (2021) Chiranjib Chakraborty et al. Expert Review of Clinical Pharmacology
- COVID-19 lessons for research
- (2021) Francis S. Collins SCIENCE
- Covid-19 controversies: the tocilizumab chapter
- (2021) Erin K McCreary et al. BMJ-British Medical Journal
- Tocilizumab plus standard care versus standard care in patients in India with moderate to severe COVID-19-associated cytokine release syndrome (COVINTOC): an open-label, multicentre, randomised, controlled, phase 3 trial
- (2021) Arvinder S Soin et al. Lancet Respiratory Medicine
- Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19
- (2021) Pierre Kory et al. AMERICAN JOURNAL OF THERAPEUTICS
- Toxicity of psychotropic drugs in patients with COVID-19: A systematic review
- (2021) Michel Sabe et al. GENERAL HOSPITAL PSYCHIATRY
- Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- (2021) Obbina Abani et al. LANCET
- RECOVERY 1 year on: a rare success in the COVID-19 clinical trial landscape
- (2021) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Neutralizing Antibody Therapeutics for COVID-19
- (2021) Aeron C. Hurt et al. Viruses-Basel
- Neutralizing antibodies for the prevention and treatment of COVID-19
- (2021) Lanying Du et al. Cellular & Molecular Immunology
- Improved Survival Among Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Treated With Remdesivir and Dexamethasone. A Nationwide Population-Based Cohort Study
- (2021) Thomas Benfield et al. CLINICAL INFECTIOUS DISEASES
- Advances in the computational landscape for repurposed drugs against COVID-19
- (2021) Illya Aronskyy et al. DRUG DISCOVERY TODAY
- Clinical outcomes of patients with mild COVID-19 following treatment with hydroxychloroquine in an outpatient setting
- (2021) Majid Mokhtari et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19
- (2021) Michael Dougan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Evolution, Mode of Transmission, and Mutational Landscape of Newly Emerging SARS-CoV-2 Variants
- (2021) Chiranjib Chakraborty et al. mBio
- Interactions of anti-COVID-19 drug candidates with hepatic transporters may cause liver toxicity and affect pharmacokinetics
- (2021) Csilla Ambrus et al. Scientific Reports
- SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants
- (2021) Fiona Tea et al. PLOS MEDICINE
- Drug repurposing against coronavirus disease 2019 (COVID-19): A review
- (2021) Lianxiang Luo et al. Journal of Pharmaceutical Analysis
- SARS-CoV-2 Brazil variants in Latin America: More serious research urgently needed on public health and vaccine protection
- (2021) Chiranjib Chakraborty et al. Annals of Medicine and Surgery
- Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
- (2020) Manli Wang et al. CELL RESEARCH
- A Systematic Review of Lopinavir Therapy for SARS Coronavirus and MERS Coronavirus–A Possible Reference for Coronavirus Disease‐19 Treatment Option
- (2020) Tian‐Tian Yao et al. JOURNAL OF MEDICAL VIROLOGY
- Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia
- (2020) Ning Tang et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Baricitinib as potential treatment for 2019-nCoV acute respiratory disease
- (2020) Peter Richardson et al. LANCET
- Escaping Pandora’s Box — Another Novel Coronavirus
- (2020) David M. Morens et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19
- (2020) Markus Hoffmann et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Of chloroquine and COVID-19
- (2020) Franck Touret et al. ANTIVIRAL RESEARCH
- Probable Molecular Mechanism of Remdesivir for the Treatment of COVID-19: Need to Know More
- (2020) Abinit Saha et al. ARCHIVES OF MEDICAL RESEARCH
- Tocilizumab: A Therapeutic Option for the Treatment of Cytokine Storm Syndrome in COVID-19
- (2020) Abinit Saha et al. ARCHIVES OF MEDICAL RESEARCH
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- Headaches During COVID‐19: My Clinical Case and Review of the Literature
- (2020) Robert Belvis HEADACHE
- Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
- (2020) Chenguang Shen et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State
- (2020) Eli S. Rosenberg et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Cardiac and arrhythmic complications in patients with COVID‐19
- (2020) Adriano Nunes Kochi et al. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
- Fast Identification of Possible Drug Treatment of Coronavirus Disease-19 (COVID-19) through Computational Drug Repurposing Study
- (2020) Junmei Wang Journal of Chemical Information and Modeling
- Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy
- (2020) Ning Tang et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- The association between treatment with heparin and survival in patients with Covid-19
- (2020) Luis Ayerbe et al. JOURNAL OF THROMBOSIS AND THROMBOLYSIS
- Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial
- (2020) Ivan Fan-Ngai Hung et al. LANCET
- Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial
- (2020) Yeming Wang et al. LANCET
- COVID-19: consider cytokine storm syndromes and immunosuppression
- (2020) Puja Mehta et al. LANCET
- A human neutralizing antibody targets the receptor binding site of SARS-CoV-2
- (2020) Rui Shi et al. NATURE
- Human neutralizing antibodies elicited by SARS-CoV-2 infection
- (2020) Bin Ju et al. NATURE
- Remdesivir for the Treatment of Covid-19 — Preliminary Report
- (2020) John H. Beigel et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
- (2020) Bin Cao et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effective treatment of severe COVID-19 patients with tocilizumab
- (2020) Xiaoling Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effectiveness of convalescent plasma therapy in severe COVID-19 patients
- (2020) Kai Duan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Covid-19: FDA approves use of convalescent plasma to treat critically ill patients
- (2020) Janice Hopkins Tanne BMJ-British Medical Journal
- The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
- (2020) Leon Caly et al. ANTIVIRAL RESEARCH
- Pharmacokinetic considerations on the repurposing of ivermectin for treatment of COVID‐19
- (2020) Ricardo Peña‐Silva et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Hydroxychloroquine in rheumatic autoimmune disorders and beyond
- (2020) Eliise Laura Nirk et al. EMBO Molecular Medicine
- Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen
- (2020) Fatemeh Heidary et al. JOURNAL OF ANTIBIOTICS
- A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19
- (2020) Andrea Cortegiani et al. JOURNAL OF CRITICAL CARE
- Beneficial impact of Baricitinib in COVID-19 moderate pneumonia; multicentre study
- (2020) Fabrizio Cantini et al. JOURNAL OF INFECTION
- Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning
- (2020) Xiangxiang Zeng et al. JOURNAL OF PROTEOME RESEARCH
- Coronavirus breakthrough: dexamethasone is first drug shown to save lives
- (2020) Heidi Ledford NATURE
- Dexamethasone nanomedicines for COVID-19
- (2020) Twan Lammers et al. Nature Nanotechnology
- Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19
- (2020) Alexandre B. Cavalcanti et al. NEW ENGLAND JOURNAL OF MEDICINE
- Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report
- (2020) NEW ENGLAND JOURNAL OF MEDICINE
- Chloroquine and hydroxychloroquine for COVID-19: time to close the chapter
- (2020) Anunay Gupta et al. POSTGRADUATE MEDICAL JOURNAL
- Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
- (2020) Thomas F. Rogers et al. SCIENCE
- Comprehensive review of coronavirus disease 2019 (COVID-19)
- (2020) Shaylika Chauhan Biomedical Journal
- Response to: Status of Remdesivir: Not Yet Beyond Question!
- (2020) Abinit Saha et al. ARCHIVES OF MEDICAL RESEARCH
- Remdesivir against COVID-19 and Other Viral Diseases
- (2020) Jakob J. Malin et al. CLINICAL MICROBIOLOGY REVIEWS
- Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial
- (2020) Yan Lou et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Development of a Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung Exposure in Humans Following Oral Administration of Ivermectin for COVID-19 Drug Repurposing
- (2020) Brian Jermain et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- (2020) Peter W Horby et al. LANCET
- Utilizing drug repurposing against COVID-19 – Efficacy, limitations, and challenges
- (2020) Vineela Parvathaneni et al. LIFE SCIENCES
- COVID‐19 drug repurposing: A review of computational screening methods, clinical trials, and protein interaction assays
- (2020) Xueqing Wang et al. MEDICINAL RESEARCH REVIEWS
- Efficacy of Tocilizumab in Patients Hospitalized with Covid-19
- (2020) John H. Stone et al. NEW ENGLAND JOURNAL OF MEDICINE
- Repurposing Drugs, Ongoing Vaccine, and New Therapeutic Development Initiatives Against COVID-19
- (2020) Rudra P. Saha et al. Frontiers in Pharmacology
- FDA approved drugs with pharmacotherapeutic potential for SARS-CoV-2 (COVID-19) therapy
- (2020) Sylwester Drożdżal et al. DRUG RESISTANCE UPDATES
- COVID-19 outpatients: early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: a retrospective case series study
- (2020) Roland Derwand et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19
- (2020) Wesley H. Self et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Clinical efficacy and safety of favipiravir in the treatment of COVID-19 patients
- (2020) Ping-Jen Chen et al. JOURNAL OF INFECTION
- The place for remdesivir in COVID-19 treatment
- (2020) Barnaby Young et al. LANCET INFECTIOUS DISEASES
- Cytokine Storm
- (2020) David C. Fajgenbaum et al. NEW ENGLAND JOURNAL OF MEDICINE
- Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19
- (2020) Andre C. Kalil et al. NEW ENGLAND JOURNAL OF MEDICINE
- Dexamethasone Treatment for Covid-19, a Curious Precedent Highlighting a Regulatory Gap
- (2020) Lucia Gozzo et al. Frontiers in Pharmacology
- Neutralizing antibodies for the treatment of COVID-19
- (2020) Shibo Jiang et al. Nature Biomedical Engineering
- Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge
- (2019) Michael K. Lo et al. Science Translational Medicine
- Tocilizumab for the treatment of chimeric antigen receptor T cell-induced cytokine release syndrome
- (2019) Chelsea Kotch et al. Expert Review of Clinical Immunology
- Drug repurposing to improve treatment of rheumatic autoimmune inflammatory diseases
- (2019) Kathryn M. Kingsmore et al. Nature Reviews Rheumatology
- Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial
- (2018) Yaseen M. Arabi et al. Trials
- Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase
- (2018) Paul C. Jordan et al. PLoS Pathogens
- Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy
- (2018) Amber J. Giles et al. Journal for ImmunoTherapy of Cancer
- Drug repurposing: progress, challenges and recommendations
- (2018) Sudeep Pushpakom et al. NATURE REVIEWS DRUG DISCOVERY
- Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
- (2017) Dustin Siegel et al. JOURNAL OF MEDICINAL CHEMISTRY
- JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
- (2017) Daniella M. Schwartz et al. NATURE REVIEWS DRUG DISCOVERY
- Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase
- (2017) Yousuke FURUTA et al. PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
- Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
- (2016) Travis K. Warren et al. NATURE
- The Next Epidemic — Lessons from Ebola
- (2015) Bill Gates NEW ENGLAND JOURNAL OF MEDICINE
- Mavrilimumab, a human monoclonal GM-CSF receptor-α antibody for the management of rheumatoid arthritis: a novel approach to therapy
- (2012) Jagdish R Nair et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
- (2008) K. Ratia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started