Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders

Alzheimer disease

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Association between Mental Disorders and Subsequent Medical Conditions

(2020) Natalie C. Momen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling

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Association of Specific Mental Disorders With Premature Mortality in the Danish Population Using Alternative Measurement Methods

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Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

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Identification of common genetic risk variants for autism spectrum disorder

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Shared genetic architecture between metabolic traits and Alzheimer’s disease: a large-scale genome-wide cross-trait analysis

(2019) Zhaozhong Zhu et al.   HUMAN GENETICS

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

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Genetic correlations of polygenic disease traits: from theory to practice

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Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

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Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives

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Converging evidence points towards a role of insulin signaling in regulating compulsive behavior

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Insulin Receptor Trafficking: Consequences for Insulin Sensitivity and Diabetes

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Genome-Wide Association Study of the Metabolic Syndrome in UK Biobank

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Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain

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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

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Ambient air pollution and diabetes: A systematic review and meta-analysis

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Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

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Mechanisms of Insulin Action and Insulin Resistance

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Exploring shared genetic bases and causal relationships of schizophrenia and bipolar disorder with 28 cardiovascular and metabolic traits

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Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

(2018) Ditte Demontis et al.   NATURE GENETICS

The Epigenetics of Alzheimer’s Disease: Factors and Therapeutic Implications

(2018) Xiaolei Liu et al.   Frontiers in Genetics

Glucose tolerance and insulin sensitivity are impaired in APP/PS1 transgenic mice prior to amyloid plaque pathogenesis and cognitive decline

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GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors

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Metabolic and Cardiovascular Complications in Obsessive-Compulsive Disorder: A Total Population, Sibling Comparison Study With Long-Term Follow-up

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An integrated molecular landscape implicates the regulation of dendritic spine formation through insulin-related signalling in obsessive–compulsive disorder

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Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model

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Association of Maternal Diabetes With Autism in Offspring

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An atlas of genetic correlations across human diseases and traits

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Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis

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Mortality in Mental Disorders and Global Disease Burden Implications

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Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

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Research Review: Polygenic methods and their application to psychiatric traits

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Metabolic syndrome and obsessive–compulsive disorder: a naturalistic Italian study

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Maternal Metabolic Conditions and Risk for Autism and Other Neurodevelopmental Disorders

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Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study

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Insulin Signaling and Autism

(2011) Michael Stern   Frontiers in Endocrinology

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

Removal of FKBP12 Enhances mTOR-Raptor Interactions, LTP, Memory, and Perseverative/Repetitive Behavior

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