4.5 Article

Chirality and the Origin of Life

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SYMMETRY-BASEL
卷 13, 期 12, 页码 -

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MDPI
DOI: 10.3390/sym13122277

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chirality; L-amino acids; D-sugars; parity violation; decay of left-handed particles; neutrinos

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The homochirality of biomolecules plays a crucial role in the origin and evolution of life, with all living creatures on Earth exhibiting chirality. The origin of life may involve various factors such as the presence of chirality in the early Universe, choices made in forms of life, and the impact of factors like heavy neutrinos and dark matter.
The origin of life, based on the homochirality of biomolecules, is a persistent mystery. Did life begin by using both forms of chirality, and then one of the forms disappeared? Or did the choice of homochirality precede the formation of biomolecules that could ensure replication and information transfer? Is the natural choice of L-amino acids and D-sugars on which life is based deterministic or random? Is the handedness present in/of the Universe from its beginning? The whole biosystem on the Earth, all living creatures are chiral. Many theories try to explain the origin of life and chirality on the Earth: e.g., the panspermia hypothesis, the primordial soup hypothesis, theory of parity violation in weak interactions. Additionally, heavy neutrinos and the impact of the fact that only left-handed particles decay, and even dark matter, all have to be considered.

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