期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 10, 期 2, 页码 214-223出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1tb02111g
关键词
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资金
- Natural Science Foundation of China [51905553, 51935014, 82072084, 81871498]
- Hunan Provincial Natural Science Foundation of China [2021JJ20061, 2020JJ3047, 2019JJ50588]
- Provincial Key R & D Projects of Jiangxi [20201BBE51012]
- Project of State Key Laboratory of High Performance Complex Manufacturing
- Fundamental Research Funds for the Central Universities of Central South University [2021zzts0143]
The study successfully improved the mechanical properties and bioactivity of the composite scaffold by grafting PDLA onto the surface of HAP nanoparticles and enhancing the interfacial bonding between PLLA and HAP through stereocomplexation in scaffold fabrication.
The poly(l-lactide) (PLLA)/hydroxyapatite (HAP) composite scaffold is expected to combine the favorable compatibility and processability of PLLA with the excellent bioactivity and osteoconductivity of HAP. Unfortunately, the poor interfacial bonding between PLLA and HAP leads to a deterioration in mechanical properties. In this study, poly(d-lactide) (PDLA) was grafted onto the surface of HAP nanoparticles (g-HAP), and then g-HAP was incorporated into PLLA to improve interfacial bonding by stereocomplexation in a scaffold fabricated via selective laser sintering (SLS). The results showed that HAP nanoparticles were grafted with PDLA at a grafting rate of 8.72% by ring-opening polymerization through chemical bonding in the presence of the hydroxyl groups of HAP. The grafted PDLA formed an interfacial stereocomplex with PLLA via an intertwined spiral structure ascribed to their antiparallel and complementary configuration under the action of hydrogen bonding. Consequently, the tensile strength and modulus of the PLLA/g-HAP scaffold increased by 86% and 69%, respectively, compared to those of the PLLA/HAP scaffold. In addition, the scaffold displayed good bioactivity by inducing apatite nucleation and deposition and possessed good cytocompatibility for cell adhesion, growth and proliferation.
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