Article
Microbiology
Rongfeng Tang, Longjun Guo, Qianjin Fan, Liaoyuan Zhang, Yiming Wang, Xin Zhang, Da Shi, Yang Wu, Hongyan Shi, Jianbo Liu, Jianfei Chen, Li Feng
Summary: In vitro experiments confirmed the antiviral activity of Griffithsin against Porcine deltacoronavirus (PDCoV), indicating its potential as a candidate drug for prevention and treatment of PDCoV infection. Griffithsin binds to the spike protein of PDCoV, wrapping the virus and blocking its entry.
VETERINARY MICROBIOLOGY
(2022)
Article
Microbiology
Likai Ji, Qianqian Liu, Na Wang, Yan Wang, Jianhe Sun, Yaxian Yan
Summary: This study demonstrates that STAU1 plays a crucial role in maintaining the binding of RIG-I/MDA5 to viral dsRNA in pigs and can suppress viral proliferation.
VETERINARY MICROBIOLOGY
(2022)
Article
Microbiology
Yujia Zhao, Dai Xiao, Luwen Zhang, Daili Song, Rui Chen, Shiqian Li, Yijie Liao, Yimin Wen, Weizhe Liu, Enbo Yu, Yiping Wen, Rui Wu, Qin Zhao, Senyan Du, Xintian Wen, Sanjie Cao, Xiaobo Huang
Summary: This study evaluated three HSP90 inhibitors for their effects on Porcine deltacoronavirus (PDCoV) infection and found that 17-AAG and VER-82576 showed inhibitory effects on PDCoV replication, possibly by targeting the host cell factor HSP90AB1.
VETERINARY MICROBIOLOGY
(2022)
Article
Virology
Zhuang Li, Puxian Fang, Panpan Duan, Jiyao Chen, Liurong Fang, Shaobo Xiao
Summary: In this study, it was found that infection by porcine deltacoronavirus (PDCoV) leads to a decrease in cellular histone deacetylase (HDAC) activity. The viral nonstructural protein 5 (nsp5), a 3C-like protease, cleaved HDAC2 during PDCoV infection. HDAC2 plays a role in inhibiting PDCoV replication. These findings suggest that cleaving HDAC2 may be a common strategy used by different mammalian coronaviruses, including the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), to counteract the antiviral effects of HDAC2.
JOURNAL OF VIROLOGY
(2022)
Review
Veterinary Sciences
Cong Duan
Summary: The recent experience with SARS-COV-2 has raised concerns about the potential for cross-species transmission of coronaviruses. In this review, the authors summarize the current knowledge on a newly emerging member of the coronavirus family called Porcine deltacoronavirus (PDCoV), which causes diarrhea in pigs and has the potential to infect other species, including humans. Understanding the epidemiology, pathogenesis, and immune evasion strategies of PDCoV is important for controlling its spread and also for gaining insights into common cellular pathways and key factors of coronaviruses.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Microbiology
Tong-Yun Wang, Ming-Xia Sun, Hong-Liang Zhang, Gang Wang, Guoqing Zhan, Zhi-Jun Tian, Xue-Hui Cai, Chenhe Su, Yan-Dong Tang
Summary: Innate immunity serves as the initial defense against viral infections, but viruses like PRRSV have evolved various strategies to evade it. PRRSV, a highly destructive virus in the global swine industry, utilizes multiple strategies to avoid porcine innate immune responses. Understanding the evasion mechanisms employed by PRRSV can aid in developing more effective methods to control and eliminate the virus.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
John A. Lednicky, Massimiliano S. Tagliamonte, Sarah K. White, Maha A. Elbadry, Md Mahbubul Alam, Caroline J. Stephenson, Tania S. Bonny, Julia C. Loeb, Taina Telisma, Sonese Chavannes, David A. Ostrov, Carla Mavian, Valery Madsen Beau De Rochars, Marco Salemi, J. Glenn Morris
Summary: Since 2003, coronaviruses have caused three major epidemics, including the ongoing SARS-CoV-2 pandemic. The emergence of coronaviruses in human species has been associated with zoonotic transmissions from animal reservoirs, emphasizing the propensity of such pathogens to spill over and adapt to new species.
Review
Biochemistry & Molecular Biology
Nur Azizah A. Rahman, Vinod R. M. T. Balasubramaniam, Wei Boon Yap
Summary: The IL-12 family consists of cytokines that play a crucial role in activating host antiviral immunity and preventing excessive immune reactions. IL-12 and IL-23 stimulate T cell proliferation and effector cytokine release, leading to host defense against virus infections. IL-27 and IL-35 have dual functions in regulating cytokine synthesis, T cell proliferation, and viral antigen presentation to enhance virus clearance. The multitasking nature of the IL-12 family makes it a highly important target for antiviral therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Sylvie M. A. Quiniou, Jonathan Crider, Kristianna L. Felch, Eva Bengten, Pierre Boudinot
Summary: In this study, we identified the complete repertoire of IFNs and IFN receptor genes in channel catfish. We found 16 type I IFN genes representing six previously defined subgroups, as well as two type II IFN genes and their respective receptors. Our findings provide a comprehensive resource for future research on the innate antiviral immunity of channel catfish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Amaro Saco, Magali Rey-Campos, Beatriz Novoa, Antonio Figueras
Summary: In this study, mussels were challenged with viral haemorrhagic septicaemia virus (VHSV), and the viral load was eliminated after 24 hours. Mussels showed antiviral activity towards VHSV, indicating that the virus was recognized and eliminated by the mussel immune system, confirming that mussels are not VHSV vectors in the marine environment. The study also revealed the involvement of cytoplasmic viral sensors, JAK-STAT pathway activation, and various downstream antiviral effectors in the mussel immune response.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Peng Gao, Xianwei Ma, Ming Yuan, Yulan Yi, Guoke Liu, Mingyue Wen, Wei Jiang, Ruihua Ji, Lingxi Zhu, Zhen Tang, Qingzhuo Yu, Jing Xu, Rui Yang, Sheng Xia, Mingjin Yang, Jianping Pan, Hongbin Yuan, Huazhang An
Summary: The study highlights the crucial role of Nedd4l in regulating antiviral immunity through promoting ubiquitination of TRAF3, and disruption of Nedd4l impairs the antiviral immune response both in vitro and in vivo.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Yunyun Guo, Fei Jiang, Lingli Kong, Haifeng Wu, Honghai Zhang, Xiaorong Chen, Jian Zhao, Baoshan Cai, Yanqi Li, Chunhong Ma, Fan Yi, Lei Zhang, Bingyu Liu, Yi Zheng, Lingqiang Zhang, Chengjiang Gao
Summary: STING is a critical adaptor protein for innate antiviral and antitumor immunity, regulated by protein ubiquitination, with OTUD5 identified as a key deubiquitinase that interacts with STING to maintain its stability. Knockout of OTUD5 resulted in impaired immune responses and increased susceptibility to viral infection and tumor development.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Line Lykke Andersen, Yiqi Huang, Christian Urban, Lila Oubraham, Elena Winheim, Che Stafford, Dennis Nagl, Fionan O'Duill, Thomas Ebert, Thomas Engleitner, Soren Riis Paludan, Anne Krug, Roland Rad, Veit Hornung, Andreas Pichlmair
Summary: The immune system plays a crucial role in maintaining tissue homeostasis and defending against invading pathogens, and extracellular nucleotides are known to contribute to immune signaling specificity. This study focused on the responses of human macrophages to extracellular nucleotides, specifically looking at the P2Y family of nucleotide-sensing GPRC receptors. The findings reveal the important functions of P2Y receptors in regulating both inflammatory and antiviral responses in macrophages.
Article
Cell Biology
Fei Qin, Baoshan Cai, Peng Wang, Runyu Cao, Yuling Zhang, Hongling Wen, Yi Zheng, Wei Zhao, Chengjiang Gao, Bingyu Liu
Summary: This study reveals the role of the ESCRT system in regulating RLR-mediated antiviral responses and identifies LTN1 as a negative regulator of RLR-mediated antiviral innate immunity. This research provides new targets for intervention in viral infections.
Article
Immunology
Jie Wang, Zhenyu Lin, Qiuju Liu, Feiyu Fu, Zhaofei Wang, Jingjiao Ma, Hengan Wang, Yaxian Yan, Yuqiang Cheng, Jianhe Sun
Summary: Bats, important hosts for various zoonotic viral diseases, rarely show signs of disease infection with such viruses. This study cloned the batMDA5 gene, a major sensor for anti-RNA viral infection, and identified its biological functions in antiviral innate immunity. The study revealed that bats employ a conserved MDA5 gene to trigger the immune response against RNA viruses.
FRONTIERS IN IMMUNOLOGY
(2022)
