Shiga Toxins as Antitumor Tools

A phase I open-label study to investigate safety and tolerability, efficacy, pharmacokinetics, pharmacodynamics, and immunogenicity of MT-5111 in patients with HER2-positive tumors.

(2021) Zev A. Wainberg et al.   JOURNAL OF CLINICAL ONCOLOGY

Potent in vitro antitumor activity of B-subunit of Shiga toxin conjugated to the diphtheria toxin against breast cancer

(2021) Zeinab Mohseni et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of Recent Therapeutic Applications and the Infection Strategies of Shiga Toxin-Producing Escherichia coli

(2021) Su-bin Hwang et al.   Frontiers in Cellular and Infection Microbiology

MT-5111: A novel HER2 targeting engineered toxin body in clinical development.

(2020) Roger J. Waltzman et al.   JOURNAL OF CLINICAL ONCOLOGY

A phase II study of MT-3724, a novel CD20-targeting engineered toxin body, to evaluate safety, pharmacodynamics, and efficacy in subjects with relapsed or refractory diffuse large B-cell lymphoma.

(2020) Adolfo Enrique Diaz Duque et al.   JOURNAL OF CLINICAL ONCOLOGY

A phase I study of the novel immunotoxin, MT-5111, in subjects (subj) with HER-2 positive tumors: Interim results.

(2020) Zev A. Wainberg et al.   JOURNAL OF CLINICAL ONCOLOGY

Verotoxin-1-Induced ER Stress Triggers Apoptotic or Survival Pathways in Burkitt Lymphoma Cells

(2020) Justine Debernardi et al.   Toxins

Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins

(2019) Nadine Eliane Schmit et al.   ACS Chemical Biology

Shiga Toxin Induces Lipid Compression: A Mechanism for Generating Membrane Curvature

(2019) Erik B. Watkins et al.   NANO LETTERS

A Phase 1 First-in-Human Study of the Anti-CD38 Dimeric Fusion Protein TAK-169 for the Treatment of Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM) Who Are Proteasome Inhibitor (PI)- and Immunomodulatory Drug (IMiD)-Refractory, Including Pts Relapsed/Refractory (R/R) or Naïve to Daratumumab (dara)

(2019) Shaji K. Kumar et al.   BLOOD

Targeted Diphtheria Toxin-Based Therapy: A Review Article

(2019) Fatemeh Shafiee et al.   Frontiers in Microbiology

Structural and Functional Characterization of Stx2k, a New Subtype of Shiga Toxin 2

(2019) Anna C. Hughes et al.   Microorganisms

Hemolytic uremic syndrome due to Shiga toxin-producing Escherichia coli infection

(2018) M. Bruyand et al.   MEDECINE ET MALADIES INFECTIEUSES

In Vivo Tumor Targeting by the B-Subunit of Shiga Toxin

(2018) Thomas Viel et al.   Molecular Imaging

Tumor Delivery of Ultrasound Contrast Agents Using Shiga Toxin B Subunit

(2018) Olivier Couture et al.   Molecular Imaging

Shiga Toxins Induce Apoptosis and ER Stress in Human Retinal Pigment Epithelial Cells

(2017) Jun-Young Park et al.   Toxins

Shiga Toxin—A Model for Glycolipid-Dependent and Lectin-Driven Endocytosis

(2017) Ludger Johannes   Toxins

Engineering of bacterial exotoxins for highly efficient and receptor-specific intracellular delivery of diverse cargos

(2016) Jeong-Hyun Ryou et al.   BIOTECHNOLOGY AND BIOENGINEERING

Gastric Adenocarcinomas Express the Glycosphingolipid Gb3/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit

(2016) P. E. Geyer et al.   MOLECULAR CANCER THERAPEUTICS

Membrane invagination induced by Shiga toxin B-subunit: from molecular structure to tube formation

(2016) W. Pezeshkian et al.   Soft Matter

Shiga toxins induce autophagic cell death in intestinal epithelial cells via the endoplasmic reticulum stress pathway

(2015) Bin Tang et al.   Autophagy

Targeted Shiga toxin–drug conjugates prepared via Cu-free click chemistry

(2015) Vesela Kostova et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A new delivery system for auristatin in STxB-drug conjugate therapy

(2015) Cornélie Batisse et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Activation of the Classical Mitogen-Activated Protein Kinases Is Part of the Shiga Toxin-Induced Ribotoxic Stress Response and May Contribute to Shiga Toxin-Induced Inflammation

(2015) Dakshina M. Jandhyala et al.   INFECTION AND IMMUNITY

Shiga Toxin 2-Induced Endoplasmic Reticulum Stress Is Minimized by Activated Protein C but Does Not Correlate with Lethal Kidney Injury

(2015) Caitlin Parello et al.   Toxins

Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin

(2015) Takayuki Hattori et al.   FEBS Open Bio

Human breast cancer and lymph node metastases express Gb3 and can be targeted by STxB-vectorized chemotherapeutic compounds

(2014) Lev Stimmer et al.   BMC CANCER

Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers

(2014) Ramya Lakshminarayan et al.   NATURE CELL BIOLOGY

Yessotoxin triggers ribotoxic stress

(2014) Mónica Suárez Korsnes et al.   TOXICOLOGY IN VITRO

Need for Long-term Follow-up in Enterohemorrhagic Escherichia coli–Associated Hemolytic Uremic Syndrome Due to Late-Emerging Sequelae

(2012) Alejandra Rosales et al.   CLINICAL INFECTIOUS DISEASES

Ceramide Glycosylation by Glucosylceramide Synthase Selectively Maintains the Properties of Breast Cancer Stem Cells

(2012) Vineet Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of Shiga toxin glycosphingolipid receptors with membrane microdomains of toxin-sensitive lymphoid and myeloid cells

(2012) Ivan U. Kouzel et al.   JOURNAL OF LIPID RESEARCH

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shiga toxins induce autophagy leading to differential signalling pathways in toxin-sensitive and toxin-resistant human cells

(2011) Moo-Seung Lee et al.   CELLULAR MICROBIOLOGY

Differential Response of the Human Renal Proximal Tubular Epithelial Cell Line HK-2 to Shiga Toxin Types 1 and 2

(2011) Erin K. Lentz et al.   INFECTION AND IMMUNITY

Tumor-Specific Targeting of Pancreatic Cancer with Shiga Toxin B-Subunit

(2011) M. Maak et al.   MOLECULAR CANCER THERAPEUTICS

Signaling through C/EBP Homologous Protein and Death Receptor 5 and Calpain Activation Differentially Regulate THP-1 Cell Maturation-Dependent Apoptosis Induced by Shiga Toxin Type 1

(2010) M.-S. Lee et al.   INFECTION AND IMMUNITY

Shiga Toxin Increases Formation of Clathrin-Coated Pits through Syk Kinase

(2010) Audrun Utskarpen et al.   PLoS One

Shiga toxin and its use in targeted cancer therapy and imaging

(2010) Nikolai Engedal et al.   Microbial Biotechnology

Expression of verotoxin-1 receptor Gb3 in breast cancer tissue and verotoxin-1 signal transduction to apoptosis

(2009) David Johansson et al.   BMC CANCER

Cisplatin-induced expression of Gb3 enables verotoxin-1 treatment of cisplatin resistance in malignant pleural mesothelioma cells

(2009) D Johansson et al.   BRITISH JOURNAL OF CANCER

Caspase-8-mediated cleavage of Bid and protein phosphatase 2A-mediated activation of Bax are necessary for Verotoxin-1-induced apoptosis in Burkitt's lymphoma cells

(2009) Julie Garibal et al.   CELLULAR SIGNALLING

Bcl-2 Regulates the Onset of Shiga Toxin 1-Induced Apoptosis in THP-1 Cells

(2009) M.-S. Lee et al.   INFECTION AND IMMUNITY

SDPR induces membrane curvature and functions in the formation of caveolae

(2009) Carsten G. Hansen et al.   NATURE CELL BIOLOGY

Shiga Toxin Receptor Gb3Cer/CD77: Tumor-Association and Promising Therapeutic Target in Pancreas and Colon Cancer

(2009) Ute Distler et al.   PLoS One

Retrograde Delivery of Photosensitizer (TPPp-O-β-GluOH)3Selectively Potentiates Its Photodynamic Activity

(2008) Mohamed Amessou et al.   BIOCONJUGATE CHEMISTRY

Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells

(2008) Sang-Yun Lee et al.   CELLULAR MICROBIOLOGY

Synthesis and Properties of a Mitochondrial Peripheral Benzodiazepine Receptor Conjugate

(2008) Abdessamad El Alaoui et al.   ChemMedChem

Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool

(2008) T. Falguieres et al.   MOLECULAR CANCER THERAPEUTICS