Article
Gastroenterology & Hepatology
Jan C. DeNofrio, Manisha Verma, Andrzej S. Kosinski, Victor Navarro, Tamar H. Taddei, Michael L. Volk, Marie Bakitas, Kavitha Ramchandran
Summary: The study demonstrates that providing palliative care education to hepatologists through an online course is feasible and effective in improving their knowledge and confidence, with over 80% of hepatologists integrating palliative care skills into routine patient care a year later.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Yoshifumi Sugiyama, Rieko Mutai, Hisashi Yoshimoto, Ryoko Horiguchi, Shuhei Yoshida, Masato Matsushima
Summary: This study verified the structural validity and internal consistency of the English version of the Patient Centred Assessment Method (PCAM) in a primary care setting in a Japanese island area. The previously reported two-factor and three-factor structures did not fit the data well, but exploratory factor analysis revealed a new two-factor structure with validated internal consistency.
Article
Medicine, General & Internal
Karen M. Goldstein, Kathleen R. Perry, Allison Lewinski, Conor Walsh, Megan E. Shepherd-Banigan, Hayden B. Bosworth, Hollis Weidenbacher, Dan Blalock, Leah L. Zullig
Summary: This study aims to develop a novel clinical algorithm to guide primary care clinics on how and when to use video visits as part of care delivery. The key findings suggest that clinical teams should have adequate technical support, encourage engagement during video visits, and use video visits for appropriate clinical situations. Patients faced challenges with broadband access, inadequate equipment, concerns about the quality of video care, the importance of visit modality choice, and preferences for in-person care experience over virtual care.
Review
Medicine, General & Internal
David T. Liss, Toshiko Uchida, Cheryl L. Wilkes, Ankitha Radakrishnan, Jeffrey A. Linder
Summary: General health checks are often not associated with decreased mortality or cardiovascular events, but are linked to increased detection and treatment of chronic diseases, control of risk factors, uptake of preventive services, and improvements in patient-reported outcomes. Primary care teams can reasonably offer general health checks, especially to high-risk groups who are overdue for preventive services, have uncontrolled risk factors, low self-rated health, or inadequate access to primary care.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Medicine, General & Internal
Alessandra Queiroga Goncalves, Ethel Sequeira-Aymar, Carina Aguilar Martin, Rosa Maria Dalmau, Angeline Cruz, Stella Evangelidou, Sally Hargreaves, Ana Requena-Mendez, Constanza Jacques-Avino
Summary: This study aimed to explore the views of general practitioners (GPs) on a multidisease screening program for migrant populations using the ISMiHealth tool. The results showed that GPs found the ISMiHealth tool to be useful for identifying specific health problems in migrants, but there were barriers to screening in primary healthcare. GPs emphasized the importance of healthcare provision for migrants and proposed ways to improve screening.
Article
Education & Educational Research
Mostafa Dehghani Poudeh, Aeen Mohammadi, Rita Mojtahedzadeh, Nikoo Yamani
Summary: The study developed and customized EPAs for Iranian Internal Medicine Residency Programs by collecting expert opinions, refining the list in a focus group, determining the entrustability level of each residency year, and establishing the EPA-competency cross-tab through validation. A total of twenty-eight EPAs were developed to cover a wide range of competencies, some suitable for higher levels of residency and some expected to be performed independently even from the first year.
BMC MEDICAL EDUCATION
(2021)
Article
Multidisciplinary Sciences
Beatriz Tarazona-Alvarez, Natalia Zamora-Martinez, Veronica Garcia-Sanz, Vanessa Paredes-Gallardo, Carlos Bellot-Arcis, Rut Lucas-Dominguez, Antonio Vidal-Infer
Summary: This study reveals the disparities in open data sharing policies among medical journals, with only a third allowing manuscript deposit and reuse, and around half agreeing to publish documents online and include supplementary material. However, only 9.5% of articles analyzed contained supplementary material, with main journals like BMJ Open, JAMA Network Open, New England Journal of Medicine, Lancet and Plos Medicine leading the way.
Article
Primary Health Care
Camilla Aakjaer Andersen, Timothy C. Guetterman, Michael D. Fetters, John Brodersen, Annette Sofie Davidsen, Ole Graumann, Martin Bach Jensen
Summary: Researchers aimed to understand general practitioners' views on appropriate ultrasound use and compare them with actual practices. They found discrepancies between the two, highlighting the need for evidence-based guidelines and training for general practitioners.
ANNALS OF FAMILY MEDICINE
(2022)
Article
Medicine, General & Internal
Danielle Mazza, Sharon James, Kirsten Black, Angela Taft, Deborah Bateson, Kevin McGeechan, Wendy Norman
Summary: This study aims to establish an online community of practice (AusCAPPS Network) to improve the provision of long-acting reversible contraception (LARC) and early medical abortion (EMA) services in Australian primary care. The study will utilize a stakeholder knowledge exchange workshop to inform the design of the network, and will evaluate its effectiveness and impact through health service data, online surveys, and interviews.
Article
Health Care Sciences & Services
Stacie Schmidt, Reena Gupta, Jennifer Bracey, Anna Volerman, Tracey Henry, Christopher Jackson, Diana Levine, Danielle Jones, James M. Richter, Jennifer Schmidt, Lisa Rotenstein, Zackary Berger, Kimberly Peairs, Harpreet Singh, Mark Schwartz, Jim Bailey, John Goodson
Summary: As members of the Clinical Practice Committee of SGIM, we support practice innovation and transformation to achieve a more just system. The COVID-19 pandemic has highlighted system shortcomings and called for reflection on lessons learned for the future. CPC members provide expertise in various areas of healthcare and advocate for accessible, equitable, patient-centered, and cost-effective care.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Samuel Etienne, Karoline Leuzinger, Hans H. Hirsch, Michael Osthoff
Summary: Primary CMV infection in immunocompetent adults presents with different clinical features compared to primary EBV infection, including older age, longer illness duration, and more frequent systemic symptoms. Over-testing may be unnecessary when diagnosing primary CMV infection.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Jill M. Huber, Mark L. Wieland, Shari L. Bornstein, Karen F. Mauck, Jason H. Szostek, Jason A. Post, Majken T. Wingo
Summary: Clinicians face challenges in keeping up with practice-changing articles. Reviewing relevant articles and guideline updates can help clinicians stay informed on new data impacting clinical practice. This study reviewed titles and abstracts from the highest impact general internal medicine outpatient journals, as well as article synopsis collections and databases to identify practice-changing articles and highlight key guideline updates. Five practice-changing articles and important guideline updates were included. © 2023 Elsevier Inc. All rights reserved. • The American Journal of Medicine (2023)
AMERICAN JOURNAL OF MEDICINE
(2023)
Review
Medicine, General & Internal
Majken T. Wingo, Jill M. Huber, Shari L. Bornstein, Karna K. Sundsted, Karen F. Mauck, Jason H. Szostek, Jason A. Post, Mark L. Wieland
Summary: This study reviewed titles and abstracts from several general internal medicine outpatient journals to identify 8 practice-changing articles that could impact clinical practice.
AMERICAN JOURNAL OF MEDICINE
(2022)
Review
Medicine, General & Internal
Majken T. Wingo, Jill M. Huber, Jason H. Szostek, Shari L. Bornstein, Jason A. Post, Karen F. Mauck, Mark L. Wieland
Summary: In a time of rapidly shifting evidence-based medicine, a group of internists reviewed 7 internal medicine journals to identify 7 practice-changing articles, aiming to enhance knowledge of practice-changing literature.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Simon Dyrlov Madsen, Lars Morso, Werner Vach, Merethe Kirstine Andersen, Jesper Lykkegaard, Berit Schiottz-Christensen, Mette Jensen Stochkendahl
Summary: This study explored the care provided by GPs, PTs, and DCs to patients with low back pain. The results showed significant variation in care elements and practice patterns between professions.
Article
Gastroenterology & Hepatology
Vincent Wai-Sun Wong, Won Young Tak, George Boon Bee Goh, Pin-Nan Cheng, Eric J. Lawitz, Zobair M. Younossi, Raj Vuppalanchi, Ziad Younes, Naim Alkhouri, Lulu Wang, Jialuo Liu, Kathryn Kersey, Robert P. Myers, Stephen A. Harrison, Zachary Goodman, Michael Trauner, Manuel Romero-Gomez, Quentin M. Anstee, Mindie H. Nguyen, Takeshi Okanoue
Summary: This study evaluated the performance of noninvasive tests in diagnosing advanced fibrosis due to NASH in white and Asian patients, and found that these tests performed similarly in both groups. However, the sensitivities of NFS, FIB-4, and ELF were low in white and Asian patients younger than 40 years.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Mathematical & Computational Biology
Hannah O'Keefe, Judith Rankin, Sheila A. Wallace, Fiona Beyer
Summary: Current methodologies for designing search strategies heavily rely on the expertise of information specialists, but the overwhelming volume and complexity of scientific literature pose challenges for even experienced specialists in producing robust search strategies for complex systematic reviews. This case study aimed to assess the benefits and limitations of using semi-automated text-mining tools for designing search strategies in a systematic review of diagnostic test accuracy. The evaluation revealed additional terms and previously unidentified relevant articles retrieved by the tools, but precision was either reduced or remained the same. Comparative analysis also showed discrepancies between similar tools. Tailored tools that meet the requirements of information specialists across disciplines are needed for the mainstream use of semi-automated techniques in information retrieval for complex systematic reviews.
RESEARCH SYNTHESIS METHODS
(2023)
Article
Primary Health Care
Joy Adamson, Helen Hanson, Adam Todd, Rachel Duncan, Barbara Hanratty, Louise Robinson
Summary: This study explores the experiences of medication management among nonagenarians and its implications for primary care practice. The findings indicate that most older people do not experience significant problems with medication management. Taking medications becomes a habitual part of daily routines and is generally accepted. However, disruptions to steady states, such as new medical diagnoses or major life events, can cause challenges in medication management.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Review
Medicine, General & Internal
Hannah O'Keefe, Rebekka Shenfine, Melissa Brown, Fiona Beyer, Judith Rankin
Summary: This systematic review assessed the diagnostic accuracy of non-invasive or minimally invasive autopsy techniques in deaths under 1 year of age. The review included 54 direct evidence studies and 134 indirect evidence studies, finding positive effects for some techniques such as postmortem ultrasound and antenatal echography. However, the effects of virtual autopsy and other techniques remain inconclusive.
Review
Health Care Sciences & Services
Fiona Beyer, Stephen Rice, Giovany Orozco-Leal, Madeleine Still, Hannah O'Keefe, Nicole O'Connor, Akvile Stoniute, Dawn Craig, Stephen Pereira, Louise Carr, John Leeds
Summary: This study assessed the effectiveness, cost-effectiveness, and risks of endoscopic bipolar radiofrequency ablation for malignant biliary obstruction. The results showed that primary radiofrequency ablation increased survival and was likely to be cost-effective. However, there is limited evidence on the impact of secondary radiofrequency ablation on survival and quality of life, highlighting the need for further research.
HEALTH TECHNOLOGY ASSESSMENT
(2023)
Article
Gastroenterology & Hepatology
Quentin M. Anstee, Kathryn J. Lucas, Sven Francque, Manal F. Abdelmalek, Arun J. Sanyal, Vlad Ratziu, Adrian C. Gadano, Mary Rinella, Michael Charlton, Rohit Loomba, Edward Mena, Joern M. Schattenberg, Mazen Noureddin, Donald Lazas, George B. B. Goh, Shiv K. Sarin, Yusuf Yilmaz, Miljen Martic, Rowan Stringer, Jossy Kochuparampil, Li Chen, Gerardo Rodriguez-Araujo, Elaine Chng, Nikolai V. Naoumov, Clifford Brass, Marcos C. Pedrosa
Summary: This study assessed the safety and efficacy of the combined treatment of tropifexor and cenicriviroc for NASH, compared to monotherapy. The combination treatment did not show substantial incremental efficacy compared to monotherapy.
Correction
Gastroenterology & Hepatology
Quentin M. Anstee, Rebecca Darlay, Simon Cockell, Marica Meroni, Olivier Govaere, Dina Tiniakos, Alastair D. Burt, Pierre Bedossa, Jeremy Palmer, Yang-Lin Liu, Guruprasad P. Aithal, Michael Allison, Hannele Yki-Jarvinen, Michele Vacca, Jean-Francois Dufour, Pietro Invernizzi, Daniele Prati, Mattias Ekstedt, Stergios Kechagias, Sven Francque, Salvatore Petta, Elisabetta Bugianesi, Karine Clement, Vlad Ratziu, Joern M. Schattenberg, Luca Valenti, Christopher P. Day, Heather J. Cordell, Ann K. Daly
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Stephen A. Harrison, Vlad Ratziu, Jeremy Magnanensi, Yacine Hajji, Sylvie Deledicque, Zouher Majd, Christian Rosenquist, Dean W. Hum, Bart Staels, Quentin M. Anstee, Arun J. Sanyal
Summary: NIS2+ (TM) is a robust optimization of NIS4(R) technology for the detection of at-risk NASH, providing improved performance through enhanced score robustness.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jia-xu Liang, Javier Ampuero, Hao Niu, Kento Imajo, Mazen Noureddin, Jaideep Behari, Dae Ho Lee, Richard L. Ehman, Fredrik Rorsman, Johan Vessby, Juan R. Lacalle, Ferenc E. Mozes, Michael Pavlides, Quentin M. Anstee, Stephen A. Harrison, Javier Castell, Rohit Loomba, Manuel Romero-Gomez
Summary: This individual patient data meta-analysis aimed to establish stiffness cut-off values for magnetic resonance elastography (MRE) in staging liver fibrosis and assess potential confounding factors. The results showed that MRE has excellent diagnostic performance for significant fibrosis, advanced fibrosis, and cirrhosis. However, elevated inflammatory activity and GGT level may lead to overestimation of early liver fibrosis, while the degree of steatosis and body mass index (BMI) do not affect the results.
JOURNAL OF HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Brian E. Ford, Shruti S. Chachra, Katrina Rodgers, Tabassum Moonira, Ziad H. Al-Oanzi, Quentin M. Anstee, Helen L. Reeves, Jorn M. Schattenberg, Rebecca J. Fairclough, David M. Smith, Dina Tiniakos, Loranne Agius
Summary: Through experiments on mice, it was found that mouse GKRP phenocopies the human GKRP:P446 > L substitution. Furthermore, the diet-challenged P446L mouse replicates several traits associated with the rs1260326 locus, including raised blood cholesterol, lower blood glucose, and lower liver glucokinase and GKRP protein, but not raised blood triglycerides.
MOLECULAR METABOLISM
(2023)
Article
Endocrinology & Metabolism
Olivier Govaere, Megan Hasoon, Leigh Alexander, Simon Cockell, Dina Tiniakos, Mattias Ekstedt, Joern M. Schattenberg, Jerome Boursier, Elisabetta Bugianesi, Vlad K. Ratziu, Ann K. M. Daly, Quentin M. Anstee, LITMUS Investigators
Summary: Govaere et al. integrated circulating protein data with transcriptomics to develop a non-invasive diagnostic tool for identifying at-risk patients with non-alcoholic fatty liver disease (NAFLD) based on body mass index, type 2 diabetes and four circulating proteins.
Article
Gastroenterology & Hepatology
Stuart McPherson, Helen Jarvis, John McGonigle, Joan Bedlington, Jill Dean, Kate Hallsworth, Elodie Hanon, Trevor Liddle, Ahai Luvai, Dina Mansour, Preya Patel, Laura Renwick, Dawn Teare, Christina Tanney, Quentin Anstee
Summary: This study aims to evaluate the performance of fibrosis biomarkers in primary care for detecting advanced fibrosis in patients with fatty liver disease. It will recruit 3000 individuals with risk factors and assess the performance of various biomarkers in staging liver fibrosis. Participants will be followed longitudinally via electronic health records to assess long-term clinical outcomes.
BMJ OPEN GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Quentin M. Anstee, Kate Hallsworth, Niall Lynch, Adrien Hauvespre, Eid Mansour, Sam Kozma, Juliana Bottomley, Gary Milligan, James Piercy, Victoria Higgins
Summary: Stratifying disease severity in NASH patients is crucial for effective treatment and management. This study compared physician assessment of fibrosis severity in NASH patients with reference thresholds, and found that physicians tended to underestimate disease severity, potentially leading to undertreatment of patients with advanced fibrosis.
PRAGMATIC AND OBSERVATIONAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Stephen A. Harrison, Vlad Ratziu, Quentin M. Anstee, Mazen Noureddin, Arun J. Sanyal, Joern M. Schattenberg, Pierre Bedossa, Mustafa R. Bashir, David Schneider, Rebecca Taub, Meena Bansal, Kris V. Kowdley, Zobair M. Younossi, Rohit Loomba
Summary: This study presents the design of the MAESTRO clinical program, which aims to evaluate the effectiveness of resmetirom in treating NASH. The program includes multiple clinical trials targeting different patient populations, assessing the efficacy and safety of the drug using various methods such as biopsies, biomarkers, and imaging.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Jeffrey Lazarus, Laurent Castera, Henry E. Mark, Alina M. Allen, Leon A. Adams, Quentin M. Anstee, Marco Arrese, Saleh A. Alqahtani, Elisabetta Bugianesi, Massimo Colombo, Kenneth Cusi, Hannes Hagstrom, Rohit Loomba, Manuel Romero-Gomez, Jorn M. Schattenberg, Maja Thiele, Luca Valenti, Vincent Wai-Sun Wong, Yusuf Yilmaz, Zobair M. Younossi, Sven M. Francque, Emmanuel A. Tsochatzis
Summary: Non-invasive tests (NITs) provide a practical solution for advanced fibrosis identification in non-alcoholic fatty liver disease (NAFLD). However, the study found variations in the cut-offs used for the same NITs by different clinicians, highlighting the importance of establishing consistent guidelines in NAFLD management.