Article
Medicine, General & Internal
Philippa Rees, Thomas Purchase, Emily Ball, Jillian Beggs, Francesca Gabriel, Sioned Gwyn, Stuart Hellard, Elena Jones, Isobel Joy McFadzean, Davide Paccagnella, Philippa Robb, Kathleen Walsh, Andrew Carson-Stevens
Summary: This study aims to explore the role of families, guardians, and parents in paediatric safety incidents and how this role may have changed during the pandemic. The findings will help in delivering safer care and developing harm prevention strategies across healthcare settings.
Article
Pediatrics
Or Steg Saban, Tal Weissbach, Reuven Achiron, Marina Pekar Zlotin, Yael Haberman, Adi Anis Heusler, Eran Kassif, Batia Weiss
Summary: This study retrospectively analyzed fetal cases diagnosed with IHPSS by ultrasound between 2006 and 2019 at a pediatric gastroenterology unit and reported their natural course and outcome. The results showed that IHPSS usually close spontaneously by 2 years of age, but some children may experience growth restriction and mild developmental delay. Therefore, close surveillance at a pediatric gastroenterology unit may be beneficial for children prenatally diagnosed with IHPSS.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Review
Medicine, General & Internal
Kasemsri Srisupundit, Suchaya Luewan, Theera Tongsong
Summary: Fetal heart failure is a condition where the fetal heart is unable to deliver sufficient blood flow to organs, leading to various complications. Fetal echocardiography is crucial in diagnosing FHF and its underlying causes.
Review
Biotechnology & Applied Microbiology
Yanyu Chen, Zhuhao Wu, Joseph Sutlive, Ke Wu, Lu Mao, Jiabao Nie, Xing-Zhong Zhao, Feng Guo, Zi Chen, Qinqin Huang
Summary: Noninvasive prenatal diagnosis (NIPD) is a method of detecting genetic disorders related to the fetus before birth by analyzing markers in the peripheral blood of pregnant women. Fetal-nucleated red blood cells (fNRBCs) can be used as biomarkers for NIPD due to their unique ability to carry the complete genetic information of the fetus. Recent advances in NIPD technologies are focused on isolating and analyzing fNRBCs, using both conventional and novel methods such as micro-/nanomaterials and microfluidic chips. The identification and clinical diagnostic potential of fNRBCs are also discussed, along with the challenges and future directions of using fNRBCs in NIPD treatment guidelines.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Susanne Pangratz-Fuehrer, Orsolya Genzel-Boroviczeny, Wolfgang Emanuel Bodensohn, Robin Eisenburger, Janne Scharpenack, Philipp E. Geyer, Johannes B. Mueller-Reif, Nadja van Hagen, Alina M. Muller, Majken Karoline Jensen, Christoph Klein, Matthias Mann, Claudia Nussbaum
Summary: The MUNICH-PreTCl birth cohort aims to uncover pathological processes contributing to infant/childhood morbidity and mortality, collecting comprehensive medical information and blood samples. Findings to date concern clinical data of 662 infants and their families, as well as recruitment and data collection procedures for different gestational age groups.
Article
Public, Environmental & Occupational Health
Tamar Wainstock, Israel Yoles, Ruslan Sergienko, Itai Kloog, Eyal Sheiner
Summary: This study found an association between PM2.5 exposure and IUFD risk among Jewish women only, suggesting ethnicity as a possible effect modifier. In a multivariable model, for every 10 μg/m3 unit increase in PM2.5, the risk for IUFD increased by 2.98 during the first trimester and by 3.61 during the entire pregnancy.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Review
Medicine, General & Internal
Megan Macdonald, Daniel Thompson, Robin Perry, Robert Brooks
Summary: This study examined the characteristics and circumstances of infants who died while sleeping or in a sleep environment, comparing deaths classified as unintentional asphyxia or an unexplained cause. The results showed that sleep environment hazards are prevalent among infants who die suddenly and unexpectedly, regardless of the cause of death determination. Female sex and fully obstructed airway condition were associated with an unexplained cause of death. Standardizing cause of death determination practices and promoting high-quality forensic investigations are essential to accurately explain, monitor, and prevent these deaths.
Review
Pediatrics
Eric S. Shinwell, Polina Gurevitz, Igor Portnov
Summary: The review article examines the current evidence for steroids in preterm infants, with antenatal corticosteroids saving lives and improving quality of life. Recent studies suggest beneficial effects may be seen with lower dosages, while most long-term outcome studies show no adverse effects. The use of antenatal corticosteroids in women with COVID-19 raises important questions, but current guidelines recommend continuing use. Alternative postnatal corticosteroids show promise in preventing bronchopulmonary dysplasia, with a combination of surfactant and corticosteroids being an area of interest for future research.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Medicine, General & Internal
Victor Ogik, Mark Muyingo, Moses Musooko, Jolly Nankunda
Summary: This study found that about a fifth of babies born at Mulago National Referral Hospital had high umbilical artery lactate levels. Factors significantly associated with high lactate levels included the baby's sex, mother's gravidity, presence of meconium-stained amniotic fluid, and use of oxytocin during labor.
Article
Medicine, General & Internal
Roxana Elena Bohiltea, Valentin-Nicolae Varlas, Vlad Dima, Ana-Maria Iordache, Teodor Salmen, Bianca-Margareta Mihai, Alexia Teodora Bohiltea, Emilia Maria Vladareanu, Ionita Ducu, Corina Grigoriu
Summary: True umbilical knot (TUK) poses a significant psychological burden on mothers and obstetricians, despite its low prenatal ultrasound diagnosis rate and adverse perinatal outcomes. Our retrospective observational study revealed a significantly increased prematurity rate due to TUK compared to the general population. Second-trimester three-dimensional ultrasound scan and cesarean delivery are recommended for diagnosis and ensuring good neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Genetics & Heredity
Jialing Yu, Na Chen, Min Chen, Min Shen, Yeqing Qian, Minyue Dong
Summary: In this study, we report a fetus with tetrasomy 9p, which was identified by non-invasive prenatal testing (NIPT) but without obvious phenotypic manifestations during the first trimester. Karyotyping of amniocytes and chromosome microarray are crucial prenatal diagnostic techniques.
FRONTIERS IN GENETICS
(2022)
Article
Pediatrics
Rebecca Naples, Sridhar Ramaiah, Judith Rankin, Janet Berrington, Sundeep Harigopal
Summary: The study describes a cohort of 153 babies with life-threatening BPD, showing high morbidity and mortality rates, along with significant practice variation in therapies. Findings suggest that the need for invasive ventilation near term and pulmonary hypertension are significantly associated with adverse outcomes such as death or major neurodevelopmental impairment.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Medicine, General & Internal
Ivonne Alexandra Bedei, Thierry A. G. M. Huisman, William Whitehead, Roland Axt-Fliedner, Michael Belfort, Magdalena Sanz Cortes
Summary: Fetal brain tumors are rare and have a poor prognosis. They differ from pediatric brain tumors in terms of location and tumor type. They can be benign or malignant and can invade or displace nearby brain structures. Their rapid growth is due to a high mitotic rate. The age of diagnosis, size, and histological tumor type are factors that determine the outcome. Polyhydramnios and macrocephaly are often associated findings on routine ultrasound. Prenatal counseling and decision making should consider both maternal and fetal prognosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Acoustics
Ramiro Diaz-Primera, Raul Sanchez-Jimenez, Julio Marin-Concha, Rafael Mena, Jose Garrido-Mendez, Manuel Marinez, Ramon Mena-Rivas, Ashley Lopez, Agustin Diaz-Rodriguez, Orlando Mogena-Sanchez, Rafael Almanzar, Rodolfo Soto-Ravelo
Summary: Fetal lymphangioma is a rare congenital malformation mainly found in the neck, chest, and axillary regions. Adequate management by a multidisciplinary team is necessary to provide a better approach to delivery for these cases.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Review
Genetics & Heredity
Shiri Shinar, David Chitayat, Patrick Shannon, Susan Blaser
Summary: Macrocephaly refers to a large head size, which can be primary or secondary. It can be caused by various factors and the prognosis depends on the specific condition, genetic factors, and central nervous system findings.
PRENATAL DIAGNOSIS
(2023)
Article
Mathematical & Computational Biology
Hannah O'Keefe, Judith Rankin, Sheila A. Wallace, Fiona Beyer
Summary: Current methodologies for designing search strategies heavily rely on the expertise of information specialists, but the overwhelming volume and complexity of scientific literature pose challenges for even experienced specialists in producing robust search strategies for complex systematic reviews. This case study aimed to assess the benefits and limitations of using semi-automated text-mining tools for designing search strategies in a systematic review of diagnostic test accuracy. The evaluation revealed additional terms and previously unidentified relevant articles retrieved by the tools, but precision was either reduced or remained the same. Comparative analysis also showed discrepancies between similar tools. Tailored tools that meet the requirements of information specialists across disciplines are needed for the mainstream use of semi-automated techniques in information retrieval for complex systematic reviews.
RESEARCH SYNTHESIS METHODS
(2023)
Article
Obstetrics & Gynecology
Nicholas Aldridge, Pranav Pandya, Judith Rankin, Nicola Miller, Jennifer Broughan, Nadia Permalloo, Annette McHugh, Sarah Stevens
Summary: This study aimed to measure the condition-specific detection rates for 14 physical conditions screened for by the NHS fetal anomaly screening programme (FASP) using fetal anomaly (FA) ultrasound scan. The retrospective audit of 12,694 diagnoses across a 3-year national cohort revealed that the performance of the FA scan exceeded expectations for most conditions, and for the remaining conditions, the majority of affected fetuses and babies were detected before the FA scan.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Dermatology
Alessio Coi, Ingeborg Barisic, Ester Garne, Anna Pierini, Marie-Claude Addor, Amaia Aizpurua Atxega, Elisa Ballardini, Paula Braz, Jennifer M. Broughan, Clara Cavero-Carbonell, Hermien E. K. de Walle, Elizabeth S. Draper, Miriam Gatt, Martin Hausler, Agnieszka Kinsner-Ovaskainen, Jennifer J. Kurinczuk, Nathalie Lelong, Karen Luyt, Lorena Mezzasalma, Carmel Mullaney, Vera Nelen, Ljubica Odak, Mary T. O'Mahony, Isabelle Perthus, Hanitra Randrianaivo, Judith Rankin, Anke Rissmann, Florence Rouget, Bruno Schaub, David Tucker, Diana Wellesley, Lyubov Yevtushok, Michele Santoro
Summary: This study investigated the epidemiology of aplasia cutis congenita (ACC) using data from the EUROCAT network. A total of 500 cases were identified from 1998 to 2017, with a prevalence of 5.10 per 100,000 births. The scalp was the most common site for ACC, and 33.8% of cases were associated with other congenital anomalies. The change in coding from ICD9 to ICD10 did not significantly affect the prevalence of ACC.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Genetics & Heredity
Jorieke E. H. Bergman, Ingeborg Barisic, Marie-Claude Addor, Paula Braz, Clara Cavero-Carbonell, Elizabeth S. Draper, Luis J. Echevarria-Gonzalez-de-Garibay, Miriam Gatt, Martin Haeusler, Babak Khoshnood, Kari Klungsoyr, Jennifer J. Kurinczuk, Anna Latos-Bielenska, Karen Luyt, Danielle Martin, Carmel Mullaney, Vera Nelen, Amanda J. Neville, Mary T. O'Mahony, Isabelle Perthus, Anna Pierini, Hanitra Randrianaivo, Judith Rankin, Anke Rissmann, Florence Rouget, Gerardine Sayers, Bruno Schaub, Sarah Stevens, David Tucker, Christine Verellen-Dumoulin, Awi Wiesel, Erica H. Gerkes, Annie Perraud, Maria A. Loane, Diana Wellesley, Hermien E. K. de Walle
Summary: This study investigated the prevalence of ABS and LBWC in Europe from 1980 to 2019 and found a low prevalence with a decreasing trend in the 1980s. Limb anomalies and neural tube defects were commonly observed in ABS, while abdominal and thoracic wall defects and limb anomalies were most prevalent in LBWC. Twinning was confirmed as a risk factor for both ABS and LBWC.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Environmental Sciences
Malcolm Moffat, Suzanne Nicholson, Joanne Darke, Melissa Brown, Stephen Minto, Sarah Sowden, Judith Rankin
Summary: Refugees and asylum seekers in the UK face barriers in accessing healthcare, and the Health Access Card in Newcastle aims to guide them to appropriate services. A qualitative evaluation was conducted to explore experiences of healthcare access and perspectives on the card. Participants described cultural, financial, and institutional barriers to care and suggested improvements such as more bespoke support and language assistance, as well as translated versions and a digital resource for the Health Access Card.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Developmental Biology
Chrysovalanto Mamasoula, Theophile Bigirumurame, Thomas Chadwick, Marie-Claude Addor, Clara Cavero-Carbonell, Carlos M. Dias, Luis-Javier Echevarria-Gonzalez-de-Garibay, Miriam Gatt, Babak Khoshnood, Kari Klungsoyr, Kay Randall, Sylvia Stoianova, Martin Haeusler, Vera Nelen, Amanda J. Neville, Isabelle Perthus, Anna Pierini, Benedicte Bertaut-Nativel, Anke Rissmann, Florence Rouget, Bruno Schaub, David Tucker, Diana Wellesley, Natalya Zymak-Zakutnia, Ingeborg Barisic, Hermien E. K. de Walle, Monica Lanzoni, Gerardine Sayers, Carmel Mullaney, Lindsay Pennington, Judith Rankin
Summary: Using population-based data from 24 registries in Europe, the study examined the association between maternal age and the prevalence of congenital heart defects (CHD) from 1995 to 2015. The results showed an increased total prevalence of CHD for younger (<= 24 years old) and older (35-44 years old) mothers. Additionally, a positive association between younger mothers and severe CHD phenotypes, as well as between older mothers and mild CHD phenotypes, was observed.
BIRTH DEFECTS RESEARCH
(2023)
Article
Pediatrics
Svetlana Glinianaia, Judith Rankin, Joachim Tan, Maria Loane, Ester Garne, Clara Cavero-Carbonell, Hermien E. K. de Walle, Miriam Gatt, Mika Gissler, Kari Klungsoyr, Natalie Lelong, Amanda Neville, Anna Pierini, David F. Tucker, Stine Kjaer Urhoj, Diana Gay Wellesley, Joan K. Morris
Summary: This study investigated the 10-year survival rate of children with trisomy 13 (T13) and trisomy 18 (T18) born between 1995 and 2014. The study found that despite high neonatal mortality, 32% of T13 children and 21% of T18 children who survived to 4 weeks were likely to survive to age 10.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Review
Health Care Sciences & Services
Fiona Beyer, Stephen Rice, Giovany Orozco-Leal, Madeleine Still, Hannah O'Keefe, Nicole O'Connor, Akvile Stoniute, Dawn Craig, Stephen Pereira, Louise Carr, John Leeds
Summary: This study assessed the effectiveness, cost-effectiveness, and risks of endoscopic bipolar radiofrequency ablation for malignant biliary obstruction. The results showed that primary radiofrequency ablation increased survival and was likely to be cost-effective. However, there is limited evidence on the impact of secondary radiofrequency ablation on survival and quality of life, highlighting the need for further research.
HEALTH TECHNOLOGY ASSESSMENT
(2023)
Article
Pediatrics
Kristina Chmelova, Janet Berrington, Natalie Shenker, Stefan Zalewski, Judith Rankin, Nick Embleton
Summary: This pilot study aims to determine if longer duration of donor human milk (DHM) exposure increases breastfeeding rates and examines the feasibility of a randomized controlled trial (RCT). The study uses both quantitative and qualitative evaluations. The quantitative evaluation focuses on breastfeeding rates at discharge, while the qualitative evaluation explores perceptions and beliefs about breastfeeding through interviews. The results of this study will be disseminated in peer-reviewed journals.
BMJ PAEDIATRICS OPEN
(2023)
Article
Public, Environmental & Occupational Health
Joachim Tan, Svetlana V. Glinianaia, Judith Rankin, Anna Pierini, Michele Santoro, Alessio Coi, Ester Garne, Maria Loane, Joanne E. Given, Joanna Brigden, Elisa Ballardini, Clara Cavero-Carbonell, Hermien E. K. de Walle, Laura Garcia-Villodre, Miriam Gatt, Mika Gissler, Anna Heino, Sue Jordan, Babak Khoshnood, Kari Klungsoyr, Nathalie Lelong, Renee L. Lutke, Amanda J. Neville, David Tucker, Stine K. Urhoj, Diana Wellesley, Joan K. Morris
Summary: This study aims to investigate the risk factors for mortality up to age 10 years in children born with specific major congenital anomalies (CAs). The study found that there is a dose-response association between preterm birth and mortality, and young maternal age (<20 years) and female sex are also risk factors for death.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Adenike M. Adesanya, Kate E. Best, Louise Coats, Judith Rankin
Summary: The study estimated the median post-operative length of stay (PLOS) and identified predictors of PLOS in patients who underwent Tetralogy of Fallot (ToF) repair at a surgical center in North England. Factors such as age, weight, previous procedures, and intubation time were found to significantly impact PLOS. This information is valuable for healthcare professionals and health commissioners in supporting parents and planning resources.
PEDIATRIC CARDIOLOGY
(2023)
Article
Family Studies
Tanha Begum, Emer Cullen, Malcolm Moffat, Judith Rankin
Summary: During the COVID-19 pandemic, there was a decrease in contraception prescribing rates in primary care in England. Socioeconomic deprivation was found to have a weak correlation with prescribing rates. Further research is needed to understand these changes and ensure appropriate healthcare services are provided.
BMJ SEXUAL & REPRODUCTIVE HEALTH
(2023)
Article
Multidisciplinary Sciences
Nicola Heslehurst, Catherine F. McParlin, Falko Sniehotta, Judith Rankin, Elaine McColl, Shahrad Taheri, Steve Zimmerman, George Vousden
Summary: This study examines the impact of an intervention called GLOWING on midwives' implementation of guidelines through a pilot trial. The results suggest that GLOWING successfully improves midwives' self-efficacy, potentially leading to positive effects on guideline implementation.