Liraglutide, a glucagon-like peptide 1 receptor agonist, exerts analgesic, anti-inflammatory and anti-degradative actions in osteoarthritis

The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date

(2021) Win Min Oo et al.   Drug Design Development and Therapy

Intra-articular sprifermin reduces cartilage loss in addition to increasing cartilage gain independent of location in the femorotibial joint: post-hoc analysis of a randomised, placebo-controlled phase II clinical trial

(2020) Felix Eckstein et al.   ANNALS OF THE RHEUMATIC DISEASES

Pain and Inflammation

(2020) James David Adams   CURRENT MEDICINAL CHEMISTRY

Clearing method for 3-dimensional immunofluorescence of osteoarthritic subchondral human bone reveals peripheral cholinergic nerves

(2020) Alice Courties et al.   Scientific Reports

Lorecivivint, a Novel Intra‐articular CLK/DYRK1A Inhibitor and Wnt Pathway Modulator for Treatment of Knee Osteoarthritis: A Phase 2 Randomized Trial

(2020) Yusuf Yazici et al.   Arthritis & Rheumatology

TissueGene-C promotes an anti-inflammatory micro-environment in a rat monoiodoacetate model of osteoarthritis via polarization of M2 macrophages leading to pain relief and structural improvement

(2020) Hyeonyoul Lee et al.   INFLAMMOPHARMACOLOGY

Liraglutide after diet-induced weight loss for pain and weight control in knee osteoarthritis: a randomized controlled trial

(2020) Henrik Gudbergsen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Using a reporter mouse to map known and novel sites of GLP-1 receptor expression in peripheral tissues of male mice

(2020) Daniel B Andersen et al.   ENDOCRINOLOGY

Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis

(2020) Noritaka Sawada et al.   Journal of Diabetes Research

Glucagon‑like peptide‑1 modulates RAW264.7 macrophage polarization by interfering with the JNK/STAT3 signaling pathway

(2019) Shan Wan et al.   Experimental and Therapeutic Medicine

Therapeutic options for targeting inflammatory osteoarthritis pain

(2019) Philip G. Conaghan et al.   Nature Reviews Rheumatology

The GLP-1 agonist, liraglutide, ameliorates inflammation through the activation of the PKA/CREB pathway in a rat model of knee osteoarthritis

(2019) Qihong Que et al.   Journal of Inflammation-London

Human osteoarthritic synovial fluid increases excitability of mouse dorsal root ganglion sensory neurons: an in-vitro translational model to study arthritic pain

(2019) Sampurna Chakrabarti et al.   RHEUMATOLOGY

Glucagon-like peptide 1 in health and disease

(2018) Andreas Andersen et al.   Nature Reviews Endocrinology

A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee

(2018) V. Deshmukh et al.   OSTEOARTHRITIS AND CARTILAGE

Glucagon-like peptide 1 receptor (GLP-1R) expression by nerve fibres in inflammatory bowel disease and functional effects in cultured neurons

(2018) Uma Anand et al.   PLoS One

Glucagon-like peptide-1 receptor regulates endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and the progression of osteoarthritis in rat

(2018) Jian Chen et al.   Cell Death & Disease

Peripheral Mechanisms Contributing to Osteoarthritis Pain

(2018) Delfien Syx et al.   Current Rheumatology Reports

The Phenotypic Approach to Osteoarthritis: A Look at Metabolic Syndrome-Associated Osteoarthritis

(2018) Alice Courties et al.   JOINT BONE SPINE

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Imbalance of M1/M2 macrophages is linked to severity level of knee osteoarthritis

(2018) Baolong Liu et al.   Experimental and Therapeutic Medicine

GLP-1 Induces Barrier Protective Expression in Brunnerʼs Glands and Regulates Colonic Inflammation

(2016) Claus H. Bang-Berthelsen et al.   INFLAMMATORY BOWEL DISEASES

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Association of Joint Inflammation With Pain Sensitization in Knee Osteoarthritis: The Multicenter Osteoarthritis Study

(2016) Tuhina Neogi et al.   Arthritis & Rheumatology

The Monoiodoacetate Model of Osteoarthritis Pain in the Mouse

(2016) Thomas Pitcher et al.   Jove-Journal of Visualized Experiments

Development of monosodium acetate-induced osteoarthritis and inflammatory pain in ageing mice

(2015) Andrea C. Ogbonna et al.   AGE

Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis

(2015) M.-C. Laiguillon et al.   OSTEOARTHRITIS AND CARTILAGE

Exogenous glucagon-like peptide 1 reduces contractions in human colon circular muscle

(2014) Antonella Amato et al.   JOURNAL OF ENDOCRINOLOGY

The Burden of Musculoskeletal Conditions

(2014) Clémence Palazzo et al.   PLoS One

Post-traumatic osteoarthritis: from mouse models to clinical trials

(2013) Christopher B. Little et al.   Nature Reviews Rheumatology

Towards a mechanism-based approach to pain management in osteoarthritis

(2013) Anne-Marie Malfait et al.   Nature Reviews Rheumatology

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes

(2012) Y.-S. Lee et al.   DIABETOLOGIA

The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain

(2012) Vadivel Parthsarathy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Arthroplasty in veterans: Analysis of cartilage, bone, serum, and synovial fluid reveals differences and similarities in osteoarthritis with and without comorbid diabetes

(2012) Trevor W. Oren et al.   JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

Systematic validation of specific phenotypic markers for in vitro polarized human macrophages

(2011) C.A. Ambarus et al.   JOURNAL OF IMMUNOLOGICAL METHODS

GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress

(2011) Bruno Schisano et al.   REGULATORY PEPTIDES

Anabolic/Catabolic Balance in Pathogenesis of Osteoarthritis: Identifying Molecular Targets

(2011) Michael B. Mueller et al.   PM&R

Dipeptidyl peptidase IV inhibitor sitagliptin reduces local inflammation in adipose tissue and in pancreatic islets of obese mice

(2010) A. D. Dobrian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Tumor necrosis factor causes persistent sensitization of joint nociceptors to mechanical stimuli in rats

(2010) Frank Richter et al.   ARTHRITIS AND RHEUMATISM

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

(2010) Jan Bondeson et al.   ARTHRITIS AND RHEUMATISM

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Pharmacologic therapy for osteoarthritis—the era of disease modification

(2010) David J. Hunter   Nature Reviews Rheumatology

Peripheral motor action of glucagon-like peptide-1 through enteric neuronal receptors

(2010) A. Amato et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The cardioprotective and inotropic components of the postconditioning effects of GLP-1 and GLP-1(9–36)a in an isolated rat heart

(2009) Alvilde Ossum et al.   PHARMACOLOGICAL RESEARCH

The discordance between clinical and radiographic knee osteoarthritis: A systematic search and summary of the literature

(2008) John Bedson et al.   BMC MUSCULOSKELETAL DISORDERS

Cardioprotective and Vasodilatory Actions of Glucagon-Like Peptide 1 Receptor Are Mediated Through Both Glucagon-Like Peptide 1 Receptor–Dependent and –Independent Pathways

(2008) Kiwon Ban et al.   CIRCULATION

Primary culture and phenotyping of murine chondrocytes

(2008) Marjolaine Gosset et al.   Nature Protocols

Effects of advanced glycation end products on the expression of COX-2, PGE2 and NO in human osteoarthritic chondrocytes

(2008) S.-S. Nah et al.   RHEUMATOLOGY