Article
Medicine, General & Internal
Sehoon Park, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Soryoung Lee, Eue-Keun Choi, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: The study found that a genetic predisposition for AF is significantly associated with lower gray matter volume but not with white matter volume. The total effect of AF on gray matter volume may be mediated by ischemic stroke.
Article
Cardiac & Cardiovascular Systems
Xingang Sun, Yunlong Lu, Zhen Wang, Qiqi Wang, Liangrong Zheng
Summary: The study found no causal association between plasma Hcy levels and AF based on Mendelian randomization analyses, suggesting that genetically elevated Hcy levels do not increase the risk of AF. The results were consistent across different methods and sensitivity analyses, indicating the robustness of the findings.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Susanna C. Larsson, Wei-Hsuan Lee, Stephen Burgess, Elias Allara
Summary: Evidence from the MR study suggests a positive association between plasma cortisol and risk of AF, likely mediated through SBP and WC.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Weiqi Chen, Xueli Cai, Hongyi Yan, Yuesong Pan
Summary: Using Mendelian randomization, this study found that genetically predicted OSA has a causal effect on an increased risk of atrial fibrillation. The results were consistent across various sensitivity analyses.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Nutrition & Dietetics
Shengyi Yang, Rupak Pudasaini, Hong Zhi, Lina Wang
Summary: The results of univariable and multivariable Mendelian randomization analysis suggest that there is no significant association between blood lipids and the risk of atrial fibrillation.
Article
Genetics & Heredity
Songzan Chen, Fangkun Yang, Tian Xu, Yao Wang, Kaijie Zhang, Guosheng Fu, Wenbin Zhang
Summary: This study used a two-sample Mendelian randomization design to investigate the causal association of plasma Hcy levels with AF risk. Results from a large-scale genome-wide association study data showed no evidence of a causal association between genetically predicted Hcy and AF. Sensitivity analyses and MR-Egger intercept test supported the finding that there is no causal association of Hcy with AF.
FRONTIERS IN GENETICS
(2021)
Article
Cardiac & Cardiovascular Systems
Guihong Liu, Tao Chen, Xin Zhang, Binbin Hu, Huashan Shi
Summary: The aim of this study was to investigate the direct causal effect of atrial fibrillation (AF) on pulmonary embolism (PE). Using a Mendelian randomization approach, no evidence was found to suggest an association between genetically predicted AF and risk of PE. These findings do not support a causal role of AF in the development of PE.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Review
Endocrinology & Metabolism
Mingjian Shi, Ali M. Manouchehri, Christian M. Shaffer, Nataraja Sarma Vaitinadin, Jacklyn N. Hellwege, Joe-Elie Salem, Lea K. Davis, Jill H. Simmons, Dan M. Roden, M. Benjamin Shoemaker, Jane F. Ferguson, Jonathan D. Mosley
Summary: Genetic predisposition to lower TSH levels is associated with increased risk of atrial fibrillation through mechanisms mediated in part by taller stature. Understanding these genetic mechanisms could lead to improved targeted therapies to mitigate AF risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Tao Cheng, Huan Wang, Yuanhui Hu
Summary: The study investigated the causal relationship between blood metabolites and atrial fibrillation (AF) using Mendelian randomization analysis. Two metabolites, tryptophan betaine and uridine, were found to be causally related to AF. These findings provide new insights into the pathogenesis of AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ya-fang Gao, Tian-yu Jin, Yan Chen, Ya-hui Ding
Summary: This study used Mendelian randomization (MR) analysis to investigate the causal genetic relationships between atrial fibrillation (AF) and vascular dementia (VaD). The results showed that there were no significant genetic relationships between AF and VaD risk, as well as between VaD and AF risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaoyu Zhang, Biyan Wang, Tao Geng, Di Liu, Qiuyue Tian, Xiaoni Meng, Qiaoyun Zhang, Mengyang Jiang, Yiqiang Zhang, Manshu Song, Wei Wang, Youxin Wang, Baoguo Wang
Summary: This MR study provides no clear evidence that COVID-19 is causally associated with the risk of AF.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Rohin K. Reddy, Maddalena Ardissino, Fu Siong Ng
Summary: This study conducted Mendelian randomization and found that type 2 diabetes (T2D) is causally associated with atrial fibrillation (AF), with mediation through systolic blood pressure. The findings suggest that besides glycemic control, reducing systolic blood pressure may provide specific benefits for AF risk in patients with T2D.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Mingxiao Li, Chao Jiang, Yiwei Lai, Yufeng Wang, Manlin Zhao, Sitong Li, Xiaodong Peng, Liu He, Xueyuan Guo, Songnan Li, Nian Liu, Chenxi Jiang, Ribo Tang, Caihua Sang, Deyong Long, Xin Du, Jianzeng Dong, Changsheng Ma
Summary: This study provides evidence supporting the causal effect of atrial fibrillation (AF) on overall dementia and vascular dementia, with ischemic stroke and low cardiac output potentially mediating this association.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Yuntao Feng, Xuebo Liu, Hongwei Tan
Summary: A recent study found a link between immune responses and atrial fibrillation (AF), but it is unclear whether the immune response is a cause or consequence of AF. Using a genetic prediction method, this study discovered a causal relationship between peripheral immune cell counts and AF, particularly in lymphocytes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Qin Wang, Tom G. Richardson, Eleanor Sanderson, Matthew J. Tudball, Mika Ala-Korpela, George Davey Smith, Michael Holmes
Summary: This study used Mendelian randomization analysis to evaluate the causes and consequences of atrial fibrillation (AF). The results showed that body mass index, height, systolic blood pressure, and genetic liability to coronary artery disease are independent causal risk factors for AF. Additionally, several proteins were identified as having therapeutic potential for AF.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qi Jiang, Buqing Ni, Jiaojiao Shi, Zhonglin Han, Rundi Qi, Wenhua Xu, Dan Wang, Dao W. Wang, Minglong Chen
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Article
Multidisciplinary Sciences
Jiaojiao Shi, Qi Jiang, Xiangwei Ding, Wenhua Xu, Dao W. Wang, Minglong Chen
Letter
Cardiac & Cardiovascular Systems
Qi Jiang, Zijun Chen, Ling Yang
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Qi Jiang, Kexin Wang, Jiaojiao Shi, Mingfang Li, Minglong Chen
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Qi Jiang, Minglong Chen
EUROPEAN HEART JOURNAL
(2020)
Letter
Cardiac & Cardiovascular Systems
Qi Jiang, Zi-jun Chen, Ling Yang
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Letter
Cardiac & Cardiovascular Systems
Debing Tong, Qi Jiang, Ling Yang
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shimeng Zhang, Hengli Zhang, Kai Gu, Mingfang Li, Hailei Liu, Cheng Wang, Minglong Chen
Summary: This study aimed to identify predictors of relapse in pemphigus patients. Retrospective analysis of clinical and immunopathological data from 143 pemphigus patients revealed that negativity of autoantibody titres at clinical remission and a body surface area score of 3 were useful tools in predicting relapse.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Wenhua Xu, Mingfang Li, Minglong Chen, Bing Yang, Daowu Wang, Xiangqing Kong, Hongwu Chen, Weizhu Ju, Kai Gu, Kejiang Cao, Hailei Liu, Qi Jiang, Jiaojiao Shi, Yan Cui, Hong Wang
JOURNAL OF BIOMEDICAL RESEARCH
(2015)