Blood Levels of the SMOC1 Hepatokine Are Not Causally Linked with Type 2 Diabetes: A Bidirectional Mendelian Randomization Study

Secreted modular calcium binding protein 1 binds/activates thrombin to account for platelet hyper-reactivity in diabetes

(2021) Fredy Andrés Delgado Lagos et al.   BLOOD

Risk factors mediating the effect of body mass index and waist-to-hip ratio on cardiovascular outcomes: Mendelian randomization analysis

(2021) Dipender Gill et al.   INTERNATIONAL JOURNAL OF OBESITY

Using human genetics to understand the disease impacts of testosterone in men and women

(2020) Katherine S Ruth et al.   NATURE MEDICINE

A comparison of robust Mendelian randomization methods using summary data

(2020) Eric A. W. Slob et al.   GENETIC EPIDEMIOLOGY

SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

(2020) Magdalene K. Montgomery et al.   Science Translational Medicine

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

(2020) Olivier Govaere et al.   Science Translational Medicine

Genetic architecture of host proteins involved in SARS-CoV-2 infection

(2020) Maik Pietzner et al.   Nature Communications

Hepatokines and metabolism: Deciphering communication from the liver

(2020) Sharon O. Jensen-Cody et al.   Molecular Metabolism

The liver as an endocrine organ - linking NAFLD and insulin resistance

(2019) Matthew J Watt et al.   ENDOCRINE REVIEWS

PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations

(2019) Mihir A Kamat et al.   BIOINFORMATICS

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

(2018) Anubha Mahajan et al.   NATURE GENETICS

Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants

(2017) Stephen Burgess et al.   EPIDEMIOLOGY

Mendelian randomization with fine-mapped genetic data: Choosing from large numbers of correlated instrumental variables

(2017) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

(2017) Ruth C. R. Meex et al.   Nature Reviews Endocrinology

PhenoScanner: a database of human genotype–phenotype associations

(2016) James R. Staley et al.   BIOINFORMATICS

Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism

(2015) Ruth C. Meex et al.   Cell Metabolism

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

New genetic loci link adipose and insulin biology to body fat distribution

(2015) Dmitry Shungin et al.   NATURE

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

(2012) Alisa K Manning et al.   NATURE GENETICS

A robust clustering algorithm for identifying problematic samples in genome-wide association studies

(2011) Céline Bellenguez et al.   BIOINFORMATICS

Avoiding bias from weak instruments in Mendelian randomization studies

(2011) Stephen Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

(2010) N. Soranzo et al.   DIABETES

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants

(2010) Brandon L Pierce et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

(2009) John R.B. Perry et al.   HUMAN MOLECULAR GENETICS

Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men

(2009) Eric L. Ding et al.   NEW ENGLAND JOURNAL OF MEDICINE