Review
Engineering, Chemical
Russell J. Wilson, Yang Li, Guangze Yang, Chun-Xia Zhao
Summary: Emulsions are liquid-liquid dispersions with one liquid phase dispersed in the other phase as small droplets. Nanoemulsions, with sizes ranging from tens to hundreds of nanometers, hold great potential in pharmaceutics, foods, and cosmetics due to their small sizes, high surface area, improved dispersion, and enhanced absorption. Surfactants are crucial in producing and stabilizing nanoemulsions, including small molecule surfactants, particle surfactants, phospholipids, peptides, and protein surfactants, which play different roles in drug delivery applications.
Review
Chemistry, Multidisciplinary
Thais Nogueira Barradas, Kattya Gyselle Silva
Summary: The increasing demand for healthier, safer, and environmentally-friendly products has brought essential oils to the forefront as a natural alternative to synthetic pharmaceuticals. Encapsulation of essential oils in nanoemulsions offers a solution to their limitations, improving the efficiency of pharmaceutical dosage.
ENVIRONMENTAL CHEMISTRY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Patrizia Nadia Hanieh, Angela Bonaccorso, Elide Zingale, Silvia Cimarelli, Eliana B. Souto, Federica Rinaldi, Carlotta Marianecci, Rosario Pignatello, Maria Carafa
Summary: The study aimed to develop oil-in-water nanoemulsions to extend the residence time of ophthalmic drugs in the eye, improving patient compliance.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ana R. Fernandes, Lorena B. Vidal, Elena Sanchez-Lopez, Tiago dos Santos, Pedro L. Granja, Amelia M. Silva, Maria L. Garcia, Eliana B. Souto
Summary: Customized cationic oil-in-water nanoemulsions were developed to enhance the bioavailability of poorly water-soluble drugs. The nanoemulsions showed high corneal penetration and stability, and demonstrated significant improvement in ocular inflammation and reduction in the risk of inflammatory processes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Hao Zhang, Lixian Xu, Xiaoxiao Gu, Dinghua Yu, Shuang Li
Summary: In this study, a novel photosensitizer C-12-MB was synthesized and found to exhibit high antibacterial photodynamic therapy efficiency on bacterial surfaces. The accumulation and high content of photoactive monomers of C-12-MB were higher than that of methylene blue, providing important insights for the design of high-efficiency photosensitizers.
Review
Pharmacology & Pharmacy
Bastien Leclercq, Dan Mejlachowicz, Francine Behar-Cohen
Summary: The eye is composed of tissues and cavities that are regulated to maintain their optical properties and functions. Specialized junctions between cells control the passage of drugs, while specific transporters regulate the movement of water, ions, and macromolecules. Ocular barriers limit the bioavailability of gene therapy products, but also allow for local treatment with minimal systemic side-effects. Understanding these barriers is essential for the development of efficient gene delivery systems.
Article
Nanoscience & Nanotechnology
Alla B. Mirgorodskaya, Marina Yu Koroleva, Rushana A. Kushnazarova, Ekaterina Mishchenko, Konstantin A. Petrov, Oxana A. Lenina, Alexandra B. Vyshtakalyuk, Alexandra D. Voloshina, Lucia Ya Zakharova
Summary: A noncovalent strategy was successfully employed to enhance the colloidal stability and efficacy of two amphiphilic formulations of the anti-inflammatory drug indomethacin. The addition of cationic surfactants improved the stability and size characteristics of nanoemulsions and microemulsions, while the carbamate modified analogue demonstrated beneficial effects. The drug-loaded emulsions showed prolonged-release compared to the free drug. In vitro and in vivo tests confirmed the anti-inflammatory activity of the modified microemulsion. Nanoemulsions without cationic surfactants appeared to be more efficient, while carbamate surfactant enhanced the effectiveness of microemulsions.
Article
Multidisciplinary Sciences
Elsa Anisa Krisanti, Dyah Paramawidya Kirana, Kamarza Mulia
Summary: The study developed a highly stable oil-in-water nanoemulsion containing mangostins extracted from the pericarp of mangosteen, prepared using the low-energy emulsification method and stabilized with xanthan gum, showing high skin penetration in vitro. This nanoemulsion has potential for topical applications.
Review
Chemistry, Physical
Azin Rashidy Ahmady, Pakshid Hosseinzadeh, Atefeh Solouk, Somaye Akbari, Adrianna M. Szulc, Bogumil E. Brycki
Summary: Gemini surfactants, composed of two cationic monomers linked together, have high surface activity and can decrease water surface tension due to their unique structure. They possess outstanding properties, such as antibacterial activity, unique aggregation behavior, and interaction with biomacromolecules. These properties can be tailored by adjusting the structure of the surfactant. Gemini surfactants demonstrate higher performance efficacy and lower toxicity compared to their monomeric counterparts. However, biocompatibility remains a limitation, leading researchers to develop alternative gemini surfactants based on amino acids and sugars.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Article
Instruments & Instrumentation
Seyedeh Negin Kassaee, Mohammad Mehdi Mahboobian
Summary: This study successfully developed nanoemulsions containing besifloxacin for ocular drug delivery. Through a series of evaluations and tests, it was shown to have good potential for application in ocular administration and could be considered as a suitable alternative for treating bacterial eye infections.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Chemistry, Physical
Carolina F. Jesus, Andreia A. S. Alves, Sonia M. Fiuza, Dina Murtinho, Filipe E. Antunes
Summary: Surfactants play a vital role in daily life, but the environmental and health concerns associated with increased production have led to a search for sustainable alternatives. Sugar-based surfactants, especially cationic ones, show promising properties and applications, making them a potential solution to the current challenges.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Food Science & Technology
K. Sneha, Ashwani Kumar
Summary: Nanoemulsions, with droplet sizes ranging from 20 to 500 nm, have various applications in the food industry for improving quality and extending shelf life.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2022)
Review
Agriculture, Multidisciplinary
Tatiana B. Schreiner, Madalena M. Dias, Maria Filomena Barreiro, Simao P. Pinho
Summary: This article provides a comprehensive review of the application of saponins as formers and stabilizers of nanoemulsions, highlighting their natural sources and biosynthetic routes. The extraction, purification, characterization, and preparation methods of saponin-containing nanoemulsions are discussed. The experimental outcomes demonstrate the high performance of saponins, but challenges such as standardization for industrial use are identified. Future perspectives include the exploration of emerging biotechnological processes and the utilization of byproducts in a circular economy context.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Energy & Fuels
Muhammad Adil, Sagheer A. Onaizi
Summary: This article reviews the formulations and applications of Pickering nanoemulsions for enhancing crude oil recovery, with a focus on the recovery mechanisms. The study found that the careful selection and engineering of nanoparticles to stabilize Pickering nanoemulsions is a critical factor. However, the relationship between the characteristics of Pickering nanoemulsions and their effectiveness in increasing recovery rates is complex and not fully understood.
Article
Chemistry, Physical
Lourdes Perez, Ramon Pons, Francisco Fabio Oliveira de Sousa, Maria del Carmen Moran, Anderson Ramos da Silva, Aurora Pinazo
Summary: This study focused on the synthesis and biological properties of two families of green cationic surfactants derived from renewable sources. Results showed that these surfactants exhibited exceptional biological properties and have great potential for use in green antimicrobial and antibiofilm agents.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Pharmacology & Pharmacy
Angela V. F. Alves, Carlisson R. Melo, Jose L. Chagas-Neto, Ricardo G. Amaral, Sergio R. Ambrosio, Monique R. Moreira, Rodrigo C. S. Veneziani, Juliana C. Cardoso, Patricia Severino, Rogerio O. Gondak, Eliana B. Souto, Ricardo L. C. de Albuquerque-Junior
Summary: The antitumor activity of inclusion complexes formed between ent-kaurenoic acid (ERKA) and beta-cyclodextrin (ERKA:beta-CD) was studied in mice, and it was found that ERKA:beta-CD300 showed significant tumor growth inhibition without side effects. This antitumor activity may be attributed to the inhibition of the NF-kB signaling pathway and LDH activity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Karine Cappuccio de Castro, Julia Cedran Coco, Erica Mendes dos Santos, Janaina Artem Ataide, Renata Miliani Martinez, Monica Helena Monteiro do Nascimento, Joao Prata, Pedro Ricardo Martins Lopes da Fonte, Patricia Severino, Priscila Gava Mazzola, Andre Rolim Baby, Eliana Barbosa Souto, Daniele Ribeiro de Araujo, Andre Moreni Lopes
Summary: This paper reviews the literature on the use of Pluronic (R) triblock copolymers for drug encapsulation in the past 10 years. It focuses on the progress of drug delivery systems (e.g. micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, polymersomes and niosomes) and discusses the benefits of Pluronic (R) triblock copolymers as biological response modifiers and pharmaceutical additives, adjuvants, and stabilizers. The paper also highlights the advantages and limitations of developing site-specific targeting approaches based on Pluronic-based nanostructures in cancer treatment, as well as innovative examples for improving tumor cytotoxicity while reducing side effects.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Review
Immunology
Aleksandra Zielinska, Piotr Eder, Jacek Karczewski, Marlena Szalata, Szymon Hryhorowicz, Karolina Wielgus, Milena Szalata, Agnieszka Dobrowolska, Atanas G. Atanasov, Ryszard Slomski, Eliana B. Souto
Summary: This study discusses the use of monoclonal antibodies for targeted drug delivery in the treatment of COVID-19. It proposes the use of solid lipid nanoparticles (SLN) loaded with tocilizumab (TCZ) and cannabidiol (CBD) for oral administration. TCZ attenuates cytokine storm in SARS-CoV-2 infected patients, while CBD has anti-inflammatory properties and can modulate gene expression. The use of SLN for oral administration of TCZ-tailored CBD-loaded SLN shows potential in managing SARS-CoV-2 and related infections. Rating: 7/10
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Andrea V. Machado, Luana R. O. Menezes, Adilson A. M. Santana, Maria N. Marques, Adriana K. de Lima, Amanda Cano, Patricia Severino, Eliana B. Souto, Juliana C. Cardoso
Summary: This work describes a new hair dyeing method using geniposide to react with the amino group in hair keratin. The study evaluated the effects of reaction conditions on color change, hair morphology, and mechanical properties. The results showed that geniposide treatment can significantly change hair color and affect its mechanical properties and morphology.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Pharmacology & Pharmacy
Camilla A. S. Valenca, Ana A. T. Barbosa, Silvio S. Dolabella, Patricia Severino, Carla Matos, Karolline Krambeck, Eliana B. Souto, Sona Jain
Summary: The global problem of antibiotic resistance is a serious threat to the treatment of infectious diseases. New antimicrobials and improved delivery systems are needed. Bacterial secondary metabolites have potential as antimicrobial agents, but few molecules make it to the clinical phase.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Food Science & Technology
Beatriz N. Guedes, Faezeh Fathi, Amelia M. Silva, Antonello Santini, M. Beatriz P. P. Oliveira, Eliana B. Souto
Summary: Prickly pear, also known as Opuntia ficus-indica (OFI), is a beneficial plant with dietary fibers, vitamins and various bioactive compounds. This article reviews its nutritional composition, biological activities, and extraction techniques commonly used for different parts of the plant.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Instruments & Instrumentation
Marismar F. do Nascimento, Clauberto R. de Oliveira, Juliana C. Cardoso, Natalia C. T. Bordignon, Rogerio Gondak, Patricia Severino, Eliana B. Souto, Ricardo L. C. de Albuquerque Jr
Summary: This study aimed to develop and analyze the healing properties of GelMA containing AEPG, gallic acid, or ellagic acid. The results showed that GPG and GGA significantly accelerated wound closure, improved collagenization, increased histological grading, and hastened myofibroblast differentiation.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Instruments & Instrumentation
Venancio A. Amaral, Juliana Ferreira de Souza, Thais F. R. Alves, Jose M. de Oliveira Junior, Patricia Severino, Norberto Aranha, Eliana B. Souto, Marco V. Chaud
Summary: The aim of this work was to develop a dense lamellar scaffold for tracheal tissue regeneration using phenolic compounds from Psidium guajava Linn. Fourier transform infrared spectroscopy and differential scanning calorimetry confirmed chemical interactions between the polymers and cross-linking of phenolic compounds. Morphological analyses showed scaffolds with porosity and a porous surface structure. The addition of phenolic compounds modulated the morphological and mechanical properties of the scaffolds.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Carlotta Coccolini, Elisa Berselli, Cristina Blanco-Llamero, Faezeh Fathi, M. Beatriz P. P. Oliveira, Karolline Krambeck, Eliana B. Souto
Summary: Lactoferrin (Lf) is a glycoprotein with the ability to bind iron and exhibits numerous biological activities such as antibacterial, antiviral, antifungal, anti-tumour, anti-obesity, antioxidant, anti-inflammatory, and immunomodulatory effects. It has shown potential in cancer treatment, neuroprotection, and even as a prophylaxis for COVID-19.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Xavier Llorente, Gerard Esteruelas, Lorena Bonilla, Mariana Garnica Agudelo, Ingrid Filgaira, Daniel Lopez-Ramajo, Ruoyi C. Gong, Concepcio Soler, Marta Espina, Maria Luisa Garcia, Joan Manils, Montserrat Pujol, Elena Sanchez-Lopez
Summary: Nanocarriers, including nanostructured lipid carriers (NLC), are highly effective for topical drug administration. Optimized NLCs loaded with the drug Riluzole (RLZ-NLCs) were developed as a potential treatment, featuring biodegradability, biocompatibility, and sustained drug release. RLZ-NLCs showed successful delivery of RLZ in a sustained manner, inhibition of keratinocyte cell proliferation, and non-angiogenic properties, making them a promising strategy for treating keratinocyte hyperproliferative conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Firas Elmsmari, Luis Maria Delgado, Fernando Duran-Sindreu, Roman A. Perez, Maria Luisa Garcia, Miriam Teule Trullb, Kelvin I. Afrashtehfar, Jose Antonio Gonzalez, Elena Sanchez-Lopez
Summary: This study investigated the antibacterial properties of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with calcium hydroxide (Ca(OH)(2)) for endodontic disinfection. The results showed that Ca(OH)(2) NPs had a significant inhibitory effect on bacterial strains tested and reduced bacterial metabolic activity in an ex vivo model.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Lorena Bonilla-Vidal, Marta Switalska, Marta Espina, Joanna Wietrzyk, Maria Luisa Garcia, Eliana B. Souto, Anna Gliszczynska, Elena Sanchez Lopez
Summary: APG-NLC containing rosehip oil was developed, which exhibited favorable physicochemical characteristics, long-term stability, sustained release of APG, and cytotoxicity in cancer cells without affecting healthy cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Smita Khairnar, Elena Sanchez-Lopez, Eliana B. Souto, Kamalinder K. Singh
Summary: Microspheres-enriched ocular gels were developed as a controlled release system for moxifloxacin hydrochloride. The ocular gel containing microspheres showed improved drug release, penetration, and therapeutic efficacy, with reduced administration frequency, which may improve patient compliance to ocular treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Agriculture, Dairy & Animal Science
Andy Wai Kan Yeung, Natalia Ksepka, Maima Matin, Dongdong Wang, Eliana B. Souto, Jivko Stoyanov, Javier Echeverria, Devesh Tewari, Jaroslaw Olav Horbanczuk, Massimo Lucarini, Alessandra Durazzo, Joanna Marchewka, Vasil Pirgozliev, Ren-You Gan, Nikolay T. Tzvetkov, Kamil Wysocki, Farhan Bin Matin, Olena Litvinova, Anupam Bishayee, Hari Prasad Devkota, Amr El-Demerdash, Mladen Brncic, Antonello Santini, Olaf. K. Horbanczuk, Michel-Edwar Mickael, Michal Lawinski, Niranjan Das, Bodrun Naher Siddiquea, Dalibor Hrg, Atanas G. Atanasov
Summary: This study provides a quantitative literature analysis on the influence of diet on non-alcoholic fatty liver disease (NAFLD). The analysis reveals that China and the United States are significant contributors to this field, and key dietary compounds such as resveratrol and polyphenols are frequently mentioned and cited, showing potential benefits for NAFLD in both human and animal studies.
ANIMAL SCIENCE PAPERS AND REPORTS
(2023)
