Article
Medicine, General & Internal
Kyung Jin Eoh, Junsik Park, Hye Min Kim, Maria Lee, Young Tae Kim
Summary: This study compared prognostic outcomes between patients with high-grade ovarian Sertoli-Leydig cell tumors (SLCTs) and those with other low-grade SLCTs, finding that grade 3 SLCT patients had significantly poorer prognosis and might require more aggressive intervention.
YONSEI MEDICAL JOURNAL
(2021)
Article
Education, Scientific Disciplines
Jingya Chen, Yuting Liu, Yu Zhang, Yaohui Wang, Xiao Chen, Zhongqiu Wang
Summary: Ovarian Sertoli-Leydig cell tumors (SLCTs) predominantly affect young women and present with clinical symptoms of androgen overproduction. Imaging characteristics include unilateral oval or round tumors with the solid part showing isoattenuation on CT and marked enhancement on contrast-enhanced images. DICER1 hotspot mutations are commonly observed in SLCTs.
Review
Oncology
Alice Bergamini, Fais Maria Luisa, Miriam Dellino, Silvestri Erica, Vera Loizzi, Luca Bocciolone, Emanuela Rabaiotti, Raffaella Cioffi, Giulia Sabetta, Gennaro Cormio, Giorgia Mangili
Summary: Sex cord stromal tumors are rare neoplasms that mainly occur in young women. For patients who want to preserve fertility, unilateral salpingo-oophorectomy is a safe alternative treatment. The spontaneous conception rate is high in granulosa cell tumors, while it is lower in Sertoli-Leydig cell tumors.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Review
Medicine, General & Internal
Elisa De Paolis, Rosa Maria Paragliola, Paola Concolino
Summary: Sertoli-Leydig Cell Tumors (SLCTs) are rare ovarian neoplasms that primarily affect adolescents and young female adults. The diagnosis and treatment of SLCTs remain challenging due to their rarity and varied presentation. DICER1 gene mutations are common in approximately 60% of SLCTs, especially in moderately or poorly differentiated types.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jinlian Liang, Hanhao Li, Jiaxin Mei, Zhen Cao, Yan Tang, Rufei Huang, Huan Xia, Qihao Zhang, Qi Xiang, Yan Yang, Yadong Huang
Summary: The study revealed that SC-derived miR-145-5p plays a significant role in regulating the functions of Leydig cells and may serve as a diagnostic biomarker for male hypogonadism developmental abnormalities during puberty.
Article
Veterinary Sciences
Rebecca Schwartz, Nicole J. Sugai, Kristin Eden, Caitlin Castaneda, Matthew Jevit, Terje Raudsepp, Julie T. Cecere
Summary: This is a case report of a 10-year-old Chinese Crested dog with symptoms of vulvar swelling, vaginal discharge, and acyclicity. Histopathologic evaluation revealed abnormal testes and chimerism in blood cells. Surgery was successful in treating the patient.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Oncology
Wei Li, Shuli Yang, Li Su, Jinwei Miao, Yumei Wu, Xingzheng Zheng
Summary: This study reviewed the medical records of 18 ovarian SLCT patients and found that patients with SLCTs exhibited various clinical presentations and had a favorable prognosis, which can contribute to improved clinical management.
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
(2022)
Article
Pathology
W. Glenn McCluggage, Barbara Rivera, Anne-Sophie Chong, Blaise A. Clarke, Kris Ann P. Schultz, Louis P. Dehner, Nairi Tchrakian, Maria Apellaniz-Ruiz, C. Blake Gilks, Friedrich Kommoss, Colin J. R. Stewart, William D. Foulkes
Summary: In this study, DICER1 molecular testing was performed on 18 cases of well-differentiated SLCT, and all were found to be DICER1 wild-type. Based on the molecular and morphological observations, it is suggested that well-differentiated SLCT is a distinct and unrelated tumor type in the ovarian sex cord-stromal tumor family, separate from the more common moderately/poorly differentiated and retiform SLCTs.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Genetics & Heredity
Mizuki Konuma, Kazue Nagasawa, Mariia Mokrina, Mutsuko Kobayashi, Makoto Osada
Summary: This study identified Bmp2a gene as a gonadal somatic cell-specific gene in the Yesso scallop. The expression of bmp2a mRNA increased during the reproductive phase and was lowest at the beginning of the growing stage, indicating the support of bmp2a-positive gonadal somatic cells to germ cell growth and differentiation.
Article
Endocrinology & Metabolism
Alexander Siegfried Busch, Marie Lindhardt Ljubicic, Emmie N. Upners, Margit Bistrup Fischer, Lars Lau Raket, Hanne Frederiksen, Jakob Albrethsen, Trine Holm Johannsen, Casper P. Hagen, Anders Juul
Summary: The male hypothalamic-pituitary-gonadal axis is transiently active during the first months of life, with surging serum concentrations of reproductive hormones, a period known as minipuberty. In healthy male infants, reproductive hormone concentrations show marked dynamics during the first 6 months, with correlations with testicular volume and establishment of reference curves for serum levels of reproductive hormones.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pathology
Zehra Ordulu, Robert H. Young
Summary: This study described 38 ovarian Sertoli-Leydig cell tumors containing follicles, with most tumors showing characteristics of intermediate differentiation Sertoli-Leydig cell tumors, but also featuring follicles mimicking juvenile granulosa cell tumors.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tao Lei, Sandra M. Blois, Nancy Freitag, Martin Bergmann, Sudhanshu Bhushan, Eva Wahle, Annie Chi-Chun Huang, Hung-Lin Chen, Michaela F. Hartmann, Stefan A. Wudy, Fu-Tong Liu, Andreas Meinhardt, Monika Fijak
Summary: Galectin 3 plays a crucial role in testicular physiology by regulating spermatogenesis initiation and testosterone biosynthesis, which ultimately affects testicular weight and reproductive function. Through its involvement in preventing germ cell apoptosis and controlling testosterone production, Galectin 3 serves as a key factor in the development of germ cells and steroidogenesis, offering potential biomarkers for testicular function.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Kaitlin McLaughlin, Kay See Tan, Joe Dycoco, Monica F. Chen, Jamie E. Chaft, Nikhil P. Mankuzhy, Andreas Rimner, Rania G. Aly, Rachel E. Fanaroff, William D. Travis, Mark Bilsky, Manjit Bains, Robert Downey, James Huang, James M. Isbell, Daniela Molena, Bernard J. Park, David R. Jones, Valerie W. Rusch
Summary: A multidisciplinary care paradigm, involving medical and radiation oncology, as well as spine neurosurgery, can improve surgical outcomes for Pancoast tumors. Spine neurosurgery allows for the resection of transverse processes and vertebral bodies. This treatment approach is associated with a high rate of R0 resection, complete response, and major pathologic response. The prognosis of cT3 and cT4 tumors is similar.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Biology
Holly Rore, Nicholas Owen, Raul Eduardo Pina-Aguilar, Kevin Docherty, Ryohei Sekido
Summary: Researchers successfully generated testicular somatic cell-like cells (TesLCs) including Sertoli cell-like cells from mouse embryonic stem cells in xeno-free culture, and created testicular organoids in co-culture with epiblast-like cells (EpiLCs). They also found that TesLC-conditioned media can induce the differentiation of EpiLCs into primordial germ-like cells (PGCLCs), providing insights into generating sperm entirely in xeno-free culture.
COMMUNICATIONS BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jinhuan Wei, Tingting Lu, Fulu Dong, Chong Zhang, Yonghui Zhang
Summary: This study investigated the toxic effects of PNP on male reproductive system using TM3 and TM4 cells, and found that the two cell types exhibited different responses to PNP. PNP significantly inhibited cell proliferation, promoted cell apoptosis, and altered cell cycle distribution and ultrastructure, with more pronounced effects observed in TM4 cells. Pathway analysis revealed that PNP influenced different biological processes in TM3 and TM4 cells, suggesting potential diverse toxic mechanisms.
Article
Chemistry, Inorganic & Nuclear
Shiyong Gao, Jiejing Zhang, Yikun Li, Shujie Jiao, Jujun Yuan, Guangning Wang, Xiang Li, Jinzhong Wang, Qingjiang Yu, Xitian Zhang
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2018)
Article
Chemistry, Inorganic & Nuclear
Jiejing Zhang, Shiyong Gao, Guangning Wang, Xinzhi Ma, Shujie Jiao, Dandan Sang, Shuo Liu, Mouwen Mao, Haitao Fang, Jinzhong Wang
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Zhi Zeng, Shiyong Gao, Guangning Wang, Xinzhi Ma, Dandan Sang, Shujie Jiao, Dongbo Wang, Jie Jia, Gengxin Hu, Jinzhong Wang
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Guangning Wang, Tingting Chen, Carlos J. Gomez-Garcia, Feng Zhang, Mingyi Zhang, Huiyuan Ma, Haijun Pang, Xinming Wang, Lichao Tan
Article
Ecology
Daesik Park, Catherine R. Propper, Guangning Wang, Matthew C. Salanga
Summary: By studying the genetic allelic variation and expression of as3mt gene in fish populations in different arsenic concentration environments, it was found that fish from high arsenic concentration site had significantly lower expression of as3mt gene, while fish populations in low arsenic environments had more SNPs. This suggests that gene expression related to arsenic detoxification plays a crucial role in influencing responses to arsenic toxicity.
Review
Obstetrics & Gynecology
Guangning Wang, Ran Zhang, Chuan Li, Aiping Chen
Summary: LMWH treatment may decrease the miscarriage rate in women with a history of 3 or more miscarriages, but does not reduce the incidence of miscarriage in women with a history of 2 or more miscarriages. More randomized controlled trials are needed to provide robust and reliable results.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Clinical Neurology
Menglu Zhao, Guangning Wang, Aimin Wang, Ling Jie Cheng, Ying Lau
Summary: The study evaluated the effects of robot-assisted distal training on motor function, dexterity, and spasticity in stroke patients. The results showed significant improvements in these areas compared to conventional therapy, with meta-regression indicating the influence of trial year, country, and duration on training effectiveness.
NEUROLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Xuwen Sun, Yan Qu, Guangming Wang, Tingting Chen, Guangning Wang
Summary: The hybrids of polyoxometalate/transition-metal complexes/graphene-based electrode materials, synthesized via a hydrothermal method, showed improved specific capacitance and rate performance when mixed with graphene, indicating a significant enhancement in electrical performance.
Article
Energy & Fuels
Shaobin Li, Tingting Yu, Fengbo Li, Tingting Chen, Li Zhang, Guangning Wang, Jianjiao Xin, Deqing Zhang
Summary: A novel composite electrode material NiCoC/O-NiCoAl LDH with a unique nanoflower-like structure and multiple surface element states was successfully synthesized. The electrode material exhibited excellent specific capacitance and cycling stability, suggesting its potential applications in green energy storage.
Article
Chemistry, Multidisciplinary
Guangning Wang, Siyu Guo, Yang Wu, Jiaqi Wu, Feng Zhang, Lu Li, Mingyi Zhang, Chengbao Yao, Carlos J. Gomez-Garcia, Tianyang Wang, Yajing Zhang, Tingting Chen, Huiyuan Ma
Summary: In this study, a high-capacity negative electrode was designed and prepared to improve the performance of supercapacitors. By improving conductivity and cycling stability, as well as preventing restacking, the performance of the capacitor was enhanced. A supercapacitor device with ultrahigh energy density and power density was fabricated by combining the negative electrode with a positive electrode. This research has great potential for practical applications.
Article
Chemistry, Inorganic & Nuclear
Xinyu Che, Qiong Wu, Sumin Hu, Guangning Wang, Haijun Pang, Weize Sun, Huiyuan Ma, Xinming Wang, Lichao Tan, Guixin Yang
Summary: In this study, a novel crystalline poly-oxometalate-based coordination polymer was used as a pre-assembled platform to successfully prepare a highly dispersed trimetallic sulfide composite electrode under hydrothermal conditions. The resulting composite electrode exhibited superior electrocatalytic performance and long-term stability for the hydrogen evolution reaction.
JOURNAL OF SOLID STATE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jiaqi Wu, Zihan Ma, Guangning Wang, Tingting Chen
Summary: In order to develop environmentally friendly and high-performance supercapacitors, the research focuses on finding low-cost, high-capacitance renewable electrode materials. In this study, celery leaves, a common biomass vegetable, were used to prepare activated carbon for supercapacitors with high voltage and high capacity. The hierarchically porous carbon materials derived from celery leaves showed a high specific capacitance of 753.0 F g(-1) at 0.5 A g(-1) and a capacity retention of 96.7% even after 5,000 cycles, indicating excellent electrochemical performance.
Article
Chemistry, Multidisciplinary
Yang Wu, Shaoqi Li, Fangxue Ning, Guangning Wang, Tianyang Wang, Tingting Chen
Summary: A multi-dimensional micro CuCo2O4/nano NiCo2S4 structure with excellent supercapacitor performance was synthesized by wrapping NiCo(2)S(4) nanosheets on urchin-like CuCo2O4 microspheres, providing a general approach for the development of high-performance materials.
Article
Materials Science, Multidisciplinary
Xiang Li, Shiyong Gao, Guangning Wang, Zhikun Xu, Shujie Jiao, Dongjun Wang, Yuewu Huang, Dandan Sang, Jinzhong Wang, Yong Zhang
JOURNAL OF MATERIALS CHEMISTRY C
(2020)