Article
Biochemistry & Molecular Biology
Yu Hong, Yuan-Yuan Zhu, Qiuqin He, Shuang-Xi Gu
Summary: This review summarizes the recent progress in the development of indole derivatives as tubulin polymerization inhibitors from 2010 to present. It provides useful clues and inspirations for the further design of outstanding inhibitors.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Dalal Sulaiman Alshaya, Rana M. O. Tawakul, Islam Zaki, Ali H. Abu Almaaty, Eman Fayad, Yasmin M. Abd El-Aziz
Summary: A new series of acrylic acid and acrylate ester derivatives were synthesized and evaluated for their antiproliferative activity against MCF-7 breast carcinoma cells. Methyl acrylate ester 6e showed the highest cytotoxicity with an IC50 value of 2.57 +/- 0.16 mu M and exhibited inhibition of beta-tubulin polymerization. Compound 6e arrested MCF-7 cells at the G2/M phase and enhanced apoptotic power, while also affecting the gene expression levels of p53, Bax, and Bcl-2.
Article
Biochemistry & Molecular Biology
Magdalena Peruzynska, Aleksandra Borzyszkowska-Ledwig, Jacek G. Sosnicki, Lukasz Struk, Tomasz J. Idzik, Gabriela Maciejewska, Lukasz Skalski, Katarzyna Piotrowska, Pawel Lukasik, Marek Drozdzik, Mateusz Kurzawski
Summary: This study successfully obtained a mitotic-specific inhibitor with high antiproliferative activity and selectivity through structural modifications. By inhibiting tubulin polymerization in a dose-dependent manner, aberrant mitotic spindle formation was induced, leading to cell cycle arrest and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Ashima Dhiman, Rupam Sharma, Rajesh K. Singh
Summary: Cancer, the second leading cause of death after heart disease, is characterized by the uncontrolled growth of cells. Targeting specific genes and proteins involved in the growth and survival of cancer cells has become a top priority in global research. Indole moiety, a combination of aromatic-heterocyclic compounds, has emerged as a promising scaffold for the development of anticancer drugs due to its bioavailability, unique chemical properties, and significant pharmacological behaviors. Recent advances in the medicinal chemistry of indole derivatives, including the synthesis of potential anticancer compounds and their mechanism of action, are discussed in this review.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Multidisciplinary
Nam Q. H. Doan, Ngan T. K. Nguyen, Vu B. Duong, Ha T. T. Nguyen, Long B. Vong, Diem N. Duong, Nguyet-Thu T. Nguyen, Tuyen L. T. Nguyen, Tuoi T. H. Do, Tuyen N. Truong
Summary: This study aims to address the burden of cancer and the limitations of chemotherapy. By improving the anticancer activity of curcumin, researchers synthesized 32 asymmetric monocarbonyl analogues (MACs) fused with 1-aryl-1H-pyrazole and identified several compounds that showed potential growth inhibition against cancer cells and affected microtubule assembly activity. Three compounds were found to induce apoptosis in breast cancer cells. This study serves as a foundation for the design of promising synthetic compounds as anticancer agents in the future.
Article
Chemistry, Physical
Ahmed A. E. Mourad, Youstina W. Rizzk, Islam Zaki, Faten Z. Mohammed, Mohammed El Behery
Summary: A series of hybrid organic nitrogen compounds were synthesized and confirmed through spectroscopic techniques, showing potent antitumor activity by inducing cell cycle arrest and apoptosis in cancer cells. The compounds also exhibited strong inhibitory effects against beta-tubulin polymerization and topoisomerase up enzyme.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Multidisciplinary
Lingyu Shi, Shanbo Yang, Jing Chang, Yujing Zhang, Wenjing Liu, Jun Zeng, Jingsen Meng, Renshuai Zhang, Chao Wang, Dongming Xing
Summary: A series of new compounds were synthesized and evaluated for their antitumor activity as tubulin polymerization inhibitors. Compound 7k showed the strongest anti-proliferative activity and could block the cell cycle and induce apoptosis.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Shu-Yi Hao, Zhi-Yuan Qi, Shuai Wang, Xing-Rong Wang, Shi-Wu Chen
Summary: A new series of N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives were synthesized as tubulin polymerization inhibitors, with compound 15c showing strong anti-proliferative activity against MCF-7 cells and anti-angiogenic effects. Molecular studies revealed compound 15c's mechanism of action in changing tubulin morphology and cell cycle arrest, highlighting its potential as a promising antitumor compound.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Hany M. Abd El-Lateef, Rasha Mohammed Saleem, Mohammed A. Bazuhair, Ali Hassan Ahmed Maghrabi, Eman Hussain Khalifa Ali, Islam Zaki, Reham E. Masoud
Summary: A new series of hydrazone derivatives were synthesized and screened for their cytotoxic activity against MCF-7 breast cancer cell line. Some compounds exhibited potent cytotoxicity and inhibition of β-tubulin. Flow cytometric analysis revealed that one compound induced cell cycle arrest at G2/M phase and increased apoptosis compared to untreated control. Molecular modeling investigations were conducted to explain the compound's exceptional cytotoxicity and superior ability to inhibit tubulin when compared to CA-4.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Oncology
Ashish Ranjan Dwivedi, Suraj Singh Rawat, Vijay Kumar, Naveen Kumar, Vinay Kumar, Ravi Prakash Yadav, Somesh Baranwal, Amit Prashad, Vinod Kumar
Summary: The study focuses on developing anticancer agents targeting tubulin protein by synthesizing and screening benzotriazole-substituted 2-phenyl quinazolines. The compounds ARV-2 and ARV-3 demonstrate potent antiproliferative activities and induce mitochondria-mediated apoptosis.
CURRENT CANCER DRUG TARGETS
(2023)
Article
Biochemistry & Molecular Biology
Rungroj Saruengkhanphasit, Chutikarn Butkinaree, Narittira Ornnork, Kriengsak Lirdprapamongkol, Worawat Niwetmarin, Jisnuson Svasti, Somsak Ruchirawat, Chatchakorn Eurtivong
Summary: Utilizing three different virtual screening techniques, eight new derivatives of 3-phenyl-1H-indole-2-carbohydrazide with antiproliferative activities were identified; among them, 27a exhibited the most potent tubulin inhibitory activity and induced G2/M phase arrest. Derivatives 27b, 27d, and 27i showed strong activities against various cell lines, with bromine substitution at R1 position demonstrating the most prominent anticancer effects.
BIOORGANIC CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Mudasir Nabi Peerzada, Mohammad Sultan Dar, Saurabh Verma
Summary: Tubulin is a promising target for drug discovery, and compounds binding in the colchicine site could be significant in overcoming drug resistance. The development of antibody drug conjugates (ADCs) for tubulin polymerization inhibition may be an important strategy for cancer treatment.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2023)
Review
Chemistry, Medicinal
Bharat Goel, Shivani Jaiswal, Shreyans K. K. Jain
Summary: Microtubules are important intracellular targets for anticancer activity. Various drugs, such as paclitaxel and vinblastine, act by altering the dynamics of microtubules. In this study, the potential of indole derivatives as colchicine-binding site inhibitors is reviewed. These derivatives have shown the ability to inhibit cancer cell proliferation, induce apoptosis, and disrupt microtubule formation. Understanding the structure-activity relationship of these compounds could lead to the development of novel and effective cancer therapies.
ARCHIV DER PHARMAZIE
(2023)
Article
Chemistry, Medicinal
Dong Liang, Chen Yu, Zhao Ma, Mingzhao Hu, Jiahui Wang, Xuhui Dong, Lupei Du, Minyong Li
Summary: In this study, the discovery of two series of parbendazole derivatives as tubulin inhibitors for the treatment of head and neck squamous cell carcinoma (HNSCC) was reported. Compound 9q exhibited the best pharmacological activities and pharmacokinetic properties, displaying reasonable inhibition activity on cell proliferation, induction of cell apoptosis, and suppression of cell migration and invasion.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Shannon Pecnard, Abdallah Hamze, Jerome Bignon, Bastien Prost, Alain Deroussent, Laura Gallego-Yerga, Rafael Pelaez, Ji Yeon Paik, Marc Diederich, Mouad Alami, Olivier Provot
Summary: In this study, various ligands related to Combretastatin A-4 and isoCombretastatin A-4 were designed, synthesized, and evaluated for their ability to inhibit tubulin polymerization. The lead compound 15d showed remarkable sub-nanomolar cytotoxicity against 9 human cancer cell lines, with an IC50 value below 1 nM.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Food Science & Technology
Zhiyun Peng, Guangcheng Wang, Qiao-Hui Zeng, Yufeng Li, Haiquan Liu, Jing Jing Wang, Yong Zhao
Summary: Tyrosinase is a copper-containing oxidation enzyme responsible for melanin production and plays a key role in browning, antibiotic resistance, pigment formation, etc. Synthetic tyrosinase inhibitors have great potential applications and have been widely reported in recent years.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Food Science & Technology
Qiandai Shi, Jing Jing Wang, Lu Chen, Zhiyun Peng, Qiao-Hui Zeng, Yongheng Zhu, Yong Zhao
Summary: By coupling calcinated melamine sponges with the Fenton reaction, a potent Photodynamic Inactivation (PDI) system has been developed, greatly improving the inactivation potency against harmful bacteria. The composite photocatalyst demonstrated nontoxic properties and effectively inactivated Salmonella in various food sources, showcasing promising applications in food safety and bacterial control.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Wenjing Liu, Min He, Yongjun Li, Zhiyun Peng, Guangcheng Wang
Summary: Chalcone derivatives have been found to disrupt the dynamic balance of microtubules, inhibit tumor cell proliferation, and exhibit anti-tumor effects. By inhibiting microtubule dynamics and disrupting microtubule homeostasis, they interfere with the process of cell mitosis.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Food Science & Technology
Lijun Tan, Yong Zhao, Yufeng Li, Zhiyun Peng, Tiantian He, Yang Liu, Qiaohui Zeng, Jing Jing Wang
Summary: This study combined photodynamic inactivation (PDI) with slightly alkaline electrolyzed water (SAlEW) to disrupt the spatial structures of biofilms and effectively control bacterial growth, demonstrating a promising strategy for biofilm contamination control in the food industry.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Wei Yang, Qianqian Feng, Zhiyun Peng, Guangcheng Wang
Summary: This article emphasizes the importance of urease inhibitors in controlling infectious diseases caused by Helicobacter pylori. The authors review the urease inhibitory activity, inhibition kinetics, structure-activity relationship, and molecular docking of various urease inhibitors. The collected information is expected to provide rational guidance and effective strategies for the development of novel, potent, and safe urease inhibitors for practical applications in the future.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Zhiyun Peng, Yufeng Li, Lijun Tan, Lu Chen, Qiandai Shi, Qiao-Hui Zeng, Haiquan Liu, Jing Jing Wang, Yong Zhao
Summary: A series of gallic acid-benzylidenehydrazine hybrids were synthesized and evaluated for their tyrosinase inhibitory activity. Two compounds, 5d and 5f, showed potent inhibition and also exhibited antioxidant and antibacterial activities, making them potential candidates for novel food preservatives.
Article
Chemistry, Applied
Yufeng Li, Zhiyun Peng, Lijun Tan, Yongheng Zhu, Cheng Zhao, Qiao-Hui Zeng, Guang Liu, Jing Jing Wang, Yong Zhao
Summary: New polyphenol-protein conjugates (SAKPs-rutin) were prepared by covalently crosslinking soluble Antarctic krill proteins with rutin. These conjugates showed improved physico-chemical and functional properties, making them a promising resource for preparing food-grade emulsions.
Article
Chemistry, Medicinal
Meiyan Fan, Wei Yang, Min He, Yongjun Li, Zhiyun Peng, Guangcheng Wang
Summary: This review mainly focuses on the natural occurrence, chemical synthesis, and biological activities of 2-(2-phenylethyl)chromones (PECs) published up until 2020.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Qianqian Feng, Wei Yang, Zhiyun Peng, Guangcheng Wang
Summary: Thymidine phosphorylase (TP) is an important enzyme involved in the synthesis and decomposition of pyrimidine. TP inhibitors have shown significant potential in cancer treatment due to their ability to inhibit angiogenesis, induce anti-apoptotic effects, and inhibit tumor growth and metastasis. In this article, the research progress of synthetic TP inhibitors was reviewed. However, there is a lack of research on the biological activities and inhibitory mechanisms of pyrimidine derivatives, as well as the application of radiolabeled inhibitors in assessing TP expression and the synergistic anticancer activity of TP inhibitors in combination with other drugs.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei Yang, Huining Peng, Yong Huang, Zhiyun Peng, Guangcheng Wang
Summary: A series of litseaone B analogues similar to 4p were synthesised and screened for their antitumor activities. Compound 4k showed excellent activity against A549, HepG2, and HCT-15 cell lines, and it could inhibit tubulin polymerisation, decrease mitochondrial membrane potential, and induce apoptosis in A549 cells.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Meiyan Fan, Qianqian Feng, Min He, Wei Yang, Zhiyun Peng, Yong Huang, Guangcheng Wang
Summary: This study designed, synthesized, and screened a series of natural product (2-phenyethyl)chromone analogues for their a-glucosidase inhibitory activity. The results showed that some of the synthesized derivatives exhibited inhibitory activities against a-glucosidase, with compound 4 displaying the most significant inhibitory activity. The compound showed potential for treating diabetes with low cytotoxicity against normal cells. It represents a new class of a-glucosidase inhibitors.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Meiyan Fan, Wei Yang, Zhiyun Peng, Yan He, Guangcheng Wang
Summary: Novel chromone-based benzohydrazide derivatives 6a-6s were synthesized and tested for their inhibitory activities against alpha-glucosidase. Compound 6i showed the highest inhibitory activity with an IC50 value of 4.51 +/- 0.09 mu M. The interaction between alpha-glucosidase and 6i was further confirmed through various studies. In vivo experiment demonstrated that 6i could suppress the rise of blood glucose levels. The cytotoxicity result indicated low toxicity of 6i.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Wei Yang, Zhiyun Peng, Guangcheng Wang
Summary: This review summarizes the metal-based inhibitors of urease, including the inhibition, structure-activity relationship, and molecular docking. Copper metal complexes exhibit strong urease inhibition and offer potential guidance for the development of novel inhibitors.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Meiyan Fan, Xu Zhong, Yong Huang, Zhiyun Peng, Guangcheng Wang
Summary: A series of chromone derivatives were designed, synthesized, and evaluated for their α-glucosidase inhibitory activity. Some new compounds exhibited excellent inhibitory activity with IC50 values ranging from 10.9 to 146.5 μM. Compound 6m showed the most potent inhibitory activity with an IC50 value of 10.9 μM. Further studies confirmed the structural changes of α-glucosidase upon binding with 6m and revealed the interactions between 6m and specific residues.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Wafa A. Bawazir, Maymoona A. Al-Mahmood, Rawan S. Almalki, Ghadi F. Alofi, Raghad S. Alharbi, Zoya Zaheer
Summary: This study investigates the interaction between sulfathiazole and three types of surfactants using UV-visible spectroscopy and conductivity measurements. The results show that the critical micelle concentration of cationic and anionic surfactants decreases with increasing sulfathiazole concentration, while the interaction with non-ionic surfactant is weak.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Musaad K. Aleid, Khalid N. Alharbi, Mona A. Aljufareen, Areej S. Aloliwi, Alhanouf K. Almutairi, Rahaf S. Alsaif, Nada K. Alshayeb, Mohammed S. Almoiqli
Summary: This study assessed the levels of trihalomethane compounds in the water network of Riyadh city and identified the factors influencing their formation. The concentrations of trihalomethane compounds were within the permissible limits, indicating the water's safety for human consumption. The presence of bromide ions, organic carbon, free chlorine, and pH values were found to affect trihalomethane formation.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Said Arhzaf, Jamal Houssaini, Mohammed Naciri Bennani, Marwa Alaqarbeh, Mohammed Bouachrine
Summary: The study shows that Mg-Al hydrotalcite catalysts intercalated with acetate and carbonate anions exhibit superior catalytic activity in the aldol condensation reaction between furfural and acetone. The optimal reaction conditions are at 90 degrees C for 2 hours, achieving conversion rates of over 98% with high selectivity towards F2A for the acetate catalyst.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Uyen-Chi Nguyen Le, Ngoc Xuan Dat Mai, Kieu-Minh Le, Hoang Anh Vu, Huynh-Nhu Thi Tran, Tan Le Hoang Doan
Summary: This study aimed to enhance the bioavailability of rosmarinic acid, a bioactive compound with high anticancer activity, by encapsulating it in tetrasulfide-based porous organosilica nanoparticles. The synthesized nanoparticles were small in size and had a high surface area and an average pore diameter. The nanoparticles showed effective accumulation in cancer cells without toxicity to normal cells. Treatment with rosmarinic acid-containing nanoparticles resulted in significant cell death in cancer cells. Overall, these findings suggest that the synthesized nanoparticles can enhance the pharmacological effects of rosmarinic acid.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Jiamin Qi, Hengxi Zhu, Tianyu Yang, Xingyuan Wang, Zixuan Wang, Xiaoli Lei, Bin Li, Wenmin Qian
Summary: This study synthesized a novel iron-biochar adsorbent using the iron content in red mud to remove heavy metals from wastewater. The adsorbent showed excellent removal efficiency and sustainability. This method addresses both industrial waste recovery and heavy metal adsorption issues.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Bo Yi, Li Zhang, Haiyang Zhou
Summary: Plasma protein binding plays a crucial role in the pharmacokinetics and pharmacodynamics of therapeutic bioactive materials. In this study, the interaction of nordentatin, a member of coumarins, with human alpha-1 acid glycoprotein (AGP) was investigated, and the anticancer potency of nordentatin against human colorectal cancer cells was evaluated. The results showed that nordentatin binds to AGP through a static quenching mechanism and exhibits inhibitory effects on the growth of HCT-116 cells by increasing intracellular ROS and [Ca2+] levels and triggering apoptosis-related gene overexpression. Therefore, nordentatin could be a promising plant-based therapy for colorectal cancer.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Qiming Pang, Cui Wang, Bangtao Li, Suli Zhang, Jiaoyang Li, Shuo Gu, Xueyu Shi
Summary: This study evaluated the effects of resveratrol loaded in copolymer nanoparticles on cerebral ischemia/reperfusion (I/R) injury in rats. The results showed that RES.CP.NPs could have neuroprotective effects through their antioxidant and anti-inflammatory activities, leading to improved neurological disability scores and decreased oxidative stress levels.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Maryam Rachmawati Sumitra, Lung-Ching Chen, Wei-Chen Tsai, Muhamad Ansar, Bashir Lawal, Ntlotlang Mokgautsi, Jih-Hwa Guh, Alexander T. H. Wu, Hsu-Shan Huang
Summary: Tetraheterocyclic compounds derived from natural sources and contemporary pharmaceuticals have shown promise as multitarget therapeutic agents. In this study, a series of synthesized compounds were evaluated for their potential in breast cancer treatment. Compounds 18 and 20 demonstrated significant antiproliferative activity against breast cancer cell lines and their mode of action was revealed through molecular docking simulations.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Mohammad Khosravani, Mohsen Dehghani Ghanatghestani, Farid Moeinpour, Hossein Parvaresh
Summary: The aim of removing Pb(II) from water is to minimize the potential harm posed by toxic metals to both human health and the environment. A covalent organic framework adsorbent called TFPOTDB-SO3H was developed with excellent properties such as high repeatability, selectivity, and easy solid-liquid separation. The adsorbent showed impressive capability of adsorbing Pb(II) and effective removal of it from a solution with various ions, suggesting its potential for effectively adsorbing and removing Pb(II) heavy metal ions from wastewater.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Ashraf H. Farha, Mohamed S. Shams, Hasna A. Alali, Zakia H. Alhashem, Shehab A. Mansour, Shrouq H. Aleithan, Ragab A. Elsad
Summary: The current study examines the dielectric and thermal properties of transformer oil incorporated with Mn0.5 Zn0.5 Fe2O4 nanoparticles. The results show that the addition of Mn-Zn ferrite NPs improves the dielectric constant, dissipation factor, AC breakdown voltage, and convective heat transfer of the nanofluid.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Limin Hou, Zongpei Jiang, Minqi Ye, Xueyan Sun, Kexin Liu, Yifan Zhu, Xiaoyu Wang, Liangzhu Chen, Ruiheng Gu, Binghu Fang
Summary: The excessive accumulation of antibiotic residue in animal-derived foods poses a threat to health. Therefore, it is necessary to establish a rapid, simple, effective, safe, and highly sensitive method for detecting lincomycin residues. By using a pre-column derivatization method on high-performance liquid chromatography equipped with ultraviolet, the UV absorption of lincomycin is improved, allowing for detection and quantification.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Kun Tang, Xin-Xin Wang, Jin-Jin Zhao, Ning Ren, Jian-Jun Zhang
Summary: This study reports the synthesis, crystal structures, and thermal degradation properties of three new rare earth coordination compounds. Compounds 1-3 exhibit binuclear structures which can form chain-like structures via hydrogen bonding. Compound 2 shows potential application value in the orange-red luminescence region.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Seoyoun Yang, Eunbi Yu, See-Hyoung Park, Sae Woong Oh, Kitae Kwon, Su Bin Han, Soo Hyun Kang, Jung Hyun Lee, Heejun Ha, Minkyung Song, Jae Youl Cho, Jongsung Lee
Summary: This study investigated the effects of blue light on the hypodermis and found that it has antiadipogenic properties by reducing lipid accumulation and downregulating the expression of adipogenic genes. Blue light also increased the phosphorylation of PPAR gamma and TRPV1, suggesting its anti-adipogenic effect through these signaling pathways.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Abdul Nasir, Abdul Waheed Khan, Hamid Rafiq Khattak, Abdus Samad, Sami Ullah, Haroon Khan, Muhammad Faheem, Qian Bai
Summary: This study evaluated the effects of isoxazolone derivatives on cisplatin-induced neuropathy in a rat model. The results showed that isoxazolone derivatives effectively reversed mechanical allodynia, similar to the known therapeutic agent pregabalin. Molecular docking analysis indicated that isoxazolone derivatives have strong binding affinity for relevant receptors and potential inhibitory activity against relevant signaling pathways. This study has innovative implications for the treatment of cisplatin-induced neuropathic pain.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Shahid Wahab, Haroon Muhammad Ali, Maham Khan, Tariq Khan, Chandran Krishnaraj, Soon-Il Yun
Summary: In this study, we synthesized chitosan nanoparticles, silver nanoparticles, and chitosan/silver nanocomposites using aqueous ginger extract as a green approach. These nanomaterials showed significant antibacterial properties and low toxicity. Furthermore, the nanomaterials conjugated with tobramycin demonstrated enhanced antibacterial efficacy and exhibited interactions with Pseudomonas aeruginosa.
ARABIAN JOURNAL OF CHEMISTRY
(2024)