Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists
出版年份 2022 全文链接
标题
Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists
作者
关键词
-
出版物
Nature Communications
Volume 13, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-02-17
DOI
10.1038/s41467-022-28561-9
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- 107-LB: Single Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MK-1092 in Healthy Subjects (HS)
- (2020) LINDA MORROW et al. DIABETES
- 106-LB: Single Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MK-1092 in Subjects with T1DM and T2DM
- (2020) LINDA MORROW et al. DIABETES
- Conformational Basis of G Protein-Coupled Receptor Signaling Versatility
- (2020) Laura M. Wingler et al. TRENDS IN CELL BIOLOGY
- Review: Glucose-sensitive insulin
- (2020) Thomas Hoeg-Jensen Molecular Metabolism
- Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex
- (2019) Emiko Uchikawa et al. eLife
- Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain
- (2019) Theresia Gutmann et al. JOURNAL OF CELL BIOLOGY
- Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis
- (2018) Giovanna Scapin et al. NATURE
- Impact of Insulin Degludec in Type 2 Diabetes: Real-World Data on Effectiveness and Safety
- (2018) Paola Ponzani et al. Diabetes Therapy
- Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice
- (2017) Masahiro Konishi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective Insulin Resistance and the Development of Cardiovascular Diseases in Diabetes: The 2015 Edwin Bierman Award Lecture
- (2016) George L. King et al. DIABETES
- Different effects of basal insulin peglispro and insulin glargine on liver enzymes and liver fat content in patients with type 1 and type 2 diabetes
- (2016) K. Cusi et al. DIABETES OBESITY & METABOLISM
- Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain
- (2016) Tristan I. Croll et al. STRUCTURE
- How Can a Good Idea Fail? Basal Insulin Peglispro [LY2605541] for the Treatment of Type 2 Diabetes
- (2016) Araceli Muñoz-Garach et al. Diabetes Therapy
- How Can a Good Idea Fail? Basal Insulin Peglispro [LY2605541] for the Treatment of Type 2 Diabetes
- (2016) Araceli Muñoz-Garach et al. Diabetes Therapy
- Randomized Clinical Trial Comparing Basal Insulin Peglispro and Insulin Glargine in Patients With Type 2 Diabetes Previously Treated With Basal Insulin: IMAGINE 5
- (2015) John B. Buse et al. DIABETES CARE
- New forms of insulin and insulin therapies for the treatment of type 2 diabetes
- (2015) Avivit Cahn et al. Lancet Diabetes & Endocrinology
- Identification of a Small Molecular Insulin Receptor Agonist With Potent Antidiabetes Activity
- (2014) G. Qiang et al. DIABETES
- Diabetes and Cardiovascular Disease in Older Adults: Current Status and Future Directions
- (2014) J. B. Halter et al. DIABETES
- Different Epidermal Growth Factor (EGF) Receptor Ligands Show Distinct Kinetics and Biased or Partial Agonism for Homodimer and Heterodimer Formation
- (2014) Jennifer L. Macdonald-Obermann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Allosteric targeting of receptor tyrosine kinases
- (2014) Frederik De Smet et al. NATURE BIOTECHNOLOGY
- Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling
- (2013) Corentin Herbert et al. CANCER CELL
- Novel PEGylated Basal Insulin LY2605541 Has a Preferential Hepatic Effect on Glucose Metabolism
- (2013) M. C. Moore et al. DIABETES
- Hepatoselectivity and the evolution of insulin
- (2013) R. Herring et al. DIABETES OBESITY & METABOLISM
- Increased Mortality of Patients With Diabetes Reporting Severe Hypoglycemia
- (2012) R. G. McCoy et al. DIABETES CARE
- Insulin Therapy and Hypoglycemia
- (2012) Anthony L. McCall ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
- The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action
- (2009) E. J. Barrett et al. DIABETOLOGIA
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now