期刊
EPIGENOMICS
卷 14, 期 2, 页码 81-100出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2021-0318
关键词
bioinformatics analysis; biomarkers; epigenetics; immune cell infiltration; SLE
资金
- National Natural Science Foundation of China [81972943, 81830097]
- Hunan Talent Young Investigator [2019RS2012]
- Hunan Outstanding Young Investigator [2020JJ2055]
- Hunan Urgency Project [2020SK3005]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2019-I2M-5-033]
This study identifies seven key genes regulated by epigenetics in multiple organs of SLE patients, providing potential diagnostic biomarkers and therapeutic targets for SLE.
Aim: To explore potential abnormal epigenetic modifications and immune-cell infiltration in tissues from systemic lupus erythematosus (SLE) patients. Materials & methods: To utilize bioinformatics analysis and 'wet lab' methods to identify and verify differentially expressed genes in multiple targeted organs in SLE. Results: Seven key genes, IFI44, IFI44L, IFIT1, IFIT3, PLSCR1, RSAD2 and OAS2, which are regulated by epigenetics and may be involved in the pathogenesis of SLE, are identified by combined long noncoding RNA-miRNA-mRNA network analysis and DNA methylation analysis. The results of quantitative reverse transcription PCR, immunohistochemistry and DNA methylation analysis confirmed the potential of these genes as biomarkers. Conclusion: This study reveals the potential mechanisms in SLE from epigenetic modifications and immune-cell infiltration, providing diagnostic biomarkers and therapeutic targets for SLE.
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