Article
Nanoscience & Nanotechnology
Li Li, Zhiyu Wang, Kepeng Wang, Siyuan Fu, Dan Li, Mao Wang, Yi Cao, Houjuan Zhu, Ziyan Li, Lixing Weng, Zhiyang Li, Xianguang Ding, Lianhui Wang
Summary: An efficient extracellular vesicle (EV) ink was developed to regulate the inflammatory microenvironment and promote vascular regeneration for wound healing. This bioactive EV ink, called PAINT, utilizes bioactive EVs derived from M2 macrophages and sodium alginate precursor to form a biocompatible EV-Gel for application on wounds. The PAINT technology reprograms macrophage polarization and enhances angiogenesis, significantly accelerating cutaneous wound healing. It demonstrates the high potential of bioactive EV ink as a portable biomedical platform for healthcare when integrated with a 3D printing pen.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biotechnology & Applied Microbiology
Victor Alfonso Solarte David, Viviana Raquel Guiza-Argueello, Martha L. Arango-Rodriguez, Claudia L. Sossa, Silvia M. Becerra-Bayona
Summary: The absence or damage of tissue is a major cause of diseases, and novel therapeutic alternatives aim to recover lost functions through tissue regeneration. Chronic cutaneous lesions are common wounds that require regenerative medicine and tissue engineering interventions to develop bioactive medical products for proper healing and prevention of complications. The coordination of cells, extracellular matrix (ECM), and biomolecules is crucial in tissue repair and regeneration, with ECM acting as a biological platform for their interactions. Tissue engineering utilizes synthetic polymers and decellularized tissues to mimic native ECM and provide necessary functionalities for cell differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Huimin Xiao, Xin Chen, Xuanzhe Liu, Gen Wen, Yaling Yu
Summary: The skin is an important organ that protects the body and interacts with the external environment. Decellularized biomaterials derived from the extracellular matrix have shown potential in promoting wound healing and skin regeneration. This article reviews the wound healing process, the role of extracellular matrix constituents in wound healing, and the various types of decellularized materials used in clinical practice. The challenges and future research directions in utilizing decellularized biomaterials for wound treatment are also discussed.
MATERIALS TODAY BIO
(2023)
Article
Medicine, Research & Experimental
Martin Albrecht, Lars Hummitzsch, Rene Rusch, Katharina Hess, Markus Steinfath, Jochen Cremer, Frank Lichte, Fred Faendrich, Rouven Berndt, Karina Zitta
Summary: This study aims to characterize the nature and function of Mreg-derived L-EV (L-EVMreg) and discover their potential in wound healing and angiogenesis. The results show that L-EVMreg have regenerative and pro-angiogenic potential, suggesting their potential therapeutic application in chronic wounds and ischemia-associated diseases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Yanzhen Yu, Hangfei Jin, Linbin Li, Xin Zhang, Chunfang Zheng, Xi Gao, Yunxi Yang, Bingwei Sun
Summary: In this study, a VEGF-aPMNEM-ECM hybrid hydrogel was developed to treat chronic diabetic wounds by combining anti-infection strategies, immune microenvironment regulation, and angiogenesis promotion, which accelerates wound healing.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Dong Jun Park, Erika Duggan, Kayla Ho, Robert A. Dorschner, Marek Dobke, John P. Nolan, Brian P. Eliceiri
Summary: Chronic metabolic diseases such as diabetes is associated with delayed wound healing and dysregulated inflammatory phase of wound repair. This study focuses on the changes in extracellular vesicles (EVs) payload that mediates communication between immune cells and stromal cells in the wound bed, which regulate the rate of wound closure. By transferring EVs from genetically defined mouse models, the functional and molecular basis for differences in the pro-reparative biological activity of diabetic (db/db) vs. wildtype EVs in wound healing is demonstrated. This study establishes a novel therapeutic approach by engineering the payload of EVs, aiming to rescue the Serpin deficiency identified by proteomics and promote wound healing in db/db mice.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Engineering, Environmental
Shuang Liu, Yingsong Zhao, Ming Li, Lei Nie, Qianqian Wei, Oseweuba Valentine Okoro, Hafez Jafari, Siyuan Wang, Jun Deng, Jianghai Chen, Amin Shavandi, Lihong Fan
Summary: Bioactive composite hydrogels were created using decellularized extracellular matrix (ECM), GelMA, and Polydopamine-loaded Asiaticoside (AC@PDA) nanoparticles as wound dressings. The hydrogels showed good mechanical properties and moisture retention, and the addition of nanoparticles improved their elasticity and shape recovery. In vitro and in vivo testing demonstrated their biocompatibility and ability to promote wound healing, with the AC@PDA/ECM-G hydrogel showing the best performance in terms of wound closure and hair follicle formation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Medicine, General & Internal
Nikolai N. Potekaev, Olga B. Borzykh, German V. Medvedev, Denis V. Pushkin, Marina M. Petrova, Artem V. Petrov, Diana V. Dmitrenko, Elena I. Karpova, Olga M. Demina, Natalia A. Shnayder
Summary: Impaired wound healing is a complex issue affecting quality of life and causing economic losses, requiring further research. Understanding the biological and physiological aspects is crucial for finding new treatment methods. Research on the multifactorial role and function of extracellular matrix in skin wound healing shows promising potential for clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Shengli Lu, Liping Lu, Yang Liu, Zenan Li, Yuan Fang, Zhizhao Chen, Jianda Zhou
Summary: Extracellular vesicles (EVs) can act as messengers to facilitate communication between cells, and have shown potential for disease treatment. Studies have demonstrated that native EVs can promote tissue repair, and engineering strategies can enhance their therapeutic effects. Further exploration is needed for the clinical application of engineered EVs in wound healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Erman Zhao, Huifang Liu, Yaru Jia, Tingshan Xiao, Jiaxin Li, Guoqiang Zhou, June Wang, Xiaohan Zhou, Xing-Jie Liang, Jinchao Zhang, Zhenhua Li
Summary: In this study, a live-drug-encapsulated hydrogel dressing was developed for the treatment of multidrug-resistant bacterial infections and full-thickness skin incision repair. The dressing, comprised of photosynthetic bacteria and extracellular matrix gel, exhibited photothermal, antibacterial, and antioxidant properties, and promoted wound healing. In vitro and in vivo studies demonstrated that the dressing effectively sterilized the wound, accelerated collagen deposition and granulation tissue formation, and facilitated skin tissue regeneration.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Medicinal
Ziyu Li, Wei Yang, Yong Yang, Jianbo Wu, Pei Luo, Yong Liu
Summary: LS-102 effectively suppresses inflammatory responses in adipose stem cells, reduces body weight, improves fat tissue inflammation, and provides protective effects in an obesity-related nephropathy model, outperforming astragaloside IV at the same concentration.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Review
Pharmacology & Pharmacy
Lin-Cui Da, Yi-Zhou Huang, Hui-Qi Xie, Bei-Hong Zheng, Yong-Can Huang, Sheng-Rong Du
Summary: Membranous extracellular matrix (ECM)-based scaffolds are promising biomaterials for skin wound healing, but they currently face limitations such as poor mechanical properties and uncontrollable degradation. Advances in scaffold modification, nanotechnology, and material manufacturing techniques have led to the development of new ECM-based membranes with improved properties for skin wound healing, making them promising candidates for future clinical translation.
Review
Cell & Tissue Engineering
Shengxi Zhou, Mengbo Xie, Jingjing Su, Bingjie Cai, Jingan Li, Kun Zhang
Summary: Scars caused by skin injuries after burns, wounds, abrasions and operations have serious physical and psychological effects on patients. In recent years, the research of scar-free wound repair has been greatly expanded. This paper reviews the types of wounds, the mechanism of scar formation in the healing process, and the current research progress on scar prevention and strategies for scar-free wound repair.
JOURNAL OF TISSUE ENGINEERING
(2023)
Review
Biotechnology & Applied Microbiology
Walker D. D. Short, Oluyinka O. O. Olutoye, Benjamin W. W. Padon, Umang M. M. Parikh, Daniel Colchado, Hima Vangapandu, Shayan Shams, Taiyun Chi, Jangwook P. P. Jung, Swathi Balaji
Summary: Impaired wound healing is a significant financial and medical burden. Disruptions in ECM deposition, structure, and composition lead to impaired healing in diseased states, such as in diabetes. Valid measures include lack of bacterial contamination, good tissue perfusion, and reduced mechanical injury and strain. This review discusses bioengineering advances in detecting biologic and physiologic factors, visualizing and modeling the ECM, and efficiently evaluating wound data. It focuses on bioelectronics and biologic interfaces for real-time sensing and actuation, advanced imaging techniques, and computational modeling. These advancements have the potential to improve healing outcomes and guide decision-making in wound care.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Wenshuai Liu, Rui Gao, Chunfang Yang, Zujian Feng, Wenbin Ou-Yang, Xiangbin Pan, Pingsheng Huang, Chuangnian Zhang, Deling Kong, Weiwei Wang
Summary: A glycopeptide hybrid hydrogel with antibacterial and tissue environment-responsive properties was developed for chronic wound healing. The hydrogel can promote cell proliferation and macrophage polarization, and has potent antibacterial effects. It accelerated the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic and scalding skin by promoting M2-type macrophages, reducing inflammation, and promoting angiogenesis.
Article
Fisheries
Rui Han, Jiu-Le Wang, Hong-Ping Chen, Xiao-Chun Luo, An-Xing Li, Xue-Ming Dan, Yan-Wei Li
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Fisheries
Jun-Jin Deng, Dan Shi, Min Zhao, Zhong-Qiu Li, De-Lin Lu, Shun Xu, Zi-Juan You, Jia-Zhou Li, Xiao-Chun Luo
Summary: The study found that the neutral protease rNpI effectively hydrolyzed soybean protein isolates, resulting in a high degree of hydrolysis and small-peptide yield, with notable antioxidant activity for fish health. rNpI complemented trypsin in soybean protein digestion better than papain or Alcalase. The addition of rNpI led to lower feed protein and energy content, reduced FCR, and improved growth performance in fish, with the best results seen in fish fed a diet with reduced rapeseed meal and wheat content.
AQUACULTURE RESEARCH
(2021)
Article
Chemistry, Medicinal
Rui Zha, Enhui Ge, Lirong Guo, Qing Gao, Qiqi Lin, Wan Zhou, Xiaobao Jin, Weiquan Xie, Hui Yin, Tao Liu
Summary: A newly identified macamide, NB-DHA, with the highest degree of unsaturation among all identified macamides was discovered in maca extract. Studies showed that NB-DHA significantly alleviated colitis-induced symptoms and could potentially be developed as a therapeutic agent for ulcerative colitis.
Article
Biochemistry & Molecular Biology
Mengya Jiao, Qun Dong, Yiting Zhang, Min Lin, Wan Zhou, Tao Liu, Baohong Yuan, Hui Yin
Summary: The study identified a new type of macamide, N-benzyl eicosapentaenamide (NB-EPA), from maca which showed significant neuroprotective effects in neonatal mice with hypoxic-ischemic brain injury. NB-EPA treatment reduced cerebral infarction size, improved neurobehavioral disorders, prevented neuronal apoptosis, and enhanced neuronal cell survival and proliferation through the activation of phosphorylated AKT signaling. The protective properties of NB-EPA against ischemic neuronal damage were found to be dependent on the suppression of the p53-PUMA pathway.
Article
Fisheries
Qing Han, Rui Han, Xueli Lai, Jiule Wang, Yingtong Hu, Xiaochun Luo, Anxing Li, Zequan Mo, Yanwei Li, Xueming Dan
Summary: The genes and predicted proteins of Pax-5 and Blimp-1 in the orange-spotted grouper have been identified, showing a high sequence identity with other teleosts and playing potential roles in B cell differentiation.
AQUACULTURE REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Miao Tian, Lingmei Yang, Zhiyuan Wang, Pengmei Lv, Junying Fu, Changlin Miao, Ming Li, Tao Liu, Wen Luo
Summary: The study successfully improved the catalytic activity and methanol tolerance of the lipase through N-glycosylation modification, demonstrating potential applications in biodiesel production.
BIOTECHNOLOGY FOR BIOFUELS
(2021)
Article
Biotechnology & Applied Microbiology
Miao Tian, Shaowei Huang, Zhiyuan Wang, Junying Fu, Pengmei Lv, Changlin Miao, Tao Liu, Lingmei Yang, Wen Luo
Summary: In this study, four highly active RML mutants were obtained through saturation mutagenesis at three propeptide positions. The S8E/P35S/P47A mutant showed good thermostability, indicating that increasing the hydrophilicity of 35 and 47 amino acid residues can promote interaction between the propeptide and mature peptide, enhancing enzyme activity. Highly conserved sites had a more significant impact on enzyme performance, as shown by the Pro35 and Pro47 mutants. This study suggests that enzyme performance can be improved through propeptide regulation.
ENZYME AND MICROBIAL TECHNOLOGY
(2021)
Article
Energy & Fuels
Miao Tian, Junying Fu, Zhiyuan Wang, Changlin Miao, Pengmei Lv, Dong He, Zhibing Li, Tao Liu, Ming Li, Wen Luo
Summary: A lipase mutant N59H, engineered with high activity, thermostability, and methanol resistance, showed excellent performance in biodiesel production, demonstrating great potential for commercial application.
Article
Obstetrics & Gynecology
Enhui Ge, Rui Zha, Qing Gao, Lirong Guo, Binglong Wang, Qiqi Lin, Guifeng Zhang, Weiquan Xie, Hui Yin, Tao Liu
Summary: SBH with M-n below 4000 Da was prepared through heating extraction, enzymatic hydrolysis, and ultrafiltration. Moderate (400 mg/kg) SBH dose showed the greatest effect on remission of ovarian injury in mice, improving estrus cycle and follicle numbers.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Agricultural Engineering
Miao Tian, Lingmei Yang, Pengmei Lv, Zhiyuan Wang, Junying Fu, Changlin Miao, Zhibing Li, Lianhua Li, Tao Liu, Wenyi Du, Wen Luo
Summary: A highly active and methanol-resistant lipase mutant was obtained through a semi-rational directed evolution method combined with N-glycosylation. The mutant exhibited significantly improved catalytic activity and methanol tolerance compared to the wild type.
BIORESOURCE TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Miao Tian, Zhiyuan Wang, Junying Fu, Pengmei Lv, Cuiyi Liang, Zhibing Li, LingMei Yang, Tao Liu, Ming Li, Wen Luo
Summary: The construction of methanol-resistant lipases with high catalytic activity is of great importance for biodiesel production. A semi-rational method using N-glycosylation sites was successfully applied to enhance the properties of Rhizomucor miehei lipase with propeptide. The mutant enzymes showed significantly increased activities and biodiesel yields, indicating the potential of improved lipase for biodiesel production.
ENZYME AND MICROBIAL TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lirong Guo, Qing Gao, Jieqiong Zhu, Xiaobao Jin, Hui Yin, Tao Liu
Summary: The study found that N-Benzyl docosahexaenamide (NB-DHA) has the potential to improve ovarian dysfunction caused by chemotherapy drugs and reduce granulosa cell apoptosis. NB-DHA can restore normal levels of estrous cycle and significantly increase the number of primordial follicles. In addition, NB-DHA restores normal levels of follicle-stimulating hormone and luteinizing hormone, and improves ovarian development by regulating the expression of related genes. This study provides a promising therapeutic agent for treating ovarian injury after chemotherapy.
Article
Immunology
Qun Dong, Jing Tian, Weiwei Zheng, Qiuxiang Fan, Xiaoyong Wu, Yanli Tang, Tao Liu, Hui Yin
Summary: Peripheral vascular disease often results in vascular injury and inflammation. This study investigates the role of IL-33 in hindlimb ischemic injury and its potential mechanisms. The findings suggest that IL-33 promotes blood flow restoration and enhances repair in ischemic hindlimb by modulating the proangiogenic function of endothelial cells through the Akt/eNOS pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tao Liu, Ziyan Peng, Wei Lai, Yan Shao, Qing Gao, Miaoxin He, Wan Zhou, Lirong Guo, Jiyao Kang, Xiaobao Jin, Hui Yin
Summary: Macamides are unique to maca and are considered to be its bioactive compounds. A total of thirty macamide monomers have been identified, but obtaining a single macamide monomer from maca is challenging due to their similar structures. In this study, we successfully synthesized and purified five typical macamides using the carbodiimide condensation method. The most abundant macamide monomer in maca, N-benzyl-hexadecanamide (NBH), was found to enhance endurance capacity and reduce fatigue-related markers in mice. Macamides potentially contribute to maca's anti-fatigue effects.
Article
Chemistry, Multidisciplinary
Shuang Liang, Jun-Jin Deng, Ming-Shu Zhang, Zi-Yang Luo, Wen-Jun Lu, De-Lin Lu, He-Hua Mao, Zhi-Wei Li, Jia-Zhou Li, Xiao-Chun Luo
Summary: This study identified the mechanism of sulfite production via cysteine dioxygenase (CDO1) oxidation in Streptomyces sp. SCUT-3, which is crucial for reducing disulfide bonds in feathers. Co-overexpression of CDO1 and protease Sep39 significantly increased SCUT-3's feather protein conversion efficiency in chicken feather medium.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)