Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress

How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?

(2021) Yana Geng et al.   Hepatology International

Modulation of multiple cellular signalling pathways as targets for anti-inflammatory and anti-tumorigenesis action of Scopoletin

(2021) Kunnathur Murugesan Sakthivel et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Oxygen radical antioxidant capacity (ORAC) and antibacterial properties of Melicope glabra bark extracts and isolated compounds

(2021) Alexandra Quek et al.   PLoS One

Hepatoprotective effects of phytochemicals berberine and umbelliferone against methotrexate-induced hepatic intoxication: experimental studies and in silico evidence

(2021) Abdel-Gawad S. Shalkami et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened

(2020) Mustafa Yalcinkaya et al.   JOURNAL OF LIPID RESEARCH

Scopoletin Activates Adenosine Monophosphate-Activated Protein Kinase/Mammalian Target of Rapamycin Signaling Pathway and Improves Functional Recovery after Spinal Cord Injury in Rats

(2020) Ruijuan Zhou et al.   PHARMACOLOGY

7-Hydroxycoumarin protects against cisplatin-induced acute kidney injury by inhibiting necroptosis and promoting Sox9-mediated tubular epithelial cell proliferation

(2020) Wei-Feng Wu et al.   PHYTOMEDICINE

7-Acetoxycoumarin Inhibits LPS-Induced Inflammatory Cytokine Synthesis by IκBα Degradation and MAPK Activation in Macrophage Cells

(2020) Taejin Park et al.   MOLECULES

Enhanced Keap1-Nrf2/Trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ASK1/JNK and Txnip/NLRP3 inflammasome activation

(2020) Hongming Lv et al.   PHYTOMEDICINE

Extracellular vesicles derived from fat-laden hepatocytes undergoing chemical hypoxia promote a pro-fibrotic phenotype in hepatic stellate cells

(2020) Alejandra Hernández et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes

(2020) Yana Geng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Isoquercitrin Ameliorates Cisplatin-Induced Nephrotoxicity Via the Inhibition of Apoptosis, Inflammation, and Oxidative Stress

(2020) Hao Wang et al.   Frontiers in Pharmacology

Umbelliferone Ameliorates CCl4-Induced Liver Fibrosis in Rats by Upregulating PPARγ and Attenuating Oxidative Stress, Inflammation, and TGF-β1/Smad3 Signaling

(2019) Ayman M. Mahmoud et al.   INFLAMMATION

Mitogen Activated Protein Kinases in Steatotic and Non-Steatotic Livers Submitted to Ischemia-Reperfusion

(2019) Jiménez-Castro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective effect of metformin against palmitate-induced hepatic cell death

(2019) Yana Geng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity

(2019) Iva Potočnjak et al.   FOOD AND CHEMICAL TOXICOLOGY

Supplementation of scopoletin improves insulin sensitivity by attenuating the derangements of insulin signaling through AMPK

(2018) Kalaivanan Kalpana et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Scopoletin Supplementation Ameliorates Steatosis and Inflammation in Diabetic Mice

(2017) Ra-Yeong Choi et al.   PHYTOTHERAPY RESEARCH

Mitogen-Activated Protein Kinase Regulation in Hepatic Metabolism

(2017) Ahmed Lawan et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The protective effect of the natural compound hesperetin against fulminant hepatitisin vivoandin vitro

(2016) Xueting Bai et al.   BRITISH JOURNAL OF PHARMACOLOGY

Umbelliferone and esculetin protect against N-nitrosodiethylamine-induced hepatotoxicity in rats

(2016) Sudhakar Raja Subramaniam et al.   CELL BIOLOGY INTERNATIONAL

Relationship between coumarin-induced hepatocellular toxicity and mitochondrial function in rats

(2016) Yasuhiro Tanaka et al.   FOOD AND CHEMICAL TOXICOLOGY

The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK

(2015) Jeng Yie Chan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The endoplasmic reticulum stress markers GRP78 and CHOP predict disease-free survival and responsiveness to chemotherapy in breast cancer

(2014) Yi-Zi Zheng et al.   BREAST CANCER RESEARCH AND TREATMENT

Scopoletin prevents alcohol-induced hepatic lipid accumulation by modulating the AMPK–SREBP pathway in diet-induced obese mice

(2014) Hae-In Lee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

JNK-Induced Apoptosis, Compensatory Growth, and Cancer Stem Cells

(2012) F. Chen   CANCER RESEARCH

Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL/6 mice

(2011) Jung-Ran Noh et al.   FOOD AND CHEMICAL TOXICOLOGY

The hepatoprotective effect of coumarin and coumarin derivates on carbon tetrachloride-induced hepatic injury by antioxidative activities in rats

(2011) Mukadder Atmaca et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway

(2011) Jung-Woo Kang et al.   JOURNAL OF PINEAL RESEARCH

Tumor necrosis factor-α accelerates apoptosis of steatotic hepatocytes from a murine model of non-alcoholic fatty liver disease

(2010) Wei Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver?

(2009) Carla J. H. van der Kallen et al.   APOPTOSIS

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY