Review
Urology & Nephrology
Farzad Mohajerani, William R. Clark, Claudio Ronco, Vivek Narsimhan
Summary: An understanding of the processes underlying mass transfer is crucial for effective solute removal in dialytic treatment. This review applies engineering principles to characterize the physical mechanisms of diffusion and convection in hemodialysis. The impact of flow rate, dialyzer geometry, and membrane microstructure on these processes is discussed, emphasizing the importance of concepts such as boundary layers, effective membrane diffusivity, and sieving coefficients. The objective is to enhance clinicians' understanding of these factors and improve the prescription and delivery of hemodialysis therapy.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ariane Duval-Sabatier, Stephane Burtey, Marion Pelletier, Manon Laforet, Laetitia Dou, Marion Sallee, Anne-Marie Lorec, Hafssa Knidiri, Floriane Darbon, Yvon Berland, Philippe Brunet
Summary: Hemodialysis can reduce uremic toxins, and hemodiafiltration improves the removal of middle molecules. However, it has no effect on indoles concentration, and different treatment methods do not significantly differ in the removal of protein-bound solutes.
Article
Biochemistry & Molecular Biology
Parsaoran Siahaan, Nurwarrohman Andre Sasongko, Retno Ariadi Lusiana, Vivitri Dewi Prasasty, Muhamad Abdulkadir Martoprawiro
Summary: The study investigated the interaction of chitosan dimer with urea and creatinine using DFT, revealing that creatinine easily binds to chitosan and transports electrons more efficiently than urea due to stronger hydrogen bond interaction. This suggests that creatinine can be transported more effectively through the chitosan membrane during hemodialysis process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Chemical
Borhan Ghofrani, Farid Alizad Oghyanous, Milad Karsaz, Mahsa Golkar, Habib Etemadi, Hamid Tayebi Khosroshahi, Reza Yegani
Summary: In this study, novel polyethersulfone nanocomposite hollow fiber membranes with silica and amine-modified silica nanoparticles were fabricated to improve the removal of urea and creatinine during hemodialysis. The results showed that the modified membranes had a higher removal rate, especially in the retentate process. The membrane samples containing 1.5% amine-modified silica nanoparticles exhibited the highest removal rate.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Review
Urology & Nephrology
Yuchao Zhao, Liangying Gan, Qingyu Niu, Mengfan Ni, Li Zuo
Summary: HDx improves the clearance of medium and large-molecular-weight uremic toxins compared to high-flux HD and HDF, without increasing albumin loss.
Review
Hematology
Thiago Reis, Colin Hutchison, Francisco de Assis Rocha Neves, Bruno Zawadzki, Monica Zanella, Claudio Ronco, Mitchell H. Rosner
Summary: A hallmark of chronic kidney disease is the retention of solutes that normally are eliminated by the kidneys. The current classification of uremic toxins based on molecular weight and protein affinity is poorly understood in terms of the role of therapies to reduce uremic toxins in chronic kidney disease patients. Most of the research on lowering serum concentrations of toxic compounds is carried out in patients with kidney failure undergoing kidney replacement therapy. The classification of uremic toxins needs to be updated and the relationship between specific solutes and clinical outcomes needs to be established to develop targeted therapies and improve understanding of the pathogenesis of chronic kidney disease.
BLOOD PURIFICATION
(2023)
Article
Engineering, Environmental
Taner Yildiz, Ilknur Erucar
Summary: In this study, the adsorption-based uremic toxin separation performance of bio-compatible MOFs was assessed and it was found that certain bio-MOFs outperformed traditional adsorbents. Furthermore, the multi-component adsorption of uremic toxins in bio-MOFs was examined and it was observed that the amount of adsorbed water slightly increased while the amount of adsorbed urea significantly decreased.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Multidisciplinary Sciences
Elizabeth M. Brookes, David A. Power
Summary: This study aimed to evaluate the epidemiology of the urea-to-creatinine ratio (UCR) in hospitalized chronic kidney disease patients and its association with clinical outcomes. The results showed that elevated UCR was associated with increased inpatient mortality, hospital readmission, and longer hospital length-of-stay. Further investigation is warranted to understand the pathophysiological basis of this relationship and identify effective interventions.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Chemical
Wenyan Li, Shen Chao, Yumei Li, Fuquan Bai, Yakun Teng, Xiang Li, Lijuan Li, Ce Wang
Summary: The dual-layer composite nanofiber membrane prepared in the study exhibits good adsorption capacity for creatinine and urea, with maximum adsorption capacities of 100.50 mg/g and 152.44 mg/g respectively. The membrane also shows excellent blood compatibility.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Review
Obstetrics & Gynecology
Fatemeh Malchi, Parvin Abedi, Shayesteh Jahanfar, Forough Talebi, Shahla Faal, Maryam Zahedian
Summary: The results of the study indicated that urea and creatinine levels show high sensitivity and specificity in diagnosing premature rupture of membranes (PROM), with creatinine performing better than urea. The mean levels of urea and creatinine were significantly higher in the case group compared to the control group.
REPRODUCTIVE SCIENCES
(2021)
Article
Medicine, General & Internal
Antonio Lacquaniti, Susanna Campo, Giuseppe Falliti, Daniele Caruso, Romana Gargano, Elena Giunta, Paolo Monardo
Summary: This study evaluated FLCs and HMGB1 levels in hemodialysis patients, finding a correlation with immune dysfunction and inflammation. The results suggest that cFLCs and HMGB1 could serve as independent markers for mortality risk in HD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Hematology
Seolhyun Lee, Tammy L. Sirich, Timothy W. Meyer
Summary: The adequacy of hemodialysis is currently assessed by measuring urea clearance, but other solutes may contribute more to the residual illness in hemodialysis patients. This article reviews methods to increase the clearance of nonurea solutes and emphasizes the need for further clinical studies to evaluate their impact on patients' health.
BLOOD PURIFICATION
(2022)
Article
Geriatrics & Gerontology
Satoru Miyazaki, Noriaki Iino, Ryo Koda, Ichiei Narita, Yoshikatsu Kaneko
Summary: This study found that plasma brain-derived neurotrophic factor (BDNF) levels are associated with muscle strength, physical performance, and the prevalence of severe sarcopenia and frailty in Japanese hemodialysis patients. However, BDNF levels were not correlated with factors such as body mass index or mental state.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Yu-Hui Hung, Tai-Shuan Lai, Mohamed Belmouaz, Ya-Chun Tu, Chun-Fu Lai, Shuei-Liong Lin, Yung-Ming Chen
Summary: Studies have shown that MCO membranes are superior to standard high flux membranes in clearing middle molecular weight uremic toxins in hemodialysis. Meta-analysis results indicate significantly higher reduction ratio of serum β2M, κFLC, and λFLC in the MCO group. However, the use of MCO membranes may result in albumin loss, which should be monitored.
Article
Engineering, Chemical
Arash Mollahosseini, Amira Abdelrasoul
Summary: Understanding the effect of different operational parameters on the hemocompatibility of dialyzers could lead to the design of more compatible materials. This study assessed the pH effect on uremic metabolites' behavior using computational simulations. Based on the findings, a new zwitterionic material was introduced and experimentally implemented on poly ether sulfone (PES) membranes. The modified membranes showed improved stability and water content, making them ideal candidates for hemocompatible dialysis membranes.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2023)
Article
Engineering, Chemical
Ezgi Gulcay, Ilknur Erucar
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2019)
Article
Engineering, Chemical
Ilknur Erucar, Seda Keskin
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2020)
Article
Engineering, Chemical
Hilal Daglar, Ilknur Erucar, Seda Keskin
Summary: The study demonstrated that many MOF membranes exceeded the upper bound established for polymer membranes in terms of permeability and selectivity, while MOF/polymer MMMs showed higher O-2 permeability and O-2/N-2 selectivity compared to MMMS composed of traditional fillers.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Gokay Avci, Ilknur Erucar, Seda Keskin
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Hilal Daglar, Hasan Can Gulbalkan, Gokay Avci, Gokhan Onder Aksu, Omer Faruk Altundal, Cigdem Altintas, Ilknur Erucar, Seda Keskin
Summary: The development of computation-ready metal-organic framework databases has accelerated high-throughput computational screening of materials for gas storage and separation. Differences in structural features due to database selection significantly impact the calculated gas uptakes and ideal selectivities of materials at low pressure. The identification of top-performing materials for gas separation strongly depends on the choice of the database used in simulations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biotechnology & Applied Microbiology
Onur Isik, Merdan Batyrow, Amr Mustafa Abdelrahman, Irem Orman, Hale Ozgun, Mustafa Evren Ersahin, Mehmet Emin Pasaoglu, Ibrahim Demir, Ismail Koyuncu
Summary: The study investigated the effect of sludge concentration on the performance of an aerobic dynamic membrane bioreactor (DMBR). It was found that selecting the optimum sludge concentration is crucial for achieving a homogeneous and stable dynamic membrane (DM) layer in DMBRs. Higher sludge concentration resulted in a larger particle size distribution in the permeate, increased transmembrane pressure, and rapid clogging.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Engineering, Environmental
Gokhan Onder Aksu, Ilknur Erucar, Zeynep Pinar Haslak, Seda Keskin
Summary: Screening of hypothetical COF database led to the discovery of promising CO2 separation materials, with simulations showing superior CO2/H2 separation performance compared to experimental COFs. Molecular insights into the unique structural features of hypothetical COFs will guide the synthesis of novel materials for enhanced CO2 separation.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Taner Yildiz, Ilknur Erucar
Summary: In this study, the adsorption-based uremic toxin separation performance of bio-compatible MOFs was assessed and it was found that certain bio-MOFs outperformed traditional adsorbents. Furthermore, the multi-component adsorption of uremic toxins in bio-MOFs was examined and it was observed that the amount of adsorbed water slightly increased while the amount of adsorbed urea significantly decreased.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Gokhan Onder Aksu, Ilknur Erucar, Zeynep Pinar Haslak, Seda Keskin
Summary: This study explores the potential of using synthesized and computer-generated covalent organic frameworks (COFs) to capture H2S+CO2 from natural gas. Through extensive calculations and simulations, it was found that NPN-3 is the best performing COF, and isosteric heats of adsorption can be used to discover efficient hypothetical COFs for natural gas separation.
JOURNAL OF CO2 UTILIZATION
(2022)
Article
Computer Science, Software Engineering
Merdan Batyrow, Ilknur Erucar, Hande Ozturk
Summary: In this study, molecular dynamics simulations were performed to calculate the mean square displacements (MSDs) of atomic vibrations in spherical gold nanocrystals of different diameters. The results showed a strong dependency of MSD on the nanocrystal size and temperature. Surface melting was observed in the high temperature simulations. These findings are important for understanding the effect of nanocrystal size on thermally activated atomic vibrations and their quantification in x-ray diffraction experiments.
CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE
(2023)
Review
Materials Science, Multidisciplinary
Hilal Daglar, Ilknur Erucar, Seda Keskin
Summary: This review discusses the state-of-the-art molecular modeling methods for simulating gas permeation through MOF membranes and reviews recent advancements in the field. The authors also address current opportunities and challenges in simulating gas permeation through MOF membranes to guide the development of high-performance MOF membranes in the future.
MATERIALS ADVANCES
(2021)
Article
Chemistry, Physical
Cigdem Altintas, Gokay Avci, Hilal Daglar, Ayda Nemati Vesali Azar, Ilknur Erucar, Sadiye Velioglu, Seda Keskin
JOURNAL OF MATERIALS CHEMISTRY A
(2019)
Article
Chemistry, Multidisciplinary
Louis Longley, Sean M. Collins, Shichun Li, Glen J. Smales, Ilknur Erucar, Ang Qiao, Jingwei Hou, Cara M. Doherty, Aaron W. Thornton, Anita J. Hill, Xiao Yu, Nicholas J. Terrill, Andrew J. Smith, Seth M. Cohen, Paul A. Midgley, David A. Keen, Shane G. Telfer, Thomas D. Bennett
Article
Engineering, Chemical
Yunfei Yu, Xue Yang, Chenchen Zhang, Jie Chen, Wei Lin, Jianqiang Meng
Summary: This study reports an environmentally friendly and simple approach for preparing double-network (DN) ion gel membranes with high strength and excellent gas separation performance. By optimizing crosslinking density, mass ratio, and the type and content of free ionic liquid, the mechanical and gas separation properties of the DN membrane are improved.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Si-qi Jiang, Qiang Gao, Xi-guang Li, Chao-zhu Deng, Jun Qiu, Xiang-nan Zhu
Summary: A dual-strengthening pretreatment method is proposed to remove PVDF more efficiently and enhance the leaching of LiCoO2. Experimental results show that dual-strengthening pretreatment can effectively remove PVDF and significantly improve the leaching efficiency compared to single pretreatment methods.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Zengchi Hu, Xiaoyu Wang, Xiaohui Zhang, Xue Li, Jiangbin Xia
Summary: The rapid fabrication of high-performance composite membranes based on CMPs using simple and low-cost methods is challenging. In this study, three CMPs-based composite membranes were rapidly fabricated with adjustable size using unidirectional diffusion synthesis. The microstructural design enhanced the rejection rates of the membranes and they showed strong hydrolytic resistance, thermal stability, and acid-base resistance. Electrostatic adsorption and the adjustable microstructures significantly varied the repellence of the membranes to different charged molecules.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Farzaneh Rouhani, Matineh Ayedi, Nasser Safari
Summary: Introducing defects into porous metal-organic frameworks is important for improving their adsorption performance. Quasi-MOFs, an underutilized variant of large-scale, fundamentally deficient MOFs, have been found to have substantial amounts of unsaturated metal sites to offset the drawbacks of MOFs. In this study, a quasi-MOF was produced using a water-stable MOF and demonstrated significantly improved phosphate adsorption capability due to the presence of defect sites.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Valentin Reungoat, Morad Chadni, Louis M. M. Mouterde, Fanny Brunissen, Florent Allais, Helene Ducatel, Irina Ioannou
Summary: This study focuses on the recovery of sinapic acid using liquid-liquid extraction assisted by a hollow fiber membrane contactor from an aqueous feed obtained through the hydrolysis of mustard bran. The screening of solvents of different chemical nature showed that all tested solvents had an extraction efficiency of more than 80% for pH < 5. Four solvents were selected for use in the hollow fiber membrane contactor, and the volatile solvents showed higher mass transfer coefficients compared to non-volatile solvents. The extraction efficiency was intensified by increasing the initial concentration of sinapic acid and the feed-to-solvent ratio. CPME was found to have optimal recovery efficiency at a phase ratio of 8:1, yielding 0.9 g of sinapic acid per liter of CPME used.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Takahiro Sakamoto, Takafumi Hanada, Hayate Sato, Mayu Kamisono, Masahiro Goto
Summary: The emergence of the battery society has led to a high demand for battery metals, resulting in a strain on their supply. This study introduces a novel technique using a hydrophobic deep eutectic solvent (DES) for leaching and recovering battery metals from low-grade nickel laterite ores. The DES enables selective leaching and recovery of the metals, offering a promising pathway for the extraction of critical battery metals.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Rongrong He, Jiarui Chen, Chunyao Zhang, Dan Lu, Lin Zhang, Tao He
Summary: Researcher has developed a method to quantify the charge density in nanofiltration (NF) membrane separation layer and applied it in NF membranes that can separate Mg2+ and Li+. The results showed that overcompensated amine groups played a major role, and there was a linear relationship between charge density and coating bi-layers or PAH layers.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Zhijian Zhang, Min Chen, Zhe Lin, Zhichao Yang, Yafeng Du, Zhihui Chen, Zhenhao Yang, Kongyin Zhao, Ligang Lin
Summary: Membrane technology plays an important role in molecular/ion separation processes, but faces challenges such as membrane fouling. This study introduces a new ion-crosslinking method to fabricate copper alginate hydrogel membranes with improved mechanical strength and antimicrobial capabilities. The membranes exhibit excellent separation performance and enhanced long-term molecule/ion separation through improved anti-swelling properties. Molecular dynamics simulations and life cycle analysis highlight the pore structure and environmental friendliness of the hydrogel membranes. These findings provide valuable insights for developing sustainable hydrogel membranes with stable performance and high separation efficiency.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Dongmei Liu, Aiying Guo, Yanling Qi, Zhixin Ji, Hongjuan Li, Zhiwei Zhang, Xinyue Zhang, Kunze Wu, Aijun Cai
Summary: In this study, a stable magnetic Mg/Mn-layered double oxide-doped biochar composite (MgMnLDO-MBC) was prepared and successfully used for the removal of antibiotics and bacteria from wastewater. The composite exhibited enhanced surface areas, adsorption sites, and free radicals, leading to improved catalytic activity. The effects of different factors on the removal efficiency were evaluated, and the composite showed good reusability.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Feng Wang, Zhaoyong Bian, Yaru Zhang, Wenchao Yu, Qiang Zhang, Hui Wang
Summary: In this study, a nanofibrous layered structure of Ff-Ti3C2Tx-Co3O4 was prepared by self-assembling nanofibrous Co3O4 with lamellar fluorine-free MXene (Ff-Ti3C2Tx). The Ff-Ti3C2Tx-Co3O4 exhibited excellent catalytic activity for degradation, resistant to ionic interference, and maintained high removal efficiency of sulfamethoxazole (SMX) in municipal wastewater. The rapid SMX degradation involved fast electron transfer in redox cycles with PMS and the generation of 1O2 via PMS ->center dot O2 -> 1O2. This work provides new insights into antibiotic degradation mechanisms and electron transfer based on PMS activation.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Weipeng He, Jiacheng Luo, Yujie Wu, Tianhao Luo, Chen Tang
Summary: This study comparatively evaluated the role of cationic, anionic, and nonionic polyacrylamides (PAMs) in ballasted flocculation of clay suspensions under different aluminum sulfate (AS) coagulant dosages. The selection of PAMs and AS dosage had a significant influence on the size and shear resistance of ballasted floc aggregates.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Lixian Wang, Lizhi Zhao, Didi Si, Zhixin Li, Huiqin An, Hui Ye, Qingping Xin, Hong Li, Yuzhong Zhang
Summary: Metalloporphyrin-based nanozymes integrated with poly (vinylidene fluoride) membrane show high catalytic activity and reusability for the decolorization of Congo Red dye in continuous flow process.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Yongfei Ma, Chenyu Zeng, Yongzhen Ding, Jiayi Tang, Ondrej Masek, Zhikang Deng, Rui Mu, Zulin Zhang
Summary: In this study, sludge-derived biochar (SBC) was functionalized with various iron salts to enhance its adsorption ability for sulfamethoxazole (SMX) and magnetic collection performance. Ball milling was further employed to treat the optimal iron salt functionalized SBC (MSBC), resulting in ball milled SBC (BMSBC) with improved adsorption performance for SMX. The dominant driving mechanism for SMX adsorption onto BMSBC was confirmed to be multiple physicochemical forces, including 7C-7C conjugation, pore filling, H-bonding, Fe-O complexation, and electrostatic interactions. BMSBC exhibited favorable adsorption ability for SMX in actual waters and could be easily collected within 1 min due to its magnetic sensitivity.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Jinglin Tan, Xiaohui Mao, Wenjihao Hu, Hongbo Zeng
Summary: This study investigates the influence of PDMS chain architectures on surface properties and reveals that PDMS coatings with looped structures exhibit superior hydrophobicity, self-cleaning, and water sliding compared to coatings with linear structures. Additionally, both looped and linear PDMS coated stainless steel mesh/polyester fibers show efficient separation of oil/water mixture.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
Article
Engineering, Chemical
Wei-Liang Chen, Chih-Chia Cheng, Chien-Hsing Lu, Jem-Kun Chen
Summary: This study designs a novel sandwich-structured capacitor that reduces the absorption time of pollutants using dielectrophoresis force. By coating graphene oxide on polystyrene microspheres as adsorbents and encapsulating them within the capacitor, the adsorption rate is significantly enhanced. Additionally, frequency manipulation allows for the recycling of adsorbents and concentration of dyes, minimizing secondary pollution.
SEPARATION AND PURIFICATION TECHNOLOGY
(2024)
