Review
Endocrinology & Metabolism
Michelle Henry, Kevin Garth Flusk Thomas, Ian Louis Ross
Summary: Sleep is critical for cognitive well-being and disruptions can lead to memory deficits, with cortisol levels potentially playing a role in this relationship. Patients with AD experience disrupted sleep and impaired memory due to consistent cortisol imbalances from glucocorticoid therapy, highlighting the importance of restoring a normal circadian rhythm. Future initiatives should focus on improving cognitive performance and quality of life for AD patients through prioritizing and optimizing sleep.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Behavioral Sciences
Roberto Zefferino, Sante Di Gioia, Massimo Conese
Summary: The article reviews the complex relations among important molecules in the CNS, IS, and ES during chronic stress. A speculative hypothesis is proposed regarding the interplay of signaling molecules, with IL-1beta highlighted as a main biomarker of these effects.
BRAIN AND BEHAVIOR
(2021)
Article
Biology
Cali Anderson, Gabriella Forte, Wei Hu, Henggui Zhang, Mark R. Boyett, Alicia D'Souza
Summary: Although the day-night rhythm in resting heart rate has traditionally been attributed to the parasympathetic nervous system, recent research shows that there is a circadian clock in the cardiac pacemaker and the rhythm in heart rate involves transcriptional remodelling of pacemaker ion channels. This study investigates the role of the sympathetic nervous system in this rhythm and finds that it directly affects pacemaker ion channel transcription. Understanding the day-night rhythm in pacemaking improves our knowledge of bradyarrhythmias during sleep.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Clinical Neurology
Emily J. Ricketts, Daniel S. Joyce, Ariel J. Rissman, Helen J. Burgess, Christopher S. Colwell, Leon C. Lack, Michael Gradisar
Summary: Light exposure plays a significant role in regulating circadian rhythms, and disruptions to this regulation can lead to various impairments. This is particularly relevant for adolescents, whose sleep-wake patterns are affected by reduced daytime light exposure and prolonged use of electronic devices in the evening. Implementing measures to adjust light intensity, spectra, duration, and delivery modality can support the sleep-wake health of adolescents in different contexts.
SLEEP MEDICINE REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Yuhong Wang, Wanli Jiang, Hu Chen, Huixin Zhou, Zhihao Liu, Zihan Liu, Zhihao Liu, Yuyang Zhou, Xiaoya Zhou, Lilei Yu, Hong Jiang
Summary: Circadian disruption may facilitate cardiac remodeling after myocardial infarction by activating the sympathetic nervous system, leading to reduced cardiac function, increased left ventricular volume, and exacerbated cardiac fibrosis. Modulating sympathetic activity through designer receptors exclusively activated by designer drugs technique can alleviate the disruption-related cardiac dysfunction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Immunology
Akiko Nakai, Sarah Leach, Kazuhiro Suzuki
Summary: Cell migration in the immune system is primarily regulated by chemokines, adhesion molecules, neuronal inputs, circadian clock, and nutritional status. These factors influence immune cell distribution among tissues, playing critical roles in immune response regulation.
INTERNATIONAL IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Yi Li, Lingzhan Shao, Yang Mou, Yan Zhang, Yong Ping
Summary: Recent studies have shown alterations in gut microbiota in Alzheimer's disease patients, as well as a correlation between sleep and circadian rhythm disruption and greater beta-amyloid deposition and AD risk. These studies aim to identify commonalities and distinct characteristics of GM alterations in these conditions, and their impact on pathophysiology.
Article
Multidisciplinary Sciences
Tianfei Hou, Wen Su, Marilyn J. Duncan, Vsevolozhskaya A. Olga, Zhenheng Guo, Ming C. Gong
Summary: The study reveals that restricting the timing of food intake can prevent nondipping blood pressure in diabetic mice and effectively restore disrupted blood pressure circadian rhythm.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Yumiko Mizuno, Yoshimitsu Nakanishi, Atsushi Kumanogoh
Summary: Upon exposure to external stressors, the body activates the sympathetic nervous system (SNS) to maintain homeostasis, which also regulates immune responses. Overactivation of the SNS can lead to inflammatory diseases. This review focuses on the role of semaphorins, axon guidance cues, in the crosstalk between the SNS and immune system.
INFLAMMATION AND REGENERATION
(2023)
Article
Geriatrics & Gerontology
Cheng-Hsien Lan, Hsiao-Chien Yeh, Wen-Huey Tsai, Shu-Chiung Lee, Shin-Shang Chou
Summary: The global phenomenon of population aging poses challenges in terms of a growing elderly population and their increased duration of living with disability. Tailored care services are vital for improving the quality of life of older adults, particularly those residing in nursing homes. Non-pharmacological interventions, such as smart humancentric lighting, can significantly reduce sleep disturbances and improve sleep quality in nursing home residents.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Clinical Neurology
Diego R. Mazzotti, Melissa A. Haendel, Julie A. McMurry, Connor J. Smith, Daniel J. Buysse, Till Roenneberg, Thomas Penzel, Shaun Purcell, Susan Redline, Ying Zhang, Kathleen R. Merikangas, Joseph P. Menetski, Janet Mullington, Eilis Boudreau
Summary: The increasing availability and complexity of sleep and circadian data present both opportunities and challenges for the field. Improving data sharing and interoperability is crucial for advancing clinical research and requires collaboration and innovation between the sleep and informatics communities.
Article
Public, Environmental & Occupational Health
Xiao-Qian Chen, Xiu-Min Jiang, Qing-Xiang Zheng, Hai-Wei Wang, Heng Xue, Yu-Qing Pan, Yan-Ping Liao, Xiao-Xia Gao
Summary: This study aimed to explore the factors influencing sub-health and circadian rhythm disorder among midwives and examine the relationship between circadian rhythm disorder and sub-health. A cross-sectional study was conducted among 91 Chinese midwives from six hospitals using cluster sampling. The results showed that sub-health and circadian rhythm disorder were common among midwives and were significantly related to age, exercise duration, working hours, job satisfaction, cortisol rhythm, and melatonin rhythm. Nurse administrators should take measures to prevent sub-health and circadian rhythm disorder among midwives.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Physiology
Martine Van Puyvelde, Gerard Rietjens, Pieter Helmhout, Olivier Mairesse, Jeroen Van Cutsem, Nathalie Pattyn
Summary: This study investigates the physiological and behavioral adjustments in the submarine working and living environment. The results show that sleep is biphasic, with melatonin secretion not adjusting to the watch standing blocks and cortisol secretion matching the work-sleep shift routine.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Biology
Ophelie Helissen, Marc Kermorgant, Sebastien Dejean, Aurelie Mercadie, Sophie Le Gonidec, Rana Zahreddine, Denis Calise, Nathalie Nasr, Celine Gales, Dina N. Arvanitis, Anne Pavy-Le Traon
Summary: The kinetics of cardiovascular adaptation and its regulation by the autonomic nervous system (ANS) remain controversial in both real or simulated microgravity environments for humans or animals. In this study, hindlimb unloading (HU) was used in conscious mice to explore the effects on blood pressure, heart rate, temperature, and locomotor activity. The study found that HU initially induced a decrease in heart rate accompanied by an increase in markers of vagal activity. It also disrupted the day/night rhythmicity of locomotor activity, temperature, and blood pressure.
Article
Clinical Neurology
Shuang Zhai, Shuman Tao, Xiaoyan Wu, Liwei Zou, Yajuan Yang, Yang Xie, Tingting Li, Dan Zhang, Yang Qu, Fangbiao Tao
Summary: The study found a significant association between sleep insufficiency and chronotype with inflammatory markers among college students, with evening-types showing a positive correlation with inflammatory factors. Moreover, neutral-types and evening-types exhibited positive interactions with inflammatory markers in individuals with sleep insufficiency.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Immunology
Anna Schoellhorn, Juliane Schuhmacher, Luciana Besedovsky, Rolf Fendel, Anja T. R. Jensen, Stefan Steyanovic, Tanja Lange, Hans-Georg Rammensee, Jan Born, Cecile Gouttefangeas, Stoyan Dimitrov
Summary: This study introduces a modified assay for sensitive detection of functional antigen-specific CD4(+) T cells using a monoclonal antibody specific for the open, high-affinity conformation of the beta(2)-integrin. The assay allows simultaneous screening of both CD4(+) and CD8(+) T cell reactivities, with versatile applicability in clinical and vaccination studies. The novel assay enables very sensitive monitoring of effector and memory CD4(+) and CD8(+) T cells specific for various viruses in both whole blood and cryopreserved peripheral blood mononuclear cells (PBMCs).
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Helma Freitag, Marvin Szklarski, Sebastian Lorenz, Franziska Sotzny, Sandra Bauer, Aurelie Philippe, Claudia Kedor, Patricia Grabowski, Tanja Lange, Gabriela Riemekasten, Harald Heidecke, Carmen Scheibenbogen
Summary: The study found that levels of specific AAB were significantly correlated with fatigue and muscle pain symptoms in patients with infection-triggered ME/CFS, while patients with non-infection-triggered ME/CFS showed fewer correlations. This suggests a potential role of AAB or respective receptor pathways in the pathomechanism of the disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Achim Kramer, Tanja Lange, Claudia Spies, Anna-Marie Finger, Daniela Berg, Henrik Oster
Summary: Circadian medicine, an emerging field, aims to utilize the mechanisms of the circadian clock for clinical diagnosis, treatment, and prevention. While it has significant health benefits over standard care, there are still open questions and challenges in the development of this field.
Article
Multidisciplinary Sciences
Christine Klein, Max Borsche, Alexander Balck, Bandik Foeh, Johann Rahmoeller, Elke Peters, Jan Knickmann, Miranda Lane, Eva-Juliane Vollstedt, Susanne A. Elsner, Nadja Kaeding, Susanne Hauswaldt, Tanja Lange, Jennifer E. Hundt, Selina Lehrian, Julia Giese, Alexander Mischnik, Stefan Niemann, Florian Maurer, Susanne Homolka, Laura Paulowski, Jan Kramer, Christoph Twesten, Christian Sina, Gabriele Gillessen-Kaesbach, Hauke Busch, Marc Ehlers, Stefan Taube, Jan Rupp, Alexander Katalinic
Summary: This study conducted long-term monitoring of COVID-19 infection rates through polymerase chain reaction and antibody testing of the local population. The study found higher infection rates in high-exposure groups, especially among nurses. Contact with COVID-19 patients was identified as the strongest risk factor, while public transportation, having children in school, or tourism did not affect infection rates.
Meeting Abstract
Rheumatology
F. Luebber, J. Strobach, H. Heidecke, T. Lange, G. Riemekasten
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Franziska Sotzny, Igor Salerno Filgueiras, Claudia Kedor, Helma Freitag, Kirsten Wittke, Sandra Bauer, Nuno Sepulveda, Dennyson Leandro Mathias da Fonseca, Gabriela Crispim Baiocchi, Alexandre H. C. Marques, Myungjin Kim, Tanja Lange, Desiree Rodrigues Placa, Finn Luebber, Frieder M. Paulus, Roberta De Vito, Igor Jurisica, Kai Schulze-Forster, Friedemann Paul, Judith Bellmann-Strobl, Rebekka Rust, Uta Hoppmann, Yehuda Shoenfeld, Gabriela Riemekasten, Harald Heidecke, Otavio Cabral-Marques, Carmen Scheibenbogen
Summary: Most patients with Post COVID Syndrome (PCS) present with a variety of symptoms, and a subset of them fulfill diagnostic criteria of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This study found alterations in the levels of natural regulatory autoantibodies (AABs) targeting G-protein coupled receptors (GPCRs) in PCS patients, with correlations between AABs and symptom severity, particularly the ADRB2 antibodies associated with fatigue and vasomotor symptoms.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Katja Bieber, Jennifer E. Hundt, Xinhua Yu, Marc Ehlers, Frank Petersen, Christian M. Karsten, Jorg Koehl, Khalaf Kridin, Kathrin Kalies, Anika Kasprick, Stephanie Goletz, Jens Y. Humrich, Rudolf A. Manz, Axel Kuenstner, Christoph M. Hammers, Reza Akbarzadeh, Hauke Busch, Christian D. Sadik, Tanja Lange, Hanna Grasshoff, Alexander M. Hackel, Jeanette Erdmann, Inke Koenig, Walter Raasch, Mareike Becker, Anja Kerstein-Staehle, Peter Lamprecht, Gabriela Riemekasten, Enno Schmidt, Ralf J. Ludwig
Summary: Approximately 5% of the world-wide population is affected by autoimmune diseases, which are still difficult to treat and have a significant economic impact. The progression from harmless to inflammatory autoimmune disease conditions is a key factor. Biomarkers that can predict this progression would be highly impactful. Factors such as genetics, environment, and lifestyle choices may influence the progression from benign to inflammatory autoimmune conditions. Research is needed to define and modulate autoimmune predisease.
AUTOIMMUNITY REVIEWS
(2023)
Review
Immunology
Sarah Stenger, Hanna Grasshoff, Jennifer Elisabeth Hundt, Tanja Lange
Summary: Shift work is associated with an increased risk of systemic autoimmune diseases due to chronic inflammation, impaired immune responses, and circadian disruption. The effects of shift work on skin-specific autoimmune diseases are still not well understood. This review examines the impact of shift work, circadian misalignment, poor sleep, and potential hormonal mediators on skin barrier functions and immunity, using both human studies and animal models. The review also discusses confounders and possible countermeasures to reduce the risk of autoimmune diseases in shift workers.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Physiology
Siska Wilantri, Hanna Grasshoff, Tanja Lange, Timo Gaber, Luciana Besedovsky, Frank Buttgereit
Summary: Research on 24-h rhythms over the past four decades has revealed their significance for immunity and various diseases through genetic, molecular, and physiological findings. Disruption and misalignment of circadian rhythms have been linked to diseases and abnormal physiological functioning, highlighting their fundamental importance to mammals. This article provides an overview of the molecular regulation of 24-h rhythms, their impact on immunity, the detrimental effects of misalignment, the association between pathological rhythms and rheumatoid arthritis (RA), and the potential use of chronobiological rhythms for chronotherapy in inflammatory autoimmune diseases like RA.
Meeting Abstract
Clinical Neurology
K. Spiegel, A. Rey, K. Ayling, C. Benedict, T. Lange, A. Prather, M. Irwin, E. Van Cauter
Article
Behavioral Sciences
Johanna F. Voges, Laura Mueller-Pinzler, Miriam Neis, Finn Luebber, Tanja Lange, Jennifer E. Hundt, Meike Kasten, Ulrike M. Kraemer, Soeren Krach, Lena Rademacher
Summary: Several studies suggest a link between acute changes in inflammatory parameters due to an endotoxin or (psychological) stressor and the brain's stress response. The extent to which basal circulating levels of inflammatory markers are associated with the brain's stress response has been hardly investigated so far. In the present study, baseline plasma levels of the cytokine interleukin (IL)-6 were obtained and linked to neural markers of psychosocial stress using a modified version of the Montreal Imaging Stress Task in a sample of N = 65 healthy subjects (N = 39 female). Of three a-priori defined regions of interest - the amygdala, anterior insula, and anterior cingulate cortex - baseline IL-6 was significantly and negatively associated with stress-related neural activation in the right amygdala and left anterior insula. Our results suggest that baseline cytokines might be related to differences in the neural stress response and that this relationship could be inverse to that previously reported for induced acute changes in inflammation markers.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2022)