Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment

Bi-Directional Communication Between Neurons and Astrocytes Modulates Spinal Motor Circuits

(2020) Matthew J. Broadhead et al.   Frontiers in Cellular Neuroscience

Cortical and Striatal Circuits in Huntington’s Disease

(2020) Sonja Blumenstock et al.   Frontiers in Neuroscience

Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease

(2020) Matthew S. Elitt et al.   NATURE

Antisense Oligonucleotide Therapies for Neurodegenerative Diseases

(2019) C. Frank Bennett et al.   Annual Review of Neuroscience

Niche stiffness underlies the ageing of central nervous system progenitor cells

(2019) Michael Segel et al.   NATURE

Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity

(2019) Rachel A Battaglia et al.   eLife

Therapeutic Antisense Targeting of Huntingtin

(2019) Anne V. Smith et al.   DNA AND CELL BIOLOGY

Antisense suppression of glial fibrillary acidic protein as a treatment for Alexander disease

(2018) Tracy L. Hagemann et al.   ANNALS OF NEUROLOGY

Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength

(2018) Kevin W. Kelley et al.   NEURON

Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease

(2018) Liqun Wang et al.   Nature Communications

Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function

(2018) Iben Lundgaard et al.   Scientific Reports

GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease

(2018) Li Li et al.   Cell Stem Cell

Astrocytes and radial glia-like cells, but not neurons, display a nonapoptotic increase in caspase-3 expression following exercise

(2018) Morgan E. Stevenson et al.   Brain and Behavior

Physiological and pathophysiological roles of hypothalamic astrocytes in metabolism

(2018) Julie A. Chowen et al.   JOURNAL OF NEUROENDOCRINOLOGY

Glial fibrillary acidic protein exhibits altered turnover kinetics in a mouse model of Alexander disease

(2017) Laura R. Moody et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Intermediate filament dynamics: What we can see now and why it matters

(2016) Amélie Robert et al.   BIOESSAYS

Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease

(2016) Michael R. Heaven et al.   JOURNAL OF PROTEOME RESEARCH

Ghrelin Regulates Glucose and Glutamate Transporters in Hypothalamic Astrocytes

(2016) Esther Fuente-Martín et al.   Scientific Reports

Neuromyelitis optica and the evolving spectrum of autoimmune aquaporin-4 channelopathies: a decade later

(2015) Sean J. Pittock et al.   Annals of the New York Academy of Sciences

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

Detrimental role of the EP1 prostanoid receptor in blood-brain barrier damage following experimental ischemic stroke

(2015) Jan C. Frankowski et al.   Scientific Reports

Astrocyte-encoded positional cues maintain sensorimotor circuit integrity

(2014) Anna V. Molofsky et al.   NATURE

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

(2014) Jae Geun Kim et al.   NATURE NEUROSCIENCE

Astrogliosis

(2014) Michael V. Sofroniew   Cold Spring Harbor Perspectives in Biology

Caspase Cleavage of GFAP Produces an Assembly-Compromised Proteolytic Fragment that Promotes Filament Aggregation

(2013) Mei-Hsuan Chen et al.   ASN Neuro

GFAP Expression as an Indicator of Disease Severity in Mouse Models of Alexander Disease

(2013) Paige L. Jany et al.   ASN Neuro

High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes

(2013) Stephan J. Guyenet et al.   BRAIN RESEARCH

Deficits in Adult Neurogenesis, Contextual Fear Conditioning, and Spatial Learning in a Gfap Mutant Mouse Model of Alexander Disease

(2013) T. L. Hagemann et al.   JOURNAL OF NEUROSCIENCE

Neuroimaging and clinical features in type II (late-onset) Alexander disease

(2013) J. Graff-Radford et al.   NEUROLOGY

White matter astrocytes in health and disease

(2013) I. Lundgaard et al.   NEUROSCIENCE

Why Can’t Rodents Vomit? A Comparative Behavioral, Anatomical, and Physiological Study

(2013) Charles C. Horn et al.   PLoS One

Caspase activation contributes to astrogliosis

(2012) Radha Aras et al.   BRAIN RESEARCH

Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes

(2012) Esther Fuente-Martín et al.   JOURNAL OF CLINICAL INVESTIGATION

Alexander Disease

(2012) A. Messing et al.   JOURNAL OF NEUROSCIENCE

Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability

(2011) Yi-Song Chen et al.   EXPERIMENTAL CELL RESEARCH

Corticospinal Motor Neurons and Related Subcerebral Projection Neurons Undergo Early and Specific Neurodegeneration in hSOD1G93A Transgenic ALS Mice

(2011) P. H. Ozdinler et al.   JOURNAL OF NEUROSCIENCE

GFAP mutations, age at onset, and clinical subtypes in Alexander disease

(2011) M. Prust et al.   NEUROLOGY

Alexander Disease Mutant Glial Fibrillary Acidic Protein Compromises Glutamate Transport in Astrocytes

(2010) Rujin Tian et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Expression of Adenomatous Polyposis Coli Protein in Reactive Astrocytes in Hippocampus of Kainic Acid-Induced Rat

(2009) Ha Na Lee et al.   NEUROCHEMICAL RESEARCH

Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice

(2008) Woosung Cho et al.   EXPERIMENTAL CELL RESEARCH

Survivin and heat shock protein 25/27 colocalize with cleaved caspase-3 in surviving reactive astrocytes following excitotoxicity to the immature brain

(2008) S. Villapol et al.   NEUROSCIENCE