Review
Engineering, Biomedical
Xing Tian, Taojian Fan, Wentian Zhao, Ghulam Abbas, Bo Han, Ke Zhang, Nan Li, Ning Liu, Weiyuan Liang, Hao Huang, Wen Chen, Bing Wang, Zhongjian Xie
Summary: This review focuses on the potential applications of nanotechnology in stroke treatment. It discusses the main molecular pathological mechanisms of ischemic stroke, the role of the blood-brain barrier, and summarizes the challenges and future prospects of nanomedicine-based stroke treatments.
BIOACTIVE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Jianglong Kong, Runxuan Chu, Yi Wang
Summary: Stroke is a major cause of death and disability worldwide. Neuroprotective therapy, combined with thrombolytic therapy, is an important treatment for stroke.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Hui-min Gao, Hao Chen, Gui-Yun Cui, Jin-Xia Hu
Summary: This article briefly describes the role and mechanism of action of the blood-brain barrier (BBB), as well as the functional proteins involved. Additionally, it discusses the mechanisms of BBB damage following an ischemic stroke and presents several therapeutic strategies addressing these impairments. The article aims to provide innovative ideas for drug delivery research via the BBB.
CELL AND BIOSCIENCE
(2023)
Article
Neurosciences
Song Ta, Xianfang Rong, Zhen-Ni Guo, Hang Jin, Peng Zhang, Fenge Li, Zhihuan Li, Lilong Lin, Chenqing Zheng, Qingquan Gu, Yuan Zhang, Wenlan Liu, Yi Yang, Junlei Chang
Summary: Variants of WNT7A and GPR124 are associated with an increased risk of parenchymal hematoma in patients with acute ischemic stroke after intravenous thrombolysis, likely through regulating the activity of canonical Wnt signaling.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Clinical Neurology
Daniel Spitzer, Sylvaine Guerit, Tim Puetz, Maryam I. Khel, Moritz Armbrust, Maika Dunst, Jadranka Macas, Jenny Zinke, Gayatri Devraj, Xiaoxiong Jia, Florian Croll, Kathleen Sommer, Katharina Filipski, Thomas M. Freiman, Mario Looso, Stefan Guenther, Mariangela Di Tacchio, Karl-Heinz Plate, Yvonne Reiss, Stefan Liebner, Patrick N. Harter, Kavi Devraj
Summary: Dysfunction of the blood-brain barrier (BBB) is an important feature of acute ischemic stroke, and targeting multiple neurovascular unit (NVU) cell types may be a promising strategy. However, methods for isolating multiple NVU cell types are lacking. Researchers have developed a method for simultaneous isolation and analysis of major NVU cell types, and identified a potential therapeutic target for improving BBB function in ischemic stroke.
ACTA NEUROPATHOLOGICA
(2022)
Article
Clinical Neurology
Juan Zhu, Zheqi Li, Zhong Ji, Yongming Wu, Yihua He, Kewei Liu, Yuan Chang, Yuqin Peng, Zhenzhou Lin, Shengnan Wang, Dongmei Wang, Kaibin Huang, Suyue Pan
Summary: The dynamic degradation and reconstruction of GCX may explain the biphasic changes in BBB permeability in ischemic stroke, and reveal the essential role of GCX in suppressing transcellular transport in brain endothelial cells to maintain BBB integrity. Targeting GCX may provide a novel strategy for managing BBB dysfunction and central nervous system drug delivery.
Review
Biochemistry & Molecular Biology
Marina S. Hernandes, Qian Xu, Kathy K. Griendling
Summary: In this review, recent findings on the role of NADPH oxidases in BBB disruption induced by ischemic stroke were highlighted, emphasizing the impact of ROS on the function of the blood-brain barrier in neurological disorders.
Article
Neurosciences
Wenxuan Han, Yang Song, Marcelo Rocha, Yejie Shi
Summary: Brain edema is a devastating consequence of ischemic stroke, with malignant cerebral edema being the main cause of high mortality in large hemispheric strokes. Despite efforts to understand the mechanisms and find therapeutic targets, current treatments for ischemic brain edema focus on relieving symptoms rather than stopping its formation and progression. Recent research has revealed novel cellular mechanisms and advancements in neuroimaging techniques that offer opportunities for early diagnosis and intervention in stroke patients. Understanding how therapeutic reperfusion affects cerebral edema formation post-stroke is critical for decision-making and management. This review summarizes these research advances in ischemic brain edema, aiming to provide insight for future research on diagnosis and treatment.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Peina Wang, Qianqian Ren, Mengtong Shi, Yuanyuan Liu, Huiyuan Bai, Yan-Zhong Chang
Summary: Blood-brain barrier (BBB) breakdown is a common feature of ischemic stroke. This study reveals that overexpression of mitochondrial ferritin (FtMt) can attenuate BBB disruption in an ischemia-reperfusion (I/R) injury model by inhibiting iron dysregulation and reactive oxygen species accumulation. These findings provide novel insights into the protective role of FtMt in maintaining BBB integrity during ischemic stroke.
Review
Biochemistry & Molecular Biology
Maria Luz Alonso-Alonso, Ana Sampedro-Viana, Sabela Fernandez-Rodicio, Marcos Bazarra-Barreiros, Alberto Ouro, Tomas Sobrino, Francisco Campos, Jose Castillo, Pablo Hervella, Ramon Iglesias-Rey
Summary: Blood-brain barrier dysfunction is closely associated with cerebrovascular disease, but its detrimental or reparative effects depend on the stage of stroke. Understanding the structure, function, and chronic alterations of the BBB related to ischemic stroke is important for new drug development and clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Wenxiu He, Qiyong Mei, Jie Li, Yuting Zhai, Yiting Chen, Rui Wang, Enhao Lu, Xiao-Yong Zhang, Zhiwen Zhang, Xianyi Sha
Summary: The study presents a novel biomimetic nanoplatform designed to enhance drug delivery to cerebral ischemic lesions, demonstrating superior neuroprotective effects.
Article
Endocrinology & Metabolism
Fengshi Li, Yueman Zhang, Ruqi Li, Yan Li, Shenghao Ding, Jianpo Zhou, Tianchen Huang, Chen Chen, Bingwei Lu, Weifeng Yu, Johannes Boltze, Peiying Li, Jieqing Wan
Summary: This study found that Serpina3n, a serine protease inhibitor, is significantly upregulated in the ischemic brain and attenuates blood-brain barrier (BBB) disruption and immune cell infiltration following stroke. Serpina3n inhibits the activity of granzyme B (GZMB) and neutrophil elastase (NE), secreted by T cells and neutrophils, and intranasal delivery of Serpina3n reduces neurologic deficits after stroke. These findings suggest that Serpina3n could be a potential therapeutic target in ischemic stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Medicine, General & Internal
Min Zhou, Samuel X. Shi, Ning Liu, Yinghua Jiang, Mardeen S. Karim, Samuel J. Vodovoz, Xiaoying Wang, Boli Zhang, Aaron S. Dumont
Summary: Disruption of the blood-brain barrier following ischemic stroke can lead to various complications, with recent studies showing a stepwise impairment of the transcellular barrier followed by the paracellular barrier as a potential cause. Increased endothelial transcytosis, which is caveolae-mediated, has been identified as a factor independent of tight junction disintegration, challenging previous beliefs and providing new insights for future research and treatment strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Min Zhou, Dongna Li, Qian Shen, Lei Gao, Pengwei Zhuang, Yanjun Zhang, Hong Guo
Summary: The study showed that treatment with Storax can inhibit the caveolae-mediated transcytosis at the blood-brain barrier (BBB) in rats with ischemic stroke. This treatment also attenuated the ultrastructural disruption of BBB and regulated the expressions of key proteins involved in BBB function.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Wei Lv, Yijiao Liu, Shengnan Li, Lingyan Lv, Hongdan Lu, Hongliang Xin
Summary: This article reviews the recent advances and challenges in the diagnosis and treatment of ischemic stroke, specifically focusing on the application of nanotechnology and the impact of the blood-brain barrier.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Anesthesiology
Hongtao Liu, Katharina M. Busl, Sylvain Dore
Summary: Dexmedetomidine (DEX), an alpha(2)-adrenergic agonist, has various beneficial effects such as anti-inflammation, antioxidation, and anticell death. It has shown potential as a protective therapy for patients with subarachnoid hemorrhage (SAH) by maintaining stable intracerebral homeostasis, repairing blood-brain barrier damage, and preventing vasospasm and cortical spreading depolarization. However, more clinical trials and translational research are needed to further evaluate its effectiveness.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Daniel A. Lichlyter, Zachary A. Krumm, Todd A. Golde, Sylvain Dore
Summary: Ischaemic neurovascular stroke is a major cause of death in developed countries, and the corticotropin-releasing factor (CRF) family of neuropeptides plays an important role in the pathology of acute neurovascular injury. However, there is still limited understanding of the pathway, temporality, and systemic impact of CRF signaling and stress biology in the progression of neurovascular injury. This review aims to investigate the potential benefits of a CRF antibody in modulating CRF and corticotropin-releasing factor receptor 1 signaling, glucocorticoids, and autonomic nervous system activity, and compare the modulation of CRF and HPA axis activity in neuropsychiatric diseases and post-stroke outcomes with lessons learned from antibody therapies in neurodegenerative diseases.
Article
Clinical Neurology
Ben Gaastra, Sheila Alexander, Mark K. Bakker, Hemant Bhagat, Philippe Bijlenga, Spiros Blackburn, Malie K. Collins, Sylvain Dore, Christoph Griessenauer, Philipp Hendrix, Eun Pyo Hong, Isabel C. Hostettler, Henry Houlden, Koji IIhara, Jin Pyeong Jeon, Bong Jun Kim, Munish Kumar, Sandrine Morel, Paul Nyquist, Dianxu Ren, Ynte M. Ruigrok, David Werring, Ian Galea, Diederik Bulters, Will Tapper
Summary: This article introduces a two-stage genome-wide association study on susceptibility loci for clinical outcome after aneurysmal subarachnoid hemorrhage (aSAH). Only a small fraction of the variation in clinical outcome can be explained by known clinical, demographic, and imaging variables, suggesting the involvement of unknown factors. Understanding the genetic determinants of outcome is crucial for improving prognostic modeling, stratifying patients in clinical trials, and developing novel treatment strategies.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Genetics & Heredity
Olivia Edwards, Alicia Burris, Josh Lua, Diana J. Wilkie, Miriam O. Ezenwa, Sylvain Dore
Summary: This review examines the role of haptoglobin genetic polymorphism and stroke occurrence in the pathophysiology of sickle cell disease. It suggests that further research should be conducted to explore potential clinical advancements in gene therapy and Hp infusions.
Article
Clinical Neurology
Eduardo Candelario-Jalil, Rick M. Dijkhuizen, Tim Magnus
Summary: The role of neuroinflammation in ischemic stroke pathology and its interactions with central nervous system and peripheral immune responses are critically discussed. Neuroinflammation is associated with blood-brain barrier breakdown, neuronal injury, and worse neurological outcomes during acute phase of stroke.
Article
Immunology
Lei Liu, Changjun Yang, Bianca P. Lavayen, Ryland J. Tishko, Jonathan Larochelle, Eduardo Candelario-Jalil
Summary: By degrading BRD4, dBET1 improves neurological deficits and reduces infarct volume in acute stroke. Additionally, dBET1 can reduce inflammation and oxidative stress reactions, and protect the integrity of the blood-brain barrier.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Jonathan Larochelle, Changjun Yang, Lei Liu, Eduardo Candelario-Jalil
Summary: Poststroke infections are common complications of stroke and have a negative impact on patient outcomes. Stroke-induced immunosuppression and autonomic signaling alterations make the body more susceptible to both external (nosocomial/community-acquired) and internal (commensal bacterial) infections. Poststroke gut permeability and gut dysbiosis play a crucial role in the hypothesis of commensal infection. Dysregulation of matrix metalloproteinase-7 (MMP-7) production may be critical in the progression of gut permeability after stroke.
Review
Neurosciences
Sean Sachdeva, Sushmita Persaud, Milani Patel, Peyton Popard, Aaron Colverson, Sylvain Dore
Summary: This review discusses the effects of music/sound on blood-brain barrier permeability and meningeal lymphatic clearance, highlighting its potential positive impact on brain and body functions. However, there is limited knowledge regarding the systematic investigation and outcomes of using music/sound in medical interventions. Further research is needed to explore the potential of music/sound in healthcare.
Article
Clinical Neurology
Changjun Yang, Lei Liu, Bianca P. Lavayen, Jonathan Larochelle, Rachel E. Gunraj, Andrew A. Butler, Eduardo Candelario-Jalil
Summary: Synthetic adropin not only provides long-lasting neuroprotection after stroke but also shows neuroprotective effects in aged animals. Treatment with adropin reduces infarct volume, improves neurological function, and decreases blood-brain barrier damage.
Article
Clinical Neurology
Ben Gaastra, Sheila Alexander, Mark K. Bakker, Hemant Bhagat, Philippe Bijlenga, Spiros L. Blackburn, Malie K. Collins, Sylvain Dore, Christoph J. Griessenauer, Philipp Hendrix, Eun Pyo Hong, Isabel C. Hostettler, Henry Houlden, Koji IIhara, Jin Pyeong Jeon, Bong Jun Kim, Jiang Li, Sandrine Morel, Paul Nyquist, Dianxu Ren, Ynte M. Ruigrok, David Werring, Will Tapper, Ian Galea, Diederik Bulters
Summary: This study identified 157 genetic variants associated with outcomes after aneurysmal subarachnoid haemorrhage (aSAH) through a genome-wide association study, with one variant in the SPNS2 gene achieving genome-wide significance. Validation of these findings will provide significant insights into the pathophysiology of outcomes after aSAH and may have implications for treatment.
TRANSLATIONAL STROKE RESEARCH
(2023)
Review
Cell Biology
Rachel E. Gunraj, Changjun Yang, Lei Liu, Jonathan Larochelle, Eduardo Candelario-Jalil
Summary: Adropin, a highly conserved secreted peptide encoded by the Enho gene, plays a crucial role in maintaining lipid homeostasis and regulating insulin sensitivity. It also participates in pathophysiological processes of CNS diseases, providing protective effects in stroke, heart disease, aging, and other diseases. Recent findings suggest its critical role in regulating endothelial cells and maintaining blood-brain barrier integrity.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Neurosciences
Ben Gaastra, Dianxu Ren, Sheila Alexander, Issam A. Awad, Spiros Blackburn, Sylvain Dore, Dan Hanley, Paul Nyquist, Diederik Bulters, Ian Galea
Summary: This study demonstrates the high correlation between the modified Rankine Scale (mRS) and Glasgow Outcome Scale (GOS) and establishes the optimal dichotomization threshold for agreement. The study also provides a method for interconversion and finds that conversion from mRS to GOS is better than the reverse direction.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Bianca P. Lavayen, Changjun Yang, Jonathan Larochelle, Lei Liu, Ryland J. Tishko, Antonio Carlos Pinheiro de Oliveira, Eduardo Munoz, Eduardo Candelario-Jalil
Summary: VCE-004.8 is a synthetic derivative of cannabidiol (CBD) that has anti-inflammatory properties and potential therapeutic effects for relapsing forms of multiple sclerosis. It has been shown to protect the brain from hypoxia and stroke.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Review
Clinical Neurology
Basma Mohamed, Keerthi Yarlagadda, Zachary Self, Alexandra Simon, Frank Rigueiro, Maryam Sohooli, Stephan Eisenschenk, Sylvain Dore
Summary: Sleep-disordered breathing, including obstructive sleep apnea, is a common sequela and risk factor for stroke. This scoping review investigates the relationship between obstructive sleep apnea and stroke outcomes, highlighting the pathophysiology and the importance of treatment. Understanding this relationship has implications for the clinical management and prognosis of patients with acute ischemic stroke.
TRANSLATIONAL STROKE RESEARCH
(2023)
Meeting Abstract
Endocrinology & Metabolism
Marietta Zille, Jaroslaw Aronowski, Nicole A. Terpolilli, Sylvain Dore
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
