CRISPR-based gene disruption and integration of high-avidity, WT1-specific T cell receptors improve antitumor T cell function

Targeting an alternate Wilms’ tumor antigen 1 peptide bypasses immunoproteasome dependency

(2022) Miranda C. Lahman et al.   Science Translational Medicine

CRISPR-engineered T cells in patients with refractory cancer

(2020) Edward A. Stadtmauer et al.   SCIENCE

CAR T Cells for Acute Myeloid Leukemia: State of the Art and Future Directions

(2020) Sherly Mardiana et al.   Frontiers in Oncology

A minority of T cells recognizing tumor-associated antigens presented in self-HLA can provoke antitumor reactivity

(2020) Marthe C. J. Roex et al.   BLOOD

Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

(2019) Maddalena Noviello et al.   Nature Communications

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation

(2019) Cristina Toffalori et al.   NATURE MEDICINE

T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant

(2019) Aude G. Chapuis et al.   NATURE MEDICINE

Orthotopic replacement of T-cell receptor α- and β-chains with preservation of near-physiological T-cell function

(2019) Kilian Schober et al.   Nature Biomedical Engineering

Clinical lessons learned from the first leg of the CAR T cell journey

(2019) Robbie G. Majzner et al.   NATURE MEDICINE

Automated optimized parameters for T-distributed stochastic neighbor embedding improve visualization and analysis of large datasets

(2019) Anna C. Belkina et al.   Nature Communications

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

(2018) Jae H. Park et al.   NEW ENGLAND JOURNAL OF MEDICINE

NetMHCpan-4.0: Improved Peptide–MHC Class I Interaction Predictions Integrating Eluted Ligand and Peptide Binding Affinity Data

(2017) Vanessa Jurtz et al.   JOURNAL OF IMMUNOLOGY

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor T cells in vitro

(2017) Thomas M Schmitt et al.   NATURE BIOTECHNOLOGY

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

(2017) Terry J Fry et al.   NATURE MEDICINE

Mapping the genomic landscape of CRISPR–Cas9 cleavage

(2017) Peter Cameron et al.   NATURE METHODS

A High-avidity WT1-reactive T-Cell Receptor Mediates Recognition of Peptide and Processed Antigen but not Naturally Occurring WT1-positive Tumor Cells

(2016) Adnan Jaigirdar et al.   JOURNAL OF IMMUNOTHERAPY

Analyzing CRISPR genome-editing experiments with CRISPResso

(2016) Luca Pinello et al.   NATURE BIOTECHNOLOGY

Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors

(2016) Daniel T. Harris et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Generation of human memory stem T cells after haploidentical T-replete hematopoietic stem cell transplantation

(2015) Nicoletta Cieri et al.   BLOOD

Analysis of the functional WT1-specific T-cell repertoire in healthy donors reveals a discrepancy between CD4+and CD8+memory formation

(2015) Sabine Schmied et al.   IMMUNOLOGY

Visualizing the spatial gene expression organization in the brain through non-linear similarity embeddings

(2015) Ahmed Mahfouz et al.   METHODS

MiXCR: software for comprehensive adaptive immunity profiling

(2015) Dmitriy A Bolotin et al.   NATURE METHODS

Long-lasting stem cell–like memory CD8 + T cells with a naïve-like profile upon yellow fever vaccination

(2015) Silvia A. Fuertes Marraco et al.   Science Translational Medicine

In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells

(2015) Luca Biasco et al.   Science Translational Medicine

High-resolution analysis of the human T-cell receptor repertoire

(2015) Eliana Ruggiero et al.   Nature Communications

Review of the Results of WT1 Peptide Vaccination Strategies for Myelodysplastic Syndromes and Acute Myeloid Leukemia from Nine Different Studies

(2015) Antonio Di Stasi et al.   Frontiers in Immunology

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

(2014) S. Bae et al.   BIOINFORMATICS

Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions

(2014) Paul F. Robbins et al.   JOURNAL OF IMMUNOLOGY

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy

(2013) Richard A. Morgan et al.   JOURNAL OF IMMUNOTHERAPY

Genetic manipulation of B cells for the isolation of rare therapeutic antibodies from the human repertoire

(2013) Mark J. Kwakkenbos et al.   METHODS

WT1-specific T-cell responses in high-risk multiple myeloma patients undergoing allogeneic T cell-depleted hematopoietic stem cell transplantation and donor lymphocyte infusions

(2012) E. M. Tyler et al.   BLOOD

Mapping of novel peptides of WT-1 and presenting HLA alleles that induce epitope-specific HLA-restricted T cells with cytotoxic activity against WT-1+ leukemias

(2012) E. Doubrovina et al.   BLOOD

IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors

(2012) N. Cieri et al.   BLOOD

Next generation sequencing for TCR repertoire profiling: Platform-specific features and correction algorithms

(2012) Dmitry A. Bolotin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Real-time PCR quantification of major Wilms’ tumor gene 1 (WT1) isoforms in acute myeloid leukemia, their characteristic expression patterns and possible functional consequences

(2012) K Kramarzova et al.   LEUKEMIA

Lentiviral Vectors Displaying Modified Measles Virus gp Overcome Pre-existing Immunity in In Vivo-like Transduction of Human T and B Cells

(2012) Camille Lévy et al.   MOLECULAR THERAPY

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

(2012) Li Ding et al.   NATURE

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

(2012) Elena Provasi et al.   NATURE MEDICINE

Human MHC Class I-restricted high avidity CD4+T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo

(2012) Shao-An Xue et al.   OncoImmunology

Allogeneic HLA-A*02-Restricted WT1-Specific T Cells from Mismatched Donors Are Highly Reactive but Show Off-Target Promiscuity

(2011) W. J. J. Falkenburg et al.   JOURNAL OF IMMUNOLOGY

TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms

(2011) O. Y. Borbulevych et al.   JOURNAL OF IMMUNOLOGY

Development of Human Anti-Murine T-Cell Receptor Antibodies in Both Responding and Nonresponding Patients Enrolled in TCR Gene Therapy Trials

(2010) J. L. Davis et al.   CLINICAL CANCER RESEARCH

WT1 (Wilms' Tumor Gene 1): Biology and Cancer Immunotherapy

(2010) H. Sugiyama   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Both CD4 and CD8 T Cells Mediate Equally Effective In Vivo Tumor Treatment When Engineered with a Highly Avid TCR Targeting Tyrosinase

(2010) T. L. Frankel et al.   JOURNAL OF IMMUNOLOGY

Mutation or loss of Wilms' tumor gene 1 (WT1) are not major reasons for immune escape in patients with AML receiving WT1 peptide vaccination

(2010) Antonia Busse et al.   Journal of Translational Medicine

T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

(2010) Maria R Parkhurst et al.   MOLECULAR THERAPY

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

(2010) Gavin M Bendle et al.   NATURE MEDICINE

Mixed T cell receptor dimers harbor potentially harmful neoreactivity

(2010) M. M. van Loenen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD8+ T-cell responses to tumor-associated antigens correlate with superior relapse-free survival after allo-SCT

(2009) M Kapp et al.   BONE MARROW TRANSPLANTATION

The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research

(2009) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

Graft-versus-host disease

(2009) James LM Ferrara et al.   LANCET

Generation of stable monoclonal antibody–producing B cell receptor–positive human memory B cells by genetic programming

(2009) Mark J Kwakkenbos et al.   NATURE MEDICINE

DNA vaccination induces WT1-specific T-cell responses with potential clinical relevance

(2008) C. Chaise et al.   BLOOD