Too complex to fail? Targeting fatty acid metabolism for cancer therapy

Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence

(2020) Huizhen Zhang et al.   Journal of Pharmaceutical Analysis

Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

(2020) Lisa M. Butler et al.   ADVANCED DRUG DELIVERY REVIEWS

Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

(2020) Zeyad D Nassar et al.   eLife

FABP5 as a novel molecular target in prostate cancer

(2020) Saoirse Elizabeth O'Sullivan et al.   DRUG DISCOVERY TODAY

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

(2019) Matthew J. Watt et al.   Science Translational Medicine

MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer

(2019) Wanming He et al.   ONCOGENE

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

(2019) Kim Vriens et al.   NATURE

Cancer cell lipid class homeostasis is altered under nutrient-deprivation but stable under hypoxia

(2019) Jan Lisec et al.   BMC CANCER

Lipid metabolism in cancer cells under metabolic stress

(2019) Rimsha Munir et al.   BRITISH JOURNAL OF CANCER

NKX2-8 deletion-induced reprogramming of fatty acid metabolism confers chemoresistance in epithelial ovarian cancer

(2019) Jinrong Zhu et al.   EBioMedicine

Steroyl-CoA Desaturase 1 (SCD1) protects ovarian cancer cells from ferroptotic cell death

(2019) Lia Tesfay et al.   CANCER RESEARCH

Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling

(2019) Junfeng Bi et al.   Cell Metabolism

Fatty acid oxidation inhibitor etomoxir suppresses tumor progression and induces cell cycle arrest via PPARγ-mediated pathway in bladder cancer

(2019) Songtao Cheng et al.   CLINICAL SCIENCE

Targeting Long Chain Acyl-CoA Synthetases for Cancer Therapy

(2019) Matteo Rossi Sebastiano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis and anti-cancer activity of ND-646 and its derivatives as acetyl-CoA carboxylase 1 inhibitors

(2019) En-Qin Li et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Docetaxel/cabazitaxel and fatty acid binding protein 5 inhibitors produce synergistic inhibition of prostate cancer growth

(2019) Gregory Carbonetti et al.   PROSTATE

Reprogramming of fatty acid metabolism in cancer

(2019) Nikos Koundouros et al.   BRITISH JOURNAL OF CANCER

JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance

(2018) Tianyi Wang et al.   Cell Metabolism

Orlistat as a FASN inhibitor and multitargeted agent for cancer therapy

(2018) Alejandro Schcolnik-Cabrera et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Hints on ATGL implications in cancer: beyond bioenergetic clues

(2018) Rolando Vegliante et al.   Cell Death & Disease

Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy

(2018) Ali Talebi et al.   Nature Communications

Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer

(2018) Yekaterina Y. Zaytseva et al.   Oncotarget

Targeting CPT1A-mediated fatty acid oxidation sensitizes nasopharyngeal carcinoma to radiation therapy

(2018) Zheqiong Tan et al.   Theranostics

Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation

(2018) Cong-Hui Yao et al.   PLOS BIOLOGY

Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer

(2018) Viktor Brovkovych et al.   Oncogenesis

Inhibition of stearoyl CoA desaturase-1 activity suppresses tumour progression and improves prognosis in human bladder cancer

(2018) Chiyuan Piao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

(2018) Maria Elena Pisanu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer

(2018) Giorgia Zadra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty acid synthase (FASN) as a therapeutic target in breast cancer

(2017) Javier A. Menendez et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Inhibition of the sterol regulatory element-binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice

(2017) Na Li et al.   HEPATOLOGY

Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

(2017) Christina A. von Roemeling et al.   Oncotarget

Lipid degradation promotes prostate cancer cell survival

(2017) Harri M. Itkonen et al.   Oncotarget

FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression

(2017) Timothy S. Heuer et al.   EBioMedicine

Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-κB-mediated epithelial-mesenchymal transition

(2016) Weiping Zhu et al.   Journal of Hematology & Oncology

The Enigma of Rapamycin Dosage

(2016) S. Mukhopadhyay et al.   MOLECULAR CANCER THERAPEUTICS

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Cancer anabolic metabolism inhibitors move into clinic

(2016) Ken Garber   NATURE BIOTECHNOLOGY

Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase

(2016) Panayotis C Theodoropoulos et al.   Nature Chemical Biology

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells

(2016) Hua Lin et al.   NEURO-ONCOLOGY

An indispensable role of CPT-1a to survive cancer cells during energy stress through rewiring cancer metabolism

(2016) Jingtao Luo et al.   TUMOR BIOLOGY

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

Molecular Pathways: Fatty Acid Synthase

(2015) S. F. Jones et al.   CLINICAL CANCER RESEARCH

Crystal Structure and Substrate Specificity of Human Thioesterase 2

(2015) Melissa K. Ritchie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme

(2015) C A Lewis et al.   ONCOGENE

Long-chain acyl-CoA esters in metabolism and signaling: Role of acyl-CoA binding proteins

(2015) Ditte Neess et al.   PROGRESS IN LIPID RESEARCH

Lysophosphatidylcholine acyltransferase 1 (LPCAT1) upregulation in breast carcinoma contributes to tumor progression and predicts early tumor recurrence

(2015) Eman Abdelzaher et al.   TUMOR BIOLOGY

Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5

(2015) Liraz Levi et al.   Nature Communications

Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion

(2015) Van T. M. Nguyen et al.   Nature Communications

Hypoxia induces a lipogenic cancer cell phenotype via HIF1α-dependent and -independent pathways

(2015) Alessandro Valli et al.   Oncotarget

Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells

(2015) Ksenia Astanina et al.   Scientific Reports

Original insights on thrombospondin-1-related antireceptor strategies in cancer

(2015) Albin Jeanne et al.   Frontiers in Pharmacology

Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer

(2015) Deliang Guo et al.   CURRENT PHARMACEUTICAL DESIGN

Silibinin inhibits aberrant lipid metabolism, proliferation and emergence of androgen-independence in prostate cancer cells via primarily targeting the sterol response element binding protein 1

(2015) Dhanya K. Nambiar et al.   Oncotarget

Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells

(2015) Bruna Corominas-Faja et al.   Oncotarget

Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

(2015) Aritro Nath et al.   Scientific Reports

Acyl-CoA Metabolism and Partitioning

(2014) Trisha J. Grevengoed et al.   Annual Review of Nutrition

Functional Regulation of Phospholipase D Expression in Cancer and Inflammation

(2014) Dong Woo Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatostatin Displays High Antitumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling

(2014) X. Li et al.   MOLECULAR CANCER THERAPEUTICS

Cancer Cells Differentially Activate and Thrive on De Novo Lipid Synthesis Pathways in a Low-Lipid Environment

(2014) Veerle W. Daniëls et al.   PLoS One

Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation

(2014) Karim Bensaad et al.   Cell Reports

Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells

(2013) L.-Y. Chu et al.   BLOOD

TOFA suppresses ovarian cancer cell growth in vitro and in vivo

(2013) SHU LI et al.   Molecular Medicine Reports

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipogenesis and lipolysis: The pathways exploited by the cancer cells to acquire fatty acids

(2013) Nousheen Zaidi et al.   PROGRESS IN LIPID RESEARCH

ATP Citrate Lyase Knockdown Induces Growth Arrest and Apoptosis through Different Cell- and Environment-Dependent Mechanisms

(2012) N. Zaidi et al.   MOLECULAR CANCER THERAPEUTICS

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

(2012) Marlen Knobloch et al.   NATURE

SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids

(2012) Paul Mason et al.   PLoS One

TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status

(2011) Natalya V. Guseva et al.   CANCER BIOLOGY & THERAPY

Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer

(2011) Lin Ye et al.   CANCER LETTERS

Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer

(2011) Daniel K. Nomura et al.   CHEMISTRY & BIOLOGY

Human Lysophosphatidylcholine Acyltransferases 1 and 2 Are Located in Lipid Droplets Where They Catalyze the Formation of Phosphatidylcholine

(2011) Christine Moessinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer Cell Dependence on Unsaturated Fatty Acids Implicates Stearoyl-CoA Desaturase as a Target for Cancer Therapy

(2011) U. V. Roongta et al.   MOLECULAR CANCER RESEARCH

Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation

(2010) Donald B. Jump et al.   BIOCHEMICAL PHARMACOLOGY

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

(2010) E. Rysman et al.   CANCER RESEARCH

Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice

(2010) Soichiro Murata et al.   CANCER SCIENCE

Acyl-coenzyme A synthetases in metabolic control

(2010) Jessica M Ellis et al.   CURRENT OPINION IN LIPIDOLOGY

Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

(2010) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of StearoylCoA Desaturase Activity Blocks Cell Cycle Progression and Induces Programmed Cell Death in Lung Cancer Cells

(2010) Daniel Hess et al.   PLoS One

Inhibition of Stearoyl-CoA Desaturase 1 Expression Induces CHOP-Dependent Cell Death in Human Cancer Cells

(2010) Mélaine Minville-Walz et al.   PLoS One

Acetyl-CoA carboxylase-α inhibitor TOFA induces human cancer cell apoptosis

(2009) Chun Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide

(2009) Tetsuo Mashima et al.   CANCER SCIENCE

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Acyl-CoA synthetases: fatty acid uptake and metabolic channeling

(2009) Margarete Digel et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Fatty acid metabolism: target for metabolic syndrome

(2008) Salih J. Wakil et al.   JOURNAL OF LIPID RESEARCH

A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction

(2008) H. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions

(2008) T Mashima et al.   ONCOGENE