Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs

Pervasive functional translation of noncanonical human open reading frames

(2020) Jin Chen et al.   SCIENCE

The Enigmatic Protein Kinase C-eta

(2019) Alakananda Basu   Cancers

Protein kinase C: perfectly balanced

(2018) Alexandra C. Newton   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The invasin D protein fromYersinia pseudotuberculosisselectively binds the Fab region of host antibodies and affects colonization of the intestine

(2018) Pooja Sadana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribosome Profiling: Global Views of Translation

(2018) Nicholas T. Ingolia et al.   Cold Spring Harbor Perspectives in Biology

Small but Mighty: Functional Peptides Encoded by Small ORFs in Plants

(2017) Polly Yingshan Hsu et al.   PROTEOMICS

Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins

(2017) Sondos Samandi et al.   eLife

Upstream ORFs are prevalent translational repressors in vertebrates

(2016) Timothy G Johnstone et al.   EMBO JOURNAL

Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress Response

(2016) Sara K. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

(2015) Corina E. Antal et al.   CELL

Myc coordinates transcription and translation to enhance transformation and suppress invasiveness

(2015) R. Elkon et al.   EMBO REPORTS

Ribosome profiling reveals an important role for translational control in circadian gene expression

(2015) Christopher Jang et al.   GENOME RESEARCH

Integrative analysis of RNA, translation, and protein levels reveals distinct regulatory variation across humans

(2015) Can Cenik et al.   GENOME RESEARCH

A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation

(2015) Alexander P. Fields et al.   MOLECULAR CELL

Many lncRNAs, 5’UTRs, and pseudogenes are translated and some are likely to express functional proteins

(2015) Zhe Ji et al.   eLife

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

(2015) Carmela Sidrauski et al.   eLife

Selective inhibition of angiotensin receptor signaling through Erk1/2 pathway by a novel peptide

(2014) Jun Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

PKCη is an anti-apoptotic kinase that predicts poor prognosis in breast and lung cancer: Figure 1

(2014) Udi Zurgil et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

PKCη promotes senescence induced by oxidative stress and chemotherapy

(2014) U Zurgil et al.   Cell Death & Disease

The A2AAdenosine Receptor Is a Dual Coding Gene

(2013) Chien-fei Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory

(2013) Lenora J. Volk et al.   NATURE

GWIPS-viz: development of a ribo-seq genome browser

(2013) Audrey M. Michel et al.   NUCLEIC ACIDS RESEARCH

Translational dynamics revealed by genome-wide profiling of ribosome footprints in Arabidopsis

(2013) P. Juntawong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Gene Expression Regulation by Upstream Open Reading Frames and Human Disease

(2013) Cristina Barbosa et al.   PLoS Genetics

Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting

(2012) C. Fritsch et al.   GENOME RESEARCH

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

Localization of PKC? in Cell Membranes as a Predictor for Breast Cancer Response to Treatment

(2012) Galia Karp et al.   ONKOLOGIE

A New Mouse Model for the Study of Human Breast Cancer Metastasis

(2012) Elizabeth Iorns et al.   PLoS One

Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution

(2012) S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved Peptide Upstream Open Reading Frames are Associated with Regulatory Genes in Angiosperms

(2012) Richard A. Jorgensen et al.   Frontiers in Plant Science

Protein kinase Cη activates NF-κB in response to camptothecin-induced DNA damage

(2011) Hadas Raveh-Amit et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

(2011) Nicholas T. Ingolia et al.   CELL

DNA damage targets PKCη to the nuclear membrane via its C1b domain

(2011) Ana Tamarkin et al.   EXPERIMENTAL CELL RESEARCH

PKC-delta and PKC-epsilon: Foes of the same family or strangers?

(2011) Nicolas Duquesnes et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Protein Kinase C   Is Required for T Cell Activation and Homeostatic Proliferation

(2011) G. Fu et al.   Science Signaling

Translational Regulation of Gene Expression during Conditions of Cell Stress

(2010) Keith A. Spriggs et al.   MOLECULAR CELL

PKC and the control of localized signal dynamics

(2010) Carine Rosse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein kinase C: poised to signal

(2009) Alexandra C. Newton   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PKCη confers protection against apoptosis by inhibiting the pro-apoptotic JNK activity in MCF-7 cells

(2009) Noa Rotem-Dai et al.   EXPERIMENTAL CELL RESEARCH

Translational Control of Protein Kinase C  by Two Upstream Open Reading Frames

(2009) H. Raveh-Amit et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

Structural Basis of Protein Kinase C Isoform Function

(2008) Susan F. Steinberg   PHYSIOLOGICAL REVIEWS