Article
Agriculture, Multidisciplinary
Tatsuya Suzuki, Seiji Yamato
Summary: Oxazosulfyl is a novel insecticide that acts by blocking voltage-gated sodium channels in insects, resulting in paralysis. This discovery sheds light on the mode of action of oxazosulfyl as a potential pest control agent in rice fields.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biology
Peter R. Strege, Luke M. Cowan, Constanza Alcaino, Amelia Mazzone, Christopher A. Ahern, Lorin S. Milescu, Gianrico Farrugia, Arthur Beyder
Summary: Shear stress and patch suction can reversibly alter the kinetic properties and maximum current of NaChBac, suggesting it is mechanosensitive. Structural analysis reveals a large displacement of the intracellular gate, supporting the proposed mechanosensitive mechanism.
Article
Multidisciplinary Sciences
Takushi Shimomura, Kiichi Hirazawa, Yoshihiro Kubo
Summary: This study reveals that different conformations of DII-S4 determine the gating modes in Two-pore channels (TPCs), with the intermediate state representing the PIP2-gating mode. TPC3 is primarily voltage-dependent, while TPC2 is PIP2-gated and nonvoltage-dependent. Furthermore, the antidepressant desipramine induces voltage dependence in TPC2, and the flavonoid naringenin biases the mode preference from PIP2-gating to desipramine-induced voltage gating.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Lea Rethore, Joohee Park, Jerome Montnach, Sebastien Nicolas, Joseph Khoury, Elodie Le Seac'h, Kamel Mabrouk, Harold De Pomyers, Helene Tricoire-Leignel, Cesar Mattei, Daniel Henrion, Ziad Fajloun, Michel De Waard, Claire Legendre, Christian Legros
Summary: This study investigates the interaction between Na+ and Ca2+ channels in GH3b6 cells, revealing a crosstalk between Na-V and LTCC and providing new insights into the mode of action of neurotoxins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Kiichi Takahashi, Takayoshi Ohba, Yosuke Okamoto, Atsuko Noguchi, Hiroko Okuda, Hatasu Kobayashi, Kouji H. Harada, Akio Koizumi, Kyoichi Ono, Tsutomu Takahashi
Summary: Inherited pain disorders can be caused by gain-of-function mutations in voltage-gated sodium channels like Na(V)1.7. A novel mutation (E44Q) in Na(V)1.7 was identified in a patient with paroxysmal pain attacks during childhood, and electrophysiological recordings showed that this mutation increased the amplitude of sodium current, indicating a gain-of-function effect. This study sheds light on the phenotypic spectrum and functional implications of Na(V)1.7 channelopathies.
Article
Cell Biology
Adam Feher, Marianna Pocsi, Ferenc Papp, Tibor G. Szanto, Agota Csoti, Zsolt Fejes, Bela Nagy, Balazs Nemes, Zoltan Varga
Summary: This study identified multiple voltage-gated sodium channels in the plasma membrane of human B cells using electrophysiological and molecular biology methods. The detected sodium currents showed sensitivity between TTX-sensitive and TTX-insensitive channels, suggesting the co-existence of multiple Na(V)1 subtypes. The results also supported the functional role of these channels in shaping and maintaining the resting membrane potential.
Article
Physiology
Xin Wu, Yawei Li, Liang Hong
Summary: The voltage-gated sodium channel Na(v)1.5 is crucial for generating and propagating action potentials in cardiomyocytes. Mutations in Na(v)1.5 have been linked to various heart rhythm disorders. This study focused on an Asian-specific mutation called Na(v)1.5-P1090L, which was associated with long QT syndrome. The mutation disrupted the function of the sodium channel and could be reversed by treatment with mexiletine.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Yang Zheng, Xiaoping Wan, Dandan Yang, Angelina Ramirez-Navarro, Haiyan Liu, Ji-Dong Fu, Isabelle Deschenes
Summary: Na(v)1.5, a predominant sodium channel in the heart, plays a crucial role in maintaining normal heart rhythm and function. Dysfunctions in Na(v)1.5 are associated with various cardiac pathologies and sudden cardiac death. In heart failure patients, a splice variant Na(v)1.5-G1642X reduces sodium currents through biophysical coupling with the wildtype channel.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Karl Josef Foehr, Michael Rapp, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, David Alexander Christian Messerer
Summary: Aripiprazole has been identified as a potent blocker of the dominant voltage-gated sodium channel of heart muscle. Its interactions with the channel differ depending on the state, with weaker affinity for the resting state and stronger affinity for the inactivated state.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Shuai Guo, Zhenhui Chen, Peng-Sheng Chen, Michael Rubart
Summary: Ondansetron inhibits hSK2 currents even under altered ionic conditions, potentially showing antiarrhythmic effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Kristopher M. Kahlig, Liam Scott, Robert J. Hatch, Andrew Griffin, Gabriel Martinez Botella, Zoe A. Hughes, Marion Wittmann
Summary: This study investigated the effects of PRAX-562 on sodium current, neuronal excitability, and protection from evoked seizures. PRAX-562 demonstrated potent inhibition of persistent sodium current and significantly improved tolerability compared to standard sodium channel blockers. It showed robust preclinical anticonvulsant activity and potentially represents a differentiated therapeutic option for hyperexcitability disorders.
Article
Multidisciplinary Sciences
Michela Panini, Olga Chiesa, Bartlomiej J. Troczka, Mark Mallott, Gian Carlo Manicardi, Stefano Cassanelli, Filippo Cominelli, Alex Hayward, Emanuele Mazzoni, Chris Bass
Summary: A study reveals a mechanism of insecticide resistance in which previously unavailable recessive resistance alleles are unlocked by transposon-mediated insertional mutagenesis, resulting in insect pests developing resistance to the insecticide bifenthrin.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Neurosciences
Mohamed A. Fouda, Mohammad-Reza Ghovanloo, Peter C. Ruben
Summary: Acquired and inherited dysfunction in voltage-gated sodium channels is the underlying cause of various diseases. Late sodium current increase is a common defect in these diseases.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Biology
Go Kasuya, Koichi Nakajo
Summary: In this study, the researchers investigated the interaction between KCNE3 and KCNQ1 voltage sensors in the KCNQ1-KCNE3-calmodulin complex. They found that the distance between the S1 segment and KCNE3 is optimized to achieve constitutive activity. In addition, they identified mutant pairs of KCNQ1 and KCNE3 that partially restored constitutive activity when expressed together.
Review
Biochemistry & Molecular Biology
Xin Wu, Liang Hong
Summary: Calmodulin (CaM) is a small protein that serves as a ubiquitous signal transducer, regulating neuronal plasticity, muscle contraction, and immune response. It interacts with ion channels and plays regulatory roles in cellular electrophysiology. Mutations in CaM-binding IQ domain can lead to various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Bianca T. A. de Greef, Janneke G. J. Hoeijmakers, Margot Geerts, Mike Oakes, Tim J. E. Church, Stephen G. Waxman, Sulayman D. Dib-Hajj, Catharina G. Faber, Ingemar S. J. Merkies
Article
Neurosciences
Ivo Eijkenboom, Maurice Sopacua, Auke B. C. Otten, Monique M. Gerrits, Janneke G. J. Hoeijmakers, Stephen G. Waxman, Raffaella Lombardi, Giuseppe Lauria, Ingemar S. J. Merkies, Hubert J. M. Smeets, Catharina G. Faber, Jo M. Vanoevelen
EXPERIMENTAL NEUROLOGY
(2019)
Article
Clinical Neurology
Ivo Eijkenboom, Maurice Sopacua, Janneke G. J. Hoeijmakers, Bianca T. A. de Greef, Patrick Lindsey, Rowida Almomani, Margherita Marchi, Jo Vanoevelen, Hubertus J. M. Smeets, Stephen G. Waxman, Giuseppe Lauria, Ingemar S. J. Merkies, Catharina G. Faber, Monique M. Gerrits
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2019)
Article
Neurosciences
Malgorzata A. Mis, yang Yang, Brian S. Tanaka, Karolina Gomis-Perez, Shujun Liu, Fadia Dib-Hajj, Talia Adi, Rolando Garcia-Milian, Betsy R. Schulman, Sulayman D. Dib-Hajj, Stephen G. Waxman
JOURNAL OF NEUROSCIENCE
(2019)
Review
Pediatrics
Luke Arthur, Kirsty Keen, Madeleine Verriotis, Judy Peters, Alison Kelly, Richard F. Howard, Sulayman D. Dib-Hajj, Stephen G. Waxman, Suellen M. Walker
JOURNAL OF PEDIATRICS
(2019)
Review
Clinical Neurology
Maurice Sopacua, Janneke G. J. Hoeijmakers, Ingemar S. J. Merkies, Giuseppe Lauria, Stephen G. Waxman, Catharina G. Faber
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2019)
Review
Neurosciences
Sulayman D. Dib-Hajj, Stephen G. Waxman
ANNUAL REVIEW OF NEUROSCIENCE, VOL 42
(2019)
Editorial Material
Neurosciences
Stephen G. Waxman, Sulayman D. Dib-Hajj
Article
Neurosciences
Mathilde R. Israel, Brian S. Tanaka, Joel Castro, Panumart Thongyoo, Samuel D. Robinson, Peng Zhao, Jennifer R. Deuis, David J. Craik, Thomas Durek, Stuart M. Brierley, Stephen G. Waxman, Sulayman D. Dib-Hajj, Irina Vetter
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Review
Anesthesiology
Stephen G. Waxman
Review
Physiology
David L. Bennett, Alex J. Clark, Jianying Huang, Stephen G. Waxman, Sulayman D. Dib-Hajj
PHYSIOLOGICAL REVIEWS
(2019)
Article
Neurosciences
Jianying Huang, Mark Estacion, Peng Zhao, Fadia B. Dib-Hajj, Betsy Schulman, Angela Abicht, Ingo Kurth, Knut Brockmann, Stephen G. Waxman, Sulayman D. Dib-Hajj
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Milena Sleczkowska, Rowida Almomani, Margherita Marchi, Erika Salvi, Bianca T. A. de Greef, Maurice Sopacua, Janneke G. J. Hoeijmakers, Patrick Lindsey, Stephen G. Waxman, Giuseppe Lauria, Catharina G. Faber, Hubert J. M. Smeets, Monique M. Gerrits
Summary: This study assessed the role of fifteen ion channel genes in neuropathic pain. Variants in ion channel genes were identified in SFN patients, with TRP genes being the most frequent. Patients with these variants reported more severe pain. This study provides promising gene candidates for future research on neuropathic pain etiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rowida Almomani, Maurice Sopacua, Margherita Marchi, Milena Sleczkowska, Patrick Lindsey, Bianca T. A. de Greef, Janneke G. J. Hoeijmakers, Erika Salvi, Ingemar S. J. Merkies, Maryam A. Ferdousi, Rayaz Malik, Dan Ziegler, Kasper W. J. Derks, Gidon Boenhof, Filippo Martinelli-Boneschi, Daniele Cazzato, Raffaella Lombardi, Sulayman G. Dib-Hajj, Stephen Waxman, Hubert J. M. M. Smeets, Monique G. Gerrits, Catharina Faber, Giuseppe Lauria
Summary: Rare SCG genetic variants may contribute to the development of painful neuropathy. Genetic profiling and SCG variant identification can provide better understanding of the genetic variability in patients with painful and painless neuropathy, leading to improved risk stratification and personalized pain treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Matthew Alsaloum, Mark Estacion, Rowida Almomani, Monique M. Gerrits, Gidon J. Boenhof, Dan Ziegler, Rayaz Malik, Maryam Ferdousi, Giuseppe Lauria, Ingemar S. J. Merkies, Catharina G. Faber, Sulayman Dib-Hajj, Stephen G. Waxman, B. de Greef, J. G. J. Hoeijmakers, M. Sopacua, H. J. M. Smeets, J. M. Vanoevelen, I Eijkenboom, P. Lindsey, R. Almomani, M. Taiana, M. Marchi, R. Lombardi, D. Cazzato, F. M. Boneschi, A. Zauli, F. Clarelli, S. Santoro, I Lopez, A. Quattrini, S. Cestele, O. Chever, M. Tavakoli, R. Malik, D. Kapetis, M. N. Xenakis, M. Mantegazza, F. Battiato, A. Strom