Cardioprotective effect of icariin against myocardial fibrosis and its molecular mechanism in diabetic cardiomyopathy based on network pharmacology: Role of ICA in DCM

Effect of non-covalent binding of phenolic derivatives with scallop (Patinopecten yessoensis) gonad protein isolates on protein structure and in vitro digestion characteristics

(2021) Jiarun Han et al.   FOOD CHEMISTRY

Identification of the constituents and the cancer-related targets of the fruit of Solanum nigrum based on molecular docking and network pharmacology

(2021) LinJiao Yang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Icariin Prevents Diabetes-Induced Bone Loss in Rats by Reducing Blood Glucose and Suppressing Bone Turnover

(2019) Shanshan Qi et al.   MOLECULES

Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice

(2019) Mei Xue et al.   CLINICAL SCIENCE

Icariin induces apoptosis by suppressing autophagy in tamoxifen-resistant breast cancer cell line MCF-7/TAM

(2019) Xia Cheng et al.   Breast Cancer

PI3K–AKT Signaling Activation and Icariin: The Potential Effects on the Perimenopausal Depression-Like Rat Model

(2019) Li-Hua Cao et al.   MOLECULES

Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cGMP-PKG activation

(2018) Li-ming Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy

(2018) Fan Yang et al.   Cell Death & Disease

Icariin Improves Functional Behavior in a Mouse Model of Traumatic Brain Injury and Promotes Synaptic Plasticity Markers

(2018) Hyejin Joo et al.   PLANTA MEDICA

Myocardial fibrosis: biomedical research from bench to bedside

(2017) Mariann Gyöngyösi et al.   EUROPEAN JOURNAL OF HEART FAILURE

Icariin, an Anti-atherosclerotic Drug from Chinese Medicinal Herb Horny Goat Weed

(2017) Jian Fang et al.   Frontiers in Pharmacology

The cGMP/PKG pathway as a common mediator of cardioprotection: translatability and mechanism

(2015) Javier Inserte et al.   BRITISH JOURNAL OF PHARMACOLOGY

The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus

(2015) Csaba Mátyás et al.   Cardiovascular Diabetology

Neuroprotective Effects of Icariin on Brain Metabolism, Mitochondrial Functions, and Cognition in Triple-Transgenic Alzheimer's Disease Mice

(2015) Yi-Jing Chen et al.   CNS Neuroscience & Therapeutics

Metabolic dysfunction in diabetic cardiomyopathy

(2013) Michael Isfort et al.   HEART FAILURE REVIEWS

An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy

(2013) Xavier Palomer et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Impaired sonic hedgehog pathway contributes to cardiac dysfunction in type 1 diabetic mice with myocardial infarction

(2012) Qing Xiao et al.   CARDIOVASCULAR RESEARCH

Diabetic Cardiomyopathy

(2012) Joel D. Schilling et al.   Heart Failure Clinics

Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions

(2011) Junmin Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Diabetic cardiomyopathy, causes and effects

(2010) Sihem Boudina et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Expression of constitutively active cGMP-dependent protein kinase inhibits glucose-induced vascular smooth muscle cell proliferation

(2009) Shuxia Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes

(2009) Honglan Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Endothelial nitric oxide synthase decreases β-adrenergic responsiveness via inhibition of the L-type Ca2+ current

(2008) Honglan Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY