Article
Cell Biology
Kangxin Li, Guiming Chen, Haihua Luo, Jianhang Li, Aihua Liu, Chen Yang, Juan Wang, Jia Xu, Shenghan Gao, Peng Chen, Yong Jiang
Summary: Myeloid-related protein 8/14 has been found to inhibit macrophage efferocytosis of apoptotic cells and promote phenotypic polarization of macrophages, potentially offering novel therapeutic strategies for inflammation resolution.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Medicine, Research & Experimental
Zhangyang Bi, Wei Zhang, Xiaoyan Yan
Summary: ICA and ICT, the main active ingredients of Epimedium, have anti-inflammatory and immunomodulatory effects and hold promising clinical applications in the treatment of various diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, Research & Experimental
Jamshid Gholizadeh Navashenaq, Arezoo Gowhari Shabgah, Mahdiyeh Hedayati-Moghadam, Nazila Ariaee, Hamed Mohammadi, Maryam Hemmatzadeh, Sara Azhdari, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Rheumatoid arthritis (RA) is an autoimmune disease affecting joints, with unclear etiology but involving immune mechanisms. Immune cells migrate to the joints during disease onset, and the shift to Th1 and Th17 immune responses is crucial in RA development. Myeloid-derived suppressor cells (MDSCs) regulate immune system, their specific functions in RA need further investigation.
Review
Immunology
Chiel van Geffen, Constantin Heiss, Astrid Deissler, Saeed Kolahian
Summary: In this article, we summarize and critically discuss different pharmacological approaches to modulate the generation, activation, and recruitment of MDSCs in vitro and in vivo, and their potential role in future immunosuppressive therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Tyler J. Loftus, Ricardo Ungaro, Marvin Dirain, Philip A. Efron, Monty B. Mazer, Kenneth E. Remy, Richard S. Hotchkiss, Luer Zhong, Rhonda Bacher, Petr Starostik, Lyle L. Moldawer, Scott C. Brakenridge
Summary: Both bacterial sepsis and SARS-CoV-2 patients showed significant immune suppression and inflammation through 21 days, but their immune dyscrasia temporal patterns and clinical outcomes were different. SARS-CoV-2 patients had less severe early inflammation and organ dysfunction, but persistent inflammation and immunosuppression, leading to worse clinical outcomes, especially when followed by secondary bacterial infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Dijoia B. Darden, Lauren S. Kelly, Brittany P. Fenner, Lyle L. Moldawer, Alicia M. Mohr, Philip A. Efron
Summary: Protocolized surveillance, diagnosis, and management of septic patients, especially surgical sepsis patients, can significantly increase the number of patients surviving their initial hospitalization. However, some patients may develop chronic critical illness, with elderly and comorbid patients being particularly susceptible to poor outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Carolin Park, Maria Miranda-Garcia, Rainer Berendes, Gerd Horneff, Jasmin Kuemmerle-Deschner, Gerd Ganser, Hans-Iko Huppertz, Kirsten Minden, Johannes-Peter Haas, Annette F. Jansson, Michael Borte, Catharina Schuetz, Prasad Oommen, Michael Frosch, Bernhard Schlueter, Annette Richter-Unruh, Christoph Kessel, Claas Hinze, Helmut Wittkowski, Johannes Roth, Dirk Foell, Dirk Holzinger
Summary: This study validated the usefulness of MRP8/14 serum analyses in supporting the diagnosis of SJIA in febrile children. The results could be confirmed with commercial ELISA and LFIA, enabling a rapid diagnostic point-of-care screening test.
Article
Oncology
Chuling Fang, Andrew E. Rinke, Jing Wang, Kevin R. Flaherty, Sem H. Phan, Tianju Liu
Summary: Elevated levels of sB7H3 and B7H3(+) cells in blood samples of IPF patients were found to be negatively correlated with lung function decline. sB7H3 was shown to induce the influx of MDSCs into lung tissue and enhance inflammation, as well as cause the accumulation of MDSCs in the bone marrow.
JOURNAL OF PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tzu-Chieh Liao, Jiung-Pang Huang, Yu-Ting Tsai, Wei-Ching Shih, Chi-Chang Juan, Po-Shiuan Hsieh, Li-Man Hung, Chao-Lan Yu
Summary: CCR5 plays a role in mediating the interaction between hepatocytes and g-MDSCs in the pathogenesis of NAFLD, and targeting g-MDSCs' CCR5 signaling might be a potential therapeutic strategy for the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Yongxiang Li, Qingyan Jiang, Lina Wang
Summary: Appetite is essential for normal metabolism, and inflammation can impact both homeostatic and non-homeostatic systems of appetite, with the physiological functions still largely unknown. This review focuses on the structures of these systems and discusses how TLR4-induced inflammatory signaling contributes to regulating appetite in both systems, providing potential for new therapeutic interventions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Siavash Bolourani, Ezgi Sari, Max Brenner, Ping Wang
Summary: The study demonstrates that eCIRP induces an inflammatory phenotype in pulmonary fibroblasts in a TLR4-dependent manner and is associated with bleomycin-induced pulmonary fibrosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Julian Revenstorff, Nadine Ludwig, Annika Hilger, Sina Mersmann, Martin Lehmann, Julia Chiara Grenzheuser, Marina Kardell, Julia Bone, Niklas Martin Koetting, Nina Christine Marx, Johannes Roth, Thomas Vogl, Jan Rossaint
Summary: This study demonstrates the role of S100A8/A9 during platelet-neutrophil interactions and neutrophil recruitment during pulmonary inflammation.
Article
Immunology
Xin Huang, Hong Shen, Yiran Liu, Sainan Qiu, Yan Guo
Summary: The study showed that Fisetin attenuated periodontitis by inhibiting inflammatory reaction through the FGFR1/TLR4/NLRP3 inflammasome pathway. It reduced alveolar bone gap, inhibited inflammatory cytokine levels, and suppressed NLRP3 priming. The research indicated that Fisetin may offer potential therapeutic benefits for periodontal inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Zhiqi Xie, Haoyang Zhou, Masanori Obana, Yasushi Fujio, Naoki Okada, Masashi Tachibana
Summary: Viral pneumonia is a global health burden, particularly for the elderly and patients with underlying diseases. Recent studies have shown that myeloid-derived suppressor cells (MDSCs) are abundant in these patients, but their role in the progression of viral pneumonia is still unclear. This study found a significant increase in MDSCs in a mouse model and in older mice. When polyinosinic-polycytidylic acid (poly(I:C)) was used to mimic viral pneumonia, mice with renal ischemia/reperfusion (I/R) injury had more severe lung inflammation compared to control mice. Additionally, depleting MDSCs attenuated lung inflammation in mice with I/R injury. Similar results were observed in older mice compared to young mice. Furthermore, transferring in vitro-differentiated MDSCs worsened poly(I:C)-induced lung inflammation. These findings suggest that the increased proportion of MDSCs in mice with renal I/R injury and in older mice exacerbates poly(I:C)-induced lung inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Violeta Duran-Laforet, Carolina Pena-Martinez, Alicia Garcia-Culebras, Maria Isabel Cuartero, Eng H. Lo, Maria Angeles Moro, Ignacio Lizasoain
Summary: The absence of TLR4 in neutrophils leads to smaller infarct volumes after ischemic stroke. TLR4-lacking neutrophils remain in a steady youth status and show higher phagocytic activity, preferential engulfment by microglia, and reduced production of ROS in the initial stages of inflammation post-stroke. These findings suggest that targeting TLR4 in specific cell types, especially neutrophils, may be a potential strategy for neuroprotection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Thu Le Trinh, Wendy M. Kandell, Sarah S. Donatelli, Nhan Tu, Melba M. Tejera, Danielle L. Gilvary, Erika A. Eksioglu, Alexis Burnette, William A. Adams, Jinhong Liu, Jamie K. Teer, Julie Y. Djeu, Domenico Coppola, Sheng Wei
Article
Oncology
Pinyang Cheng, Erika A. Eksioglu, Xianghong Chen, Wendy Kandell, Thu Le Trinh, Ling Cen, Jin Qi, David A. Sallman, Yu Zhang, Nhan Tu, William A. Adams, Chunze Zhang, Jinhong Liu, John L. Cleveland, Alan F. List, Sheng Wei
Letter
Dermatology
Xiao Liu, Jun Mi, Haihong Qin, Zheng Li, Jingxiu Chai, Ming Li, Jinfeng Xu, Jinhua Xu
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Article
Medicine, Research & Experimental
Qiuping Li, Jing Sun, Yuxue Cao, Baojun Liu, Lulu Li, Nabijan Mohammadtursun, Hu Zhang, Jingcheng Dong, Jinfeng Wu
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Multidisciplinary Sciences
Wendy M. Kandell, Sarah S. Donatelli, Thu Le Trinh, Alexandra R. Calescibetta, Tina So, Nhan Tu, Danielle L. Gilvary, Xianghong Chen, Pingyan Cheng, William A. Adams, Yin-Kai Chen, Jinhong Liu, Julie Y. Djeu, Sheng Wei, Erika A. Eksioglu
Article
Oncology
Zheng Li, Xiao Liu, Ming Li, Jingxiu Chai, Shan He, Jinfeng Wu, Jinhua Xu
MOLECULAR MEDICINE REPORTS
(2020)
Article
Oncology
Romela Irene Ramos, Matias A. Bustos, Jinfeng Wu, Peter Jones, Shu Ching Chang, Eiji Kiyohara, Kevin Tran, Xiaoqing Zhang, Stacey L. Stern, Sivan Izraely, Orit Sagi-Assif, Isaac P. Witz, Michael A. Davies, Gordon B. Mills, Daniel F. Kelly, Reiko F. Irie, Dave S. B. Hoon
MOLECULAR ONCOLOGY
(2020)
Article
Oncology
Xiao Liu, Zheng Li, Ming Li, Jingxiu Chai, Shan He, Jinfeng Wu, Jinhua Xu
Article
Hematology
David A. Sallman, Amy F. McLemore, Amy L. Aldrich, Rami S. Komrokji, Kathy L. McGraw, Abhishek Dhawan, Susan Geyer, Hsin-An Hou, Erika Adriana Eksioglu, Amy Sullivan, Sarah Warren, Kyle J. MacBeth, Manja Meggendorfer, Torsten Haferlach, Steffen Boettcher, Benjamin L. Ebert, Najla Al-Ali, Jeffrey E. Lancet, John L. Cleveland, Eric Padron, Alan F. List
Article
Plant Sciences
Qiuping Li, Guifang Wang, Shi Hang Xiong, Yuxue Cao, Baojun Liu, Jing Sun, Lulu Li, Nabijan Mohammadtursun, Hua Yu, Jingcheng Dong, Jinfeng Wu
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Immunology
Shan He, Jinhua Xu, Jinfeng Wu
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Robert Dalton, Alexandra Calescibetta, Jun Min Zhou, Michelle Maurin, Grace Ward, Thu Le Trinh, Nhan Tu, Danielle Gilvary, Xianghong Chen, Pingyan Cheng, Elena Kostenko, Sheng Wei, Kenneth L. Wright, Erika A. Eksioglu
Summary: The study developed constitutively active DAP12 mutants that can promote activation of monocyte-derived DCs, inducing their maturation and activation as well as enhancing migration and T cell stimulation in vitro. Additionally, constitutively active DAP12 stimulated a strong immune response in a murine melanoma model, reducing tumor burden and providing proof-of-concept for enhancing the effectiveness of anti-tumor immunotherapies by pre-activating antigen presenting cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Shan He, Jinhua Xu, Jinfeng Wu
Summary: Vitiligo is a chronic autoimmune skin disorder characterized by depigmented patches and destruction of melanocytes. Oxidative stress, as a key factor, leads to melanocyte loss by altering the redox status and impairing the defense mechanism. There is a connection between oxidative stress and autoimmunity in vitiligo, with chemokines playing a role in disease progression.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Grace A. Ward, Robert P. P. Dalton III, Benjamin S. Meyer, Amy F. McLemore, Amy L. Aldrich, Nghi B. Lam, Alexis H. Onimus, Nicole D. Vincelette, Thu Le Trinh, Xianghong Chen, Alexandra R. Calescibetta, Sean M. Christiansen, Hsin-An Hou, Joseph O. Johnson, Kenneth L. Wright, Eric Padron, Erika A. Eksioglu, Alan F. List
Summary: Myelodysplastic Syndromes (MDSs) are characterized by innate immune activation and pyroptotic cell death driven by NLRP3 inflammasome. The release of oxidized mitochondrial DNA (ox-mtDNA) into the cytosol enhances the inflammatory response in healthy tissues via engagement with Toll-like receptor 9 (TLR9). Blocking the TLR9/ox-mtDNA axis may be a promising therapeutic strategy for MDS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ming Li, Qingmei Liu, Shan He, Xiangzhen Kong, Jinpei Lin, Yan Huang, Wenyu Wu, Jinfeng Wu
Summary: Icaritin (IT) can inhibit skin fibrosis by activating AMPK signaling and suppressing WNT/beta-catenin signaling pathways.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)