Article
Biochemistry & Molecular Biology
Federica Armeli, Beatrice Mengoni, Elisa Maggi, Cristina Mazzoni, Adele Preziosi, Patrizia Mancini, Rita Businaro, Thomas Lenz, Trevor Archer
Summary: Microglial cell polarization and gut microbial imbalance are associated with neurodegenerative diseases. The gut-brain axis is important, and probiotic treatment can reduce inflammation. Milmed yeast can reverse microglial cell polarization and promote anti-inflammatory response.
Article
Plant Sciences
Liu Yang, Xinyan Han, Faping Xing, Hui Wu, Hailian Shi, Fei Huang, Qi Xu, Xiaojun Wu
Summary: The study demonstrated that total flavonoids of Astragalus (TFA) could alleviate the severity of experimental autoimmune encephalomyelitis (EAE) in mice by inhibiting excessive activation of microglia. TFA may exert its anti-neuroinflammation effects through deactivating JNK/AKT/NFκB signaling pathways.
Article
Cell Biology
Jia Li, Shanshan Yu, Xi Lu, Kaixuan Cui, Xiaoyu Tang, Yue Xu, Xiaoling Liang
Summary: This study investigated the role and regulatory mechanism of M1/M2 microglia/macrophage in oxygen-induced retinopathy (OIR). The results showed that M1 microglia/macrophage were activated in neovascularization tufts in both central and peripheral retina during the early phase of OIR, while M2 phenotype took over during the late phase, leading to the regression of neovascular tufts.
INFLAMMATION RESEARCH
(2021)
Article
Nutrition & Dietetics
Cheng-Fang Tsai, Guan-Wei Chen, Yen-Chang Chen, Ching-Kai Shen, Dah-Yuu Lu, Liang-Yo Yang, Jia-Hong Chen, Wei-Lan Yeh
Summary: Macrophage polarization plays essential roles in various diseases, and the natural compound quercetin has been found to inhibit inflammation and enhance M2 macrophage polarization and antioxidant expression. These findings are important for the potential use of quercetin as a drug for the treatment of inflammatory disorders in the central nervous system.
Article
Cell Biology
Guang-Ping Lang, Can Li, Ying-Ying Han
Summary: Pretreatment with rutin can promote the phenotypic switch of microglia from M1 to M2 by inhibiting the Toll-like receptor 4/nuclear factor-κB signaling pathway to alleviate lipopolysaccharide-induced neuroinflammation.
NEURAL REGENERATION RESEARCH
(2021)
Review
Geriatrics & Gerontology
Shenrui Guo, Hui Wang, Yafu Yin
Summary: Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases, and microglia can be categorized into M1 and M2 types with opposite functions. Modulating microglia M1/M2 polarization shows promising therapeutic potential in neurodegenerative diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Toshio Okada, Eisuke Muto, Tsuyoshi Yamanaka, Hiroyuki Uchino, Masato Inazu
Summary: This study investigated the mechanism of choline uptake in microglia and its association with microglial M1/M2 polarization. The results suggest that inhibiting CTL1-mediated choline uptake can preferentially induce M2 microglia polarization, which has a potential therapeutic significance for inflammatory brain diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Haijian Wu, Jingwei Zheng, Shenbin Xu, Yuanjian Fang, Yingxi Wu, Jianxiong Zeng, Anwen Shao, Ligen Shi, Jianan Lu, Shuhao Mei, Xiaoyu Wang, Xinying Guo, Yirong Wang, Zhen Zhao, Jianmin Zhang
Summary: Mer plays an important role in regulating microglial/macrophage M1/M2 polarization and neuroinflammation following TBI, potentially serving as a therapeutic target for intervention. Activation of the STAT1/SOCS1/3 pathway by Mer contributes to its regulatory function in this process.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Guoqing Wang, Xingran Li, Na Li, Xiaotang Wang, Siyuan He, Wanqian Li, Wei Fan, Ruonan Li, Jiangyi Liu, Shengping Hou
Summary: Icariin (ICA) alleviates uveitis by modulating the phenotypic polarization of proinflammatory microglia into anti-inflammatory microglia. It binds to peroxiredoxin-3 (PRDX3) and increases PRDX3 protein expression, activating related pathways and reducing intraocular inflammation.
Review
Immunology
Salar Pashangzadeh, Morteza Motallebnezhad, Fatemeh Vafashoar, Azadeh Khalvandi, Nazanin Mojtabavi
Summary: miRNAs, especially miR-155, play crucial roles in immune system regulation, and their altered expression and function may contribute to vulnerability to autoimmune diseases and significant dysfunction of the immune system.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jiping Li, Xinping Dai, Liuyi Zhou, Xinxiu Li, Dongxiao Pan
Summary: This study demonstrates that Edaravone (EDA) can improve neurobehavioral functions and alleviate neuroinflammation in a rat model of Parkinson's disease by inhibiting NLRP3 inflammasome activation and regulating microglia M1/M2 polarization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Ping Zhao, Xin Chen, Xudong Han, Yanping Wang, Yu Shi, Jiayu Ji, Yanting Lei, Ying Liu, Qingfei Kong, Lili Mu, Jinghua Wang, Wei Zhao, Guangyou Wang, Xijun Liu, Tongshuai Zhang, Yao Zhang, Bo Sun, Yumei Liu, Hulun Li
Summary: Electroacupuncture (EA) treatment can alleviate clinical symptoms of EAE, reduce spinal cord demyelination, regulate inflammatory cytokine levels, and modulate miR-155 and POMC expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Xiao-Long Wang, Fei Chen, Hui Shi, Man Zhang, Lin Yan, Xiu-Ying Pei, Xiao-Dong Peng
Summary: The study revealed that OMT can regulate the polarization of microglia towards the M2 phenotype by inhibiting the TLR4/NF-Kappa B signaling pathway, effectively attenuating the LPS-induced inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Dongying Yan, Liang Gao, Jing Lang, Xianhui Gao, Honglin Ma
Summary: Excessive exposure to manganese can lead to neurological diseases characterized by behavioral and motor impairments. Microglia-mediated neuroinflammation plays a key role in the pathogenesis of neurodegenerative diseases. SIRT1, PGC-1 alpha, NF-kappa B, and STAT3 are important factors in the regulation of neuroinflammatory responses and microglial polarization in mice exposed to manganese.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shishi Shen, Xi Cheng, Luyao Zhou, Yipeng Zhao, Hai Wang, Jie Zhang, Xiaobo Sun, Yuge Wang, Yaqing Shu, Yanteng Xu, Yu Tao, Mingqiang Li, Zhengqi Lu, Wei Cai, Guangjun Nie, Wei Qiu
Summary: This study developed neutrophil-derived nanovesicles (NNVs) to enhance the efficiency of myelin debris clearance in microglia for multiple sclerosis (MS) therapy. The results showed that NNVs treatment ameliorated lesional neuroinflammation and improved neurological functions and white matter integrity in a mouse model of MS. Additionally, NNVs treatment upregulated the expression of NRF2 in microglia and activated the transcription of RUBCN, leading to enhanced phagocytosis of myelin debris.