Astragaloside IV Alleviates Cerebral Ischemia-Reperfusion Injury through NLRP3 Inflammasome-Mediated Pyroptosis Inhibition via Activating Nrf2

Receptors, Channel Proteins, and Enzymes Involved in Microglia-mediated Neuroinflammation and Treatments by Targeting Microglia in Ischemic Stroke

(2021) Kun Hou et al.   NEUROSCIENCE

Protective effects of Astragaloside IV against oxidative injury and apoptosis in cultured astrocytes by regulating Nrf2/JNK signaling

(2021) Jintao Yang et al.   EXPERIMENTAL BRAIN RESEARCH

Effect of the combination of astragaloside IV and Panax notoginseng saponins on pyroptosis and necroptosis in rat models of cerebral ischemia‑reperfusion

(2021) Biao Tang et al.   Experimental and Therapeutic Medicine

The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging

(2020) Allison K. Meyers et al.   Cells

Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation

(2020) Zijian Yan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Andrade-Oliveira Salvianolic Acid B Modulates Caspase-1–Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via Nrf2 Pathway

(2020) Yu Pang et al.   Frontiers in Pharmacology

Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro

(2019) Dongping Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Chlorpyrifos activates cell pyroptosis and increases susceptibility on oxidative stress-induced toxicity by miR-181/SIRT1/PGC-1α/Nrf2 signaling pathway in human neuroblastoma SH-SY5Y cells: Implication for association between chlorpyrifos and Parkinson's

(2019) Meng-Wen Zhao et al.   ENVIRONMENTAL TOXICOLOGY

Inflammasomes in neuroinflammatory and neurodegenerative diseases

(2019) Sofie Voet et al.   EMBO Molecular Medicine

The Role of Astragaloside IV against Cerebral Ischemia/Reperfusion Injury: Suppression of Apoptosis via Promotion of P62-LC3-Autophagy

(2019) Yi Zhang et al.   MOLECULES

Astragaloside IV Protects Primary Cerebral Cortical Neurons from Oxygen and Glucose Deprivation/Reoxygenation by Activating the PKA/CREB Pathway

(2019) Bingjie Xue et al.   NEUROSCIENCE

Astragaloside IV ameliorates motor deficits and dopaminergic neuron degeneration via inhibiting neuroinflammation and oxidative stress in a Parkinson's disease mouse model

(2019) Cong Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Astragaloside IV Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the Janus Kinase 2 and Signal Transducer and Activator of Transcription 3 Signaling Pathway

(2019) ZhengHu Xu et al.   PHARMACOLOGY

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury

(2018) Yanghao Hou et al.   BEHAVIOURAL BRAIN RESEARCH

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

(2018) Meng-Yu Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Canonical and non-canonical mechanisms of Nrf2 activation

(2018) Carlos Alfredo Silva-Islas et al.   PHARMACOLOGICAL RESEARCH

The Possibility and Molecular Mechanisms of Cell Pyroptosis After Cerebral Ischemia

(2018) Zhaofei Dong et al.   Neuroscience Bulletin

Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion

(2017) Xiujian Xu et al.   INFLAMMATION RESEARCH

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke

(2017) David Yang-Wei Fann et al.   MOLECULAR NEUROBIOLOGY

Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms

(2017) Min Li et al.   NEUROSCIENCE LETTERS

Astragaloside IV for Experimental Focal Cerebral Ischemia: Preclinical Evidence and Possible Mechanisms

(2017) Hui-Lin Wang et al.   Oxidative Medicine and Cellular Longevity

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

(2016) Anju Singh et al.   ACS Chemical Biology

Research review on the pharmacological effects of astragaloside IV

(2016) Lei Li et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

NLRP3 inflammasome: a promising target in ischemic stroke

(2016) Li Gao et al.   INFLAMMATION RESEARCH

NOD-Like Receptors in Infection, Immunity, and Diseases

(2016) Young Keun Kim et al.   YONSEI MEDICAL JOURNAL

EGFR mediates astragaloside IV-induced Nrf2 activation to protect cortical neurons against in vitro ischemia/reperfusion damages

(2015) Da-min Gu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Acute Ischemic Stroke

(2014) Nathan W. Manning et al.   STROKE

NRF2-regulation in brain health and disease: Implication of cerebral inflammation

(2013) Mats Sandberg et al.   NEUROPHARMACOLOGY

Ischemia and reperfusion—from mechanism to translation

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