Research review on the pharmacological effects of astragaloside IV

Improved cardiac function after sarcoplasmic reticulum Ca2+-ATPase gene transfer in a heart failure model induced by chronic myocardial ischaemia

(2017) Wei Xin et al.   ACTA CARDIOLOGICA

Combination of total Astragalus extract and total Panax notoginseng saponins strengthened the protective effects on brain damage through improving energy metabolism and inhibiting apoptosis after cerebral ischemia-reperfusion in mice

(2015) Xiao-ping Huang et al.   Chinese Journal of Integrative Medicine

Enrichment and purification process of astragalosides and their anti-human gastric cancer MKN-74 cell proliferation effect

(2014) Yang OuYang et al.   African Health Sciences

Astragaloside IV possesses antiarthritic effect by preventing interleukin 1β-induced joint inflammation and cartilage damage

(2014) Bin Wang et al.   ARCHIVES OF PHARMACAL RESEARCH

Simultaneous determination of calycosin-7-O-β-d-glucoside, calycosin, formononetin, astragaloside IV and schisandrin in rat plasma by LC-MS/MS: application to a pharmacokinetic study after oral administration of Shenqi Wuwei chewable tablets

(2014) Xuehui Sun et al.   BIOMEDICAL CHROMATOGRAPHY

Simultaneous Determination of Calycosin-7-O-β-d-Glucoside, Ononin, Calycosin, Formononetin, Astragaloside IV, and Astragaloside II in Rat Plasma After Oral Administration of Radix Astragali Extraction for Their Pharmacokinetic Studies by Ultra-Pressure Liquid Chromatography with Tandem Mass Spectrometry

(2014) Xiao-hua Liu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Astragaloside IV Inhibits the Up-Regulation of Wnt/β-Catenin Signaling in Rats with Unilateral Ureteral Obstruction

(2014) Li Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Down-Regulation of PERK-ATF4-CHOP Pathway by Astragaloside IV is Associated with the Inhibition of Endoplasmic Reticulum Stress-Induced Podocyte Apoptosis in Diabetic Rats

(2014) Yifang Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Astragaloside IV Inhibits Doxorubicin-Induced Cardiomyocyte Apoptosis Mediated by Mitochondrial Apoptotic Pathway via Activating the PI3K/Akt Pathway

(2014) Yuanyuan Jia et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Astragaloside IV ameliorates diabetic nephropathy involving protection of podocytes in streptozotocin induced diabetic rats

(2014) Jianguo Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Astragaloside IV inhibits renal tubulointerstitial fibrosis by blocking TGF-β/Smad signaling pathway in vivo and in vitro

(2014) Li Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Astragaloside IV attenuates allergic inflammation by regulation Th1/Th2 cytokine and enhancement CD4+CD25+Foxp3 T cells in ovalbumin-induced asthma

(2014) Xianfeng Huang et al.   IMMUNOBIOLOGY

Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-α-ERK1/2-NF-κB pathway

(2014) Xudong Cheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Astragaloside IV Alleviates Early Brain Injury Following Experimental Subarachnoid Hemorrhage in Rats

(2014) Anwen Shao et al.   International Journal of Medical Sciences

Astragaloside IV inhibits progression of lung cancer by mediating immune function of Tregs and CTLs by interfering with IDO

(2014) Anle Zhang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Huangqi−Honghua combination and its main components ameliorate cerebral infarction with Qi deficiency and blood stasis syndrome by antioxidant action in rats

(2014) Jinyi Cao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-stress effect of astragaloside IV in immobilized mice

(2014) Hyun-A. Oh et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management

(2014) Fanny C.F. Ip et al.   NEUROSIGNALS

Effects of Astragaloside IV combined with the active components of Panax notoginseng on oxidative stress injury and nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 signaling pathway after cerebral ischemia-reperfusion in mice

(2014) Chang-Qing Deng et al.   Pharmacognosy Magazine

Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/Fas L-Mediated Apoptotic Signaling

(2014) Mi Hye Kim et al.   PLoS One

Protective Effects of Astragaloside IV against Amyloid Beta1-42 Neurotoxicity by Inhibiting the Mitochondrial Permeability Transition Pore Opening

(2014) Qinru Sun et al.   PLoS One

HIF-1α Signaling Activation by Post-Ischemia Treatment with Astragaloside IV Attenuates Myocardial Ischemia-Reperfusion Injury

(2014) Jingwen Si et al.   PLoS One

Astragalosides IV inhibits high glucose-induced cell apoptosis through HGF activation in cultured human tubular epithelial cells

(2014) Qin Wang et al.   RENAL FAILURE

Ferulic acid combined with astragaloside IV protects against vascular endothelial dysfunction in diabetic rats

(2014) Yonghui Yin et al.   BioScience Trends

Chinese herbs and their active ingredients for activating xue (blood) promote the proliferation and differentiation of neural stem cells and mesenchymal stem cells

(2014) Yin-chu Si et al.   Chinese Medicine

Genetic and Pharmacological Inhibition of Rheb1-mTORC1 Signaling Exerts Cardioprotection against Adverse Cardiac Remodeling in Mice

(2013) Xiangqi Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Astragaloside IV prevents acute kidney injury in two rodent models by inhibiting oxidative stress and apoptosis pathways

(2013) Dingkun Gui et al.   APOPTOSIS

Effects of Astragaloside IV on Action Potentials and Ionic Currents in Guinea-Pig Ventricular Myocytes

(2013) Meimi Zhao et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Astragaloside IV attenuates glycated albumin-induced epithelial-to-mesenchymal transition by inhibiting oxidative stress in renal proximal tubular cells

(2013) Weiwei Qi et al.   CELL STRESS & CHAPERONES

Astragaloside IV ameliorates renal injury in streptozotocin-induced diabetic rats through inhibiting NF-κB-mediated inflammatory genes expression

(2013) Dingkun Gui et al.   CYTOKINE

Astragaloside IV reduces cerebral edema post-ischemia/reperfusion correlating the suppression of MMP-9 and AQP4

(2013) Min Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Preventive Effects of a Natural Anti-Inflammatory Agent, Astragaloside IV, on Ischemic Acute Kidney Injury in Rats

(2013) Shufeng Tan et al.   Evidence-based Complementary and Alternative Medicine

Astragaloside IV suppresses collagen production of activated hepatic stellate cells via oxidative stress-mediated p38 MAPK pathway

(2013) Xiaoming Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antihepatitis B therapy: a review of current medications and novel small molecule inhibitors

(2013) Li-Peng Qiu et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Astragaloside IV-loaded nanoparticle-enriched hydrogel induces wound healing and anti-scar activity through topical delivery

(2013) Xi Chen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Astragaloside IV attenuates inflammatory cytokines by inhibiting TLR4/NF-кB signaling pathway in isoproterenol-induced myocardial hypertrophy

(2013) Juan Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-Inflammatory Cycloartane-Type Saponins of Astragalus membranaceus

(2013) Dae-Young Lee et al.   MOLECULES

Astragaloside IV Stimulates Angiogenesis and Increases Nitric Oxide Accumulation via JAK2/STAT3 and ERK1/2 Pathway

(2013) Shi-Guang Wang et al.   MOLECULES

Astragaloside IV Attenuates Experimental Autoimmune Encephalomyelitis of Mice by Counteracting Oxidative Stress at Multiple Levels

(2013) Yixin He et al.   PLoS One

Astragaloside IV inhibits apoptotic cell death in the guinea pig cochlea exposed to impulse noise

(2012) Min Xiong et al.   ACTA OTO-LARYNGOLOGICA

Astragalus Extract Alleviates Nerve Injury after Cerebral Ischemia by Improving Energy Metabolism and Inhibiting Apoptosis

(2012) Xiao-Ping Huang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Topical Astragaloside IV-Releasing Hydrogel Improves Healing of Skin Wounds in Vivo

(2012) Li-Hua Peng et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Cardioprotection during cardiac surgery

(2012) D. J. Hausenloy et al.   CARDIOVASCULAR RESEARCH

Pharmacokinetic Evidence on the Contribution of Intestinal Bacterial Conversion to Beneficial Effects of Astragaloside IV, a Marker Compound of Astragali Radix, in Traditional Oral Use of the Herb

(2012) Rui-Na Zhou et al.   Drug Metabolism and Pharmacokinetics

The effect of Astragaloside IV on immune function of regulatory T cell mediated by high mobility group box 1 protein in vitro

(2012) Li-feng Huang et al.   FITOTERAPIA

Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-κB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells

(2012) Chang-Liang He et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

The experimental study of Astragalus membranaceus on meridian tropsim: The distribution study of astragaloside IV in rat tissues

(2012) Yan-xu chang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Astragaloside IV inhibited the activity of CYP1A2 in liver microsomes and influenced theophylline pharmacokinetics in rats

(2012) Yan-Hui Zhang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

NADPH-Oxidase 4 Protects against Kidney Fibrosis during Chronic Renal Injury

(2012) S. Nlandu Khodo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Astragaloside IV prevents MPP+-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production

(2012) Zhi-guo Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Astragaloside IV Inhibits Oxidative Stress-Induced Mitochondrial Permeability Transition Pore Opening by Inactivating GSK-3βvia Nitric Oxide in H9c2 Cardiac Cells

(2012) Yonggui He et al.   Oxidative Medicine and Cellular Longevity

Astragaloside IV Alleviates Hypoxia/Reoxygenation-Induced Neonatal Rat Cardiomyocyte Injury via the Protein Kinase A Pathway

(2012) Da-Wei Zhang et al.   PHARMACOLOGY

Isolation of Anti-Inflammatory Fractions and Compounds from the Root ofAstragalus membranaceus

(2012) Patrick Kwok-Kin Lai et al.   PHYTOTHERAPY RESEARCH

Astragaloside IV, a Novel Antioxidant, Prevents Glucose-Induced Podocyte Apoptosis In Vitro and In Vivo

(2012) Dingkun Gui et al.   PLoS One

Astragaloside IV attenuates impulse noise-induced trauma in guinea pig

(2011) Min Xiong et al.   ACTA OTO-LARYNGOLOGICA

Protective effect of astragaloside IV against matrix metalloproteinase-1 expression in ultraviolet-irradiated human dermal fibroblasts

(2011) Bo Yang et al.   ARCHIVES OF PHARMACAL RESEARCH

Astragaloside IV synergizes with ferulic acid to inhibit renal tubulointerstitial fibrosis in rats with obstructive nephropathy

(2011) LQ Meng et al.   BRITISH JOURNAL OF PHARMACOLOGY

The toll-like receptor 4-antagonist eritoran reduces murine cardiac hypertrophy

(2011) Heidi Ehrentraut et al.   EUROPEAN JOURNAL OF HEART FAILURE

Astragaloside IV attenuates myocardial fibrosis by inhibiting TGF-β1 signaling in coxsackievirus B3-induced cardiomyopathy

(2011) Ping Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of Encapsulated Propolis on Blood Glycemic Control, Lipid Metabolism, and Insulin Resistance in Type 2 Diabetes Mellitus Rats

(2011) Yajing Li et al.   Evidence-based Complementary and Alternative Medicine

NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis

(2011) Chamutal Gur et al.   GUT

In vitro growth stimulatory and in vivo wound healing studies on cycloartane-type saponins of Astragalus genus

(2011) Canan Sevimli-Gür et al.   JOURNAL OF ETHNOPHARMACOLOGY

Synergistic protective effect of astragaloside IV–tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia

(2011) Jiehong Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

The healing and anti-scar effects of astragaloside IV on the wound repair in vitro and in vivo

(2011) Xi Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Astragaloside IV Stimulates Angiogenesis and Increases Hypoxia-Inducible Factor-1  Accumulation via Phosphatidylinositol 3-Kinase/Akt Pathway

(2011) L. Zhang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Roles of microRNA-29a in the Antifibrotic Effect of Farnesoid X Receptor in Hepatic Stellate Cells

(2011) J. Li et al.   MOLECULAR PHARMACOLOGY

Astragaloside IV Improves Metabolic Syndrome and Endothelium Dysfunction in Fructose-Fed Rats

(2011) Ning Zhang et al.   MOLECULES

Astragaloside IV Attenuates Complement Membranous Attack Complex Induced Podocyte Injury Through the MAPK Pathway

(2011) Rong Zheng et al.   PHYTOTHERAPY RESEARCH

Astragaloside IV and Cycloastragenol Stimulate the Phosphorylation of Extracellular Signal-Regulated Protein Kinase in Multiple Cell Types

(2011) Lisa Yung et al.   PLANTA MEDICA

Astragaloside IV Protects Against Ischemia Reperfusion in a Murine Model of Orthotopic Liver Transplantation

(2011) M.-X. Cheng et al.   TRANSPLANTATION PROCEEDINGS

Disruption of Hypoxia-Inducible Transcription Factor-Prolyl Hydroxylase Domain-1 (PHD-1−/−) Attenuates Ex Vivo Myocardial Ischemia/Reperfusion Injury Through Hypoxia-Inducible Factor-1α Transcription Factor and Its Target Genes in Mice

(2010) Ram Sudheer Adluri et al.   ANTIOXIDANTS & REDOX SIGNALING

Astragaloside IV Improves Homocysteine-Induced Acute Phase Endothelial Dysfunction via Antioxidation

(2010) Li-Hong Qiu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator

(2010) Jing Zhu et al.   Drug Metabolism and Pharmacokinetics

Effect of Astragaloside IV on the General and Peripartum Reproductive Toxicity in Sprague-Dawley Rats

(2010) Wan Xuying et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mechanisms of Tubulointerstitial Fibrosis

(2010) M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Astragaloside IV inhibits spontaneous synaptic transmission and synchronized Ca2+ oscillations on hippocampal neurons

(2009) Shao-qing Zhu et al.   ACTA PHARMACOLOGICA SINICA

Morphine prevents the mitochondrial permeability transition pore opening through NO/cGMP/PKG/Zn2+/GSK-3β signal pathway in cardiomyocytes

(2009) Jinkun Xi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

TGF-β and fibrosis in different organs — molecular pathway imprints

(2009) Dirk Pohlers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Anti-hepatitis B Virus Activities of Astragaloside IV Isolated from Radix Astragali

(2009) Shuguang Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

ASTRAGALOSIDE IV ATTENUATES HYPOXIA-INDUCED CARDIOMYOCYTE DAMAGE IN RATS BY UPREGULATING SUPEROXIDE DISMUTASE-1 LEVELS

(2009) Jiong-Yu Hu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The complexity of neurobiological processes in acute ischemic stroke

(2009) R. Brouns et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Astragaloside IV attenuates cerebral ischemia–reperfusion-induced increase in permeability of the blood-brain barrier in rats

(2009) You Zhi Qu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of astragaloside IV on the embryo-fetal development of Sprague-Dawley rats and New Zealand White rabbits

(2009) Zhu Jiangbo et al.   JOURNAL OF APPLIED TOXICOLOGY

Protective effects of astragaloside IV on porcine-serum-induced hepatic fibrosis in rats and in vitro effects on hepatic stellate cells

(2009) Hao Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Mesangial Cell Revisited: No Cell Is an Island

(2009) D. Schlondorff et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis

(2009) Y. Liu   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Alzheimer's disease: a global challenge for the 21st century

(2009) Jean François Dartigues   LANCET NEUROLOGY

Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture

(2009) Wing-Sai Chan et al.   NEUROCHEMISTRY INTERNATIONAL

Repeated electroacupuncture preconditioning attenuates matrix metalloproteinase-9 expression and activity after focal cerebral ischemia in rats

(2009) Hui Dong et al.   NEUROLOGICAL RESEARCH

Effects of Astragaloside IV on heart failure in rats

(2009) Zhuanyou Zhao et al.   Chinese Medicine

The Changing Face of Neural Stem Cell Therapy in Neurologic Diseases

(2008) Ofira Einstein et al.   ARCHIVES OF NEUROLOGY

Astragaloside IV improves high glucose-induced podocyte adhesion dysfunction via α3β1 integrin upregulation and integrin-linked kinase inhibition

(2008) Jianguo Chen et al.   BIOCHEMICAL PHARMACOLOGY

Inhibitory effects of astragaloside IV on ovalbumin-induced chronic experimental asthma

(2008) Qiang Du et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Inflammatory Pathways Are Activated during Cardiomyocyte Hypertrophy and Attenuated by Peroxisome Proliferator-activated Receptors PPARα and PPARδ

(2008) Pascal J. H. Smeets et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological Roles for the NOX Family NADPH Oxidases

(2008) William M. Nauseef   JOURNAL OF BIOLOGICAL CHEMISTRY

Qualitative and quantitative analysis of Radix Astragali products by fast high-performance liquid chromatography-diode array detection coupled with time-of-flight mass spectrometry through dynamic adjustment of fragmentor voltage

(2008) Lian-Wen Qi et al.   JOURNAL OF CHROMATOGRAPHY A

Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia

(2008) Wenlan Liu et al.   JOURNAL OF NEUROCHEMISTRY

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Astragaloside IV Improved Intracellular Calcium Handling in Hypoxia-Reoxygenated Cardiomyocytes via the Sarcoplasmic Reticulum Ca2+-ATPase

(2008) Xiao-Le Xu et al.   PHARMACOLOGY

Astragaloside IV Inhibits Proliferation and Promotes Apoptosis in Rat Vascular Smooth Muscle Cells under High Glucose Concentrationin vitro

(2008) Wei Yuan et al.   PLANTA MEDICA

Adiponectin Prevents Cerebral Ischemic Injury Through Endothelial Nitric Oxide Synthase–Dependent Mechanisms

(2007) Masaki Nishimura et al.   CIRCULATION

STAT3: A critical transcription activator in angiogenesis

(2007) Zhong Chen et al.   MEDICINAL RESEARCH REVIEWS