Phase-Transfer-Catalyzed Asymmetric Annulations of Alkyl Dihalides with Oxindoles: Unified Access to Chiral Spirocarbocyclic Oxindoles

A Unified Catalytic Asymmetric (4+1) and (5+1) Annulation Strategy to Access Chiral Spirooxindole‐Fused Oxacycles

(2021) Min Gao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phase-Transfer Catalyzed Asymmetric [4 + 1] Annulations for the Synthesis of Chiral 2,2-Disubstituted Tetrahydrothiophenes

(2021) Qi Yin et al.   ORGANIC LETTERS

Ubrogepant: First Approval

(2020) Lesley J. Scott   DRUGS

An overview of spirooxindole as a promising scaffold for novel drug discovery

(2020) Li-Ming Zhou et al.   Expert Opinion on Drug Discovery

Catalytic Enantioselective Construction of Spiro Quaternary Carbon Stereocenters

(2019) Peng-Wei Xu et al.   ACS Catalysis

Asymmetric Organocatalytic [4 + 1] Annulations: Enantioselective Construction of Multifunctionalized Spirocyclopentane Oxindoles Bearing α,α-Disubstituted α-Amino-β-keto Esters

(2018) Chuan-Chuan Wang et al.   ORGANIC LETTERS

On the Origin of and a Solution for Uneven Efficiency by Cinchona Alkaloid-Derived, Pseudoenantiomeric Catalysts for Asymmetric Reactions

(2018) Bin Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spirooxindoles as Potential Pharmacophores

(2017) Siva S. Panda et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Practical Asymmetric Synthesis of a Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist Ubrogepant

(2017) Nobuyoshi Yasuda et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Catalyst-Controlled Switch in Chemo- and Diastereoselectivities: Annulations of Morita-Baylis-Hillman Carbonates from Isatins

(2016) Gu Zhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Therapeutic Potential of Spirooxindoles as Antiviral Agents

(2016) Na Ye et al.   ACS Infectious Diseases

Formal [4+1] Annulation Reactions in the Synthesis of Carbocyclic and Heterocyclic Systems

(2015) Jia-Rong Chen et al.   CHEMICAL REVIEWS

Contemporary Asymmetric Phase Transfer Catalysis: Large-Scale Industrial Applications

(2015) Jiajing Tan et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Highly diastereo- and enantioselective construction of a spiro[cyclopenta[b]indole-1,3′-oxindole] scaffold via catalytic asymmetric formal [3+2] cycloadditions

(2014) Wei Tan et al.   CHEMICAL COMMUNICATIONS

Synthesis and antitumor activity of a new 7-azaindole derivative

(2014) Peng Zhang et al.   CHEMICAL RESEARCH IN CHINESE UNIVERSITIES

Stereoselective cyclization reactions under phase-transfer catalysis

(2014) Richard Herchl et al.   TETRAHEDRON

Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies

(2014) Daojuan Cheng et al.   ACS Catalysis

Recent Developments in Asymmetric Phase-Transfer Reactions

(2013) Seiji Shirakawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Six-Membered Spirocyclic Oxindoles with Five Consecutive Stereocenters in an Asymmetric Organocatalytic One-Pot Michael/Michael/Aldol Addition Sequence

(2013) Bing Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly enantioselective [4 + 2] annulations catalyzed by amino acid-based phosphines: Synthesis of functionalized cyclohexenes and 3-spirocyclohexene-2-oxindoles

(2012) Fangrui Zhong et al.   Chemical Science

Highly Enantioselective [3+2] Annulation of Morita-Baylis-Hillman Adducts Mediated by L-Threonine-Derived Phosphines: Synthesis of 3-Spirocyclopentene-2-oxindoles having Two Contiguous Quaternary Centers

(2011) Fangrui Zhong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A highly organocatalytic stereoselective double Michael reaction: efficient construction of optically enriched spirocyclic oxindoles

(2011) Liang-Liang Wang et al.   CHEMICAL COMMUNICATIONS

Asymmetric Organocatalytic Cyclization and Cycloaddition Reactions

(2011) Albert Moyano et al.   CHEMICAL REVIEWS

Core-Structure-Motivated Design of a Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles

(2011) Bin Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trienamines in Asymmetric Organocatalysis: Diels−Alder and Tandem Reactions

(2011) Zhi-Jun Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic synthesis of spiro compounds via a cascade Michael–Michael-aldol reaction

(2010) Xavier Companyó et al.   CHEMICAL COMMUNICATIONS

Organocatalytic Tandem Reaction to Construct Six-Membered Spirocyclic Oxindoles with Multiple Chiral Centres through a Formal [2+2+2] Annulation

(2010) Kun Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Organocatalytic [3+2] Cyclisation Strategy for the Highly Enantioselective Synthesis of Spirooxindoles

(2010) Arnaud Voituriez et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organocatalytic Asymmetric Formal [4 + 2] Cycloaddition for the Synthesis of Spiro[4-cyclohexanone-1,3′-oxindoline] Derivatives in High Optical Purity

(2010) Qiang Wei et al.   ORGANIC LETTERS

Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

(2009) Giorgio Bencivenni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION