Article
Medicine, General & Internal
Shane Sakamaki-Ching, Suzaynn Schick, Gabriela Grigorean, Jun Li, Prue Talbot
Summary: The study found that acute dermal exposure to THS can alter the human plasma proteome, initiate mechanisms of skin inflammatory disease, and elevate urinary biomarkers of oxidative harm.
Article
Biochemistry & Molecular Biology
Kun Zhang, Miao-Yu Guo, Qiu-Gen Li, Xiao-Hua Wang, Yu-Ying Wan, Zhang-Jian Yang, Min He, Yun-Min Yi, Li-Ping Jiang, Xin-Hui Qu, Xiao-Jian Han
Summary: The study revealed that the expression and phosphorylation of mitochondrial fission protein Drp1 increased after corneal alkali burn, while mitochondrial fusion protein Mfn2 was down-regulated. Treatment with Drp1 inhibitor Mdivi-1 prevented NaOH-induced mitochondrial fission, reducing oxidative stress, inflammatory responses, and corneal neovascularization after the injury. Additionally, targeting Drp1-dependent mitochondrial fission may offer a novel therapeutic strategy for corneal injury post alkali burn.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Virology
Jiahui He, Yukun Zhang, Zezhong Hu, Luxuan Zhang, Guanming Shao, Zi Xie, Yu Nie, Wenxue Li, Yajuan Li, Liyi Chen, Benli Huang, Fengsheng Chu, Keyu Feng, Wencheng Lin, Hongxin Li, Weiguo Chen, Xinheng Zhang, Qingmei Xie
Summary: This study found that infection with recombinant Muscovy duck parvovirus (rMDPV) can lead to early intestinal barrier dysfunction, inflammation, disturbance of ileal microbiota, and oxidative stress.
Article
Biochemistry & Molecular Biology
Ji-Eun Bae, Daejin Min, Ji Yeon Choi, Hyunjung Choi, Joon Bum Kim, Na Yeon Park, Doo Sin Jo, Yong Hwan Kim, Hye-Won Na, Yoon Jae Kim, Eun Sung Kim, Hyoung-June Kim, Dong-Hyung Cho
Summary: 2-Isopropylmalic acid (2-IPMA) promotes primary ciliogenesis in dermal fibroblasts, ameliorating PM2.5-induced inflammation. Additionally, 2-IPMA inhibits oxidative stress and inflammatory response caused by PM2.5.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Yoonhee So, DaBin Yim, Wooic Son, Hyunji Lee, Sin Lee, Chanhee Choi, Chul Su Yang, Jong-Ho Kim
Summary: This study developed antioxidative and anti-inflammatory 2H-WS2 nanosheets as a biocompatible topical antipyrotic for deep burn wounds. The nanosheets effectively suppressed oxidative stress, inflammation, and apoptosis in human keratinocytes, while enhancing the intrinsic defense systems of skin cells. In animal experiments, the nanosheets showed higher efficacy in wound healing compared to commercial silver sulfadiazine. The therapeutic mechanism of the nanosheets was found to be distinct from that of silver sulfadiazine and showed potential for the treatment of other oxidative stress-induced and inflammatory diseases.
APPLIED MATERIALS TODAY
(2022)
Article
Medicine, Research & Experimental
Peng Guo, Nan Zhang, Juan Li, Yang Liu, Yi Li, Xuedong Wang, Jingyu Wang, Yupeng Wang, Aiguo Wang
Summary: The application of LTP in medical treatment for cisplatin-induced nephrotoxicity has shown significant protective effects, improving clinical, physiological, and pathological indicators while maintaining the anticancer effect of cisplatin and demonstrating biological safety in normal rats.
Article
Immunology
Yu-Hsien Chang, Chung-Hsi Hsing, Chiao-Juno Chiu, Yi-Rou Wu, Sheng-Min Hsu, Yu-Hsiang Hsu
Summary: This study found a protective effect of IL-17A in a laser-induced CNV mouse model and revealed a novel regulatory role of IL-17A-producing gamma delta T cells in the ocular microenvironment in wet AMD.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Physiology
Melissa E. Heard-Lipsmeyer, Iad Alhallak, Frank A. Simmen, Stepan B. Melnyk, Rosalia C. M. Simmen
Summary: Endometriosis is a chronic gynecologic disorder affected by genetic and environmental factors. Research suggests that a high-fat diet may reduce lesion incidence and numbers, but the effect varies depending on lesion genotype. These findings could be significant in providing nutritional guidelines for women with or predisposed to endometriosis.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biology
Yang Zhao, Junhao Liu, Zhao Ding, Wenhao Ge, Shiming Wang, Jianfa Zhang
Summary: ATP-induced hypothermia significantly improves burn depth progression, reduces collagen degradation, alleviates burn-induced hyperinflammatory responses and oxidative stress. It also relieves nociceptive and inflammatory pain caused by burn injury.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Medicine, General & Internal
Ewa Dudzinska, Kinga Szymona, Jacek Bogucki, Wojciech Koch, Ewelina Cholewinska, Robert Sitarz, Katarzyna Ognik
Summary: The study found that oxidative stress markers in the plasma of patients with schizophrenia were elevated, indicating lipid damage and decreased antioxidant capacity. In addition, there was a positive correlation between CRP and the PANSS P scale.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Aya E. Mohamed, Ayman M. Mahmoud, Wafaa R. Mohamed, Tarek Mohamed
Summary: This study aimed to investigate the therapeutic potential and underlying mechanism of low-level laser therapy (LLLT) for liver fibrosis in rats. The results showed that LLLT attenuated CCl4-induced liver fibrosis by suppressing extracellular matrix (ECM) production and deposition, reducing oxidative injury and inflammation, and upregulating PPAR gamma and Nrf2/HO-1 signaling.
Article
Biochemistry & Molecular Biology
Ting Luo, Xiaoyu Wang, Yuanxiang Jin
Summary: This study found that low concentrations of IMI exposure induced gut toxicity in adult zebrafish, leading to tissue damage, oxidative stress, inflammation, and alterations in gut microbiota.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Matthew C. Babcock, Lyndsey E. DuBose, Teresa L. Witten, Brian L. Stauffer, Kerry L. Hildreth, Robert S. Schwartz, Wendy M. Kohrt, Kerrie L. Moreau
Summary: Low testosterone in middle-aged/older men is associated with age-associated endothelial dysfunction, potentially due to increased oxidative stress and inflammation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biotechnology & Applied Microbiology
Jing Jia, Yueping Wang, Ruijuan Huang, Fengxia Du, Xiaozhu Shen, Qiurong Yang, Juan Li
Summary: This study found that downregulating PDIA3 expression can alleviate oxidative stress, inflammation, and endothelial dysfunction in atherosclerosis. This discovery shows promise for future treatments of atherosclerosis.
Article
Biochemistry & Molecular Biology
Marika Cordaro, Angela Trovato Salinaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Roberto Crea, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Vittorio Calabrese
Summary: Traumatic brain injuries are a significant public health issue with long-term consequences such as cerebral atrophy and increased risk of dementia and Alzheimer's Disease. Hidrox (R) treatment has shown benefits in reducing TBI-induced neurodegeneration and improving cognitive function and memory impairment.
Article
Cell Biology
Leticia Ramos Dantas, Victoria Stadler Tasca Ribeiro, Leticia Kraft, Ricardo Aurino Pinho, Paula Hansen Suss, Franciane Thais Falcao Vasconcellos, Lucia de Noronha, Felipe Francisco Tuon
Summary: The decellularization of bovine bone is an effective method for repairing bone defects. The new protocol used in this study successfully removed bone marrow components and cell debris, while preserving the structure of collagen fibers and extracellular matrix. However, the decellularized bovine bone showed moderate toxicity.
CELL AND TISSUE BANKING
(2022)
Article
Engineering, Biomedical
Germano Duarte Porto, Daniela Pacheco dos Santos Haupenthal, Priscila Soares Souza, Gustavo de Bem Silveira, Renata Tiscoski Nesi, Paulo Emilio Feuser, Jonathann Correa Possato, Vanessa Moraes de Andrade, Ricardo Aurino Pinho, Paulo Cesar Lock Silveira
Summary: This study evaluated the therapeutic effects of gold nanoparticles on chronic obstructive pulmonary disease, showing significant effects in reducing oxidative stress and inflammation with different doses of GNPs. The highest dose showed the best anti-inflammatory effects, while the dose of 7.5 mg/L of GNPs demonstrated better efficacy in reducing DNA damage.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Environmental Sciences
Ana Paula Coelho Figueira Freire, Fabio Santos Lira, Ana Elisa von Ah Morano, Telmo Pereira, Manuel-Joao Coelho-E-Silva, Armando Caseiro, Diego Giulliano Destro Christofaro, Osmar Marchioto Junior, Gilson Pires Dorneles, Luciele Guerra Minuzzi, Ricardo Aurino Pinho, Bruna Spolador de Alencar Silva
Summary: COVID-19 can affect the autonomic nervous system and endothelial function, and its multiorgan effects may be caused by deregulations in the ANS. Investigating the differences in ANS response in overweight/obese and physically inactive individuals who had COVID-19 compared to those who did not is necessary.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
Aline L. Takejima, Julio C. Francisco, Rossana B. Simeoni, Lucia de Noronha, Luiz A. F. M. Garbers, Katia M. Foltz, Paulo A. B. Machado Junior, Isio C. Souza, Ricardo A. Pinho, Katherine A. T. Carvalho, Luiz C. Guarita-Souza
Summary: The application of stem cells and amniotic membrane can accelerate the initial healing phase of skin wounds, promoting the early formation of collagen and elastic fibers to facilitate tissue repair.
Article
Neurosciences
Amanda Della Giustina, Judite Filgueiras Rodrigues, Erick Bagio, Sandra Bonfante, Larissa Joaquim, Graciela Zarbato, Solange Stork, Richard Simon Machado, Mariana Pereira de Souza Goldim, Lucineia Gainski Danielski, Khiany Mathias, Carlos Dacoregio, Taise Cardoso, Giulia S. Predroso, Ligia Milanez Venturini, Rubya Pereira Zaccaron, Paulo Cesar Lock Silveira, Ricardo Aurino Pinho, Fabricia Petronilho
Summary: Sepsis is a life-threatening condition caused by a dysregulated response to infection, which leads to organ dysfunction. Inflammation and oxidative stress play major roles in the damage to the lungs and brain in sepsis. A physical exercise program has protective effects against inflammation and oxidative stress in the lungs and brain of septic rats.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Pauline S. Effting, Anand Thirupathi, Alexandre P. Muller, Barbara C. Pereira, Diane M. Sepa-Kishi, Luis F. B. Marqueze, Franciane T. F. Vasconcellos, Renata T. Nesi, Talita C. B. Pereira, Luiza W. Kist, Mauricio R. Bogo, Rolando B. Ceddia, Ricardo A. Pinho
Summary: This study found that ladder climbing, as a model of resistance exercise, can reverse the metabolic and inflammatory effects of high-fat diet-induced obesity in mice. The training reduced body weight, adipocyte size, improved glycemic control, and reduced inflammation in skeletal muscles.
Editorial Material
Physiology
Anand Thirupathi, Yaodong Gu, Huw David Wiltshire, Ricardo A. Pinho
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dora Aczel, Bernadett Gyorgy, Peter Bakonyi, RehAn BukhAri, Ricardo Pinho, Istvan Boldogh, Gu Yaodong, Zsolt Radak
Summary: Alzheimer's disease is a complex disorder that affects not only the brain but also other organs in the body. Regular physical activity has been found to have a positive impact on the disease, although effective medications have not yet been discovered.
Review
Immunology
Ricardo A. Pinho, Daniela P. S. Haupenthal, Paulo Emilio Fauser, Anand Thirupathi, Paulo C. L. Silveira
Summary: Gold nanoparticles (AuNPs) have anti-inflammatory and antioxidant properties, and can be used to control muscle inflammatory response and promote muscle regeneration. This review summarizes the effects of AuNPs on muscle inflammation and redox mechanisms by synthesizing the results of multiple studies.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Amanda K. Costa, Luis F. B. Marqueze, Bruna B. Gattiboni, Giulia S. Pedroso, Franciane F. Vasconcellos, Eduardo B. B. Cunha, Hanna C. Justa, Antonielle B. Baldissera, Seigo Nagashima, Lucia de Noronha, Zsolt Radak, Luiz C. Fernandes, Ricardo A. Pinho
Summary: This study evaluated the effects of a physical exercise program on animals with experimental glioblastoma. The results showed that the trained animals exhibited changes in behavior and lower expression of certain proteins related to tumorigenesis. However, no significant alterations were observed in oxidative stress and inflammatory mediators after physical exercise. These findings provide consistent evidence for the relationship between exercise and improvement in tumorigenic parameters against neurotoxicity.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lucas Baena Carstens, Raissa Campos D'amico, Karen Fernandes de Moura, Eduardo Morais de Castro, Flavia Centenaro, Giovanna Silva Barbosa, Guilherme Vieira Cavalcante da Silva, Isadora Brenny, Julio Cesar Honorio D'Agostini, Elisa Carolina Hlatchuk, Sabrina Pissette de Lima, Ana Paula Camargo Martins, Marina De Castro Deus, Carolline Konzen Klein, Ana Paula Kubaski Benevides, Seigo Nagashima, Cleber Machado-Souza, Ricardo A. Pinho, Cristina Pellegrino Baena, Lucia de Noronha
Summary: The activation of the inflammasome complex is significantly increased in COVID-19 patients, indicating its involvement in the pathogenesis of the disease. Additionally, levels of cell pyroptosis and inflammasome-derived cytokines are greatly elevated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Isio Carvalho de Souza, Aline Luri Takejima, Rossana Baggio Simeoni, Luize Kremer Gamba, Victoria Stadler Tasca Ribeiro, Katia Martins Foltz, Lucia de Noronha, Meila Bastos de Almeida, Jose Rocha Faria Neto, Katherine Athayde Teixeira de Carvalho, Paulo Cesar Lock da Silveira, Ricardo Aurino Pinho, Julio Cesar Francisco, Luiz Cesar Guarita-Souza
Summary: This study aimed to evaluate the effect of BMSCs and AM therapeutic strategies on tissue repair and found that AM + BMSCs could promote skin wound healing by promoting the production of new collagen through extracellular signaling.
Article
Engineering, Biomedical
Iago Carvalho Vendramini, Calue Papcke, Pedro Soares da Veiga Neto, Christiano Francisco dos Santos, Ricardo Aurino de Pinho, Eduardo Mendonca Scheeren
Summary: The study aimed to investigate the influence of pre-sarcopenia/sarcopenia on the ability of older adults to recover postural stability during balance perturbation. The results showed that older adults with pre-sarcopenia/sarcopenia required greater ankle plantarflexor activation to remain standing in response to perturbation compared to those without sarcopenia.
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2023)
Article
Immunology
Bruna Spolador de Alencar Silva, Telmo Pereira, Luciele Guerra Minuzzi, Camila Souza Padilha, Caique Figueiredo, Tiago Olean-Oliveira, Ivete Vera Medeiros dos Santos, Ana Elisa von Ah Morano, Osmar Marchioto, Jose Procopio Jabur Ribeiro, Vanessa Ribeiro Dos Santos, Marilia Seelaender, Alexandre Abilio Teixeira, Ronaldo Vagner T. Dos Santos, Valdir de Aquino Lemos, Ana Paula Coelho Figueira Freire, Gilson Pires Dorneles, Bruna Marmett, Andre Olean-Oliveira, Marcos F. S. Teixeira, Patricia M. Seraphim, Armando Caseiro, Ricardo Aurino Pinho, Hashim Islam, Jonathan Peter Little, Karsten Krueger, Jose Cesar Rosa-Neto, Manuel-Joao Coelho-E-Silva, Fabio Santos Lira
Summary: This study aimed to evaluate the association between physical activity and immunometabolic responses in young adults after mild-to-moderate COVID-19 infection. The results showed that COVID-19 patients had lower physical activity levels and exhibited impacts on lung function, immune cell phenotype, and cytokine production.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Luis F. B. Marqueze, Amanda K. Costa, Giulia S. Pedroso, Franciane F. Vasconcellos, Bruna I. Pilger, Schellen Kindermann, Vanessa M. Andrade, Tatyana Nery, Ana C. B. Alves, Aderbal A. Silva, Stephanie R. S. Carvalhal, Matheus F. Zazula, Katya Naliwaiko, Luiz C. Fernandes, Zsolt Radak, Ricardo A. Pinho
Summary: This study investigated the effects of physical training on behavior, redox balance, and genomic stability in models of aggressive brain cancer. The results showed that moderate aerobic exercise could have a beneficial impact on GBM treatment by improving behavior and reducing genomic instability.