Article
Cell Biology
Qingyu Li, Xia Hua, Liangpin Li, Xueyan Zhou, Ye Tian, Yang Deng, Min Zhang, Xiaoyong Yuan, Wei Chi
Summary: This study reveals the role of AIP1 and NOX4 in regulating corneal inflammation and neovascularization after alkali burn injury. The expression of AIP1 is decreased while the expression of clv-IL-1 beta and VEGFa is increased after alkali burns. NOX4 activation is due to decreased AIP1 expression in murine corneas with alkali burns. AIP1-knockout mice show increased NOX4 expression, exacerbated imbalance in NLRP3/NLRP6, and significantly increased corneal neovascularization. These effects are reversed by AIP1 overexpression. Additionally, in the corneal alkali burn murine model, there is an imbalance in NLRP3/NLRP6 expression, with NLRP3 activation and NLRP6 suppression. The use of GLX351322 eye drops as a NOX4 inhibitor can reverse the imbalance in NLRP3/NLRP6 by reducing ROS expression. This treatment also reduces the expression of clv-IL-1 beta and VEGFa, reducing neovascularization. Therefore, new gene therapeutic strategies are provided for patients.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Immunology
Tianye Yang, Xiaoli Wang, Liang Guo, Fang Zheng, Chun Meng, Yongzheng Zheng, Guanghui Liu
Summary: Research has shown that Daphnetin (DAP) can inhibit corneal inflammation and neovascularization caused by alkali burn. DAP acts by suppressing angiogenesis processes and the activation of downstream signaling molecules, and it can also alleviate the inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Ophthalmology
Shengguo Li, Shuizhen Shi, Fan Xia, Ban Luo, Yonju Ha, Jonathan Luisi, Parveen K. Gupta, Kevin H. Merkley, Massoud Motamedi, Hua Liu, Wenbo Zhang
Summary: Corneal neovascularization can cause devastating consequences, and current anti-inflammatory approaches have limited efficacy. This study investigates the role of chemokine receptor CXCR3 in corneal neovascularization after alkali burn. The results demonstrate that CXCR3 plays a key role in regulating leukocyte migration and inhibiting neovascularization in the cornea after alkali burn. This sheds light on the potential development of new therapeutic strategies that specifically target inflammatory pathways to prevent corneal neovascularization.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Immunology
Jianfeng Yu, Yao Shen, Jiawei Luo, Juan Jin, Pengfei Li, Peida Feng, Huaijin Guan
Summary: This study found that upadacitinib can effectively alleviate corneal inflammation and neovascularization caused by alkali burns by inhibiting the infiltration of M1 macrophages. Therefore, upadacitinib may be an effective drug for the treatment of corneal alkali burns.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Ophthalmology
Jiande Li, Jiangyuan Han, Yongpeng Shi, Minrui Liu
Summary: This study found that rapamycin can inhibit corneal inflammation and neovascularization caused by alkali burns by regulating gene expression and suppressing the infiltration of inflammatory cells. This research provides important insights for the development of new drugs to treat alkali burns.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Peihong Wang, Peng Hao, Xi Chen, Linghan Li, Yongying Zhou, Xiaohan Zhang, Lin Zhu, Ming Ying, Ruifang Han, Liming Wang, Xuan Li
Summary: This study found that inhibiting HMGB1 expression with GLY can alleviate inflammation and neovascularization in corneal alkali burn. GLY reduced VEGF expression by inhibiting the HMGB1/NF-kappa B/HIF-1 alpha signaling pathway, resulting in a reduction in corneal neovascularization. In addition, GLY reduced infiltrating inflammatory cells and the expression of inflammatory cytokines. GLY also reduced corneal opacity by inhibiting the extracellular function of HMGB1.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Ophthalmology
Chunlin Lan, Guo Liu, Longxiang Huang, Xizhen Wang, Junkai Tan, Yun Wang, Ning Fan, Yihua Zhu, Man Yu, Xuyang Liu
Summary: This study investigated the effects of Forkhead Domain Inhibitor-6 (FDI-6) on regulating inflammatory corneal angiogenesis and subsequent fibrosis induced by alkali burn. The results showed that FDI-6 significantly attenuated corneal inflammation, neovascularization, and fibrosis. FDI-6 suppressed the expression of angiogenic factors, fibrotic factors, and pro-inflammatory factors. It also inhibited the proliferation, migration, and tube formation of endothelial cells in vitro.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Kai Wang, Li Jiang, Yueyang Zhong, Yin Zhang, Qichuan Yin, Su Li, Xiaobo Zhang, Haijie Han, Ke Yao
Summary: The study identified that Fer-1-NPs exerted remarkable therapeutic effects on corneal alkali burn by suppressing ferroptosis, inflammation, and neovascularization without causing cytotoxicity or adverse reactions, demonstrating good biocompatibility.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Physical
Yuexin Cui, Yan Huo, Zitong Li, Yongkang Qiu, Qi Yang, Zhao Chen, Sijun Fan, Xing Huang, Jianchen Hao, Lei Kang, Ge Liang
Summary: A novel anti-vascular endothelial growth factor (VEGF) single-chain variable fragment (scFv) was developed and evaluated for its anti-inflammatory and anti-corneal neovascularization (CoNV) effects in an alkali burn model. VEGF-scFv showed high specificity and good affinity with VEGF antigen and HUVEC cells. It significantly inhibited CoNV by regulating the VEGF/VEGFR2/STAT3 pathway.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Ophthalmology
Valeria Villabona-Martinez, Lycia Pedral Sampaio, Thomas Michael Shiju, Steven E. Wilson
Summary: Alkali burns are commonly used in corneal wound healing studies. The extent of injury and fibrosis in the cornea depends on whether Descemet's membrane and the endothelium are injured during the initial exposure. A method using filter paper soaked in alkali solution for 15 seconds before irrigation in rabbit corneas showed that higher concentrations of NaOH led to more severe fibrosis and increased likelihood of corneal neovascularization and persistent epithelial defects.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Eunice E. To, Jonathan R. Erlich, Felicia Liong, Stella Liong, Raymond Luong, Osezua Oseghale, Mark A. Miles, Paris C. Papagianis, Kylie M. Quinn, Steven Bozinovski, Ross Vlahos, Robert D. Brooks, John J. O'Leary, Doug A. Brooks, Stavros Selemidis
Summary: The combination of an endosome-targeted NOX2 oxidase inhibitor and a mitochondrial ROS scavenger is more effective than monotherapy in reducing inflammation and improving lung pathology in influenza A virus (IAV) infection. This approach also enhances Type I interferon expression and increases IAV-specific CD8(+) T cells in the lungs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Ophthalmology
Tao Jiang, Chun-Yang Wang, Ying Chen
Summary: This study investigated the role of tetramethylpyrazine (TMP) in corneal alkali burn in rats. The results showed that TMP could ameliorate the pathological damage, inhibit inflammation and neovascularization. These effects were possibly mediated by the suppression of TLR4/NF-κB pathway and NLRP1/NLRP3 inflammasomes.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Medicine, Research & Experimental
Lingling Zhou, Yang Liu, Zhaojia Wang, Daiqi Liu, Bingxin Xie, Yue Zhang, Meng Yuan, Gary Tse, Guangping Li, Gang Xu, Tong Liu
Summary: The study found that NADPH oxidase activity is associated with the occurrence of atrial fibrillation in diabetic patients by promoting adverse atrial remodeling. The drug apocynin can inhibit NADPH oxidase activity, thus improving atrial oxidative stress and mitochondrial dysfunction. It may be a potential drug for atrial fibrillation treatment.
Article
Ophthalmology
Jiande Li, Shaobo Du, Yongpeng Shi, Jiangyuan Han, Zhanyu Niu, Li Wei, Pengfei Yang, Linchi Chen, Huanbing Tian, Lan Gao
Summary: The study investigated the involvement of DNA methylation and the PI3K/AKT/mTOR signaling pathway in alkali-induced corneal injury mechanism. Results showed that rapamycin can significantly reduce corneal opacity and neovascularization by suppressing immune cell infiltration, angiogenesis, myofibroblast differentiation, while promoting corneal cell proliferation and PI3K/AKT/mTOR signaling. Epigenetic regulatory mechanisms by DNA methylation play a crucial role in corneal neovascularization, including alkali burn-induced methylation modification and rapamycin-induced DNA demethylation.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Cell & Tissue Engineering
Mingxiong Chen, Xiaoniao Chen, Xiaoqi Li, Junyi Wang, Jie Wu, Qun Wang, Yifei Huang, Zongjin Li, Liqiang Wang
Summary: Subconjunctival injection of human placental mesenchymal stem cells (hP-MSCs) can protect ocular tissues from damage caused by corneal alkali burns. It reduces inflammation, apoptosis, and promotes corneal repair.
Article
Food Science & Technology
Xiaohua Wang, Wei Gong, Yu Chen, Hao Liu, Ying Liang, Jinshui Wang
Summary: The influence of low-sodium salt on noodle quality was studied, and compared with NaCl and KCl. Low-sodium salt increased cooking loss, hardness, chewiness, tensile strength, and fracture distance of noodles. It enhanced water and non-aqueous components interaction, induced oxidation and strengthened chemical bonds of gluten, and changed the microenvironment of gluten molecules. Scanning electron microscopy images showed a more continuous and compact microstructure of low-sodium salt noodles. Some qualities of low-sodium salt noodles were equivalent to or slightly worse than NaCl noodles, but higher than KCl noodles.
JOURNAL OF TEXTURE STUDIES
(2023)
Article
Cell Biology
Fang Yang, Wen-Zhi Chen, Shi-Shi Jiang, Xiao-Hua Wang, Ren-Shi Xu
Summary: Heterogenous nuclear ribonucleoprotein G is down-regulated in the spinal cord of the amyotrophic lateral sclerosis mouse model, but its effects on disease pathogenesis are unknown. In this study, the expression and distribution of heterogenous nuclear ribonucleoprotein G in the spinal cord were analyzed, and its role in inducing apoptosis was examined using a siRNA-transfected cell model. The findings shed light on the potential mechanisms of heterogenous nuclear ribonucleoprotein G in neuronal death and apoptosis in amyotrophic lateral sclerosis.
NEURAL REGENERATION RESEARCH
(2023)
Article
Psychology, Multidisciplinary
Qing Yang, Kunqiang Zhao, Lanjuan Cao, Xiaohua Wang, Qizhe Guo, Xingxing Liu
Summary: The combination of technology and finance has a significant impact on regional social and economic development. Strategic emerging industries, as the convergence of technological innovation and financial support, are of great significance for industrial structure adjustment and improvement of industrial quality. However, the geographical distribution of emerging strategic industries in China is uneven. Thus, this study investigates the input-output efficiency of science and technology finance integration and examines the path of integrated development of science and technology innovation and financial support. The findings reveal the large demand for financial support and obvious regional differences in the development of strategic emerging industries, with the government playing a strong guiding role. Measures and suggestions for the development of strategic emerging industries are proposed accordingly.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Anesthesiology
XiaoHua Wang, SiYuan Zhang, Chunxiu Wang, Yi Huang, Hao Wu, Guoguang Zhao, TianLong Wang
Summary: This double-blind, randomized controlled trial aimed to evaluate the independent analgesic effect of dexmedetomidine during surgery. The study found that the dexmedetomidine group had a higher rate of achieving the nociception index target and a faster attainment time compared to the midazolam group, with fewer side effects.
BMC ANESTHESIOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Qiqi Lin, Yuhe Zhang, Chenjun Yang, Xiaohua Wang, Tao Lei, Chengwei Ju, Zhanyong Yao, Kai Yao
Summary: Highway widening is an important method to improve the capacity of existing expressways and promote transportation system development. The differential settlement between old and new subgrades is crucial in determining the need for ground improvement. A fluid-structure coupling settlement analysis model was developed and different working conditions were simulated to analyze the influence on differential settlement. The research results provide theoretical value and reference for foundation treatment in roadbed-widening engineering.
Article
Endocrinology & Metabolism
Ming Zhong, Enyi Zhu, Na Li, Lian Gong, Hai Xu, Yong Zhong, Kai Gong, Shan Jiang, Xiaohua Wang, Lingyan Fei, Chun Tang, Yan Lei, Zhongli Wang, Zhihua Zheng
Summary: This study aimed to find key diagnostic markers and therapeutic targets for diabetic kidney disease (DKD) through bioinformatics analysis. Four potential diagnostic markers were identified and their reliability was confirmed through experiments. These results contribute to the understanding and treatment of DKD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiaohua Wang, Shuo Yang, Gansheng He, Lin Xie
Summary: This study aimed to investigate the relationship between weight-adjusted waist index (WWI) and total bone mineral density (BMD) in US adolescents. The results showed a significant negative association between WWI and total BMD, with a non-linear relationship and saturation effect.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Wei Gong, Xiaohua Wang, Fengjiao Wang, Jinshui Wang
Summary: Solvent retention capacity (SRC) is a test used to evaluate the solvation of wheat flour. This study analyzed the correlations between flour quality, gluten aggregation, and solvent retention capacity using ten different commercial wheat flour varieties. The results showed significant correlations between protein content, gluten content, swelling index, and torque values with the solvent retention capacity. These findings provide a theoretical basis for assessing the quality of wheat flour.
Article
Immunology
Hui Guan, Ming Zhong, Kongyang Ma, Chun Tang, Xiaohua Wang, Muzi Ouyang, Rencai Qin, Jiasi Chen, Enyi Zhu, Ting Zhu, Yongping Lu, Yu Liu, Chengzi Tian, Zhihua Zheng
Summary: This study comprehensively investigated the roles and mechanisms of HMGB1 in different tumors. HMGB1 was found to be differentially expressed in many tumors and normal tissues, and was closely related to tumor burden, drug resistance, and various pathways of tumors. HMGB1 may serve as a novel biomarker for predicting tumor prognosis and efficacy of immune checkpoint inhibitors, and a potential target for anti-tumor therapy.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Orthopedics
Xiaohua Wang, Lin Xie, Shuo Yang
Summary: This research investigates the correlation between the weight-adjusted-waist Index (WWI) and the incidence of Rheumatoid Arthritis (RA) and Osteoarthritis (OA). The findings reveal a linear positive correlation between WWI and OA prevalence, and a complex non-linear relationship with RA prevalence.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Environmental Sciences
Xiaohua Wang, Yimeng Wang, Nannan Liu
Summary: The economic differentiation between the north and the south of China is aggravating, and environmental regulation plays a significant role in widening the economic gap. Based on panel data of 285 cities in China from 2004 to 2019, the study finds that environmental regulation has a significant positive impact on narrowing the economic gap between the North and the South, but its effect shows a non-linear relationship.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Medicine, Research & Experimental
Xiaohua Wang, Xiang Shi, Dahua Sun, Meiping Wan
Summary: This case report analyzed the clinical symptoms, fine-needle aspiration cytology, histopathological and immunohistochemical results of a patient with angiolymphoid hyperplasia with eosinophilia (ALHE), and summarized the clinicopathological diagnostic features of the disease. As far as we know, this is the first comprehensive report on the cytological, histopathological and immunophenotypic characteristics of ALHE, which could contribute to a better understanding of this rare proliferative tumor for clinicians.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Clinical Neurology
Xiaohua Wang, Qiyuan Zhu, Zichun Yan, Zhuowei Shi, Yuhui Xu, Yanbing Liu, Yongmei Li
Summary: The volume of choroid plexus (CP) in patients with multiple sclerosis (MS) is larger than that in healthy controls, and it is associated with inflammatory lesions, particularly iron rim lesions (IRLs), and deep gray matter atrophy. Additionally, the larger CP volume is related to higher disability and lower cognitive scores. CP volume may serve as an imaging marker for assessing MS disease activity.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Letter
Medicine, General & Internal
Jiebin Hou, Yabin Zhang, Jie Zhang, Yang Liu, Xiaohua Wang, Zhen Wu, Jiayu Guo, Xiaoli Sun, Qingli Cheng, Qiangguo Ao
CHINESE MEDICAL JOURNAL
(2023)
Article
Optics
Ye Zhe, Yuan Huan, Dingxin Liu, Xiaohua Wang, Aijun Yang, Mingzhe Rong
Summary: In this study, laser-induced breakdown spectroscopy (LIBS) was used to detect particulate matter in transformer oil. Data processing algorithms for baseline correction, dimensionality reduction, and classification of the original data were developed and implemented, improving data-processing efficiency and reducing errors. The results proved the scientificity and robustness of the method and provided a theoretical foundation for LIBS detection of particulate matter in transformer oil.
CHINESE JOURNAL OF LASERS-ZHONGGUO JIGUANG
(2023)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)