Article
Biochemistry & Molecular Biology
Marilesia Ferreira Souza, Ilce Mara Syllos Colus, Aline Simoneti Fonseca, Valquiria Casanova Antunes, Deepak Kumar, Luciane Regina Cavalli
Summary: MiR-182-5p plays a regulatory role in modulating aggressive tumor phenotypes in androgen-refractory prostate cancer cells by targeting epithelial-mesenchymal transition (EMT)-associated pathways.
Editorial Material
Biology
Matthieu Le Hars, Luis Jaime Castro-Vega, Fatemeh Rajabi, David Tabatadze, Martha Romero, Marina Pinskaya, Irina Groisman
Summary: This study identified a novel potential competing endogenous lncRNA, lnc-ZNF30-3, which is highly expressed in prostate cancer and associated with poor prognosis. It was found that lnc-ZNF30-3 can interact with miR-145-5p and inhibit its function, leading to increased migration and metastasis in prostate cancer.
Article
Medicine, Research & Experimental
Zengshu Xing, Sailian Li, Zhenxiang Liu, Chong Zhang, Zhiming Bai
Summary: This study found that circSERPINA3 is up-regulated in PCa cells and inhibits cell apoptosis while promoting aerobic glycolysis and autophagy. Additionally, circSERPINA3 and SERPINA3 were shown to bind to miR-653-5p through competitive binding, with circSERPINA3 stabilizing SERPINA3 mRNA by recruiting BUD13.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Anqi Yan, Guanhao Chen, Jichan Nie
Summary: This study revealed that DGUOK-AS1 promotes proliferation of cervical cancer cells by regulating the miR-653-5p/EMSY pathway. miR-653-5p, which is lowly expressed in cervical cancer cells, is sponged by DGUOK-AS1 and inhibits proliferation of cervical cancer. EMSY, a target gene of miR-653-5p, is regulated by DGUOK-AS1 through sponging miR-653-5p and shows significantly high expression in cervical cancer cells.
CANCER BIOLOGY & THERAPY
(2021)
Article
Cell Biology
Maristella Canovai, Monica Evangelista, Alberto Mercatanti, Romina D'Aurizio, Letizia Pitto, Francesca Marrocolo, Valentina Casieri, Marco Pellegrini, Vincenzo Lionetti, Sergio Bracarda, Milena Rizzo
Summary: In this study, we found that miR-96-5p, miR-183-5p, and miR-210-3p released by DCT resistant PCa clones decrease the efficacy of DCT in PCa cells. These miRNAs were found to interact with genes including FOXO1, IGFBP3, PDCD4, PPP2CB, and INSIG1, affecting the sensitivity of DCT. Additionally, circulating miR-183-5p and miR-21-5p were identified as potential biomarkers for predicting DCT resistance in PCa patients.
CELL DEATH DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Cindy Van Branteghem, Alice Augenlicht, Pieter Demetter, Ligia Craciun, Carine Maenhaut
Summary: Thyroid cancer is a common endocrine malignant tumor with increasing incidence. This study focused on miR-204-5p, which is downregulated in aggressive papillary thyroid carcinoma. Gain-of-function experiments showed that miR-204-5p inhibits cell invasion by regulating targets involved in epithelial-mesenchymal transition. The inhibition of cell invasion is achieved through direct binding and repression of HMGA2. In vivo experiments confirmed the relationship between miR-204-5p and HMGA2, suggesting that targeting HMGA2 holds promise for thyroid cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Duanyang Zhai, Tianfu Li, Runyi Ye, Jiong Bi, Xiaying Kuang, Yawei Shi, Nan Shao, Ying Lin
Summary: This study identified that the lncRNA LGALS8-AS1 is highly expressed in breast cancer and promotes the metastasis of breast cancer cells. LGALS8-AS1 upregulates SOX12 by sponging miR-125b-5p, thus activating the PI3K/AKT signaling pathway to facilitate breast cancer metastasis. The reciprocal regulatory loop of LGALS8-AS1/miR-125b-5p/SOX12 may serve as a potential therapeutic target for breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Mei Zhang, Hongwei Wang, Xiaomei Zhang, Fengping Liu
Summary: miR-653-5p functions as a tumor suppressor in breast cancer, inhibiting cell proliferation and invasion by targeting MAPK6. This study suggests that miR-653-5p may be a potential target for breast cancer therapy.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Carmela Ferri, Anna Di Biase, Marco Bocchetti, Silvia Zappavigna, Sarah Wagner, Pauline Le Vu, Amalia Luce, Alessia Maria Cossu, Jayakumar Vadakekolathu, Amanda Miles, David J. Boocock, Alex Robinson, Melanie Schwerdtfeger, Virginia Tirino, Federica Papaccio, Michele Caraglia, Tarik Regad, Vincenzo Desiderio
Summary: This study found that MALAT1 expression is associated with high Gleason grade, metastasis occurrence, and reduced survival in PCa patients. The study also revealed a direct interaction between miR-423-5p and MALAT1, which inhibits MALAT1's activity and suppresses cell proliferation, migration, and invasion in PCa.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Jingpeng Liu, Xiao Jiang, Ailing Zou, Zhaoyi Mai, Zhijie Huang, Liying Sun, Jianjiang Zhao
Summary: The study identified a unique circRNA, circIGHG, which is significantly upregulated in oral squamous cell carcinoma (OSCC) and associated with poor prognosis. It promotes OSCC invasion and metastasis by interacting with miR-142-5p and IGF2BP3, with epithelial-mesenchymal transition being the main mechanism. These findings suggest that circIGHG could serve as a biomarker and therapeutic target for early diagnosis and treatment of OSCC.
Article
Biotechnology & Applied Microbiology
Ziyu Liang, Shaomei Tang, Rongquan He, Wei Luo, Shanyu Qin, Haixing Jiang
Summary: miR-30e-5p expression is downregulated in pancreatic cancer and inhibits cell growth, invasion, migration, EMT, and promotes apoptosis. It may function through the SNAI1/EMT axis.
Article
Biochemistry & Molecular Biology
Sugang Ma, Hui Wei, Chunyan Wang, Jixia Han, Xiumin Chen, Yang Li
Summary: The study revealed the association and functional roles of miR-26b-5p and MYCBP in TNBC, showing that miR-26b-5p directly targets MYCBP to inhibit its expression, leading to suppressed proliferation, migration, and invasion of TNBC cells.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Cell Biology
Tao Yang, Jufeng Sun, Wei Wang, Dongsheng Li, Xianxu Yang, Ang Jia, Yinda Ma, Zhongkai Fan
Summary: This study found that hsa_circ_0006732 is highly expressed in colorectal cancer and plays a role in promoting cancer cell proliferation, migration, and invasion through regulation of the miR-127-5p/RAB3D axis. Therefore, hsa_circ_0006732 may serve as a potential therapeutic target for the treatment of colorectal cancer.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Xiang Chen, Yao Xu, Zhengyang Zhou, Ping Zhao, Zhou Zhou, Feng Wang, Fengyun Zhong, Hong Du
Summary: This study found that the circular RNA circUSP10 is upregulated in liver cancer and is associated with tumor size, lymph node metastasis staging, and prognosis. CircUSP10 promotes liver cancer progression by modulating the miR-211-5p/TCF12/EMT signaling cascade, suggesting it may serve as a potential biomarker for diagnosis and prognosis of liver cancer.
Article
Biochemistry & Molecular Biology
Yu-Ting Yen, Jou-Chun Yang, Jiun-Bo Chang, Shih-Chang Tsai
Summary: miR-194-5p plays a regulatory role in breast cancer, and is associated with the epithelial-mesenchymal transition and metastasis of breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Lei Zhang, Biwei Ye, Zhuo Chen, Zhe-Sheng Chen
Summary: Chemotherapy is an important method for treating cancer, but multi-drug resistance (MDR) is a major reason for its failure. Almost all anti-tumor drugs develop drug resistance over time, reducing their effectiveness in killing cancer cells. Chemoresistance can lead to rapid cancer recurrence and patient death.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Chemistry, Multidisciplinary
Shaowen Xie, Feiyan Zhan, Jingjie Zhu, Yuan Sun, Huajian Zhu, Jie Liu, Jian Chen, Zheying Zhu, Dong-Hua Yang, Zhe-Sheng Chen, Hong Yao, Jinyi Xu, Shengtao Xu
Summary: Hydrophobic tagging (HyT) is a potential therapeutic strategy for targeted protein degradation (TPD). In this study, norbornene was discovered as an unprecedented hydrophobic tag and successfully used to degrade ALK fusion protein and EZH2. The most promising degrader, Hyt-9, showed effective reduction of ALK levels without compensatory upregulation of ALK in vitro and exhibited significant tumor inhibition effect in vivo with moderate oral bioavailability. The discovery of novel hydrophobic norbornene tags shows promise for the future development of TPD technology.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Yi Li, Yunchun Luo, Jing Wang, Hao Shi, Jun Liao, Yan Wang, Zhesheng Chen, Liyan Xiong, Chuan Zhang, Tingfang Wang
Summary: Novel danshensu derivatives with dual antioxidant effects were synthesized for the treatment of ischemic stroke. Del03 exhibited the strongest dose-dependent neuroprotective activity in vitro, reduced oxidative stress and promoted Nrf2 translocation.
BIOORGANIC CHEMISTRY
(2023)
Editorial Material
Pharmacology & Pharmacy
Ting Wang, Zhe-Sheng Chen, Chen Shi, Liang Ouyang, Hongtao Xiao
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Tingting Guo, Zixu Sa, Pengfei Wei, Yuxuan Jian, Xiang Chen, Zhesheng Chen, Jose Avila, Pavel Dudin, Zai-xing Yang, Xiufeng Song, Fengjing Liu, Shengli Zhang
Summary: Flexible broadband optoelectronic devices have great potential in various applications such as wearable optoelectronic systems, health care, and bio-imaging systems. This study demonstrates a high-performance photodetector based on Ta2NiSe5 nanosheets, which exhibit adjustable bandgap and excellent optical and electrical properties. The photodetector shows broad photodetection capability in the visible-infrared spectrum and retains its performance after bending cycles, indicating the great potential of 2D Ta2NiSe5 semiconductor in future wearable IR optoelectronic devices.
Article
Chemistry, Multidisciplinary
Yutian Zou, Feng Ye, Yanan Kong, Xiaoqian Hu, Xinpei Deng, Jindong Xie, Cailu Song, Xueqi Ou, Song Wu, Linyu Wu, Yi Xie, Wenwen Tian, Yuhui Tang, Chau-Wei Wong, Zhe-Sheng Chen, Xinhua Xie, Hailin Tang
Summary: This study utilizes single-cell RNA sequencing to construct a high-resolution map of the tumor ecosystem in liver and brain metastases of breast cancer. The results show remarkable reprogramming of immunosuppressive cells in the metastatic ecosystem, as well as the negligible expression of PD-1 and PD-L1/2 in CD8+ T cells and cancer/immune/stromal cells. The interactions between LAG3-LGALS3 and TIGIT-NECTIN2 are found to play dominant roles in immune escape.
Article
Chemistry, Multidisciplinary
Xin Peng, Shaolu Zhang, Yingying Wang, Zhicheng Zhou, Zixiang Yu, Zhenxing Zhong, Liang Zhang, Zhe-Sheng Chen, Francois X. Claret, Moshe Elkabets, Feng Wang, Fan Sun, Ran Wang, Han Liang, Hou-Wen Lin, Dexin Kong
Summary: The triterpene compound STELB enhances the sensitivity of GBM to DNA-damaging treatments by inhibiting the expression of HR factors and can penetrate the blood-brain barrier to exert anti-GBM effects.
Review
Pharmacology & Pharmacy
Jia Fu, Wei Qin, Lu-Qi Cao, Zhe-Sheng Chen, Hui-Ling Cao
Summary: This review summarizes the applications and immobilization methods of receptor chromatography, which is widely used for high-throughput separation and accurate drug screening. The review focuses on screening active compounds in natural products, as well as the design and application of receptor chromatography in drug-receptor interactions.
DRUG DISCOVERY TODAY
(2023)
Review
Pharmacology & Pharmacy
Juan Jin, Yuhao Xie, Jin-Shi Zhang, Jing-Quan Wang, Shi-Jie Dai, Wen-fang He, Shou-Ye Li, Charles R. Ashby Jr, Zhe-Sheng Chen, Qiang He
Summary: Renal cell carcinoma (RCC) is the most prevalent type of kidney cancer, and targeted therapy with Sunitinib has become the main treatment option due to the lack of efficacy in radiation therapy and chemotherapy. However, many patients develop resistance to Sunitinib within months of therapy. In this review, we discuss the molecular mechanisms of Sunitinib resistance, strategies to overcome it, and potential predictive biomarkers.
DRUG RESISTANCE UPDATES
(2023)
Review
Pharmacology & Pharmacy
Jiaqi Xuan, Weiguo Feng, Jiaye Wang, Ruichen Wang, Bowen Zhang, Letao Bo, Zhe-Sheng Chen, Hui Yang, Leming Sun
Summary: The long-term use of antibiotics leading to drug resistance has become a major concern. As the problem worsens, infections caused by multiple bacteria are increasing rapidly and posing serious threats to human health. Antimicrobial peptides (AMPs) offer a promising alternative to traditional antibiotics as they exhibit strong antimicrobial activity and unique mechanisms against drug-resistant bacterial infections. Current research on AMPs focuses on integrating new technologies, such as modifying the amino acid structure and exploring different delivery methods. This article provides valuable insights into the properties, mechanisms, and advancements of AMPs in combating drug-resistant bacterial infections.
DRUG RESISTANCE UPDATES
(2023)
Article
Chemistry, Medicinal
Xinnan Li, Xiaotong Ze, Shengnan Zhou, Zhaoxin Hu, Chen He, Yilin Jia, Lihua Liu, Tao Wang, Junda Li, Shengtao Xu, Dong-Hua Yang, Zhe-Sheng Chen, Hequan Yao, Jinyi Xu, Hong Yao
Summary: A novel compound D26, identified through the exploration and optimization of the first-in-class POLRMT inhibitor IMT1B, exhibits a strong antiproliferative effect on cancer cells and decreases mitochondrial-related gene expression. Mechanism studies revealed that D26 arrests the cell cycle at the G1 phase without affecting apoptosis, mitochondrial depolarization, or reactive oxidative stress generation. In vivo studies further demonstrated that D26 has more potent anticancer activity than the lead compound IMT1B, and no toxicity was observed.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Longyang Liu, Chunlin Chen, Ping Liu, Jing Li, Zhanjun Pang, Jiayu Zhu, Zhongqiu Lin, Haixu Zhou, Yingying Xie, Tiancai Lan, Zhe-Sheng Chen, Zhaoyang Zeng, Weiyi Fang
Summary: In this study, the expression and function of MYH10 in serous ovarian cancer (SOC) were investigated. It was found that MYH10 is associated with the invasive capacity and cisplatin resistance of SOC cells. Further experiments revealed that MYH10 interacts with MYH9 to promote tumorigenesis, progression, and cisplatin resistance in SOC. Clinical samples also showed elevated expression of MYH10 in SOC samples, which correlated positively with MYH9 expression. Co-expression of MYH10+/MYH9+ was identified as an independent prognostic factor for SOC patient survival.
Editorial Material
Immunology
Jingxian Chen, Zhesheng Chen, Barkat Ali Khan, Kaijian Hou
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Letao Bo, Youyou Wang, Yidong Li, John N. D. Wurpel, Zoufang Huang, Zhe-Sheng Chen
Summary: The survival rate for pediatric cancers has significantly improved in recent years. Conventional chemotherapy is crucial, especially in low- and middle-income countries with limited access to advanced treatments. Despite the expanded FDA approval of chemotherapy drugs for children, patients still face side effects and multidrug resistance remains a major challenge. This review focuses on the severe side effects of pediatric chemotherapy, mechanisms of multidrug resistance, and potential therapeutic options offered by drug transporters in pediatric tumors.
Article
Oncology
Chong Wang, Tao Wang, Kang-Jing Li, Ling-Hong Hu, Yue Li, Yu-Zhong Yu, Tao Xie, Sha Zhu, Du-Jiang Fu, Yang Wang, Xian-Zi Zeng, Feng-Ping Liu, Hong Chen, Zhe-Sheng Chen, Ning-Han Feng, Jinghua Liu, Yong Jiang, Shan-Chao Zhao
Summary: The SETD4 protein plays a crucial role in prostate cancer by catalyzing histone lysine methylation and suppressing NUPR1 transcription, leading to the inhibition of Akt signaling pathway and preventing PCa development.