SETD4 inhibits prostate cancer development by promoting H3K27me3-mediated NUPR1 transcriptional repression and cell cycle arrest

EZH2 and NF-κB: A context-dependent crosstalk and transcriptional regulation in cancer

(2023) Parminder Kaur et al.   CANCER LETTERS

Current therapy and drug resistance in metastatic castration-resistant prostate cancer

(2023) Maoping Cai et al.   DRUG RESISTANCE UPDATES

KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis

(2022) Tanja Limberger et al.   Molecular Cancer

SETD4-mediated KU70 methylation suppresses apoptosis

(2022) Yuan Wang et al.   Cell Reports

CircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322/CCL20/CCR6 signaling

(2022) Tao Xie et al.   Molecular Cancer

SETD4 cells contribute to brain development and maintain adult stem cell reservoir for neurogenesis

(2022) Sun-Li Cai et al.   Stem Cell Reports

Embryogenic stem cell-derived intestinal crypt fission directs de novo crypt genesis

(2022) Xue-Ting Huang et al.   Cell Reports

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury

(2021) Jin-Ze Tian et al.   Scientific Reports

Experimental challenges to modeling prostate cancer heterogeneity

(2021) Teresita del N.J. Flores-Téllez et al.   CANCER LETTERS

Prostate cancer dormancy and recurrence

(2021) Frank C. Cackowski et al.   CANCER LETTERS

Non-histone methylation of SET7/9 and its biological functions

(2021) Lili Gao et al.   Recent Patents on Anti-Cancer Drug Discovery

NUPR1 Silencing Induces Autophagy-Mediated Apoptosis in Multiple Myeloma Cells Through the PI3K/AKT/mTOR Pathway

(2020) Anmao Li et al.   DNA AND CELL BIOLOGY

The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling

(2020) Boris Y. Shorning et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SET domain-containing protein 4 epigenetically controls breast cancer stem cell quiescence

(2019) Sen Ye et al.   CANCER RESEARCH

The novel methyltransferase SETD4 regulates TLR agonist-induced expression of cytokines through methylation of lysine 4 at histone 3 in macrophages

(2019) Yuyun Zhong et al.   MOLECULAR IMMUNOLOGY

Loss of Setd4 delays radiation-induced thymic lymphoma in mice

(2019) Xing Feng et al.   DNA REPAIR

Intratumoral and Intertumoral Genomic Heterogeneity of Multifocal Localized Prostate Cancer Impacts Molecular Classifications and Genomic Prognosticators

(2017) Lei Wei et al.   EUROPEAN UROLOGY

N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer

(2016) Etienne Dardenne et al.   CANCER CELL

SETD4 Regulates Cell Quiescence and Catalyzes the Trimethylation of H4K20 during Diapause Formation in Artemia

(2016) Li Dai et al.   MOLECULAR AND CELLULAR BIOLOGY

Epigenetic Determinants of Cancer

(2016) Stephen B. Baylin et al.   Cold Spring Harbor Perspectives in Biology

Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer

(2016) Akash K. Kaushik et al.   Nature Communications

Epigenetic modulators as therapeutic targets in prostate cancer

(2016) Inês Graça et al.   Clinical Epigenetics

Androgen deprivation of prostate cancer: Leading to a therapeutic dead end

(2015) Arndt Katzenwadel et al.   CANCER LETTERS

Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity

(2013) S. Jorgensen et al.   NUCLEIC ACIDS RESEARCH

Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance

(2012) Andrew J. Vincent et al.   FEBS LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma

(2009) Li-Ru He et al.   BMC CANCER

Emerging role of nuclear protein 1 (NUPR1) in cancer biology

(2009) Uttio Roy Chowdhury et al.   CANCER AND METASTASIS REVIEWS

DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

(2008) D. J. Steger et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers

(2008) Yongkun Wei et al.   MOLECULAR CARCINOGENESIS