Engineered exosomes as an in situ DC-primed vaccine to boost antitumor immunity in breast cancer

Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

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Engineered Tumor-Derived Extracellular Vesicles: Potentials in Cancer Immunotherapy

(2020) Adeleh Taghikhani et al.   Frontiers in Immunology

Metabolic labeling and targeted modulation of dendritic cells

(2020) Hua Wang et al.   NATURE MATERIALS

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19

(2020) Vikram Sengupta et al.   STEM CELLS AND DEVELOPMENT

IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer

(2020) Margaux Hubert et al.   Science Immunology

Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis

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cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity

(2020) Stephen T. Ferris et al.   NATURE

Antitumour dendritic cell vaccination in a priming and boosting approach

(2020) Alexandre Harari et al.   NATURE REVIEWS DRUG DISCOVERY

Gold/alpha-lactalbumin nanoprobes for the imaging and treatment of breast cancer

(2020) Jiang Yang et al.   Nature Biomedical Engineering

CDK12/13 inhibition induces immunogenic cell death and enhances anti-PD-1 anticancer activity in breast cancer

(2020) Yi Li et al.   CANCER LETTERS

Tumor Heterogeneity Correlates with Less Immune Response and Worse Survival in Breast Cancer Patients

(2019) Kerry-Ann McDonald et al.   ANNALS OF SURGICAL ONCOLOGY

Exosomes: cell-created drug delivery systems

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Vaccine Therapies for Breast Cancer

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Personalized Dendritic Cell Vaccines—Recent Breakthroughs and Encouraging Clinical Results

(2019) Beatris Mastelic-Gavillet et al.   Frontiers in Immunology

A multipeptide vaccine plus toll-like receptor agonists LPS or polyICLC in combination with incomplete Freund’s adjuvant in melanoma patients

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cGAS/STING axis mediates a topoisomerase II inhibitor–induced tumor immunogenicity

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(2019) Chiara M. Cattaneo et al.   Nature Protocols

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2019) Zhaogang Yang et al.   Nature Biomedical Engineering

Combined immunotherapy encompassing intratumoral poly-ICLC, dendritic-cell vaccination and radiotherapy in advanced cancer patients

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Developing a xenograft human tumor model in immunocompetent mice

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A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Therapeutic Immune Modulation Against Solid Cancers with Intratumoral Poly-ICLC: A Pilot Trial

(2018) Chrisann Kyi et al.   CLINICAL CANCER RESEARCH

Therapeutically active RIG-I agonist induces immunogenic tumor cell killing in breast cancers

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Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

The Journey of in vivo Virus Engineered Dendritic Cells From Bench to Bedside: A Bumpy Road

(2018) Cleo Goyvaerts et al.   Frontiers in Immunology

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Molecular alterations in triple-negative breast cancer—the road to new treatment strategies

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Integrating Next-Generation Dendritic Cell Vaccines into the Current Cancer Immunotherapy Landscape

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Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

(2017) Michel Enamorado et al.   Nature Communications

Dendritic Cell-Based Immunotherapy: State of the Art and Beyond

(2016) K. F. Bol et al.   CLINICAL CANCER RESEARCH

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

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Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models

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Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

(2016) Nambin Yim et al.   Nature Communications

Inherited Mutations in 17 Breast Cancer Susceptibility Genes Among a Large Triple-Negative Breast Cancer Cohort Unselected for Family History of Breast Cancer

(2015) Fergus J. Couch et al.   JOURNAL OF CLINICAL ONCOLOGY

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

(2015) Robert H.I. Andtbacka et al.   JOURNAL OF CLINICAL ONCOLOGY

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

(2015) Benjamin Besse et al.   OncoImmunology

Therapeutic vaccines for cancer: an overview of clinical trials

(2014) Ignacio Melero et al.   Nature Reviews Clinical Oncology

Induction of Antigen-Specific Immunity with a Vaccine Targeting NY-ESO-1 to the Dendritic Cell Receptor DEC-205

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Up to 15-year clinical follow-up of a pilot Phase III immunotherapy study in stage II breast cancer patients using oxidized mannan–MUC1

(2013) Stamatis Vassilaros et al.   Immunotherapy

Similar antigen cross-presentation capacity and phagocytic functions in all freshly isolated human lymphoid organ–resident dendritic cells

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An autoimmune-mediated strategy for prophylactic breast cancer vaccination

(2010) Ritika Jaini et al.   NATURE MEDICINE

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

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